Protein: SAHH
Adenosylhomocysteinase (AdoHcyase) (EC 3.13.2.1) (S-adenosyl-L-homocysteine hydrolase)

Gene: SAHH, Ahcy
Organism: Drosophila melanogaster
Interactions: 112
UniProt ID: Q27580

Gene Ontology (top 5):
GO:0004013 - adenosylhomocysteinase activity
GO:0005829 - cytosol
GO:0006730 - one-carbon metabolic process
GO:0033353 - S-adenosylmethionine cycle

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1176704

SAHH
Adenosylhomocysteinase

1

10

Small-scale

0.618

High

1176770

SAHH2
Adenosylhomocysteinase-like 1

1

10

Small-scale

0.618

High

1176710

Q8INX1
Uncharacterized protein

2

2

High-throughput

0.521

High

829710

ARF6
ADP-ribosylation factor 6

1

0

High-throughput

0.518

High

1176760

PYRG
CTP synthase

1

1

High-throughput

0.479

High

304964

CRY1
Cryptochrome-1

1

0

High-throughput

0.458

High

121218

ALDR
Aldo-keto reductase 1B

1

4

High-throughput

0.445

High

578072

ENO
Enolase

1

1

High-throughput

0.445

High

835138

6PGD
6-phosphogluconate dehydrogenase, decarboxylating

1

1

High-throughput

0.445

High

855999

MOEH
Moesin/ezrin/radixin homolog 1

1

3

High-throughput

0.445

High

1176711

Q8IQZ7
FI19014p1

1

1

High-throughput

0.445

High

1176724

PSA3
Proteasome subunit alpha type-3

1

1

High-throughput

0.445

High

1176731

Q9VH81
protein-serine/threonine phosphatase

1

2

High-throughput

0.445

High

1176735

Q9VHX4
LD24679p

1

4

High-throughput

0.445

High

1176741

Q9VKW5
Prolyl endopeptidase

1

1

High-throughput

0.445

High

1176742

EF1D
Probable elongation factor 1-delta

1

2

High-throughput

0.445

High

1176747

AK200
A-kinase anchor protein 200

1

3

High-throughput

0.445

High

1176750

PSB4
Proteasome subunit beta type-4

1

2

High-throughput

0.445

High

1176758

Q9VTY2
Uncharacterized protein, isoform A

1

4

High-throughput

0.445

High

1176759

Q9VUC1
Hsc70Cb, isoform A

1

2

High-throughput

0.445

High

1176768

CLIC
Chloride intracellular channel Clic

1

1

High-throughput

0.445

High

1176780

Q9Y112
BcDNA.GH10614

1

4

High-throughput

0.445

High

1176719

Q9N6D8
GH11591p

1

3

High-throughput

0.437

High

54000

A1Z892
1-Cys peroxiredoxin

1

0

High-throughput

0.426

High

357285

O97428
Ciboulot, isoform A

1

0

High-throughput

0.426

High

460038

ALF
Fructose-bisphosphate aldolase

1

0

High-throughput

0.426

High

556662

PSA1
Proteasome subunit alpha type-1

1

0

High-throughput

0.426

High

611478

PSA4
Proteasome subunit alpha type-4

1

0

High-throughput

0.426

High

874640

RIR2
Ribonucleoside-diphosphate reductase subunit M2

1

0

High-throughput

0.426

High

1031180

PGK
Phosphoglycerate kinase

1

0

High-throughput

0.426

High

1176706

Q7K148
Proteasome subunit beta

1

0

High-throughput

0.426

High

1176709

Q8INK3
Fatty acid-binding protein, muscle

1

0

High-throughput

0.426

High

1176712

Q8IRD3
Glutathione peroxidase

1

0

High-throughput

0.426

High

1176713

Q8MT58
Carnosine dipeptidase 2, isoform A

1

0

High-throughput

0.426

High

1176718

PUR6
Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase

1

0

High-throughput

0.426

High

1176726

Q9VAN7
Phosphoglycerate mutase

1

0

High-throughput

0.426

High

1176727

Q9VCK6
LD34157p

1

0

High-throughput

0.426

High

1176729

Q9VG31
Malic enzyme

1

0

High-throughput

0.426

High

1176732

TEBPH
Cytosolic Prostaglandin E synthase

1

0

High-throughput

0.426

High

1176733

Q9VHN7
transketolase

1

0

High-throughput

0.426

High

1176734

DPP3
Dipeptidyl peptidase 3

1

0

High-throughput

0.426

High

1176736

Q9VIE8
Aconitate hydratase, mitochondrial

1

0

High-throughput

0.426

High

1176737

Q9VII9
Glyoxylate reductase/hydroxypyruvate reductase

1

0

High-throughput

0.426

High

1176746

Q9VLB7
Rab GDP dissociation inhibitor

1

0

High-throughput

0.426

High

1176754

Q9VRL1
GEO06356p1

1

0

High-throughput

0.426

High

1176756

Q9VSI6
Isocitrate dehydrogenase [NADP]

1

0

High-throughput

0.426

High

1176763

Q9VW59
Rho GDP-dissociation inhibitor 3

1

0

High-throughput

0.426

High

1176766

Q9VXF9
AT13091p

1

0

High-throughput

0.426

High

1176772

SND1
Staphylococcal nuclease domain-containing protein 1

1

0

High-throughput

0.426

High

648885

ANXB9
Annexin B9

1

1

High-throughput

0.407

High

649032

ANX10
Annexin B10

1

1

High-throughput

0.407

High

762539

UCHL
Ubiquitin carboxyl-terminal hydrolase

1

3

High-throughput

0.407

High

1052223

HMGD
High mobility group protein D

1

2

High-throughput

0.407

High

1176715

Q8T0L3
E1 ubiquitin-activating enzyme

1

1

High-throughput

0.407

High

1176722

Q9V3V2
peptidylprolyl isomerase

1

3

High-throughput

0.407

High

1176730

Q9VGK3
peptidylprolyl isomerase

1

3

High-throughput

0.407

High

1176738

Q9VJD4
LD24721p

1

1

High-throughput

0.407

High

1176740

Q9VKB0
threonine--tRNA ligase

1

1

High-throughput

0.407

High

1176745

FKB59
FK506-binding protein 59

1

2

High-throughput

0.407

High

1176751

Q9VPN5
Stress-induced-phosphoprotein 1

1

2

High-throughput

0.407

High

1176757

Q9VSL2
Glutathione S transferase O3

1

1

High-throughput

0.407

High

1176773

Q9W227
Peptidyl-prolyl cis-trans isomerase

1

1

High-throughput

0.407

High

1176777

Q9W457
Serine hydroxymethyltransferase

1

1

High-throughput

0.407

High

1171960

HID
Cell death protein hid

1

0

High-throughput

0.265

Low

1176707

ACOX1
Acyl-coenzyme A oxidase 1

1

0

High-throughput

0.265

Low

1176739

MABI
Protein Mabiki

1

0

High-throughput

0.265

Low

1176764

OSGP2
Probable tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial

1

0

High-throughput

0.265

Low

1069699

Q0E924
Prohibitin

1

0

High-throughput

0.238

Low

56147

A1Z9X4
Hibris, isoform B

1

0

High-throughput

0.232

Low

57550

A1ZB71
Glutathione S transferase E6

1

0

High-throughput

0.232

Low

57771

A1ZB77
Uncharacterized protein, isoform J

1

0

High-throughput

0.232

Low

145958

UGDH
UDP-glucose 6-dehydrogenase

1

0

High-throughput

0.232

Low

195029

O16043
Anon1A4

1

0

High-throughput

0.232

Low

197760

HCD2
3-hydroxyacyl-CoA dehydrogenase type-2

1

0

High-throughput

0.232

Low

234559

VINC
Vinculin

1

0

High-throughput

0.232

Low

356541

O97121
cystathionine gamma-lyase

1

0

High-throughput

0.232

Low

357496

INO1
Inositol-3-phosphate synthase

1

0

High-throughput

0.232

Low

476937

NDKA
Nucleoside diphosphate kinase

1

0

High-throughput

0.232

Low

609386

PCNA
Proliferating cell nuclear antigen

1

0

High-throughput

0.232

Low

682739

PROF
Profilin

1

0

High-throughput

0.232

Low

930130

VATE
V-type proton ATPase subunit E

1

0

High-throughput

0.232

Low

1026626

SODM
Superoxide dismutase [Mn], mitochondrial

1

0

High-throughput

0.232

Low

1171806

ATPB2
Sodium/potassium-transporting ATPase subunit beta-2

1

0

High-throughput

0.232

Low

1176705

Q76NR6
Regucalcin

1

0

High-throughput

0.232

Low

1176708

Q7KTW5
Inositol-1-monophosphatase

1

0

High-throughput

0.232

Low

1176714

Q8STA5
Histidine triad nucleotide binding protein 1, isoform A

1

0

High-throughput

0.232

Low

1176716

NACA
Nascent polypeptide-associated complex subunit alpha

1

0

High-throughput

0.232

Low

1176717

FAXC
Failed axon connections

1

0

High-throughput

0.232

Low

1176720

SH3BG
SH3 domain-binding glutamic acid-rich protein homolog

1

0

High-throughput

0.232

Low

1176721

Q9V3I1
Deoxyuridine 5'-triphosphate nucleotidohydrolase

1

0

High-throughput

0.232

Low

1176723

Q9V3V9
Endonuclease G inhibitor, isoform A

1

0

High-throughput

0.232

Low

1176725

Q9V9U3
LD45254p

1

0

High-throughput

0.232

Low

1176728

Q9VEB1
Malate dehydrogenase, mitochondrial

1

0

High-throughput

0.232

Low

1176743

Q9VL68
Enoyl-CoA delta isomerase 1, mitochondrial

1

0

High-throughput

0.232

Low

1176744

Q9VL70
HL08109p

1

0

High-throughput

0.232

Low

1176748

Q9VLS7
LD21067p

1

0

High-throughput

0.232

Low

1176749

ITPA
Inosine triphosphate pyrophosphatase

1

0

High-throughput

0.232

Low

1176752

Q9VPX6
Adenylyl cyclase-associated protein

1

0

High-throughput

0.232

Low

1176753

Q9VQ61
Aspartate aminotransferase

1

0

High-throughput

0.232

Low

1176755

Q9VRP2
Uncharacterized protein, isoform A

1

0

High-throughput

0.232

Low

1176761

Y9705
Cold shock domain-containing protein CG9705

1

0

High-throughput

0.232

Low

1176762

Q9VVL7
Dihydrolipoyl dehydrogenase

1

0

High-throughput

0.232

Low

1176765

Q9VWQ7
Coactosin-like protein

1

0

High-throughput

0.232

Low

1176767

DHB4
Peroxisomal multifunctional enzyme type 2

1

0

High-throughput

0.232

Low

1176769

TXND5
Thioredoxin domain-containing protein 5 homolog

1

0

High-throughput

0.232

Low

1176771

Q9W0H8
Reticulocalbin-3

1

0

High-throughput

0.232

Low

1176774

Q9W3X6
fumarate hydratase

1

0

High-throughput

0.232

Low

1176775

Q9W3Y3
Calcyclin-binding protein

1

0

High-throughput

0.232

Low

1176776

CISY
Probable citrate synthase, mitochondrial

1

0

High-throughput

0.232

Low

1176778

NSUN2
tRNA

1

0

High-throughput

0.232

Low

1176779

PURA
Adenylosuccinate synthetase

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025