Protein: Q9W457
Serine hydroxymethyltransferase (EC 2.1.2.1)

Gene: Q9W457, Shmt
Organism: Drosophila melanogaster
Interactions: 195
UniProt ID: Q9W457

Gene Ontology (top 5):
GO:0004372 - glycine hydroxymethyltransferase activity
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005739 - mitochondrion
GO:0005759 - mitochondrial matrix

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

119440

M9NFI9
Neurabin-1

1

0

High-throughput

0.464

High

1481193

Q9VLS7
LD21067p

1

0

High-throughput

0.464

High

1010822

KAPR2
cAMP-dependent protein kinase type II regulatory subunit

1

1

High-throughput

0.457

High

1285493

MMD4
Modifier of mdg4

1

1

High-throughput

0.457

High

47826

A0AQH0
Proteasome subunit beta

1

1

High-throughput

0.445

High

57692

A1ZB71
Glutathione S transferase E6

1

1

High-throughput

0.445

High

121371

ALDR
Aldo-keto reductase 1B

1

4

High-throughput

0.445

High

356487

O97102
Small ubiquitin-related modifier

1

2

High-throughput

0.445

High

477086

NDKA
Nucleoside diphosphate kinase

1

1

High-throughput

0.445

High

556824

PSA1
Proteasome subunit alpha type-1

1

1

High-throughput

0.445

High

561868

MODU
DNA-binding protein modulo

1

2

High-throughput

0.445

High

609518

PCNA
Proliferating cell nuclear antigen

1

1

High-throughput

0.445

High

611570

PSA4
Proteasome subunit alpha type-4

1

1

High-throughput

0.445

High

648993

ANXB9
Annexin B9

1

1

High-throughput

0.445

High

649165

ANX10
Annexin B10

1

1

High-throughput

0.445

High

652819

PSA71
Proteasome subunit alpha type-7-1

1

1

High-throughput

0.445

High

712461

CALR
Calreticulin

1

1

High-throughput

0.445

High

762681

UCHL
Ubiquitin carboxyl-terminal hydrolase

1

3

High-throughput

0.445

High

871738

FKB12
Peptidyl-prolyl cis-trans isomerase Fkbp12

1

3

High-throughput

0.445

High

929624

PDI
Protein disulfide-isomerase

1

3

High-throughput

0.445

High

1019708

TRXR1
Thioredoxin reductase 1, mitochondrial

1

2

High-throughput

0.445

High

1052318

HMGD
High mobility group protein D

1

2

High-throughput

0.445

High

1052530

ATPB
ATP synthase subunit beta, mitochondrial

1

1

High-throughput

0.445

High

1176658

NLP
Nucleoplasmin-like protein

1

1

High-throughput

0.445

High

1263116

Q7JXC4
CG6459 protein

1

1

High-throughput

0.445

High

1264771

Q7K148
Proteasome subunit beta

1

1

High-throughput

0.445

High

1268018

TERA
Transitional endoplasmic reticulum ATPase TER94

1

2

High-throughput

0.445

High

1305819

Q8IQZ7
FI19014p1

1

1

High-throughput

0.445

High

1322024

Q8MYY7
RE44624p

1

2

High-throughput

0.445

High

1343101

Q8STA5
Histidine triad nucleotide binding protein 1, isoform A

1

2

High-throughput

0.445

High

1343387

OLA1
Obg-like ATPase 1

1

1

High-throughput

0.445

High

1374648

NACA
Nascent polypeptide-associated complex subunit alpha

1

1

High-throughput

0.445

High

1374814

SUCA
Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial

1

1

High-throughput

0.445

High

1377754

FAXC
Failed axon connections

1

1

High-throughput

0.445

High

1465104

THIO2
Thioredoxin-2

1

2

High-throughput

0.445

High

1466128

PSA3
Proteasome subunit alpha type-3

1

2

High-throughput

0.445

High

1467792

Q9VAC4
GEO09167p1

1

1

High-throughput

0.445

High

1472546

Q9VEB1
Malate dehydrogenase, mitochondrial

1

1

High-throughput

0.445

High

1472997

FLNA
Filamin-A

1

1

High-throughput

0.445

High

1474453

Q9VG69
LP03547p

1

1

High-throughput

0.445

High

1476003

TEBPH
Cytosolic Prostaglandin E synthase

1

1

High-throughput

0.445

High

1477435

Q9VIE8
Aconitate hydratase, mitochondrial

1

2

High-throughput

0.445

High

1478522

Q9VJJ0
Proteasome subunit beta

1

3

High-throughput

0.445

High

1480398

Q9VL68
Enoyl-CoA delta isomerase 1, mitochondrial

1

2

High-throughput

0.445

High

1480463

Q9VL70
HL08109p

1

1

High-throughput

0.445

High

1480538

FKB59
FK506-binding protein 59

1

2

High-throughput

0.445

High

1480876

AK200
A-kinase anchor protein 200

1

2

High-throughput

0.445

High

1480927

SYAC
Alanine--tRNA ligase, cytoplasmic

1

2

High-throughput

0.445

High

1482489

PSB4
Proteasome subunit beta type-4

1

5

High-throughput

0.445

High

1483428

Q9VPN5
Stress-induced-phosphoprotein 1

1

3

High-throughput

0.445

High

1484340

Q9VQL1
serine--tRNA ligase

1

1

High-throughput

0.445

High

1485650

Q9VSI6
Isocitrate dehydrogenase [NADP]

1

1

High-throughput

0.445

High

1485702

Q9VSL2
Glutathione S transferase O3

1

1

High-throughput

0.445

High

1486497

Q9VU35
10 kDa heat shock protein, mitochondrial

1

1

High-throughput

0.445

High

1486643

Q9VUC1
Hsc70Cb, isoform A

1

3

High-throughput

0.445

High

1487376

Q9VVL7
Dihydrolipoyl dehydrogenase

1

2

High-throughput

0.445

High

1487857

RS10B
Small ribosomal subunit protein eS10B

1

1

High-throughput

0.445

High

1488598

CLIC
Chloride intracellular channel Clic

1

1

High-throughput

0.445

High

1489214

Q9W022
GEO01508p1

1

3

High-throughput

0.445

High

1489315

Q9W0E4
Aminopeptidase

1

2

High-throughput

0.445

High

1489938

Q9W3X6
fumarate hydratase

1

1

High-throughput

0.445

High

1489972

CISY
Probable citrate synthase, mitochondrial

1

2

High-throughput

0.445

High

1490018

PSB3
Proteasome subunit beta type-3

1

2

High-throughput

0.445

High

1490019

Q9XYZ9
Glutathione S transferase E12, isoform A

1

2

High-throughput

0.445

High

1490021

PSA6
Proteasome subunit alpha type-6

1

2

High-throughput

0.445

High

57911

A1ZB77
Uncharacterized protein, isoform J

1

0

High-throughput

0.426

High

146013

UGDH
UDP-glucose 6-dehydrogenase

1

0

High-throughput

0.426

High

195180

O16043
Anon1A4

1

0

High-throughput

0.426

High

197398

O18335
Rab11

1

0

High-throughput

0.426

High

197542

SPS1
Inactive selenide, water dikinase-like protein

1

0

High-throughput

0.426

High

197913

HCD2
3-hydroxyacyl-CoA dehydrogenase type-2

1

0

High-throughput

0.426

High

234659

VINC
Vinculin

1

0

High-throughput

0.426

High

234813

O46067
Hypoxia up-regulated protein 1

1

0

High-throughput

0.426

High

305298

TRMB
tRNA

1

0

High-throughput

0.426

High

305765

IPYR
Inorganic pyrophosphatase

1

0

High-throughput

0.426

High

356605

O97121
cystathionine gamma-lyase

1

0

High-throughput

0.426

High

357649

INO1
Inositol-3-phosphate synthase

1

0

High-throughput

0.426

High

426872

HP1
Heterochromatin protein 1

1

0

High-throughput

0.426

High

578193

ENO
Enolase

1

0

High-throughput

0.426

High

633026

GLNA1
Glutamine synthetase 1, mitochondrial

1

0

High-throughput

0.426

High

682863

PROF
Profilin

1

0

High-throughput

0.426

High

856193

MOEH
Moesin/ezrin/radixin homolog 1

1

0

High-throughput

0.426

High

875515

KARG
Arginine kinase 1

1

0

High-throughput

0.426

High

929104

DOD
Putative peptidyl-prolyl cis-trans isomerase dodo

1

0

High-throughput

0.426

High

1019968

1433E
14-3-3 protein epsilon

1

0

High-throughput

0.426

High

1026689

SODM
Superoxide dismutase [Mn], mitochondrial

1

0

High-throughput

0.426

High

1070856

Q0KHZ6
Electron transfer flavoprotein subunit beta

1

0

High-throughput

0.426

High

1260930

Q76NR6
Regucalcin

1

0

High-throughput

0.426

High

1264186

Q7K0E6
Aspartate--tRNA ligase, cytoplasmic

1

0

High-throughput

0.426

High

1268322

Q7KN99
Phosphopantothenoylcysteine synthetase, isoform A

1

0

High-throughput

0.426

High

1269540

Q7KTW5
Inositol-1-monophosphatase

1

0

High-throughput

0.426

High

1304015

Q8INK3
Fatty acid-binding protein, muscle

1

0

High-throughput

0.426

High

1306216

Q8IRD3
Glutathione peroxidase

1

0

High-throughput

0.426

High

1321773

Q8MT58
Carnosine dipeptidase 2, isoform A

1

0

High-throughput

0.426

High

1345344

Q8T0L3
E1 ubiquitin-activating enzyme

1

0

High-throughput

0.426

High

1374761

ACPM
Acyl carrier protein, mitochondrial

1

0

High-throughput

0.426

High

1427927

IF5A
Eukaryotic translation initiation factor 5A

1

0

High-throughput

0.426

High

1440107

JUPIT
Microtubule-associated protein Jupiter

1

0

High-throughput

0.426

High

1440236

NASP
Nuclear autoantigenic sperm protein homolog

1

0

High-throughput

0.426

High

1440649

PUR6
Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase

1

0

High-throughput

0.426

High

1445503

SH3BG
SH3 domain-binding glutamic acid-rich protein homolog

1

0

High-throughput

0.426

High

1463360

Q9V3D8
GH27579p

1

0

High-throughput

0.426

High

1463739

Q9V3I1
Deoxyuridine 5'-triphosphate nucleotidohydrolase

1

0

High-throughput

0.426

High

1464559

SPC25
Kinetochore protein Spc25

1

0

High-throughput

0.426

High

1464653

Q9V3V9
Endonuclease G inhibitor, isoform A

1

0

High-throughput

0.426

High

1467038

Q9V9U3
LD45254p

1

0

High-throughput

0.426

High

1467704

Q9VAC1
GM14349p

1

0

High-throughput

0.426

High

1471193

Q9VD29
small monomeric GTPase

1

0

High-throughput

0.426

High

1472175

INO80
Chromatin-remodeling ATPase INO80

1

0

High-throughput

0.426

High

1474341

Q9VG31
Malic enzyme

1

0

High-throughput

0.426

High

1475170

TCTP
Translationally-controlled tumor protein homolog

1

0

High-throughput

0.426

High

1476654

DPP3
Dipeptidyl peptidase 3

1

0

High-throughput

0.426

High

1479344

Q9VKB0
threonine--tRNA ligase

1

0

High-throughput

0.426

High

1481767

Q9VMH3
LD04103p

1

0

High-throughput

0.426

High

1482370

Q9VN44
FI07923p

1

0

High-throughput

0.426

High

1483722

Q9VPX6
Adenylyl cyclase-associated protein

1

0

High-throughput

0.426

High

1483844

Q9VQ61
Aspartate aminotransferase

1

0

High-throughput

0.426

High

1484167

BACC
Bacchus

1

0

High-throughput

0.426

High

1484860

Q9VRD6
NTF2-related export protein

1

0

High-throughput

0.426

High

1484987

Q9VRL1
GEO06356p1

1

0

High-throughput

0.426

High

1486803

GARS
Glycine--tRNA ligase

1

0

High-throughput

0.426

High

1487206

Y9705
Cold shock domain-containing protein CG9705

1

0

High-throughput

0.426

High

1489352

Q9W0H8
Reticulocalbin-3

1

0

High-throughput

0.426

High

1489465

SND1
Staphylococcal nuclease domain-containing protein 1

1

0

High-throughput

0.426

High

1489696

Q9W227
Peptidyl-prolyl cis-trans isomerase

1

0

High-throughput

0.426

High

1489784

Q9W2M4
Farnesoic acid O-methyl transferase domain-containing protein

1

0

High-throughput

0.426

High

1489864

Q9W3F6
Bleomycin hydrolase

1

0

High-throughput

0.426

High

1489957

Q9W3Y3
Calcyclin-binding protein

1

0

High-throughput

0.426

High

1489995

WUHO
tRNA

1

0

High-throughput

0.426

High

1490017

NSUN2
tRNA

1

0

High-throughput

0.426

High

1490020

Q9XZ57
Eb1, isoform E

1

0

High-throughput

0.426

High

1490022

PURA
Adenylosuccinate synthetase

1

0

High-throughput

0.426

High

1305365

Q8IQG0
Uncharacterized protein, isoform A

1

1

High-throughput

0.417

High

1345378

Q8T0N1
GH18717p

1

1

High-throughput

0.417

High

1473596

Q9VF72
RH63657p

1

1

High-throughput

0.417

High

54128

A1Z892
1-Cys peroxiredoxin

1

2

High-throughput

0.407

High

726537

VATB
V-type proton ATPase subunit B

1

1

High-throughput

0.407

High

821957

PSA2
Proteasome subunit alpha type-2

1

1

High-throughput

0.407

High

1176398

VATA2
V-type proton ATPase catalytic subunit A isoform 2

1

2

High-throughput

0.407

High

1176777

SAHH
Adenosylhomocysteinase

1

1

High-throughput

0.407

High

1191750

Q3YMU0
Protein disulfide-isomerase

1

2

High-throughput

0.407

High

1246634

Q6QU65
ADAM metalloprotease

1

1

High-throughput

0.407

High

1262217

Q7JVH6
LD24696p

1

4

High-throughput

0.407

High

1262912

Q7JX87
1-Cys peroxiredoxin

1

2

High-throughput

0.407

High

1268139

Q7KN85
ATP-citrate synthase

1

1

High-throughput

0.407

High

1464397

Q9V3V2
peptidylprolyl isomerase

1

3

High-throughput

0.407

High

1465321

PDIA6
Protein disulfide-isomerase A6 homolog

1

2

High-throughput

0.407

High

1468711

Q9VAY2
Heat shock protein 83

1

3

High-throughput

0.407

High

1471030

Q9VD02
GH14779p

1

1

High-throughput

0.407

High

1474813

Q9VGK3
peptidylprolyl isomerase

1

3

High-throughput

0.407

High

1476914

Q9VHX4
LD24679p

1

4

High-throughput

0.407

High

1479960

Q9VKW5
Prolyl endopeptidase

1

2

High-throughput

0.407

High

1483100

Q9VP52
GH24315p

1

1

High-throughput

0.407

High

1484373

Q9VQL7
Fatty acid synthase

1

1

High-throughput

0.407

High

1486360

Q9VTY2
Uncharacterized protein, isoform A

1

4

High-throughput

0.407

High

1489061

Q9VZI1
Transgelin

1

1

High-throughput

0.407

High

1490023

Q9Y112
BcDNA.GH10614

1

4

High-throughput

0.407

High

1301093

Q8I0D1
GH14831p

1

0

High-throughput

0.238

Low

86622

B9EQV3
Endoplasmic reticulum transmembrane protein

1

0

High-throughput

0.232

Low

304757

RS21
Small ribosomal subunit protein eS21

1

0

High-throughput

0.232

Low

357413

O97428
Ciboulot, isoform A

1

0

High-throughput

0.232

Low

460225

ALF
Fructose-bisphosphate aldolase

1

0

High-throughput

0.232

Low

835245

6PGD
6-phosphogluconate dehydrogenase, decarboxylating

1

0

High-throughput

0.232

Low

874748

RIR2
Ribonucleoside-diphosphate reductase subunit M2

1

0

High-throughput

0.232

Low

930270

VATE
V-type proton ATPase subunit E

1

0

High-throughput

0.232

Low

1031317

PGK
Phosphoglycerate kinase

1

0

High-throughput

0.232

Low

1173786

SEM2A
Semaphorin-2A

1

0

High-throughput

0.232

Low

1175541

NETB
Netrin-B

1

0

High-throughput

0.232

Low

1176841

NCPR
NADPH--cytochrome P450 reductase

1

0

High-throughput

0.232

Low

1262692

Q7JWV7
Tetraspanin

1

0

High-throughput

0.232

Low

1263192

SEELE
Protein seele

1

0

High-throughput

0.232

Low

1265352

Q7K2K2
FI04612p

1

0

High-throughput

0.232

Low

1265893

Q7K3J0
T-complex protein 1 subunit theta

1

0

High-throughput

0.232

Low

1305958

Q8IR42
Drop dead

1

0

High-throughput

0.232

Low

1344498

Q8SYG3
E2 ubiquitin-conjugating enzyme

1

0

High-throughput

0.232

Low

1445669

CP2B
Cardio acceleratory peptide 2b

1

0

High-throughput

0.232

Low

1466297

TPP2
Tripeptidyl-peptidase 2

1

0

High-throughput

0.232

Low

1468247

Q9VAN7
Phosphoglycerate mutase

1

0

High-throughput

0.232

Low

1469562

Q9VBR6
RE74917p

1

0

High-throughput

0.232

Low

1469647

Q9VBT1
CHK kinase-like domain-containing protein

1

0

High-throughput

0.232

Low

1470567

Q9VCK6
LD34157p

1

0

High-throughput

0.232

Low

1474389

Q9VG33
Sulfurtransferase

1

0

High-throughput

0.232

Low

1476522

Q9VHN7
transketolase

1

0

High-throughput

0.232

Low

1480110

Q9VKZ8
Ubiquitin carboxyl-terminal hydrolase

1

0

High-throughput

0.232

Low

1480217

EF1D
Probable elongation factor 1-delta

1

0

High-throughput

0.232

Low

1480670

Q9VLB7
Rab GDP dissociation inhibitor

1

0

High-throughput

0.232

Low

1482022

Q9VMU6
LD31822p

1

0

High-throughput

0.232

Low

1482529

Q9VNB2
RE42193p

1

0

High-throughput

0.232

Low

1485063

Q9VRP2
Uncharacterized protein, isoform A

1

0

High-throughput

0.232

Low

1487682

Q9VW59
Rho GDP-dissociation inhibitor 3

1

0

High-throughput

0.232

Low

1487714

Q9VW70
FI21813p1

1

0

High-throughput

0.232

Low

1487995

Q9VWQ7
Coactosin-like protein

1

0

High-throughput

0.232

Low

1488277

DHB4
Peroxisomal multifunctional enzyme type 2

1

0

High-throughput

0.232

Low

1488397

Q9VXQ3
Diphosphomevalonate decarboxylase

1

0

High-throughput

0.232

Low

1490016

Q9W478
RE43153p

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025