Protein: HEAT1
HEAT repeat-containing protein 1 (Protein BAP28) (U3 small nucleolar RNA-associated protein 10 homolog) [Cleaved into: HEAT repeat-containing protein 1, N-terminally processed]

Gene: HEAT1, HEATR1
Organism: Homo sapiens
Interactions: 231
UniProt ID: Q9H583

Gene Ontology (top 5):
GO:0000462 - maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0001650 - fibrillar center
GO:0003723 - RNA binding
GO:0005654 - nucleoplasm
GO:0005730 - nucleolus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

373147

MYC
Myc proto-oncogene protein

3

0

High-throughput

0.622

High

326781

DUS14
Dual specificity protein phosphatase 14

2

0

High-throughput

0.602

High

1098672

SBP1
Methanethiol oxidase

2

0

High-throughput

0.602

High

218777

TGON2
Trans-Golgi network integral membrane protein 2

2

0

High-throughput

0.585

High

1434536

CAH14
Carbonic anhydrase 14

2

0

High-throughput

0.585

High

644055

FBRL
rRNA 2'-O-methyltransferase fibrillarin

2

1

High-throughput

0.584

High

979236

RS6
Small ribosomal subunit protein eS6

2

1

High-throughput

0.584

High

1100379

TIF1B
Transcription intermediary factor 1-beta

2

1

Small-scale

0.584

High

1434539

TN13B
Tumor necrosis factor ligand superfamily member 13B

2

1

High-throughput

0.584

High

1022474

IDD
Integral membrane protein DGCR2/IDD

2

0

High-throughput

0.576

High

1353662

LRC15
Leucine-rich repeat-containing protein 15

2

1

High-throughput

0.574

High

396941

ESR1
Estrogen receptor

2

2

High-throughput

0.571

High

831428

CCNF
Cyclin-F

2

0

High-throughput

0.559

High

1434523

ANLN
Anillin

2

0

High-throughput

0.559

High

1101308

SLAF1
Signaling lymphocytic activation molecule

2

2

High-throughput

0.558

High

1420322

CD244
Natural killer cell receptor 2B4

2

2

High-throughput

0.558

High

171581

S27A2
Long-chain fatty acid transport protein 2

2

2

High-throughput

0.549

High

683337

TNR5
Tumor necrosis factor receptor superfamily member 5

2

1

High-throughput

0.549

High

1293906

VSIG1
V-set and immunoglobulin domain-containing protein 1

2

2

High-throughput

0.549

High

1434522

TMM9B
Transmembrane protein 9B

2

1

High-throughput

0.549

High

50696

HACL2
2-hydroxyacyl-CoA lyase 2

1

1

High-throughput

0.536

High

182771

GP182
G-protein coupled receptor 182

1

4

High-throughput

0.536

High

380657

DQB1
HLA class II histocompatibility antigen, DQ beta 1 chain

1

2

High-throughput

0.536

High

521008

HLAC
HLA class I histocompatibility antigen, C alpha chain

1

1

High-throughput

0.536

High

774623

BASI
Basigin

1

1

High-throughput

0.536

High

937653

FOXG1
Forkhead box protein G1

1

4

High-throughput

0.536

High

1091250

FOXI1
Forkhead box protein I1

1

4

High-throughput

0.536

High

1309710

WDR75
WD repeat-containing protein 75

1

6

High-throughput

0.536

High

1402671

SMC6
Structural maintenance of chromosomes protein 6

1

1

High-throughput

0.536

High

1434540

VSIG4
V-set and immunoglobulin domain-containing protein 4

1

2

High-throughput

0.536

High

262307

SCN2B
Sodium channel regulatory subunit beta-2

2

2

High-throughput

0.521

High

1279520

ARHG8
Neuroepithelial cell-transforming gene 1 protein

2

1

High-throughput

0.521

High

1326802

ARG39
Rho guanine nucleotide exchange factor 39

2

1

High-throughput

0.521

High

592744

LEUK
Leukosialin

1

0

High-throughput

0.513

High

634806

GRAH
Granzyme H

1

0

High-throughput

0.513

High

690385

STOM
Stomatin

1

0

High-throughput

0.513

High

749808

CADH5
Cadherin-5

1

0

High-throughput

0.513

High

1007604

PRAME
Melanoma antigen preferentially expressed in tumors

1

0

High-throughput

0.513

High

1273282

HS2ST
Heparan sulfate 2-O-sulfotransferase 1

1

0

High-throughput

0.513

High

1291682

CMTD1
Catechol O-methyltransferase domain-containing protein 1

1

0

High-throughput

0.513

High

1325918

MFD4A
Major facilitator superfamily domain-containing protein 4A

1

0

High-throughput

0.513

High

1349119

F174A
Membrane protein FAM174A

1

0

High-throughput

0.513

High

1350887

HUMMR
Protein MGARP

1

0

High-throughput

0.513

High

1430686

F234A
Protein FAM234A

1

0

High-throughput

0.513

High

1434520

NOL11
Nucleolar protein 11

1

0

High-throughput

0.513

High

1434534

CLC2D
C-type lectin domain family 2 member D

1

0

High-throughput

0.513

High

1316454

XRN1
5'-3' exoribonuclease 1

1

1

High-throughput

0.508

High

1216051

TTBK1
Tau-tubulin kinase 1

1

0

High-throughput

0.493

High

133131

FOXE1
Forkhead box protein E1

1

4

High-throughput

0.489

High

133312

P2Y10
Putative P2Y purinoceptor 10

1

7

High-throughput

0.489

High

210424

MTLR
Motilin receptor

1

2

High-throughput

0.489

High

288138

FOXH1
Forkhead box protein H1

1

5

High-throughput

0.489

High

333205

VAPB
Vesicle-associated membrane protein-associated protein B/C

1

1

High-throughput

0.489

High

833871

P2RY2
P2Y purinoceptor 2

1

6

High-throughput

0.489

High

936123

PAR2
Proteinase-activated receptor 2

1

4

High-throughput

0.489

High

1057698

TNR9
Tumor necrosis factor receptor superfamily member 9

1

1

High-throughput

0.489

High

1091345

FOXL1
Forkhead box protein L1

1

4

High-throughput

0.489

High

1101662

GPR17
Uracil nucleotide/cysteinyl leukotriene receptor

1

6

High-throughput

0.489

High

1291897

P2RY8
S-geranylgeranyl-glutathione receptor P2RY8

1

6

High-throughput

0.489

High

1387272

HDA11
Histone deacetylase 11

1

1

High-throughput

0.489

High

1407758

FOXB1
Forkhead box protein B1

1

5

High-throughput

0.489

High

1420498

FOXQ1
Forkhead box protein Q1

1

5

High-throughput

0.489

High

1434531

TMEM9
Proton-transporting V-type ATPase complex assembly regulator TMEM9

1

1

High-throughput

0.489

High

1434545

NPTN
Neuroplastin

1

1

High-throughput

0.489

High

1323344

VPS52
Vacuolar protein sorting-associated protein 52 homolog

1

1

High-throughput

0.481

High

363859

EGFR
Epidermal growth factor receptor

1

0

High-throughput

0.479

High

141108

NOP56
Nucleolar protein 56

1

2

High-throughput

0.479

High

260454

BRD4
Bromodomain-containing protein 4

1

1

High-throughput

0.479

High

285475

EED
Polycomb protein EED

1

5

High-throughput

0.479

High

331326

KI20A
Kinesin-like protein KIF20A

1

2

High-throughput

0.479

High

714429

PML
Protein PML

1

1

High-throughput

0.479

High

765891

BMI1
Polycomb complex protein BMI-1

1

1

High-throughput

0.479

High

789572

PPARG
Peroxisome proliferator-activated receptor gamma

1

2

Small-scale

0.479

High

840794

RS27
Small ribosomal subunit protein eS27

1

2

High-throughput

0.479

High

862460

YAP1
Transcriptional coactivator YAP1

1

3

High-throughput

0.479

High

955596

CDC42
Cell division control protein 42 homolog

1

1

High-throughput

0.479

High

965243

WDR5
WD repeat-containing protein 5

1

3

High-throughput

0.479

High

980322

H4
Histone H4

1

1

High-throughput

0.479

High

981096

H2B1C
Histone H2B type 1-C/E/F/G/I

1

1

High-throughput

0.479

High

982827

RS24
Small ribosomal subunit protein eS24

1

1

High-throughput

0.479

High

984984

RL31
Large ribosomal subunit protein eL31

1

2

High-throughput

0.479

High

1032244

EXOSX
Exosome complex component 10

1

1

High-throughput

0.479

High

1035915

KIF23
Kinesin-like protein KIF23

1

1

High-throughput

0.479

High

1087551

GRSF1
G-rich sequence factor 1

1

1

High-throughput

0.479

High

1127165

RBM39
RNA-binding protein 39

1

1

High-throughput

0.479

High

1138059

TNIP1
TNFAIP3-interacting protein 1

1

1

High-throughput

0.479

High

1208810

TDIF2
Deoxynucleotidyltransferase terminal-interacting protein 2

1

1

High-throughput

0.479

High

1228327

UTP25
U3 small nucleolar RNA-associated protein 25 homolog

1

1

High-throughput

0.479

High

1280498

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

1

High-throughput

0.479

High

1313431

SMC5
Structural maintenance of chromosomes protein 5

1

1

High-throughput

0.479

High

1338961

NUP43
Nucleoporin Nup43

1

4

High-throughput

0.479

High

1356882

PTPM1
Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1

1

2

High-throughput

0.479

High

1361234

DNJC9
DnaJ homolog subfamily C member 9

1

2

High-throughput

0.479

High

1364256

TOPB1
DNA topoisomerase 2-binding protein 1

1

1

High-throughput

0.479

High

1367274

ESR2
Estrogen receptor beta

1

1

High-throughput

0.479

High

1381586

UTP4
U3 small nucleolar RNA-associated protein 4 homolog

1

4

High-throughput

0.479

High

1387559

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

4

High-throughput

0.479

High

1404761

RING2
E3 ubiquitin-protein ligase RING2

1

1

High-throughput

0.479

High

1414570

DDX23
Probable ATP-dependent RNA helicase DDX23

1

2

High-throughput

0.479

High

1417471

FACD2
Fanconi anemia group D2 protein

1

1

High-throughput

0.479

High

1418581

MK67I
MKI67 FHA domain-interacting nucleolar phosphoprotein

1

1

High-throughput

0.479

High

1420162

B2L14
Apoptosis facilitator Bcl-2-like protein 14

1

1

High-throughput

0.479

High

1428622

RPA49
DNA-directed RNA polymerase I subunit RPA49

1

1

High-throughput

0.479

High

1428970

WWTR1
WW domain-containing transcription regulator protein 1

1

1

High-throughput

0.479

High

1434521

ECT2
Protein ECT2

1

2

High-throughput

0.479

High

1434524

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

1

High-throughput

0.479

High

1434527

NLE1
Notchless protein homolog 1

1

3

High-throughput

0.479

High

1434529

AATF
Protein AATF

1

1

High-throughput

0.479

High

277407

TP4A3
Protein tyrosine phosphatase type IVA 3

1

2

High-throughput

0.470

High

129431

MEN1
Menin

1

0

High-throughput

0.458

High

157851

CTRO
Citron Rho-interacting kinase

1

0

High-throughput

0.458

High

191092

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

0

High-throughput

0.458

High

223331

PRC1
Protein regulator of cytokinesis 1

1

0

High-throughput

0.458

High

248089

NUPR1
Nuclear protein 1

1

0

High-throughput

0.458

High

274755

DNJB6
DnaJ homolog subfamily B member 6

1

0

High-throughput

0.458

High

346327

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

0

High-throughput

0.458

High

412612

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.458

High

447442

NPM
Nucleophosmin

1

0

High-throughput

0.458

High

487756

PARP1
Poly [ADP-ribose] polymerase 1

1

0

High-throughput

0.458

High

521438

ARAF
Serine/threonine-protein kinase A-Raf

1

0

Small-scale

0.458

High

565475

ITA4
Integrin alpha-4

1

0

High-throughput

0.458

High

589684

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.458

High

696503

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

697253

APEX1
DNA repair nuclease/redox regulator APEX1

1

0

High-throughput

0.458

High

731617

STIP1
Stress-induced-phosphoprotein 1

1

0

High-throughput

0.458

High

769174

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.458

High

791731

SYUA
Alpha-synuclein

1

0

High-throughput

0.458

High

872746

SOX2
Transcription factor SOX-2

1

0

High-throughput

0.458

High

879463

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.458

High

888330

MCM2
DNA replication licensing factor MCM2

1

0

High-throughput

0.458

High

935137

TERA
Transitional endoplasmic reticulum ATPase

1

0

High-throughput

0.458

High

986725

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

0

High-throughput

0.458

High

1005095

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.458

High

1097561

CBX3
Chromobox protein homolog 3

1

0

High-throughput

0.458

High

1104490

ILK
Scaffold protein ILK

1

0

High-throughput

0.458

High

1107211

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.458

High

1112454

MTMR3
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR3

1

0

High-throughput

0.458

High

1114299

CUL3
Cullin-3

1

0

High-throughput

0.458

High

1137524

SUZ12
Polycomb protein SUZ12

1

0

High-throughput

0.458

High

1140859

KIF14
Kinesin-like protein KIF14

1

0

High-throughput

0.458

High

1161398

HIF1A
Hypoxia-inducible factor 1-alpha

1

0

High-throughput

0.458

High

1161670

IF16
Gamma-interferon-inducible protein 16

1

0

High-throughput

0.458

High

1229681

VIR
Protein virilizer homolog

1

0

High-throughput

0.458

High

1289629

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

1290727

ZCH18
Zinc finger CCCH domain-containing protein 18

1

0

High-throughput

0.458

High

1346929

SNIP1
Smad nuclear-interacting protein 1

1

0

High-throughput

0.458

High

1352754

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.458

High

1368125

HDAC2
Histone deacetylase 2

1

0

High-throughput

0.458

High

1384878

CHCH1
Small ribosomal subunit protein mS37

1

0

High-throughput

0.458

High

1393693

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.458

High

1418448

ACE2
Angiotensin-converting enzyme 2

1

0

High-throughput

0.458

High

1430582

CCDC8
Coiled-coil domain-containing protein 8

1

0

High-throughput

0.458

High

1434528

HIF1N
Hypoxia-inducible factor 1-alpha inhibitor

1

0

High-throughput

0.458

High

1434530

PD1L1
Programmed cell death 1 ligand 1

1

0

High-throughput

0.458

High

1434532

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

1

0

High-throughput

0.458

High

1434541

ZN330
Zinc finger protein 330

1

0

High-throughput

0.458

High

1434542

TRRAP
Transformation/transcription domain-associated protein

1

0

High-throughput

0.458

High

351253

MOT3
Monocarboxylate transporter 3

1

1

High-throughput

0.445

High

380143

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

1

High-throughput

0.445

High

516720

VSIG8
V-set and immunoglobulin domain-containing protein 8

1

2

High-throughput

0.445

High

638521

FPR1
fMet-Leu-Phe receptor

1

2

High-throughput

0.445

High

1130454

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

1

High-throughput

0.445

High

1234029

S35E4
Solute carrier family 35 member E4

1

1

High-throughput

0.445

High

1240959

S27A4
Long-chain fatty acid transport protein 4

1

2

High-throughput

0.445

High

1243663

S27A1
Long-chain fatty acid transport protein 1

1

2

High-throughput

0.445

High

1243898

AAGAB
Alpha- and gamma-adaptin-binding protein p34

1

1

High-throughput

0.439

High

1434525

DISC1
Disrupted in schizophrenia 1 protein

1

0

High-throughput

0.438

High

318876

RHBT1
Rho-related BTB domain-containing protein 1

1

2

High-throughput

0.437

High

962485

RHOA
Transforming protein RhoA

1

1

High-throughput

0.437

High

962829

RND3
Rho-related GTP-binding protein RhoE

1

1

High-throughput

0.437

High

1031544

IFM3
Interferon-induced transmembrane protein 3

1

1

High-throughput

0.437

High

1141306

BRD3
Bromodomain-containing protein 3

1

1

High-throughput

0.437

High

1142179

P2RY6
P2Y purinoceptor 6

1

7

High-throughput

0.437

High

1313840

S15A3
Solute carrier family 15 member 3

1

1

High-throughput

0.437

High

1416680

LGR4
Leucine-rich repeat-containing G-protein coupled receptor 4

1

1

High-throughput

0.437

High

1430951

UN93B
Protein unc-93 homolog B1

1

1

High-throughput

0.437

High

430358

JUN
Transcription factor Jun

1

0

High-throughput

0.426

High

1034065

OCRL
Inositol polyphosphate 5-phosphatase OCRL

1

0

High-throughput

0.426

High

1395665

S35E1
Solute carrier family 35 member E1

1

0

High-throughput

0.426

High

1434537

XCT
Cystine/glutamate transporter

1

0

High-throughput

0.426

High

516868

RPAC2
DNA-directed RNA polymerases I and III subunit RPAC2

1

1

High-throughput

0.407

High

1227459

A16L1
Autophagy-related protein 16-1

1

4

High-throughput

0.407

High

1335719

MOT11
Monocarboxylate transporter 11

1

1

High-throughput

0.407

High

1330835

TSYL6
Testis-specific Y-encoded-like protein 6

2

0

High-throughput

0.328

High

1434538

LAMP3
Lysosome-associated membrane glycoprotein 3

2

0

High-throughput

0.328

High

906177

AL3A2
Aldehyde dehydrogenase family 3 member A2

2

0

High-throughput

0.318

High

619928

VCAM1
Vascular cell adhesion protein 1

2

0

High-throughput

0.298

High

1253743

RHG36
Rho GTPase-activating protein 36

2

0

High-throughput

0.298

High

139316

UPK2
Uroplakin-2

1

0

High-throughput

0.279

Low

253903

TPST2
Protein-tyrosine sulfotransferase 2

1

0

High-throughput

0.279

Low

378652

IL2RA
Interleukin-2 receptor subunit alpha

1

0

High-throughput

0.279

Low

570600

GFAP
Glial fibrillary acidic protein

1

0

High-throughput

0.279

Low

749277

CD70
CD70 antigen

1

0

High-throughput

0.279

Low

835389

VIPR2
Vasoactive intestinal polypeptide receptor 2

1

0

High-throughput

0.279

Low

1022959

EFNB1
Ephrin-B1

1

0

High-throughput

0.279

Low

1159233

SGCA
Alpha-sarcoglycan

1

0

High-throughput

0.279

Low

1235331

STYK1
Tyrosine-protein kinase STYK1

1

0

High-throughput

0.279

Low

1249507

VSTM1
V-set and transmembrane domain-containing protein 1

1

0

High-throughput

0.279

Low

1272627

PCAT2
Lysophosphatidylcholine acyltransferase 2

1

0

High-throughput

0.279

Low

1350236

PKR1
Prokineticin receptor 1

1

0

High-throughput

0.279

Low

1369488

TANK
TRAF family member-associated NF-kappa-B activator

1

0

High-throughput

0.279

Low

1399612

OPALI
Opalin

1

0

High-throughput

0.279

Low

1434533

P2RX2
P2X purinoceptor 2

1

0

High-throughput

0.279

Low

1434544

GPR45
Probable G-protein coupled receptor 45

1

0

High-throughput

0.279

Low

1181345

CR021
UPF0711 protein C18orf21

1

0

High-throughput

0.269

Low

125610

LEG9
Galectin-9

1

0

High-throughput

0.249

Low

247429

PHLP1
PH domain leucine-rich repeat-containing protein phosphatase 1

1

0

High-throughput

0.249

Low

272462

OBSL1
Obscurin-like protein 1

1

0

High-throughput

0.249

Low

294328

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.249

Low

1126176

GRM2
Metabotropic glutamate receptor 2

1

0

High-throughput

0.249

Low

1135105

CUL7
Cullin-7

1

0

High-throughput

0.249

Low

1135814

HAPR1
HUWE1-associated protein modifying stress responses 1

1

0

High-throughput

0.249

Low

1178379

CL16A
Protein CLEC16A

1

0

High-throughput

0.249

Low

1203086

TM41B
Transmembrane protein 41B

1

0

High-throughput

0.249

Low

1249213

LMBRL
Protein LMBR1L

1

0

High-throughput

0.249

Low

1255541

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

1311969

SKA3
Spindle and kinetochore-associated protein 3

1

0

Small-scale

0.249

Low

1329549

IQCF1
IQ domain-containing protein F1

1

0

High-throughput

0.249

Low

1411948

PELO
Protein pelota homolog

1

0

High-throughput

0.249

Low

1433885

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.249

Low

1434535

HECD1
E3 ubiquitin-protein ligase HECTD1

1

0

High-throughput

0.249

Low

1434543

MAGD1
Melanoma-associated antigen D1

1

0

High-throughput

0.249

Low

166416

ZNT4
Probable proton-coupled zinc antiporter SLC30A4

1

0

High-throughput

0.232

Low

704079

5HT1E
5-hydroxytryptamine receptor 1E

1

0

High-throughput

0.232

Low

1279085

RIC3
Protein RIC-3

1

0

High-throughput

0.232

Low

1292408

OSTM1
Osteopetrosis-associated transmembrane protein 1

1

0

High-throughput

0.232

Low

1334413

UXS1
UDP-glucuronic acid decarboxylase 1

1

0

High-throughput

0.232

Low

1391462

S35A4
Probable UDP-sugar transporter protein SLC35A4

1

0

High-throughput

0.232

Low

1404945

S1PR3
Sphingosine 1-phosphate receptor 3

1

0

High-throughput

0.232

Low

1412067

S39A3
Zinc transporter ZIP3

1

0

High-throughput

0.232

Low

1434526

S22AB
Solute carrier family 22 member 11

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025