Protein: SYRC
Arginine--tRNA ligase, cytoplasmic (EC 6.1.1.19) (Arginyl-tRNA synthetase) (ArgRS)

Gene: SYRC, RARS1
Organism: Homo sapiens
Interactions: 206
UniProt ID: P54136

Gene Ontology (top 5):
GO:0000049 - tRNA binding
GO:0004814 - arginine-tRNA ligase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

926458

AIMP1
Aminoacyl tRNA synthase complex-interacting multifunctional protein 1

6

3

Small-scale

0.732

High

926460

AIMP2
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

6

1

Small-scale

0.731

High

868122

SYQ
Glutamine--tRNA ligase

5

4

Small-scale

0.721

High

926552

SYLC
Leucine--tRNA ligase, cytoplasmic

4

2

Small-scale

0.705

High

460471

SYEP
Bifunctional glutamate/proline--tRNA ligase

3

5

Small-scale

0.674

High

576736

SYDC
Aspartate--tRNA ligase, cytoplasmic

3

4

High-throughput

0.667

High

760748

CD68
Macrosialin

3

1

High-throughput

0.667

High

834402

SYIC
Isoleucine--tRNA ligase, cytoplasmic

3

2

Small-scale

0.667

High

926497

CMTD1
Catechol O-methyltransferase domain-containing protein 1

3

1

High-throughput

0.667

High

140195

SDCB1
Syntenin-1

3

0

High-throughput

0.638

High

926529

VMA22
Vacuolar ATPase assembly protein VMA22

3

0

High-throughput

0.636

High

60497

SYTC2
Threonine--tRNA ligase 2, cytoplasmic

2

3

High-throughput

0.628

High

214189

MCA3
Eukaryotic translation elongation factor 1 epsilon-1

2

2

High-throughput

0.628

High

540376

LAMP1
Lysosome-associated membrane glycoprotein 1

2

1

High-throughput

0.628

High

926446

SYMC
Methionine--tRNA ligase, cytoplasmic

2

4

High-throughput

0.628

High

926475

SYK
Lysine--tRNA ligase

2

4

High-throughput

0.628

High

371558

MYC
Myc proto-oncogene protein

3

0

High-throughput

0.628

High

926442

SYRC
Arginine--tRNA ligase, cytoplasmic

1

1

High-throughput

0.618

High

241189

PRKN
E3 ubiquitin-protein ligase parkin

3

0

High-throughput

0.613

High

926464

CUL3
Cullin-3

2

2

High-throughput

0.611

High

596629

NCPR
NADPH--cytochrome P450 reductase

2

0

High-throughput

0.602

High

926512

NECT2
Nectin-2

2

0

High-throughput

0.602

High

563474

CFTR
Cystic fibrosis transmembrane conductance regulator

2

0

High-throughput

0.585

High

926450

WDR5
WD repeat-containing protein 5

2

1

Small-scale

0.584

High

926554

ZRAN1
Ubiquitin thioesterase ZRANB1

2

1

High-throughput

0.584

High

926526

ZN521
Zinc finger protein 521

2

0

High-throughput

0.580

High

395750

ESR1
Estrogen receptor

2

1

High-throughput

0.571

High

541408

FGFR1
Fibroblast growth factor receptor 1

2

4

High-throughput

0.571

High

926445

TERA
Transitional endoplasmic reticulum ATPase

2

1

High-throughput

0.571

High

926481

LARP7
La-related protein 7

2

0

High-throughput

0.559

High

400534

RAF1
RAF proto-oncogene serine/threonine-protein kinase

2

0

High-throughput

0.547

High

440006

LCK
Tyrosine-protein kinase Lck

2

0

High-throughput

0.547

High

584731

NDKA
Nucleoside diphosphate kinase A

2

0

High-throughput

0.547

High

619637

VCAM1
Vascular cell adhesion protein 1

2

0

High-throughput

0.547

High

791215

SYUA
Alpha-synuclein

2

0

High-throughput

0.547

High

135557

DNM1L
Dynamin-1-like protein

1

1

High-throughput

0.536

High

140825

NOP56
Nucleolar protein 56

1

1

High-throughput

0.536

High

215522

EMC8
ER membrane protein complex subunit 8

1

1

High-throughput

0.536

High

470942

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

1

High-throughput

0.536

High

926461

G3BP1
Ras GTPase-activating protein-binding protein 1

1

1

High-throughput

0.536

High

926463

CUL1
Cullin-1

1

2

High-throughput

0.536

High

926485

C102B
Coiled-coil domain-containing protein 102B

1

1

High-throughput

0.536

High

926557

G3BP2
Ras GTPase-activating protein-binding protein 2

1

1

High-throughput

0.536

High

926563

EMC9
ER membrane protein complex subunit 9

1

1

High-throughput

0.536

High

271457

ATG13
Autophagy-related protein 13

1

0

High-throughput

0.513

High

484450

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

0

High-throughput

0.513

High

773835

SOAT1
Sterol O-acyltransferase 1

1

0

High-throughput

0.513

High

866929

CAPZB
F-actin-capping protein subunit beta

1

0

High-throughput

0.513

High

926451

RS16
Small ribosomal subunit protein uS9

1

0

High-throughput

0.513

High

926469

CAPR1
Caprin-1

1

0

High-throughput

0.513

High

926472

CND2
Condensin complex subunit 2

1

0

High-throughput

0.513

High

926478

PKN2
Serine/threonine-protein kinase N2

1

0

High-throughput

0.513

High

926502

RYBP
RING1 and YY1-binding protein

1

0

High-throughput

0.513

High

926505

PDZD8
PDZ domain-containing protein 8

1

0

High-throughput

0.513

High

926507

RIN3
Ras and Rab interactor 3

1

0

High-throughput

0.513

High

926509

PSPC1
Paraspeckle component 1

1

0

High-throughput

0.513

High

926514

TFG
Protein TFG

1

0

High-throughput

0.513

High

185551

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

2

High-throughput

0.501

High

926447

CDC42
Cell division control protein 42 homolog

1

3

High-throughput

0.501

High

926465

TF2H3
General transcription factor IIH subunit 3

1

0

High-throughput

0.493

High

926476

RNPS1
RNA-binding protein with serine-rich domain 1

1

0

High-throughput

0.493

High

286438

WBP4
WW domain-binding protein 4

1

1

High-throughput

0.481

High

926449

SUMO2
Small ubiquitin-related modifier 2

1

0

High-throughput

0.480

High

605184

TAL1
T-cell acute lymphocytic leukemia protein 1

1

0

High-throughput

0.479

High

127770

IKBE
NF-kappa-B inhibitor epsilon

1

1

High-throughput

0.479

High

138030

PSDE
26S proteasome non-ATPase regulatory subunit 14

1

1

High-throughput

0.479

High

157134

CTRO
Citron Rho-interacting kinase

1

1

High-throughput

0.479

High

247272

PHLP1
PH domain leucine-rich repeat-containing protein phosphatase 1

1

1

High-throughput

0.479

High

293419

CD123
Translation initiation factor eIF2 assembly protein

1

1

High-throughput

0.479

High

315327

RECQ4
ATP-dependent DNA helicase Q4

1

1

High-throughput

0.479

High

349893

SNAI1
Zinc finger protein SNAI1

1

1

High-throughput

0.479

High

411643

NTRK1
High affinity nerve growth factor receptor

1

2

High-throughput

0.479

High

425398

ISG15
Ubiquitin-like protein ISG15

1

2

High-throughput

0.479

High

507719

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

1

High-throughput

0.479

High

588294

RFA2
Replication protein A 32 kDa subunit

1

2

High-throughput

0.479

High

606493

CEBPB
CCAAT/enhancer-binding protein beta

1

1

High-throughput

0.479

High

609971

VGFR1
Vascular endothelial growth factor receptor 1

1

2

High-throughput

0.479

High

695021

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.479

High

720166

UFO
Tyrosine-protein kinase receptor UFO

1

1

High-throughput

0.479

High

731120

STIP1
Stress-induced-phosphoprotein 1

1

2

High-throughput

0.479

High

764573

CTNB1
Catenin beta-1

1

1

High-throughput

0.479

High

786990

FLT3
Receptor-type tyrosine-protein kinase FLT3

1

2

High-throughput

0.479

High

798893

BRCA1
Breast cancer type 1 susceptibility protein

1

2

High-throughput

0.479

High

830407

CCNF
Cyclin-F

1

1

High-throughput

0.479

High

861946

YAP1
Transcriptional coactivator YAP1

1

2

High-throughput

0.479

High

887861

MCM2
DNA replication licensing factor MCM2

1

2

High-throughput

0.479

High

891394

GSK3B
Glycogen synthase kinase-3 beta

1

1

High-throughput

0.479

High

926444

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

1

High-throughput

0.479

High

926448

UBC12
NEDD8-conjugating enzyme Ubc12

1

1

High-throughput

0.479

High

926452

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

1

High-throughput

0.479

High

926453

GRB2
Growth factor receptor-bound protein 2

1

1

High-throughput

0.479

High

926455

NFKB2
Nuclear factor NF-kappa-B p100 subunit

1

1

High-throughput

0.479

High

926470

GRB7
Growth factor receptor-bound protein 7

1

2

Small-scale

0.479

High

926471

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

1

Small-scale

0.479

High

926473

TNIP1
TNFAIP3-interacting protein 1

1

2

High-throughput

0.479

High

926484

A16L1
Autophagy-related protein 16-1

1

3

High-throughput

0.479

High

926492

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.479

High

926499

SLX4
Structure-specific endonuclease subunit SLX4

1

1

High-throughput

0.479

High

926500

RPTOR
Regulatory-associated protein of mTOR

1

2

High-throughput

0.479

High

926513

ESR2
Estrogen receptor beta

1

1

High-throughput

0.479

High

926515

HDAC2
Histone deacetylase 2

1

1

High-throughput

0.479

High

926517

FBXW7
F-box/WD repeat-containing protein 7

1

1

High-throughput

0.479

High

926519

ARMC5
Armadillo repeat-containing protein 5

1

1

High-throughput

0.479

High

926521

CHM4C
Charged multivesicular body protein 4c

1

1

High-throughput

0.479

High

926522

OPTN
Optineurin

1

3

High-throughput

0.479

High

926525

DDRGK
DDRGK domain-containing protein 1

1

1

High-throughput

0.479

High

926527

CI072
Guanine nucleotide exchange factor C9orf72

1

1

High-throughput

0.479

High

926530

RUFY1
RUN and FYVE domain-containing protein 1

1

1

High-throughput

0.479

High

926531

RING2
E3 ubiquitin-protein ligase RING2

1

2

High-throughput

0.479

High

926532

M3K14
Mitogen-activated protein kinase kinase kinase 14

1

1

High-throughput

0.479

High

926540

CCDC8
Coiled-coil domain-containing protein 8

1

1

High-throughput

0.479

High

926541

PKHA4
Pleckstrin homology domain-containing family A member 4

1

2

High-throughput

0.479

High

926553

HDAC6
Protein deacetylase HDAC6

1

2

High-throughput

0.479

High

926559

HDAC5
Histone deacetylase 5

1

2

High-throughput

0.479

High

926565

NEMO
NF-kappa-B essential modulator

1

2

High-throughput

0.479

High

125350

LEG9
Galectin-9

1

0

High-throughput

0.458

High

131852

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

0

High-throughput

0.458

High

141386

DDX3X
ATP-dependent RNA helicase DDX3X

1

0

Small-scale

0.458

High

194072

R113A
E3 ubiquitin-protein ligase RNF113A

1

0

High-throughput

0.458

High

319563

UFL1
E3 UFM1-protein ligase 1

1

0

High-throughput

0.458

High

324669

HEXI1
Protein HEXIM1

1

0

High-throughput

0.458

High

339331

MET18
Histidine protein methyltransferase 1 homolog

1

0

High-throughput

0.458

High

345561

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

0

High-throughput

0.458

High

352374

TOP3B
DNA topoisomerase 3-beta-1

1

0

High-throughput

0.458

High

363025

EGFR
Epidermal growth factor receptor

1

0

High-throughput

0.458

High

379961

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

0

High-throughput

0.458

High

459254

CATL1
Procathepsin L

1

0

High-throughput

0.458

High

555975

CADH1
Cadherin-1

1

0

High-throughput

0.458

High

622558

TNR1A
Tumor necrosis factor receptor superfamily member 1A

1

0

High-throughput

0.458

High

766347

PHB1
Prohibitin 1

1

0

High-throughput

0.458

High

767143

MERL
Merlin

1

0

High-throughput

0.458

High

767783

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.458

High

837484

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

0

High-throughput

0.458

High

861084

MAP1B
Microtubule-associated protein 1B

1

0

High-throughput

0.458

High

872108

SOX2
Transcription factor SOX-2

1

0

High-throughput

0.458

High

878832

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.458

High

926443

ATX3
Ataxin-3

1

0

High-throughput

0.458

High

926454

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.458

High

926456

MDM2
E3 ubiquitin-protein ligase Mdm2

1

0

Small-scale

0.458

High

926457

RUNX1
Runt-related transcription factor 1

1

0

High-throughput

0.458

High

926459

NFX1
Transcriptional repressor NF-X1

1

0

High-throughput

0.458

High

926462

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.458

High

926466

PEBB
Core-binding factor subunit beta

1

0

High-throughput

0.458

High

926467

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

0

High-throughput

0.458

High

926474

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

0

High-throughput

0.458

High

926477

EZH2
Histone-lysine N-methyltransferase EZH2

1

0

High-throughput

0.458

High

926479

CRY1
Cryptochrome-1

1

0

High-throughput

0.458

High

926483

RN123
E3 ubiquitin-protein ligase RNF123

1

0

High-throughput

0.458

High

926486

VIR
Protein virilizer homolog

1

0

High-throughput

0.458

High

926488

CDC73
Parafibromin

1

0

High-throughput

0.458

High

926489

PRP8
Pre-mRNA-processing-splicing factor 8

1

0

High-throughput

0.458

High

926490

RICTR
Rapamycin-insensitive companion of mTOR

1

0

High-throughput

0.458

High

926493

MOB3C
MOB kinase activator 3C

1

0

High-throughput

0.458

High

926494

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.458

High

926495

ZN598
E3 ubiquitin-protein ligase ZNF598

1

0

High-throughput

0.458

High

926498

IFT20
Intraflagellar transport protein 20 homolog

1

0

High-throughput

0.458

High

926501

RHG24
Rho GTPase-activating protein 24

1

0

High-throughput

0.458

High

926503

SERB1
SERPINE1 mRNA-binding protein 1

1

0

High-throughput

0.458

High

926504

FSAF1
40S small subunit processome assembly factor 1

1

0

High-throughput

0.458

High

926508

TIP
T-cell immunomodulatory protein

1

0

High-throughput

0.458

High

926510

TOPB1
DNA topoisomerase 2-binding protein 1

1

0

High-throughput

0.458

High

926511

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

0

High-throughput

0.458

High

926516

TANK
TRAF family member-associated NF-kappa-B activator

1

0

High-throughput

0.458

High

926518

LENG1
Leukocyte receptor cluster member 1

1

0

High-throughput

0.458

High

926520

DCPS
m7GpppX diphosphatase

1

0

High-throughput

0.458

High

926533

ANM1
Protein arginine N-methyltransferase 1

1

0

High-throughput

0.458

High

926534

RIOK1
Serine/threonine-protein kinase RIO1

1

0

High-throughput

0.458

High

926535

GCP2
Gamma-tubulin complex component 2

1

0

High-throughput

0.458

High

926536

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

0

High-throughput

0.458

High

926538

ACE2
Angiotensin-converting enzyme 2

1

0

High-throughput

0.458

High

926539

SPRTN
DNA-dependent metalloprotease SPRTN

1

0

High-throughput

0.458

High

926544

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

0

High-throughput

0.458

High

926545

ANLN
Anillin

1

0

High-throughput

0.458

High

926546

FBX6
F-box only protein 6

1

0

High-throughput

0.458

High

926547

RAD18
E3 ubiquitin-protein ligase RAD18

1

0

High-throughput

0.458

High

926548

PIHD1
PIH1 domain-containing protein 1

1

0

High-throughput

0.458

High

926550

WWOX
WW domain-containing oxidoreductase

1

0

High-throughput

0.458

High

926551

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

1

0

High-throughput

0.458

High

926555

MKRN1
E3 ubiquitin-protein ligase makorin-1

1

0

High-throughput

0.458

High

926556

BAG5
BAG family molecular chaperone regulator 5

1

0

High-throughput

0.458

High

926558

TRI33
E3 ubiquitin-protein ligase TRIM33

1

0

High-throughput

0.458

High

926560

MTMR7
Phosphatidylinositol-3-phosphate phosphatase MTMR7

1

0

High-throughput

0.458

High

926564

LOXL2
Lysyl oxidase homolog 2

1

0

High-throughput

0.458

High

429578

JUN
Transcription factor Jun

1

1

High-throughput

0.445

High

926487

PKHA7
Pleckstrin homology domain-containing family A member 7

1

4

High-throughput

0.445

High

926506

MSPD2
Motile sperm domain-containing protein 2

1

1

High-throughput

0.445

High

926528

CEP63
Centrosomal protein of 63 kDa

1

2

High-throughput

0.445

High

926480

ANR55
Ankyrin repeat domain-containing protein 55

1

1

High-throughput

0.437

High

529411

TAU
Microtubule-associated protein tau

1

0

High-throughput

0.426

High

567317

TCTP
Translationally-controlled tumor protein

1

0

Small-scale

0.426

High

926482

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

0

High-throughput

0.426

High

926561

ITM2B
Integral membrane protein 2B

1

0

High-throughput

0.426

High

886672

CEBPA
CCAAT/enhancer-binding protein alpha

1

1

High-throughput

0.408

High

926543

C1QR1
Complement component C1q receptor

2

0

High-throughput

0.328

High

926524

RMC1
Regulator of MON1-CCZ1 complex

1

0

High-throughput

0.279

Low

926537

TX101
Testis-expressed protein 101

1

0

High-throughput

0.279

Low

353143

AGR2
Anterior gradient protein 2 homolog

1

0

High-throughput

0.249

Low

926468

GRM2
Metabotropic glutamate receptor 2

1

0

High-throughput

0.249

Low

926491

LMBRL
Protein LMBR1L

1

0

High-throughput

0.249

Low

926496

ZCH18
Zinc finger CCCH domain-containing protein 18

1

0

High-throughput

0.249

Low

926523

KCD12
BTB/POZ domain-containing protein KCTD12

1

0

Small-scale

0.249

Low

926549

B3GN2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

1

0

High-throughput

0.249

Low

926562

AAR2
Protein AAR2 homolog

1

0

High-throughput

0.249

Low

987

SIM26
Small integral membrane protein 26

1

0

High-throughput

0.232

Low

926542

VIAAT
Vesicular inhibitory amino acid transporter

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025