Protein: MSH6
DNA mismatch repair protein Msh6 (hMSH6) (G/T mismatch-binding protein) (GTBP) (GTMBP) (MutS protein homolog 6) (MutS-alpha 160 kDa subunit) (p160)

Gene: MSH6
Organism: Homo sapiens
Interactions: 220
UniProt ID: P52701

Gene Ontology (top 5):
GO:0000710 - meiotic mismatch repair
GO:0000785 - chromatin
GO:0003682 - chromatin binding
GO:0003684 - damaged DNA binding
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

794216

MSH2
DNA mismatch repair protein Msh2

18

12

Small-scale

0.987

High

776273

MLH1
DNA mismatch repair protein Mlh1

5

20

Small-scale

0.902

High

469978

H2AZ
Histone H2A.Z

3

8

Small-scale

0.839

High

855452

H31
Histone H3.1

3

20

Small-scale

0.834

High

855442

PMS2
Mismatch repair endonuclease PMS2

3

20

Small-scale

0.827

High

555365

H2AX
Histone H2AX

2

9

Small-scale

0.754

High

855454

H33
Histone H3.3

2

20

High-throughput

0.754

High

517148

PCNA
Proliferating cell nuclear antigen

9

7

Small-scale

0.753

High

855488

H2B2E
Histone H2B type 2-E

1

14

High-throughput

0.691

High

855539

H2A1J
Histone H2A type 1-J

1

7

High-throughput

0.691

High

346294

MYC
Myc proto-oncogene protein

4

4

High-throughput

0.691

High

855564

MCM9
DNA helicase MCM9

3

4

Small-scale

0.656

High

749266

BRCA1
Breast cancer type 1 susceptibility protein

3

8

Small-scale

0.647

High

244155

BRD4
Bromodomain-containing protein 4

3

12

High-throughput

0.640

High

855506

SLX4
Structure-specific endonuclease subunit SLX4

3

6

Small-scale

0.640

High

523618

XRCC6
X-ray repair cross-complementing protein 6

2

3

Small-scale

0.620

High

260808

H2AY
Core histone macro-H2A.1

1

9

High-throughput

0.618

High

828177

CENPA
Histone H3-like centromeric protein A

1

20

High-throughput

0.618

High

855441

PMS1
PMS1 protein homolog 1

1

20

Small-scale

0.618

High

855445

H2B1D
Histone H2B type 1-D

1

14

High-throughput

0.618

High

855449

H2B1C
Histone H2B type 1-C/E/F/G/I

1

14

High-throughput

0.618

High

855474

CUL3
Cullin-3

2

2

High-throughput

0.611

High

855551

SMRCD
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1

2

12

High-throughput

0.611

High

855538

BARD1
BRCA1-associated RING domain protein 1

2

3

Small-scale

0.585

High

855462

EP300
Histone acetyltransferase p300

2

14

Small-scale

0.584

High

855511

SIR6
NAD-dependent protein deacylase sirtuin-6

2

4

Small-scale

0.584

High

855466

CAF1A
Chromatin assembly factor 1 subunit A

1

5

Small-scale

0.578

High

111558

K7EK07
Histone H3

1

20

High-throughput

0.575

High

855491

H2B2F
Histone H2B type 2-F

1

14

High-throughput

0.575

High

369231

ESR1
Estrogen receptor

2

8

High-throughput

0.571

High

855440

BLM
RecQ-like DNA helicase BLM

2

7

Small-scale

0.571

High

855451

CSK21
Casein kinase II subunit alpha

1

1

High-throughput

0.569

High

238262

RAD1
Cell cycle checkpoint protein RAD1

1

2

Small-scale

0.561

High

245892

HUS1
Checkpoint protein HUS1

1

2

Small-scale

0.561

High

855537

RAD9A
Cell cycle checkpoint control protein RAD9A

1

2

Small-scale

0.561

High

855576

MUTYH
Adenine DNA glycosylase

1

1

Small-scale

0.561

High

855523

FBXW7
F-box/WD repeat-containing protein 7

2

0

Small-scale

0.559

High

349210

RASH
GTPase HRas

1

2

High-throughput

0.541

High

855457

MP2K1
Dual specificity mitogen-activated protein kinase kinase 1

1

5

High-throughput

0.541

High

157022

AIM2
Interferon-inducible protein AIM2

1

4

High-throughput

0.536

High

455247

PARP1
Poly [ADP-ribose] polymerase 1

1

11

High-throughput

0.536

High

508412

TOP1
DNA topoisomerase 1

1

1

High-throughput

0.536

High

764348

FEN1
Flap endonuclease 1

1

7

High-throughput

0.536

High

855461

SSRP1
FACT complex subunit SSRP1

1

6

High-throughput

0.536

High

855473

SNW1
SNW domain-containing protein 1

1

1

High-throughput

0.536

High

855485

IF16
Gamma-interferon-inducible protein 16

1

4

High-throughput

0.536

High

855502

MTA70
N6-adenosine-methyltransferase catalytic subunit

1

2

High-throughput

0.536

High

855528

HDA11
Histone deacetylase 11

1

7

High-throughput

0.536

High

855536

CDC5L
Cell division cycle 5-like protein

1

1

High-throughput

0.536

High

855555

WDR76
WD repeat-containing protein 76

1

8

High-throughput

0.536

High

855558

CHD8
Chromodomain-helicase-DNA-binding protein 8

1

7

High-throughput

0.536

High

855577

MCM8
DNA helicase MCM8

1

4

High-throughput

0.536

High

855582

EXO1
Exonuclease 1

1

7

High-throughput

0.536

High

855583

TN13B
Tumor necrosis factor ligand superfamily member 13B

1

1

High-throughput

0.536

High

855586

BIG1
Brefeldin A-inhibited guanine nucleotide-exchange protein 1

1

1

High-throughput

0.536

High

855561

SIAS
Sialic acid synthase

1

0

High-throughput

0.518

High

552296

RFA2
Replication protein A 32 kDa subunit

1

5

High-throughput

0.515

High

830273

CASP4
Caspase-4

1

2

High-throughput

0.515

High

204484

ARK72
Aflatoxin B1 aldehyde reductase member 2

1

0

High-throughput

0.513

High

855468

STX3
Syntaxin-3

1

0

High-throughput

0.513

High

855483

TEBP
Prostaglandin E synthase 3

1

0

High-throughput

0.513

High

855487

DECR
2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial

1

0

High-throughput

0.513

High

855489

TATD3
Putative deoxyribonuclease TATDN3

1

0

High-throughput

0.513

High

855507

RUSC2
AP-4 complex accessory subunit RUSC2

1

0

High-throughput

0.513

High

855508

HROB
Homologous recombination OB-fold protein

1

0

High-throughput

0.513

High

855514

RIN3
Ras and Rab interactor 3

1

0

High-throughput

0.513

High

855574

AAKG3
5'-AMP-activated protein kinase subunit gamma-3

1

0

High-throughput

0.513

High

855446

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

6

High-throughput

0.501

High

855447

SUMO2
Small ubiquitin-related modifier 2

1

3

High-throughput

0.501

High

855478

SMC1A
Structural maintenance of chromosomes protein 1A

1

1

Small-scale

0.501

High

148561

CTRO
Citron Rho-interacting kinase

1

1

High-throughput

0.479

High

154154

CHK1
Serine/threonine-protein kinase Chk1

1

1

Small-scale

0.479

High

161803

ZN263
Zinc finger protein 263

1

1

Small-scale

0.479

High

217462

AIRE
Autoimmune regulator

1

12

Small-scale

0.479

High

226933

PRKN
E3 ubiquitin-protein ligase parkin

1

1

High-throughput

0.479

High

239315

CC14B
Dual specificity protein phosphatase CDC14B

1

8

High-throughput

0.479

High

294565

RECQ4
ATP-dependent DNA helicase Q4

1

9

High-throughput

0.479

High

326523

SNAI1
Zinc finger protein SNAI1

1

2

High-throughput

0.479

High

384536

NTRK1
High affinity nerve growth factor receptor

1

6

High-throughput

0.479

High

386359

P53
Cellular tumor antigen p53

1

2

Small-scale

0.479

High

388326

HSPB1
Heat shock protein beta-1

1

1

Small-scale

0.479

High

441969

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

1

High-throughput

0.479

High

503730

HSP7C
Heat shock cognate 71 kDa protein

1

1

High-throughput

0.479

High

524847

XRCC5
X-ray repair cross-complementing protein 5

1

3

Small-scale

0.479

High

569439

CEBPB
CCAAT/enhancer-binding protein beta

1

4

High-throughput

0.479

High

582152

NUCL
Nucleolin

1

2

High-throughput

0.479

High

617486

CRCM
Colorectal mutant cancer protein

1

1

High-throughput

0.479

High

650738

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

6

High-throughput

0.479

High

673458

MPIP2
M-phase inducer phosphatase 2

1

1

High-throughput

0.479

High

720033

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.479

High

742147

SYUA
Alpha-synuclein

1

1

High-throughput

0.479

High

750187

COIL
Coilin

1

4

High-throughput

0.479

High

779069

CCNF
Cyclin-F

1

1

High-throughput

0.479

High

793858

MATR3
Matrin-3

1

1

High-throughput

0.479

High

798813

GATA4
Transcription factor GATA-4

1

2

High-throughput

0.479

High

801834

RECQ1
ATP-dependent DNA helicase Q1

1

7

High-throughput

0.479

High

808414

YAP1
Transcriptional coactivator YAP1

1

4

High-throughput

0.479

High

823738

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

2

High-throughput

0.479

High

827880

UB2R1
Ubiquitin-conjugating enzyme E2 R1

1

4

High-throughput

0.479

High

855444

DSRAD
Double-stranded RNA-specific adenosine deaminase

1

9

High-throughput

0.479

High

855448

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

1

High-throughput

0.479

High

855450

ACTC
Actin, alpha cardiac muscle 1

1

1

High-throughput

0.479

High

855453

PRKDC
DNA-dependent protein kinase catalytic subunit

1

7

Small-scale

0.479

High

855455

PO5F1
POU domain, class 5, transcription factor 1

1

3

High-throughput

0.479

High

855456

KIF23
Kinesin-like protein KIF23

1

2

High-throughput

0.479

High

855458

MECOM
Histone-lysine N-methyltransferase MECOM

1

3

High-throughput

0.479

High

855459

KPCZ
Protein kinase C zeta type

1

4

Small-scale

0.479

High

855460

RAD51
DNA repair protein RAD51 homolog 1

1

4

Small-scale

0.479

High

855463

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

5

High-throughput

0.479

High

855464

FOXC1
Forkhead box protein C1

1

1

High-throughput

0.479

High

855467

TIF1B
Transcription intermediary factor 1-beta

1

8

High-throughput

0.479

High

855471

BIRC3
Baculoviral IAP repeat-containing protein 3

1

1

High-throughput

0.479

High

855472

ATR
Serine/threonine-protein kinase ATR

1

7

Small-scale

0.479

High

855476

TRI14
Tripartite motif-containing protein 14

1

2

High-throughput

0.479

High

855477

GRB7
Growth factor receptor-bound protein 7

1

2

Small-scale

0.479

High

855480

CUL7
Cullin-7

1

2

High-throughput

0.479

High

855481

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

1

High-throughput

0.479

High

855484

HIF1A
Hypoxia-inducible factor 1-alpha

1

2

High-throughput

0.479

High

855493

RN123
E3 ubiquitin-protein ligase RNF123

1

3

High-throughput

0.479

High

855495

VIR
Protein virilizer homolog

1

1

High-throughput

0.479

High

855496

ZN746
Zinc finger protein 746

1

2

High-throughput

0.479

High

855500

MOB3C
MOB kinase activator 3C

1

1

High-throughput

0.479

High

855501

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

4

High-throughput

0.479

High

855505

S15A3
Solute carrier family 15 member 3

1

1

High-throughput

0.479

High

855510

ZBTB2
Zinc finger and BTB domain-containing protein 2

1

2

High-throughput

0.479

High

855512

ZBT38
Zinc finger and BTB domain-containing protein 38

1

3

Small-scale

0.479

High

855516

FBX25
F-box only protein 25

1

1

High-throughput

0.479

High

855517

PTPM1
Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1

1

5

High-throughput

0.479

High

855518

DGCR8
Microprocessor complex subunit DGCR8

1

2

Small-scale

0.479

High

855519

TOPB1
DNA topoisomerase 2-binding protein 1

1

1

Small-scale

0.479

High

855521

CBP
CREB-binding protein

1

12

Small-scale

0.479

High

855526

ZUP1
Zinc finger-containing ubiquitin peptidase 1

1

2

High-throughput

0.479

High

855530

SPDLY
Protein Spindly

1

1

High-throughput

0.479

High

855531

AURKB
Aurora kinase B

1

4

High-throughput

0.479

High

855532

CEP19
Centrosomal protein of 19 kDa

1

1

High-throughput

0.479

High

855534

RUFY1
RUN and FYVE domain-containing protein 1

1

2

High-throughput

0.479

High

855535

UHRF1
E3 ubiquitin-protein ligase UHRF1

1

6

Small-scale

0.479

High

855542

RN126
E3 ubiquitin-protein ligase RNF126

1

1

High-throughput

0.479

High

855543

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

4

High-throughput

0.479

High

855546

WWTR1
WW domain-containing transcription regulator protein 1

1

4

High-throughput

0.479

High

855547

AICDA
Single-stranded DNA cytosine deaminase

1

1

Small-scale

0.479

High

855553

EGLN3
Prolyl hydroxylase EGLN3

1

1

High-throughput

0.479

High

855554

BRD9
Bromodomain-containing protein 9

1

6

High-throughput

0.479

High

855560

ANLN
Anillin

1

2

High-throughput

0.479

High

855562

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

4

High-throughput

0.479

High

855565

MTMR4
Myotubularin-related protein 4

1

1

High-throughput

0.479

High

855566

TLS1
Splicing factor C9orf78

1

1

High-throughput

0.479

High

855567

WWOX
WW domain-containing oxidoreductase

1

1

High-throughput

0.479

High

855568

DTL
Denticleless protein homolog

1

5

Small-scale

0.479

High

855569

HDAC6
Histone deacetylase 6

1

6

Small-scale

0.479

High

855570

KS6B2
Ribosomal protein S6 kinase beta-2

1

2

High-throughput

0.479

High

855571

POLK
DNA polymerase kappa

1

3

Small-scale

0.479

High

855573

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.479

High

855575

PARP2
Poly [ADP-ribose] polymerase 2

1

6

High-throughput

0.479

High

855579

FZR1
Fizzy-related protein homolog

1

3

High-throughput

0.479

High

855580

CC14A
Dual specificity protein phosphatase CDC14A

1

8

High-throughput

0.479

High

855581

TRI33
E3 ubiquitin-protein ligase TRIM33

1

10

High-throughput

0.479

High

855584

ZN330
Zinc finger protein 330

1

3

High-throughput

0.479

High

182630

R113A
E3 ubiquitin-protein ligase RNF113A

1

0

High-throughput

0.458

High

304083

UBR5
E3 ubiquitin-protein ligase UBR5

1

0

Small-scale

0.458

High

622412

CCND1
G1/S-specific cyclin-D1

1

0

High-throughput

0.458

High

855443

PSMD4
26S proteasome non-ATPase regulatory subunit 4

1

0

Small-scale

0.458

High

855469

G3BP1
Ras GTPase-activating protein-binding protein 1

1

0

High-throughput

0.458

High

855486

CDKN3
Cyclin-dependent kinase inhibitor 3

1

0

High-throughput

0.458

High

855490

CL16A
Protein CLEC16A

1

0

High-throughput

0.458

High

855504

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

855520

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

0

High-throughput

0.458

High

855540

RIOK1
Serine/threonine-protein kinase RIO1

1

0

High-throughput

0.458

High

855548

SPRTN
DNA-dependent metalloprotease SPRTN

1

0

High-throughput

0.458

High

855556

CLSPN
Claspin

1

0

Small-scale

0.458

High

855559

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

0

High-throughput

0.458

High

855572

MO4L1
Mortality factor 4-like protein 1

1

0

Small-scale

0.458

High

102360

G3V167
Poly [ADP-ribose] polymerase

1

6

High-throughput

0.445

High

135231

E2F3
Transcription factor E2F3

1

1

Small-scale

0.445

High

246195

NBN
Nibrin

1

1

Small-scale

0.445

High

306040

GBRAP
Gamma-aminobutyric acid receptor-associated protein

1

1

High-throughput

0.445

High

330921

PAK4
Serine/threonine-protein kinase PAK 4

1

2

High-throughput

0.445

High

371382

ANGI
Angiogenin

1

1

High-throughput

0.445

High

632657

TYY1
Transcriptional repressor protein YY1

1

1

Small-scale

0.445

High

722199

RFC1
Replication factor C subunit 1

1

1

Small-scale

0.445

High

836976

MRE11
Double-strand break repair protein MRE11

1

2

Small-scale

0.445

High

855465

STK4
Serine/threonine-protein kinase 4

1

1

High-throughput

0.445

High

855470

ATM
Serine-protein kinase ATM

1

7

Small-scale

0.445

High

855479

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

1

High-throughput

0.445

High

855492

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

2

High-throughput

0.445

High

855522

RAD50
DNA repair protein RAD50

1

4

Small-scale

0.445

High

855541

AN32E
Acidic leucine-rich nuclear phosphoprotein 32 family member E

1

2

Small-scale

0.445

High

855545

ZDHC5
Palmitoyltransferase ZDHHC5

1

1

High-throughput

0.445

High

855550

MLP3A
Microtubule-associated proteins 1A/1B light chain 3A

1

1

High-throughput

0.445

High

855475

TRI29
Tripartite motif-containing protein 29

1

3

Small-scale

0.437

High

855497

LRC31
Leucine-rich repeat-containing protein 31

1

2

High-throughput

0.437

High

855498

TRI67
Tripartite motif-containing protein 67

1

10

High-throughput

0.437

High

855503

GPAT4
Glycerol-3-phosphate acyltransferase 4

1

1

High-throughput

0.437

High

855527

FAF2
FAS-associated factor 2

1

2

High-throughput

0.437

High

855544

ACE2
Angiotensin-converting enzyme 2

1

2

High-throughput

0.437

High

855552

PKHA4
Pleckstrin homology domain-containing family A member 4

1

3

High-throughput

0.437

High

855578

HECD1
E3 ubiquitin-protein ligase HECTD1

1

3

High-throughput

0.437

High

321024

PTBP3
Polypyrimidine tract-binding protein 3

1

0

High-throughput

0.426

High

855509

RYBP
RING1 and YY1-binding protein

1

0

High-throughput

0.426

High

855533

NUDC1
NudC domain-containing protein 1

1

0

High-throughput

0.426

High

855563

MED9
Mediator of RNA polymerase II transcription subunit 9

1

0

High-throughput

0.426

High

831127

CEBPA
CCAAT/enhancer-binding protein alpha

1

4

High-throughput

0.408

High

99576

F5H1C8
Solute carrier family 15 member 3

1

1

High-throughput

0.407

High

168175

PLCB
1-acyl-sn-glycerol-3-phosphate acyltransferase beta

1

1

High-throughput

0.407

High

234649

BRNP1
BMP/retinoic acid-inducible neural-specific protein 1

1

0

High-throughput

0.279

Low

855482

P2RY6
P2Y purinoceptor 6

1

0

High-throughput

0.279

Low

855515

F174A
Membrane protein FAM174A

1

0

High-throughput

0.279

Low

855524

P33MX
Putative monooxygenase p33MONOX

1

0

High-throughput

0.279

Low

855529

RMC1
Regulator of MON1-CCZ1 complex

1

0

High-throughput

0.279

Low

855549

UN93B
Protein unc-93 homolog B1

1

0

High-throughput

0.279

Low

855557

ZDBF2
DBF4-type zinc finger-containing protein 2

1

0

High-throughput

0.279

Low

855585

GPR45
Probable G-protein coupled receptor 45

1

0

High-throughput

0.279

Low

329522

AGR2
Anterior gradient protein 2 homolog

1

0

High-throughput

0.269

Low

541230

GBRA1
Gamma-aminobutyric acid receptor subunit alpha-1

1

0

High-throughput

0.249

Low

660838

PTPRM
Receptor-type tyrosine-protein phosphatase mu

1

0

High-throughput

0.249

Low

855499

UBP53
Inactive ubiquitin carboxyl-terminal hydrolase 53

1

0

Small-scale

0.249

Low

855525

LRC59
Leucine-rich repeat-containing protein 59

1

0

High-throughput

0.249

Low

985

SIM26
Small integral membrane protein 26

1

0

High-throughput

0.232

Low

855494

KANK2
KN motif and ankyrin repeat domain-containing protein 2

1

0

Small-scale

0.232

Low

855513

MOT11
Monocarboxylate transporter 11

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024