Protein: AKA11
A-kinase anchor protein 11 (AKAP-11) (A-kinase anchor protein 220 kDa) (AKAP 220) (hAKAP220) (Protein kinase A-anchoring protein 11) (PRKA11)

Gene: AKA11, AKAP11
Organism: Homo sapiens
Interactions: 111
UniProt ID: Q9UKA4

Gene Ontology (top 5):
GO:0003091 - renal water homeostasis
GO:0005730 - nucleolus
GO:0005737 - cytoplasm
GO:0005813 - centrosome
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

891871

GSK3B
Glycogen synthase kinase-3 beta

6

1

Small-scale

0.739

High

651733

KAPCB
cAMP-dependent protein kinase catalytic subunit beta

6

2

High-throughput

0.735

High

531173

KAP0
cAMP-dependent protein kinase type I-alpha regulatory subunit

6

6

Small-scale

0.729

High

605843

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

5

2

Small-scale

0.720

High

725564

KAP3
cAMP-dependent protein kinase type II-beta regulatory subunit

5

6

Small-scale

0.720

High

333252

VAPB
Vesicle-associated membrane protein-associated protein B/C

5

1

High-throughput

0.716

High

1453836

VAPA
Vesicle-associated membrane protein-associated protein A

4

1

High-throughput

0.697

High

891349

GSK3A
Glycogen synthase kinase-3 alpha

3

1

High-throughput

0.664

High

921579

PGTB2
Geranylgeranyl transferase type-2 subunit beta

3

0

High-throughput

0.638

High

946218

MLF1
Myeloid leukemia factor 1

3

0

High-throughput

0.638

High

1386740

AP2M1
AP-2 complex subunit mu

3

0

High-throughput

0.638

High

1460911

VPS28
Vacuolar protein sorting-associated protein 28 homolog

3

0

High-throughput

0.638

High

568864

KAP2
cAMP-dependent protein kinase type II-alpha regulatory subunit

3

5

Small-scale

0.635

High

1430551

TSYL1
Testis-specific Y-encoded-like protein 1

3

0

High-throughput

0.634

High

1460993

DYR1B
Dual specificity tyrosine-phosphorylation-regulated kinase 1B

2

1

High-throughput

0.628

High

1114616

CUL3
Cullin-3

2

1

High-throughput

0.611

High

903100

DNA2
DNA replication ATP-dependent helicase/nuclease DNA2

2

0

High-throughput

0.602

High

1399825

ERMAP
Erythroid membrane-associated protein

2

0

High-throughput

0.602

High

1452117

KLH28
Kelch-like protein 28

2

0

High-throughput

0.602

High

968031

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

2

2

Small-scale

0.595

High

1232385

SFRP4
Secreted frizzled-related protein 4

2

0

High-throughput

0.585

High

244287

NUAK1
NUAK family SNF1-like kinase 1

1

1

High-throughput

0.536

High

650588

KAPCG
cAMP-dependent protein kinase catalytic subunit gamma

1

2

High-throughput

0.536

High

725474

KAP1
cAMP-dependent protein kinase type I-beta regulatory subunit

1

5

High-throughput

0.536

High

1253245

FGD5
FYVE, RhoGEF and PH domain-containing protein 5

1

1

High-throughput

0.536

High

1370589

FGF11
Fibroblast growth factor 11

1

1

High-throughput

0.536

High

1370607

FGF14
Fibroblast growth factor 14

1

1

High-throughput

0.536

High

1163275

H2B2E
Histone H2B type 2-E

1

2

High-throughput

0.515

High

1372335

H2B1H
Histone H2B type 1-H

1

2

High-throughput

0.515

High

169320

LECT2
Leukocyte cell-derived chemotaxin-2

1

0

High-throughput

0.513

High

788811

SRP14
Signal recognition particle 14 kDa protein

1

0

High-throughput

0.513

High

860049

RL28
Large ribosomal subunit protein eL28

1

0

High-throughput

0.513

High

872867

SOX2
Transcription factor SOX-2

1

0

High-throughput

0.513

High

1103807

PLD1
Phospholipase D1

1

0

High-throughput

0.513

High

1178913

CF184
Cilia- and flagella-associated protein 184

1

0

High-throughput

0.513

High

1228219

CR3L3
Cyclic AMP-responsive element-binding protein 3-like protein 3

1

0

High-throughput

0.513

High

1310513

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.513

High

1311050

SULF2
Extracellular sulfatase Sulf-2

1

0

High-throughput

0.513

High

1417903

DUS16
Dual specificity protein phosphatase 16

1

0

High-throughput

0.513

High

1437638

ROP1A
Ropporin-1A

1

0

High-throughput

0.513

High

1448394

PICK1
PRKCA-binding protein

1

0

High-throughput

0.513

High

1452036

TRM1
tRNA

1

0

High-throughput

0.513

High

1452152

CARF
CDKN2A-interacting protein

1

0

High-throughput

0.513

High

1454590

MAP10
Microtubule-associated protein 10

1

0

High-throughput

0.513

High

1460789

HSPB8
Heat shock protein beta-8

1

0

High-throughput

0.513

High

255275

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

1

High-throughput

0.500

High

1448456

SMYD2
N-lysine methyltransferase SMYD2

1

0

High-throughput

0.493

High

1406910

LITAF
Lipopolysaccharide-induced tumor necrosis factor-alpha factor

1

0

High-throughput

0.493

High

136995

AGRIN
Agrin [Cleaved into: Agrin N-terminal 110 kDa subunit; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 90 kDa fragment

1

1

High-throughput

0.479

High

691524

1433T
14-3-3 protein theta

1

6

High-throughput

0.479

High

730339

1433B
14-3-3 protein beta/alpha

1

6

High-throughput

0.479

High

730948

1433S
14-3-3 protein sigma

1

6

High-throughput

0.479

High

786917

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

2

Small-scale

0.479

High

967000

1433G
14-3-3 protein gamma

1

6

High-throughput

0.479

High

968475

PP1B
Serine/threonine-protein phosphatase PP1-beta catalytic subunit

1

2

Small-scale

0.479

High

981171

H2B1C
Histone H2B type 1-C/E/F/G/I

1

2

High-throughput

0.479

High

990849

1433Z
14-3-3 protein zeta/delta

1

6

High-throughput

0.479

High

1049893

1433F
14-3-3 protein eta

1

6

High-throughput

0.479

High

1116115

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

1

High-throughput

0.479

High

1141011

KIF14
Kinesin-like protein KIF14

1

1

High-throughput

0.479

High

243250

PRKN
E3 ubiquitin-protein ligase parkin

1

0

High-throughput

0.458

High

294508

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.458

High

342057

CEP43
Centrosomal protein 43

1

0

High-throughput

0.458

High

437382

K2C8
Keratin, type II cytoskeletal 8

1

0

High-throughput

0.458

High

447558

NPM
Nucleophosmin

1

0

High-throughput

0.458

High

603385

KPCA
Protein kinase C alpha type

1

0

High-throughput

0.458

High

766929

PHB1
Prohibitin 1

1

0

High-throughput

0.458

High

861832

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

0

Small-scale

0.458

High

901663

RAB7A
Ras-related protein Rab-7a

1

0

High-throughput

0.458

High

951509

SC61B
Protein transport protein Sec61 subunit beta

1

0

High-throughput

0.458

High

971265

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

972111

1433E
14-3-3 protein epsilon

1

0

High-throughput

0.458

High

1106744

SMAD4
Mothers against decapentaplegic homolog 4

1

0

High-throughput

0.458

High

1142011

EEA1
Early endosome antigen 1

1

0

High-throughput

0.458

High

1156242

ZYX
Zyxin

1

0

High-throughput

0.458

High

1204664

TFDP3
Transcription factor Dp family member 3

1

0

High-throughput

0.458

High

1256027

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.458

High

1348002

DPTOR
DEP domain-containing mTOR-interacting protein

1

0

Small-scale

0.458

High

1383158

LRC59
Leucine-rich repeat-containing protein 59

1

0

High-throughput

0.458

High

1395987

DNJC1
DnaJ homolog subfamily C member 1

1

0

High-throughput

0.458

High

1405702

NECD
Necdin

1

0

High-throughput

0.458

High

1428411

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

0

High-throughput

0.458

High

1431561

VP33B
Vacuolar protein sorting-associated protein 33B

1

0

High-throughput

0.458

High

1433115

CHM4B
Charged multivesicular body protein 4b

1

0

High-throughput

0.458

High

1435431

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

1460990

MYO6
Unconventional myosin-VI

1

0

High-throughput

0.458

High

1460991

ALK
ALK tyrosine kinase receptor

1

0

High-throughput

0.458

High

1448546

DISC1
Disrupted in schizophrenia 1 protein

1

0

High-throughput

0.438

High

842886

CDN2A
Cyclin-dependent kinase inhibitor 2A

1

0

High-throughput

0.426

High

1010981

BAT1
b(0,+)-type amino acid transporter 1

1

0

High-throughput

0.426

High

1227672

A16L1
Autophagy-related protein 16-1

1

0

High-throughput

0.426

High

1458881

SL9A2
Sodium/hydrogen exchanger 2

1

0

High-throughput

0.426

High

1460992

S27A6
Long-chain fatty acid transport protein 6

1

0

High-throughput

0.426

High

1332287

GG6L2
Golgin subfamily A member 6-like protein 2

1

1

High-throughput

0.407

High

793782

ETFB
Electron transfer flavoprotein subunit beta

2

0

High-throughput

0.328

High

1402091

CRML
Protein cramped-like

2

0

High-throughput

0.328

High

1402691

DCR1C
Protein artemis

2

0

High-throughput

0.318

High

1407056

SNAG
Gamma-soluble NSF attachment protein

2

0

High-throughput

0.318

High

756082

MCM5
DNA replication licensing factor MCM5

1

0

High-throughput

0.279

Low

774813

TIMP3
Metalloproteinase inhibitor 3

1

0

High-throughput

0.279

Low

1126384

PIGH
Phosphatidylinositol N-acetylglucosaminyltransferase subunit H

1

0

High-throughput

0.279

Low

1312668

IQCF2
IQ domain-containing protein F2

1

0

High-throughput

0.279

Low

1407014

NPAS1
Neuronal PAS domain-containing protein 1

1

0

High-throughput

0.279

Low

596411

H12
Histone H1.2

1

0

High-throughput

0.269

Low

124529

HAX1
HCLS1-associated protein X-1

1

0

High-throughput

0.249

Low

502171

H2AZ
Histone H2A.Z

1

0

High-throughput

0.249

Low

1324514

FA43A
Protein FAM43A

1

0

High-throughput

0.249

Low

1404273

SEC62
Translocation protein SEC62

1

0

High-throughput

0.249

Low

1414499

DERL1
Derlin-1

1

0

High-throughput

0.249

Low

1458451

RBL2A
Rab-like protein 2A

1

0

High-throughput

0.249

Low

1314474

SLX4
Structure-specific endonuclease subunit SLX4

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025