Protein: TOPRS
E3 ubiquitin-protein ligase Topors (EC 2.3.2.27) (RING-type E3 ubiquitin transferase Topors) (SUMO1-protein E3 ligase Topors) (Topoisomerase I-binding RING finger protein) (Topoisomerase I-binding arginine/serine-rich protein) (Tumor suppressor p53-binding protein 3) (p53-binding protein 3) (p53BP3)

Gene: TOPRS, TOPORS
Organism: Homo sapiens
Interactions: 94
UniProt ID: Q9NS56

Gene Ontology (top 5):
GO:0000151 - ubiquitin ligase complex
GO:0000209 - protein polyubiquitination
GO:0000922 - spindle pole
GO:0000930 - gamma-tubulin complex
GO:0003677 - DNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

849457

UB2D1
Ubiquitin-conjugating enzyme E2 D1

5

6

Small-scale

0.935

High

1282352

UB2E3
Ubiquitin-conjugating enzyme E2 E3

2

6

High-throughput

0.811

High

895925

UB2D3
Ubiquitin-conjugating enzyme E2 D3

2

6

Small-scale

0.800

High

919873

UB2D2
Ubiquitin-conjugating enzyme E2 D2

2

6

High-throughput

0.800

High

930412

UBC9
SUMO-conjugating enzyme UBC9

2

6

Small-scale

0.767

High

669004

PML
Protein PML

2

3

Small-scale

0.754

High

387590

P53
Cellular tumor antigen p53

6

5

Small-scale

0.729

High

159095

UB2L6
Ubiquitin/ISG15-conjugating enzyme E2 L6

1

7

High-throughput

0.698

High

896550

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

6

High-throughput

0.698

High

1284889

UBE2W
Ubiquitin-conjugating enzyme E2 W

1

6

High-throughput

0.698

High

1345306

UB2D4
Ubiquitin-conjugating enzyme E2 D4

1

6

High-throughput

0.698

High

1345307

UB2J1
Ubiquitin-conjugating enzyme E2 J1

1

6

High-throughput

0.698

High

299474

UBXN7
UBX domain-containing protein 7

4

0

High-throughput

0.674

High

508737

TOP1
DNA topoisomerase 1

3

6

Small-scale

0.667

High

1308689

SPI2B
Spindlin-2B

3

1

High-throughput

0.667

High

1316901

MK67I
MKI67 FHA domain-interacting nucleolar phosphoprotein

3

2

High-throughput

0.667

High

1345309

SPIN1
Spindlin-1

3

1

High-throughput

0.667

High

861943

PLK1
Serine/threonine-protein kinase PLK1

3

2

Small-scale

0.664

High

476441

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

2

Small-scale

0.647

High

851891

UB2E1
Ubiquitin-conjugating enzyme E2 E1

1

6

Small-scale

0.647

High

834130

CLK3
Dual specificity protein kinase CLK3

2

3

High-throughput

0.628

High

1201704

ZCH18
Zinc finger CCCH domain-containing protein 18

2

3

High-throughput

0.628

High

1329856

PININ
Pinin

2

3

High-throughput

0.628

High

555662

H2AX
Histone H2AX

2

3

Small-scale

0.624

High

1029921

TIF1B
Transcription intermediary factor 1-beta

1

3

Small-scale

0.618

High

161878

ZN263
Zinc finger protein 263

2

0

High-throughput

0.602

High

1012658

ZN816
Zinc finger protein 816

2

0

High-throughput

0.602

High

1149635

Z324B
Zinc finger protein 324B

2

0

High-throughput

0.602

High

1232154

ZN786
Zinc finger protein 786

2

0

High-throughput

0.602

High

1345304

ZN214
Zinc finger protein 214

2

0

High-throughput

0.602

High

928207

SUMO1
Small ubiquitin-related modifier 1

2

3

Small-scale

0.584

High

967004

SATB1
DNA-binding protein SATB1

2

0

Small-scale

0.570

High

988139

RAD51
DNA repair protein RAD51 homolog 1

1

0

Small-scale

0.561

High

906930

PRS4
26S proteasome regulatory subunit 4

1

1

Small-scale

0.552

High

579744

XRCC1
DNA repair protein XRCC1

1

0

Small-scale

0.537

High

1302454

SIN3A
Paired amphipathic helix protein Sin3a

1

0

Small-scale

0.537

High

1306496

NKX31
Homeobox protein Nkx-3.1

1

3

Small-scale

0.536

High

993848

SRSF4
Serine/arginine-rich splicing factor 4

1

5

High-throughput

0.536

High

1029123

SRSF6
Serine/arginine-rich splicing factor 6

1

5

High-throughput

0.536

High

1070660

RNPS1
RNA-binding protein with serine-rich domain 1

1

1

High-throughput

0.536

High

1059379

CASP8
Caspase-8

1

1

Small-scale

0.515

High

127875

SAP18
Histone deacetylase complex subunit SAP18

1

0

High-throughput

0.513

High

578157

RL17
Large ribosomal subunit protein uL22

1

0

High-throughput

0.513

High

642628

RL13
Large ribosomal subunit protein eL13

1

0

High-throughput

0.513

High

899374

RL15
Large ribosomal subunit protein eL15

1

0

High-throughput

0.513

High

931893

CSK2B
Casein kinase II subunit beta

1

0

High-throughput

0.513

High

1055992

ZN460
Zinc finger protein 460

1

0

High-throughput

0.513

High

1234438

NKAP
NF-kappa-B-activating protein

1

0

High-throughput

0.513

High

1345305

ABT1
Activator of basal transcription 1

1

0

High-throughput

0.513

High

1188067

SETX
Probable helicase senataxin

1

1

Small-scale

0.508

High

1199431

LYRIC
Protein LYRIC

1

0

Small-scale

0.504

High

1345302

TOPRS
E3 ubiquitin-protein ligase Topors

1

5

High-throughput

0.501

High

1252889

ZCH10
Zinc finger CCHC domain-containing protein 10

1

1

High-throughput

0.489

High

214387

SPOP
Speckle-type POZ protein

1

2

Small-scale

0.481

High

902769

SUMO2
Small ubiquitin-related modifier 2

1

3

Small-scale

0.481

High

1128547

HABP4
Intracellular hyaluronan-binding protein 4

1

1

Small-scale

0.481

High

1241020

SERB1
SERPINE1 mRNA-binding protein 1

1

1

Small-scale

0.481

High

1270805

CBP
CREB-binding protein

1

3

Small-scale

0.481

High

1307005

ANM1
Protein arginine N-methyltransferase 1

1

3

Small-scale

0.481

High

195560

DHX15
ATP-dependent RNA helicase DHX15

1

3

Small-scale

0.479

High

268878

SF3B1
Splicing factor 3B subunit 1

1

2

Small-scale

0.479

High

416523

S10A9
Protein S100-A9

1

1

Small-scale

0.479

High

453645

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

1

Small-scale

0.479

High

455913

PARP1
Poly [ADP-ribose] polymerase 1

1

5

Small-scale

0.479

High

541174

HNRPL
Heterogeneous nuclear ribonucleoprotein L

1

1

Small-scale

0.479

High

613592

SFPQ
Splicing factor, proline- and glutamine-rich

1

2

Small-scale

0.479

High

799014

GATA4
Transcription factor GATA-4

1

1

High-throughput

0.479

High

835535

GSK3A
Glycogen synthase kinase-3 alpha

1

6

High-throughput

0.479

High

932889

EF1A1
Elongation factor 1-alpha 1

1

2

Small-scale

0.479

High

941472

RNF4
E3 ubiquitin-protein ligase RNF4

1

2

High-throughput

0.479

High

997927

RBBP4
Histone-binding protein RBBP4

1

2

Small-scale

0.479

High

1019140

TP53B
TP53-binding protein 1

1

2

High-throughput

0.479

High

1049532

SAFB2
Scaffold attachment factor B2

1

2

Small-scale

0.479

High

1050279

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

1

Small-scale

0.479

High

1067159

BRD3
Bromodomain-containing protein 3

1

4

High-throughput

0.479

High

1069806

NONO
Non-POU domain-containing octamer-binding protein

1

2

Small-scale

0.479

High

1083405

RBBP7
Histone-binding protein RBBP7

1

3

Small-scale

0.479

High

1265902

DDB2
DNA damage-binding protein 2

1

2

Small-scale

0.479

High

1328748

REN3A
Regulator of nonsense transcripts 3A

1

4

Small-scale

0.479

High

1343663

ANLN
Anillin

1

2

High-throughput

0.479

High

1345303

ZRAN1
Ubiquitin thioesterase ZRANB1

1

5

High-throughput

0.479

High

310413

EPM2A
Laforin

1

0

Small-scale

0.460

High

801788

RAGP1
Ran GTPase-activating protein 1

1

0

Small-scale

0.458

High

853098

HNRPM
Heterogeneous nuclear ribonucleoprotein M

1

0

Small-scale

0.458

High

942263

GTF2I
General transcription factor II-I

1

0

Small-scale

0.458

High

1251636

SMRC2
SWI/SNF complex subunit SMARCC2

1

0

Small-scale

0.458

High

1251039

SNIP1
Smad nuclear-interacting protein 1

1

1

High-throughput

0.457

High

361531

APOE
Apolipoprotein E

1

0

High-throughput

0.438

High

1255702

RBCC1
RB1-inducible coiled-coil protein 1

1

5

High-throughput

0.437

High

1158582

L2GL2
LLGL scribble cell polarity complex component 2

2

0

High-throughput

0.328

High

327114

GPAN1
G patch domain and ankyrin repeat-containing protein 1

1

0

High-throughput

0.279

Low

1345308

RL36
Large ribosomal subunit protein eL36

1

0

High-throughput

0.279

Low

1188407

ATG9A
Autophagy-related protein 9A

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024