Protein: IPYR2
Inorganic pyrophosphatase 2, mitochondrial (EC 3.6.1.1) (Pyrophosphatase SID6-306) (Pyrophosphate phospho-hydrolase 2) (PPase 2)

Gene: IPYR2, PPA2
Organism: Homo sapiens
Interactions: 93
UniProt ID: Q9H2U2

Gene Ontology (top 5):
GO:0000287 - magnesium ion binding
GO:0004427 - inorganic diphosphate phosphatase activity
GO:0004722 - protein serine/threonine phosphatase activity
GO:0005739 - mitochondrion
GO:0005759 - mitochondrial matrix

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

856381

IF2M
Translation initiation factor IF-2, mitochondrial

4

3

High-throughput

0.694

High

1432191

ACS2L
Acetyl-coenzyme A synthetase 2-like, mitochondrial

3

1

High-throughput

0.667

High

1162545

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

4

0

High-throughput

0.657

High

1217054

LYRM7
Complex III assembly factor LYRM7

3

0

High-throughput

0.638

High

1143976

IPYR
Inorganic pyrophosphatase

1

6

High-throughput

0.618

High

1386083

ACSF2
Medium-chain acyl-CoA ligase ACSF2, mitochondrial

2

1

High-throughput

0.611

High

273103

CLU
Clustered mitochondria protein homolog

2

0

High-throughput

0.585

High

1414997

MECR
Enoyl-[acyl-carrier-protein] reductase, mitochondrial

2

0

High-throughput

0.585

High

1432194

NPS3A
Protein NipSnap homolog 3A

2

0

High-throughput

0.585

High

279909

CISY
Citrate synthase, mitochondrial

2

1

High-throughput

0.584

High

1209649

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

2

2

High-throughput

0.571

High

373129

MYC
Myc proto-oncogene protein

2

2

High-throughput

0.521

High

642289

COMT
Catechol O-methyltransferase

1

0

High-throughput

0.513

High

1216285

NDUF5
Arginine-hydroxylase NDUFAF5, mitochondrial

1

0

High-throughput

0.513

High

1432187

KDM4C
Lysine-specific demethylase 4C

1

2

High-throughput

0.489

High

1432198

SAR1B
Small COPII coat GTPase SAR1B

1

2

High-throughput

0.489

High

282082

MPPB
Mitochondrial-processing peptidase subunit beta

1

1

High-throughput

0.479

High

287378

RF1M
Peptide chain release factor 1, mitochondrial

1

1

High-throughput

0.479

High

532960

CH60
60 kDa heat shock protein, mitochondrial

1

1

High-throughput

0.479

High

828954

MDHM
Malate dehydrogenase, mitochondrial

1

1

High-throughput

0.479

High

882881

EFTU
Elongation factor Tu, mitochondrial

1

4

High-throughput

0.479

High

1058270

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

1

High-throughput

0.479

High

1090535

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

3

High-throughput

0.479

High

1117840

AUHM
Methylglutaconyl-CoA hydratase, mitochondrial

1

2

High-throughput

0.479

High

1207137

SYAM
Alanine--tRNA ligase, mitochondrial

1

1

High-throughput

0.479

High

1272992

FAKD5
FAST kinase domain-containing protein 5, mitochondrial

1

1

High-throughput

0.479

High

1290969

TAXB1
Tax1-binding protein 1

1

1

High-throughput

0.479

High

1335920

PDPR
Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial

1

1

High-throughput

0.479

High

1381720

FAKD4
FAST kinase domain-containing protein 4

1

1

High-throughput

0.479

High

1397652

IMP1L
Mitochondrial inner membrane protease subunit 1

1

1

High-throughput

0.479

High

1401612

EFGM
Elongation factor G, mitochondrial

1

1

High-throughput

0.479

High

1403424

IMP2L
Mitochondrial inner membrane protease subunit 2

1

1

High-throughput

0.479

High

1416540

HINT2
Adenosine 5'-monophosphoramidase HINT2

1

1

High-throughput

0.479

High

1432188

MTG2
Mitochondrial ribosome-associated GTPase 2

1

1

High-throughput

0.479

High

1432195

RF1ML
Peptide chain release factor 1-like, mitochondrial

1

1

High-throughput

0.479

High

1432197

DS13B
Dual specificity protein phosphatase 13B

1

1

High-throughput

0.479

High

61631

VWA8
von Willebrand factor A domain-containing protein 8

1

0

High-throughput

0.458

High

136976

AGRIN
Agrin [Cleaved into: Agrin N-terminal 110 kDa subunit; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 90 kDa fragment

1

0

High-throughput

0.458

High

322310

GLSK
Glutaminase kidney isoform, mitochondrial

1

0

High-throughput

0.458

High

347928

BAG3
BAG family molecular chaperone regulator 3

1

0

High-throughput

0.458

High

425958

PCCB
Propionyl-CoA carboxylase beta chain, mitochondrial

1

0

High-throughput

0.458

High

471245

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

0

High-throughput

0.458

High

727960

DNJA1
DnaJ homolog subfamily A member 1

1

0

High-throughput

0.458

High

841941

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

0

High-throughput

0.458

High

852028

EFTS
Elongation factor Ts, mitochondrial

1

0

High-throughput

0.458

High

888559

ACADV
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial

1

0

High-throughput

0.458

High

1024180

TFAM
Transcription factor A, mitochondrial

1

0

High-throughput

0.458

High

1048692

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

0

High-throughput

0.458

High

1087547

GRSF1
G-rich sequence factor 1

1

0

High-throughput

0.458

High

1104763

NNTM
NAD(P) transhydrogenase, mitochondrial

1

0

High-throughput

0.458

High

1142665

PDK1
[Pyruvate dehydrogenase

1

0

High-throughput

0.458

High

1234526

MRM1
rRNA methyltransferase 1, mitochondrial

1

0

High-throughput

0.458

High

1349937

PNPT1
Polyribonucleotide nucleotidyltransferase 1, mitochondrial

1

0

High-throughput

0.458

High

1383557

MCUR1
Mitochondrial calcium uniporter regulator 1

1

0

High-throughput

0.458

High

1388404

MTEF3
Transcription termination factor 3, mitochondrial

1

0

High-throughput

0.458

High

1415668

TR61B
tRNA

1

0

High-throughput

0.458

High

1431961

IF3M
Translation initiation factor IF-3, mitochondrial

1

0

High-throughput

0.458

High

1432190

MET17
Ribosome assembly protein METTL17, mitochondrial

1

0

High-throughput

0.458

High

1432192

EXD2
Exonuclease 3'-5' domain-containing protein 2

1

0

High-throughput

0.458

High

1432193

MRES1
Mitochondrial transcription rescue factor 1

1

0

High-throughput

0.458

High

1380849

TRI63
E3 ubiquitin-protein ligase TRIM63

1

2

High-throughput

0.439

High

106640

APRIO
Alternative prion protein

1

1

High-throughput

0.437

High

353556

AGR2
Anterior gradient protein 2 homolog

1

1

High-throughput

0.437

High

769153

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.437

High

831415

CCNF
Cyclin-F

1

1

High-throughput

0.437

High

971069

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

1

High-throughput

0.437

High

1015776

RHOG
Rho-related GTP-binding protein RhoG

1

7

High-throughput

0.437

High

1107202

BIRC3
Baculoviral IAP repeat-containing protein 3

1

1

High-throughput

0.437

High

1253237

FGD5
FYVE, RhoGEF and PH domain-containing protein 5

1

1

High-throughput

0.437

High

1255507

TRI67
Tripartite motif-containing protein 67

1

2

High-throughput

0.437

High

1260626

ASXL2
Putative Polycomb group protein ASXL2

1

1

High-throughput

0.437

High

1364248

TOPB1
DNA topoisomerase 2-binding protein 1

1

2

High-throughput

0.437

High

1421196

ASXL3
Putative Polycomb group protein ASXL3

1

1

High-throughput

0.437

High

1432196

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.437

High

1432199

SIR4
NAD-dependent protein lipoamidase sirtuin-4, mitochondrial

1

0

High-throughput

0.426

High

142415

PEX7
Peroxisomal targeting signal 2 receptor

1

3

High-throughput

0.407

High

404911

PRIO
Major prion protein

1

1

High-throughput

0.407

High

595867

H13
Histone H1.3

3

0

High-throughput

0.347

High

1280156

ARPIN
Arpin

3

0

High-throughput

0.347

High

1432189

SYNCI
Syncoilin

2

0

High-throughput

0.328

High

843977

HD
Huntingtin

2

0

High-throughput

0.311

High

329975

ZWINT
Outer kinetochore KNL1 complex subunit ZWINT

1

0

High-throughput

0.279

Low

369089

ASSY
Argininosuccinate synthase

1

0

High-throughput

0.279

Low

156079

SOCS6
Suppressor of cytokine signaling 6

1

0

High-throughput

0.269

Low

1410457

VKOR1
Vitamin K epoxide reductase complex subunit 1

1

0

Small-scale

0.251

Low

208564

PJA2
E3 ubiquitin-protein ligase Praja-2

1

0

Small-scale

0.249

Low

316006

RECQ4
ATP-dependent DNA helicase Q4

1

0

High-throughput

0.249

Low

615590

NELFE
Negative elongation factor E

1

0

High-throughput

0.249

Low

904380

BRCA2
Breast cancer type 2 susceptibility protein

1

0

Small-scale

0.249

Low

1271855

MEPCE
7SK snRNA methylphosphate capping enzyme

1

0

High-throughput

0.249

Low

1383243

CLUA1
Clusterin-associated protein 1

1

0

High-throughput

0.249

Low

330313

VENTX
Homeobox protein VENTX

1

0

High-throughput

0.232

Low

1227445

A16L1
Autophagy-related protein 16-1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025