Protein: SMHD1
Structural maintenance of chromosomes flexible hinge domain-containing protein 1 (SMC hinge domain-containing protein 1) (EC 3.6.1.-)

Gene: SMHD1, SMCHD1
Organism: Homo sapiens
Interactions: 198
UniProt ID: A6NHR9

Gene Ontology (top 5):
GO:0001740 - Barr body
GO:0003677 - DNA binding
GO:0005524 - ATP binding
GO:0005654 - nucleoplasm
GO:0006302 - double-strand break repair

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

65733

H31
Histone H3.1

4

2

High-throughput

0.676

High

65671

MYC
Myc proto-oncogene protein

3

1

High-throughput

0.640

High

65732

H2B1C
Histone H2B type 1-C/E/F/G/I

3

2

High-throughput

0.640

High

65768

LRIF1
Ligand-dependent nuclear receptor-interacting factor 1

2

0

Small-scale

0.602

High

65797

AURKB
Aurora kinase B

2

0

High-throughput

0.602

High

65644

SMHD1
Structural maintenance of chromosomes flexible hinge domain-containing protein 1

1

0

High-throughput

0.586

High

65685

ANDR
Androgen receptor

2

3

High-throughput

0.584

High

65727

SUMO2
Small ubiquitin-related modifier 2

2

0

High-throughput

0.577

High

65745

CBX3
Chromobox protein homolog 3

2

0

High-throughput

0.576

High

65687

XRCC6
X-ray repair cross-complementing protein 6

2

0

High-throughput

0.559

High

65731

H4
Histone H4

2

0

High-throughput

0.559

High

65751

KCC1A
Calcium/calmodulin-dependent protein kinase type 1

1

1

High-throughput

0.536

High

65764

H2B2E
Histone H2B type 2-E

1

2

High-throughput

0.536

High

65770

KDM4D
Lysine-specific demethylase 4D

1

1

High-throughput

0.536

High

65779

STING
Stimulator of interferon genes protein

1

1

High-throughput

0.536

High

65793

OPTN
Optineurin

1

1

High-throughput

0.536

High

65815

KDM4C
Lysine-specific demethylase 4C

1

1

High-throughput

0.536

High

65833

KCC2A
Calcium/calmodulin-dependent protein kinase type II subunit alpha

1

1

High-throughput

0.536

High

65682

NFIC
Nuclear factor 1 C-type

1

3

High-throughput

0.515

High

65654

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

0

High-throughput

0.513

High

65686

PRPS2
Ribose-phosphate pyrophosphokinase 2

1

0

High-throughput

0.513

High

65713

NOTC1
Neurogenic locus notch homolog protein 1

1

0

High-throughput

0.513

High

65720

DGKG
Diacylglycerol kinase gamma

1

0

High-throughput

0.513

High

65723

NEK4
Serine/threonine-protein kinase Nek4

1

0

High-throughput

0.513

High

65735

HMGN5
High mobility group nucleosome-binding domain-containing protein 5

1

0

High-throughput

0.513

High

65746

NMI
N-myc-interactor

1

0

High-throughput

0.513

High

65755

NOLC1
Nucleolar and coiled-body phosphoprotein 1

1

0

High-throughput

0.513

High

65787

IASPP
RelA-associated inhibitor

1

0

High-throughput

0.513

High

65791

EFMT3
EEF1A lysine methyltransferase 3

1

0

High-throughput

0.513

High

65801

CEP19
Centrosomal protein of 19 kDa

1

0

High-throughput

0.513

High

65803

CDC5L
Cell division cycle 5-like protein

1

0

High-throughput

0.513

High

65819

MAGF1
Melanoma-associated antigen F1

1

0

High-throughput

0.513

High

65726

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

1

High-throughput

0.501

High

65734

SRPK2
SRSF protein kinase 2

1

0

High-throughput

0.480

High

65648

TAF4
Transcription initiation factor TFIID subunit 4

1

1

High-throughput

0.479

High

65650

NFIB
Nuclear factor 1 B-type

1

3

High-throughput

0.479

High

65655

TNC18
Trinucleotide repeat-containing gene 18 protein

1

1

High-throughput

0.479

High

65656

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

1

High-throughput

0.479

High

65659

SGTA
Small glutamine-rich tetratricopeptide repeat-containing protein alpha

1

2

Small-scale

0.479

High

65660

SOX15
Transcription factor SOX-15

1

4

High-throughput

0.479

High

65662

H2B1K
Histone H2B type 1-K

1

2

High-throughput

0.479

High

65664

BRD4
Bromodomain-containing protein 4

1

2

High-throughput

0.479

High

65666

EED
Polycomb protein EED

1

2

High-throughput

0.479

High

65675

ESR1
Estrogen receptor

1

3

High-throughput

0.479

High

65677

GCR
Glucocorticoid receptor

1

3

Small-scale

0.479

High

65678

MYCN
N-myc proto-oncogene protein

1

1

High-throughput

0.479

High

65684

PARP1
Poly [ADP-ribose] polymerase 1

1

1

High-throughput

0.479

High

65689

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.479

High

65690

CEBPB
CCAAT/enhancer-binding protein beta

1

1

High-throughput

0.479

High

65695

BRD2
Bromodomain-containing protein 2

1

2

High-throughput

0.479

High

65702

PML
Protein PML

1

1

High-throughput

0.479

High

65703

ELF1
ETS-related transcription factor Elf-1

1

3

High-throughput

0.479

High

65707

SOX6
Transcription factor SOX-6

1

4

High-throughput

0.479

High

65709

BRCA1
Breast cancer type 1 susceptibility protein

1

2

High-throughput

0.479

High

65710

ETV3
ETS translocation variant 3

1

3

High-throughput

0.479

High

65711

ELK3
ETS domain-containing protein Elk-3

1

3

High-throughput

0.479

High

65715

SOX2
Transcription factor SOX-2

1

4

High-throughput

0.479

High

65718

CENPA
Histone H3-like centromeric protein A

1

2

High-throughput

0.479

High

65729

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

1

High-throughput

0.479

High

65736

H33
Histone H3.3

1

2

High-throughput

0.479

High

65741

NFIA
Nuclear factor 1 A-type

1

3

High-throughput

0.479

High

65744

RFA4
Replication protein A 30 kDa subunit

1

1

High-throughput

0.479

High

65753

MDC1
Mediator of DNA damage checkpoint protein 1

1

1

High-throughput

0.479

High

65769

RIF1
Telomere-associated protein RIF1

1

1

High-throughput

0.479

High

65780

CHERP
Calcium homeostasis endoplasmic reticulum protein

1

2

High-throughput

0.479

High

65782

SLX4
Structure-specific endonuclease subunit SLX4

1

1

High-throughput

0.479

High

65788

ESR2
Estrogen receptor beta

1

3

High-throughput

0.479

High

65802

CIC
Protein capicua homolog

1

4

High-throughput

0.479

High

65804

RING2
E3 ubiquitin-protein ligase RING2

1

3

High-throughput

0.479

High

65805

ELF4
ETS-related transcription factor Elf-4

1

3

High-throughput

0.479

High

65818

WDR76
WD repeat-containing protein 76

1

1

High-throughput

0.479

High

65830

FZR1
Fizzy-related protein homolog

1

1

High-throughput

0.479

High

65832

CC14A
Dual specificity protein phosphatase CDC14A

1

1

High-throughput

0.479

High

65795

SGTB
Small glutamine-rich tetratricopeptide repeat-containing protein beta

1

2

High-throughput

0.470

High

65776

PEG10
Retrotransposon-derived protein PEG10

1

0

High-throughput

0.460

High

65806

BARD1
BRCA1-associated RING domain protein 1

1

0

High-throughput

0.460

High

65647

MEN1
Menin

1

0

High-throughput

0.458

High

65651

CTRO
Citron Rho-interacting kinase

1

0

High-throughput

0.458

High

65652

SR140
U2 snRNP-associated SURP motif-containing protein

1

0

High-throughput

0.458

High

65653

PER2
Period circadian protein homolog 2

1

0

Small-scale

0.458

High

65658

ACTN4
Alpha-actinin-4

1

0

High-throughput

0.458

High

65661

NUPR1
Nuclear protein 1

1

0

High-throughput

0.458

High

65663

PAGE4
P antigen family member 4

1

0

High-throughput

0.458

High

65668

UFL1
E3 UFM1-protein ligase 1

1

0

High-throughput

0.458

High

65673

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

0

High-throughput

0.458

High

65676

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.458

High

65679

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.458

High

65693

RO52
E3 ubiquitin-protein ligase TRIM21

1

0

High-throughput

0.458

High

65696

TYY1
Transcriptional repressor protein YY1

1

0

High-throughput

0.458

High

65697

PAX6
Paired box protein Pax-6

1

0

High-throughput

0.458

High

65698

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

65699

APEX1
DNA repair nuclease/redox regulator APEX1

1

0

High-throughput

0.458

High

65700

TEAD1
Transcriptional enhancer factor TEF-1

1

0

High-throughput

0.458

High

65705

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.458

High

65714

YAP1
Transcriptional coactivator YAP1

1

0

High-throughput

0.458

High

65717

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.458

High

65719

UBE2A
Ubiquitin-conjugating enzyme E2 A

1

0

High-throughput

0.458

High

65725

P5CS
Delta-1-pyrroline-5-carboxylate synthase

1

0

High-throughput

0.458

High

65728

WDR5
WD repeat-containing protein 5

1

0

High-throughput

0.458

High

65739

HSF1
Heat shock factor protein 1

1

0

High-throughput

0.458

High

65740

MECOM
Histone-lysine N-methyltransferase MECOM

1

0

High-throughput

0.458

High

65742

SF3A3
Splicing factor 3A subunit 3

1

0

High-throughput

0.458

High

65743

FOXC1
Forkhead box protein C1

1

0

High-throughput

0.458

High

65747

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.458

High

65748

SNW1
SNW domain-containing protein 1

1

0

High-throughput

0.458

High

65749

CUL3
Cullin-3

1

0

High-throughput

0.458

High

65752

NBR1
Next to BRCA1 gene 1 protein

1

0

High-throughput

0.458

High

65757

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

0

High-throughput

0.458

High

65759

SF3A1
Splicing factor 3A subunit 1

1

0

High-throughput

0.458

High

65761

EZH2
Histone-lysine N-methyltransferase EZH2

1

0

High-throughput

0.458

High

65763

IF16
Gamma-interferon-inducible protein 16

1

0

High-throughput

0.458

High

65777

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

65781

SMC5
Structural maintenance of chromosomes protein 5

1

0

High-throughput

0.458

High

65784

CMTR1
Cap-specific mRNA

1

0

High-throughput

0.458

High

65792

DCPS
m7GpppX diphosphatase

1

0

High-throughput

0.458

High

65811

FACD2
Fanconi anemia group D2 protein

1

0

High-throughput

0.458

High

65813

TOLIP
Toll-interacting protein

1

0

High-throughput

0.458

High

65814

CCDC8
Coiled-coil domain-containing protein 8

1

0

High-throughput

0.458

High

65820

ANLN
Anillin

1

0

High-throughput

0.458

High

65821

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

0

High-throughput

0.458

High

65823

GNL3L
Guanine nucleotide-binding protein-like 3-like protein

1

0

High-throughput

0.458

High

65824

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

0

High-throughput

0.458

High

65826

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

65831

UBQL1
Ubiquilin-1

1

0

High-throughput

0.458

High

65835

ZN330
Zinc finger protein 330

1

0

High-throughput

0.458

High

65836

TRRAP
Transformation/transcription domain-associated protein

1

0

High-throughput

0.458

High

65669

VENTX
Homeobox protein VENTX

1

1

High-throughput

0.445

High

65680

JUN
Transcription factor Jun

1

1

High-throughput

0.445

High

65828

TNIK
TRAF2 and NCK-interacting protein kinase

1

0

High-throughput

0.438

High

65706

SOX5
Transcription factor SOX-5

1

4

High-throughput

0.437

High

65750

SPTN1
Spectrin alpha chain, non-erythrocytic 1

1

1

High-throughput

0.437

High

65754

NFIX
Nuclear factor 1 X-type

1

3

High-throughput

0.437

High

65758

BRD3
Bromodomain-containing protein 3

1

2

High-throughput

0.437

High

65773

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.437

High

65829

HECD1
E3 ubiquitin-protein ligase HECTD1

1

1

High-throughput

0.437

High

65701

MK01
Mitogen-activated protein kinase 1

1

0

High-throughput

0.426

High

65778

S2611
Sodium-independent sulfate anion transporter

1

0

High-throughput

0.426

High

65783

DND1
Dead end protein homolog 1

1

0

High-throughput

0.426

High

65721

CEBPA
CCAAT/enhancer-binding protein alpha

1

1

High-throughput

0.408

High

65786

TP4AP
Short transient receptor potential channel 4-associated protein

3

0

High-throughput

0.345

High

65672

TSHB
Thyrotropin subunit beta

2

0

High-throughput

0.328

High

65649

BIN1
Myc box-dependent-interacting protein 1

2

0

High-throughput

0.316

High

65645

HNRC2
Heterogeneous nuclear ribonucleoprotein C-like 2

1

0

High-throughput

0.279

Low

65657

SRGP3
SLIT-ROBO Rho GTPase-activating protein 3

1

0

High-throughput

0.279

Low

65667

MPDZ
Multiple PDZ domain protein

1

0

High-throughput

0.279

Low

65674

FINC
Fibronectin

1

0

High-throughput

0.279

Low

65691

RL35A
Large ribosomal subunit protein eL33

1

0

High-throughput

0.279

Low

65775

SPRE2
Sprouty-related, EVH1 domain-containing protein 2

1

0

High-throughput

0.279

Low

65837

MB212
Protein mab-21-like 2

1

0

High-throughput

0.279

Low

65838

WIF1
Wnt inhibitory factor 1

1

0

High-throughput

0.279

Low

65762

SEPT7
Septin-7

1

0

High-throughput

0.269

Low

65767

DACT2
Dapper homolog 2

1

0

High-throughput

0.269

Low

65796

PHIPL
Phytanoyl-CoA hydroxylase-interacting protein-like

1

0

High-throughput

0.269

Low

65646

LEG9
Galectin-9

1

0

High-throughput

0.249

Low

65665

OBSL1
Obscurin-like protein 1

1

0

High-throughput

0.249

Low

65670

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

0

High-throughput

0.249

Low

65681

K1C18
Keratin, type I cytoskeletal 18

1

0

High-throughput

0.249

Low

65683

F16P1
Fructose-1,6-bisphosphatase 1

1

0

High-throughput

0.249

Low

65688

ITA4
Integrin alpha-4

1

0

High-throughput

0.249

Low

65694

SAHH
Adenosylhomocysteinase

1

0

High-throughput

0.249

Low

65704

GLYM
Serine hydroxymethyltransferase, mitochondrial

1

0

High-throughput

0.249

Low

65708

SYUA
Alpha-synuclein

1

0

High-throughput

0.249

Low

65712

MATR3
Matrin-3

1

0

High-throughput

0.249

Low

65716

IDHP
Isocitrate dehydrogenase [NADP], mitochondrial

1

0

High-throughput

0.249

Low

65722

LHX2
LIM/homeobox protein Lhx2

1

0

High-throughput

0.249

Low

65724

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

0

High-throughput

0.249

Low

65730

CNBP
CCHC-type zinc finger nucleic acid binding protein

1

0

High-throughput

0.249

Low

65737

VIGLN
Vigilin

1

0

High-throughput

0.249

Low

65738

CLH1
Clathrin heavy chain 1

1

0

High-throughput

0.249

Low

65756

CUL7
Cullin-7

1

0

High-throughput

0.249

Low

65765

PDCD4
Programmed cell death protein 4

1

0

High-throughput

0.249

Low

65772

LRC31
Leucine-rich repeat-containing protein 31

1

0

High-throughput

0.249

Low

65774

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.249

Low

65789

FGF11
Fibroblast growth factor 11

1

0

High-throughput

0.249

Low

65794

SPDLY
Protein Spindly

1

0

High-throughput

0.249

Low

65799

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.249

Low

65807

ERP44
Endoplasmic reticulum resident protein 44

1

0

High-throughput

0.249

Low

65808

DERL1
Derlin-1

1

0

Small-scale

0.249

Low

65809

LGR4
Leucine-rich repeat-containing G-protein coupled receptor 4

1

0

High-throughput

0.249

Low

65810

KLF16
Krueppel-like factor 16

1

0

High-throughput

0.249

Low

65816

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.249

Low

65822

FBX6
F-box only protein 6

1

0

High-throughput

0.249

Low

65825

HECW2
E3 ubiquitin-protein ligase HECW2

1

0

High-throughput

0.249

Low

65827

MKRN1
E3 ubiquitin-protein ligase makorin-1

1

0

High-throughput

0.249

Low

65834

E41L3
Band 4.1-like protein 3

1

0

High-throughput

0.249

Low

47001

PNT87
Transcriptional regulator PINT87aa

1

0

Small-scale

0.232

Low

62408

S35F4
Solute carrier family 35 member F4

1

0

High-throughput

0.232

Low

65692

VCAM1
Vascular cell adhesion protein 1

1

0

High-throughput

0.232

Low

65760

UT2
Urea transporter 2

1

0

High-throughput

0.232

Low

65766

KLH22
Kelch-like protein 22

1

0

High-throughput

0.232

Low

65771

TM154
Transmembrane protein 154

1

0

High-throughput

0.232

Low

65785

S35G3
Solute carrier family 35 member G3

1

0

High-throughput

0.232

Low

65790

P33MX
Putative monooxygenase p33MONOX

1

0

High-throughput

0.232

Low

65798

S41A3
Solute carrier family 41 member 3

1

0

High-throughput

0.232

Low

65800

S45A3
Solute carrier family 45 member 3

1

0

High-throughput

0.232

Low

65812

SC11C
Signal peptidase complex catalytic subunit SEC11C

1

0

High-throughput

0.232

Low

65817

VIAAT
Vesicular inhibitory amino acid transporter

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025