Protein: PDCD1
Programmed cell death protein 1 (Protein PD-1) (hPD-1) (CD antigen CD279)

Gene: PDCD1
Organism: Homo sapiens
Interactions: 84
UniProt ID: Q15116

Gene Ontology (top 5):
GO:0001783 - B cell apoptotic process
GO:0002250 - adaptive immune response
GO:0002644 - negative regulation of tolerance induction
GO:0002841 - negative regulation of T cell mediated immune response to tumor cell
GO:0002903 - negative regulation of B cell apoptotic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1142534

PD1L1
Programmed cell death 1 ligand 1

9

4

Small-scale

0.976

High

1142522

PD1L2
Programmed cell death 1 ligand 2

3

4

Small-scale

0.884

High

787165

BMR1A
Bone morphogenetic protein receptor type-1A

2

0

High-throughput

0.770

High

1142503

WDFY3
WD repeat and FYVE domain-containing protein 3

2

0

High-throughput

0.770

High

1142506

DGLB
Diacylglycerol lipase-beta

2

0

High-throughput

0.770

High

691744

MK03
Mitogen-activated protein kinase 3

1

1

Small-scale

0.747

High

853470

UBP5
Ubiquitin carboxyl-terminal hydrolase 5

1

1

Small-scale

0.747

High

1028207

MDM2
E3 ubiquitin-protein ligase Mdm2

1

1

Small-scale

0.747

High

593590

GDC
Solute carrier family 25 member 16

2

4

High-throughput

0.726

High

1142516

MFRN2
Mitoferrin-2

2

4

High-throughput

0.726

High

1142525

SCMC3
Mitochondrial adenyl nucleotide antiporter SLC25A23

2

4

High-throughput

0.726

High

1142543

ORNT1
Mitochondrial ornithine transporter 1

2

4

High-throughput

0.726

High

332217

UCP5
Brain mitochondrial carrier protein 1

1

3

High-throughput

0.691

High

552249

ADT3
ADP/ATP translocase 3

1

3

High-throughput

0.691

High

1142507

GLT11
Polypeptide N-acetylgalactosaminyltransferase 11

2

0

High-throughput

0.679

High

1142508

MCU
Calcium uniporter protein, mitochondrial

2

0

High-throughput

0.679

High

1142517

S2546
Mitochondrial outer membrane protein SLC25A46

2

0

High-throughput

0.679

High

1142539

NOCT
Nocturnin

2

0

High-throughput

0.679

High

1127717

HLTF
Helicase-like transcription factor

1

0

High-throughput

0.656

High

1142527

LGR4
Leucine-rich repeat-containing G-protein coupled receptor 4

1

0

High-throughput

0.656

High

1142528

S26A6
Solute carrier family 26 member 6

1

0

High-throughput

0.656

High

754026

CD80
T-lymphocyte activation antigen CD80

1

3

Small-scale

0.647

High

1142495

SCMC2
Mitochondrial adenyl nucleotide antiporter SLC25A25

1

4

High-throughput

0.618

High

1142505

RPTOR
Regulatory-associated protein of mTOR

1

1

High-throughput

0.618

High

703598

MK01
Mitogen-activated protein kinase 1

1

1

Small-scale

0.618

High

1142520

NGLY1
Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase

1

0

Small-scale

0.606

High

1142497

RHDF2
Inactive rhomboid protein 2

2

0

High-throughput

0.602

High

1142510

SPPL3
Signal peptide peptidase-like 3

2

0

High-throughput

0.602

High

1142536

S53A1
Solute carrier family 53 member 1

2

0

High-throughput

0.602

High

1053666

PTN11
Tyrosine-protein phosphatase non-receptor type 11

3

1

Small-scale

0.593

High

728246

AKT1
RAC-alpha serine/threonine-protein kinase

1

0

High-throughput

0.586

High

269014

ABCB7
Iron-sulfur clusters transporter ABCB7, mitochondrial

1

0

High-throughput

0.578

High

849001

PTN9
Tyrosine-protein phosphatase non-receptor type 9

2

1

High-throughput

0.574

High

1142537

GCP4
Gamma-tubulin complex component 4

2

1

High-throughput

0.574

High

1142492

DCAF8
DDB1- and CUL4-associated factor 8

1

1

Small-scale

0.553

High

1099917

TIF1B
Transcription intermediary factor 1-beta

1

0

Small-scale

0.517

High

1142491

KLH22
Kelch-like protein 22

1

0

Small-scale

0.517

High

1142514

FBXW7
F-box/WD repeat-containing protein 7

1

0

Small-scale

0.517

High

658708

JAK1
Tyrosine-protein kinase JAK1

1

0

High-throughput

0.513

High

896382

ERF
ETS domain-containing transcription factor ERF

1

0

High-throughput

0.513

High

963567

DAD1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1

1

0

High-throughput

0.513

High

975044

ARF6
ADP-ribosylation factor 6

1

0

High-throughput

0.513

High

1130688

DIP2A
Disco-interacting protein 2 homolog A

1

0

High-throughput

0.513

High

1142493

LMBD2
G-protein coupled receptor-associated protein LMBRD2

1

0

High-throughput

0.513

High

1142498

GOLI
E3 ubiquitin-protein ligase RNF130

1

3

Small-scale

0.501

High

1142530

RN167
E3 ubiquitin-protein ligase RNF167

1

2

Small-scale

0.501

High

1142518

GCP3
Gamma-tubulin complex component 3

1

1

High-throughput

0.489

High

1142521

ARL5B
ADP-ribosylation factor-like protein 5B

1

1

High-throughput

0.489

High

988969

AP2B1
AP-2 complex subunit beta

1

0

High-throughput

0.480

High

1142540

AMFR
E3 ubiquitin-protein ligase AMFR

1

1

Small-scale

0.479

High

1142490

DDB1
DNA damage-binding protein 1

1

0

Small-scale

0.458

High

1142511

RN128
E3 ubiquitin-protein ligase RNF128

1

3

Small-scale

0.457

High

711129

PTN6
Tyrosine-protein phosphatase non-receptor type 6

1

1

Small-scale

0.445

High

67368

RTL8C
Retrotransposon Gag-like protein 8C

2

0

High-throughput

0.328

High

732818

GLPK
Glycerol kinase

2

0

High-throughput

0.328

High

1071216

ABD18
Protein ABHD18

2

0

High-throughput

0.328

High

1142500

T126B
Complex I assembly factor TMEM126B, mitochondrial

2

0

High-throughput

0.328

High

1142501

DEN6A
Protein DENND6A

2

0

High-throughput

0.328

High

1142502

PLPL6
Patatin-like phospholipase domain-containing protein 6

2

0

High-throughput

0.328

High

1142512

CHPT1
Cholinephosphotransferase 1

2

0

High-throughput

0.328

High

1142513

FAM3C
Protein FAM3C

2

0

High-throughput

0.328

High

1142515

POP5
Ribonuclease P/MRP protein subunit POP5

2

0

High-throughput

0.328

High

1142519

INT4
Integrator complex subunit 4

2

0

High-throughput

0.328

High

1142524

RCAF1
GEL complex subunit OPTI

2

0

High-throughput

0.328

High

1142526

SFXN3
Sideroflexin-3

2

0

High-throughput

0.328

High

1142532

INT7
Integrator complex subunit 7

2

0

High-throughput

0.328

High

1142538

XPO7
Exportin-7

2

0

High-throughput

0.328

High

193276

SOCS1
Suppressor of cytokine signaling 1

2

0

Small-scale

0.313

High

49447

TM223
Transmembrane protein 223

1

0

High-throughput

0.279

Low

536253

PPAL
Lysosomal acid phosphatase

1

0

High-throughput

0.279

Low

1142494

HEAT6
HEAT repeat-containing protein 6

1

0

High-throughput

0.279

Low

1142496

CC033
Protein C3orf33

1

0

High-throughput

0.279

Low

1142499

DCP2
m7GpppN-mRNA hydrolase

1

0

High-throughput

0.279

Low

1142504

CKLF8
CKLF-like MARVEL transmembrane domain-containing protein 8

1

0

High-throughput

0.279

Low

1142509

NAV1
Neuron navigator 1

1

0

High-throughput

0.279

Low

1142523

TBCD
Tubulin-specific chaperone D

1

0

High-throughput

0.279

Low

1142529

EMRE
Essential MCU regulator, mitochondrial

1

0

High-throughput

0.279

Low

1142531

FIRRM
FIGNL1-interacting regulator of recombination and mitosis

1

0

High-throughput

0.279

Low

1142533

RTEL1
Regulator of telomere elongation helicase 1

1

0

High-throughput

0.279

Low

1142535

SH3B4
SH3 domain-binding protein 4

1

0

High-throughput

0.279

Low

1142542

T184B
Transmembrane protein 184B

1

0

High-throughput

0.279

Low

1142544

BIG2
Brefeldin A-inhibited guanine nucleotide-exchange protein 2

1

0

High-throughput

0.279

Low

325846

UBR5
E3 ubiquitin-protein ligase UBR5

1

0

Small-scale

0.249

Low

1142541

AGO1
Protein argonaute-1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025