Protein: KIF22
Kinesin-like protein KIF22 (Kinesin-like DNA-binding protein) (Kinesin-like protein 4)

Gene: KIF22
Organism: Homo sapiens
Interactions: 125
UniProt ID: Q14807

Gene Ontology (top 5):
GO:0000278 - mitotic cell cycle
GO:0000776 - kinetochore
GO:0000785 - chromatin
GO:0003677 - DNA binding
GO:0003777 - microtubule motor activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

138687

IMA4
Importin subunit alpha-4

4

3

High-throughput

0.704

High

142551

IMA3
Importin subunit alpha-3

4

3

High-throughput

0.704

High

1132608

MK14
Mitogen-activated protein kinase 14

3

3

High-throughput

0.667

High

1132622

TBC15
TBC1 domain family member 15

3

2

High-throughput

0.662

High

998323

H31
Histone H3.1

3

16

High-throughput

0.640

High

1132629

UBP47
Ubiquitin carboxyl-terminal hydrolase 47

2

6

High-throughput

0.628

High

1132603

KIF14
Kinesin-like protein KIF14

1

15

High-throughput

0.618

High

1132627

CHFR
E3 ubiquitin-protein ligase CHFR

1

7

Small-scale

0.618

High

487324

PARP1
Poly [ADP-ribose] polymerase 1

2

7

High-throughput

0.611

High

1132623

CKAP2
Cytoskeleton-associated protein 2

2

0

High-throughput

0.602

High

272181

OBSL1
Obscurin-like protein 1

2

3

High-throughput

0.584

High

372047

MYC
Myc proto-oncogene protein

2

11

High-throughput

0.584

High

980772

H2B1C
Histone H2B type 1-C/E/F/G/I

2

14

High-throughput

0.584

High

1132619

SIAH1
E3 ubiquitin-protein ligase SIAH1

1

3

Small-scale

0.573

High

396127

ESR1
Estrogen receptor

2

14

High-throughput

0.571

High

1132650

HECD1
E3 ubiquitin-protein ligase HECTD1

1

7

High-throughput

0.553

High

248398

GDF9
Growth/differentiation factor 9

1

1

High-throughput

0.541

High

1132621

PJA1
E3 ubiquitin-protein ligase Praja-1

1

2

High-throughput

0.541

High

74488

HNRC2
Heterogeneous nuclear ribonucleoprotein C-like 2

1

6

High-throughput

0.536

High

133113

FOXE1
Forkhead box protein E1

1

1

High-throughput

0.536

High

299761

MPDZ
Multiple PDZ domain protein

1

20

High-throughput

0.536

High

594000

NCK1
SH2/SH3 adapter protein NCK1

1

6

High-throughput

0.536

High

698284

MAP4
Microtubule-associated protein 4

1

11

High-throughput

0.536

High

838232

STAT6
Signal transducer and activator of transcription 6

1

1

High-throughput

0.536

High

870128

LIMS1
LIM and senescent cell antigen-like-containing domain protein 1

1

2

High-throughput

0.536

High

910900

IMA1
Importin subunit alpha-1

1

3

High-throughput

0.536

High

1061580

FOXM1
Forkhead box protein M1

1

2

High-throughput

0.536

High

1091282

FOXL1
Forkhead box protein L1

1

1

High-throughput

0.536

High

1091666

MYO1E
Unconventional myosin-Ie

1

4

High-throughput

0.536

High

1132600

IMB1
Importin subunit beta-1

1

2

High-throughput

0.536

High

1132601

NUMA1
Nuclear mitotic apparatus protein 1

1

5

High-throughput

0.536

High

1132604

TEBP
Prostaglandin E synthase 3

1

4

High-throughput

0.536

High

1132607

TAF12
Transcription initiation factor TFIID subunit 12

1

1

High-throughput

0.536

High

1132610

H2B2E
Histone H2B type 2-E

1

14

High-throughput

0.536

High

1132613

CE350
Centrosome-associated protein 350

1

17

High-throughput

0.536

High

1132614

PGM2L
Glucose 1,6-bisphosphate synthase

1

1

High-throughput

0.536

High

1132618

RBM45
RNA-binding protein 45

1

1

High-throughput

0.536

High

1132626

PF21A
PHD finger protein 21A

1

6

High-throughput

0.536

High

1132631

CCNL2
Cyclin-L2

1

1

High-throughput

0.536

High

1132632

TCPQM
T-complex protein 1 subunit theta-like 2

1

4

High-throughput

0.536

High

1132633

VRK1
Serine/threonine-protein kinase VRK1

1

4

High-throughput

0.536

High

1132637

FOXQ1
Forkhead box protein Q1

1

2

High-throughput

0.536

High

1132640

DNAI2
Dynein axonemal intermediate chain 2

1

8

High-throughput

0.536

High

1132641

E41LB
Band 4.1-like protein 4B

1

6

High-throughput

0.536

High

1132644

SP110
Sp110 nuclear body protein

1

11

High-throughput

0.536

High

1132646

BIRC6
Dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6

1

4

High-throughput

0.536

High

1132648

HMGX4
HMG domain-containing protein 4

1

2

High-throughput

0.536

High

1132649

SMBT1
Scm-like with four MBT domains protein 1

1

2

High-throughput

0.536

High

927299

ATX1
Ataxin-1

1

0

High-throughput

0.518

High

447027

NPM
Nucleophosmin

1

1

High-throughput

0.515

High

521689

H14
Histone H1.4

1

2

High-throughput

0.515

High

595433

H15
Histone H1.5

1

2

High-throughput

0.515

High

943354

H2BFS
Histone H2B type F-S

1

14

High-throughput

0.515

High

1132609

H31T
Histone H3.1t

1

16

High-throughput

0.515

High

219630

B2L11
Bcl-2-like protein 11

1

0

High-throughput

0.513

High

335841

CD2B2
CD2 antigen cytoplasmic tail-binding protein 2

1

0

High-throughput

0.513

High

573826

CCNB1
G2/mitotic-specific cyclin-B1

1

0

High-throughput

0.513

High

693744

RL10
Large ribosomal subunit protein uL16

1

0

High-throughput

0.513

High

775085

FUS
RNA-binding protein FUS

1

0

High-throughput

0.513

High

1013057

HMGN5
High mobility group nucleosome-binding domain-containing protein 5

1

0

High-throughput

0.513

High

1086589

SNF5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

1

0

High-throughput

0.513

High

1132606

TEAD2
Transcriptional enhancer factor TEF-4

1

0

High-throughput

0.513

High

1132615

PSRC1
Proline/serine-rich coiled-coil protein 1

1

0

High-throughput

0.513

High

1132620

NECP1
Adaptin ear-binding coat-associated protein 1

1

0

High-throughput

0.513

High

1132628

ZN668
Zinc finger protein 668

1

0

High-throughput

0.513

High

1132638

ZY11B
Protein zyg-11 homolog B

1

0

High-throughput

0.513

High

1132655

SKAP
Small kinetochore-associated protein

1

0

High-throughput

0.513

High

507982

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

2

High-throughput

0.501

High

706125

S10A2
Protein S100-A2

1

7

High-throughput

0.489

High

1132612

CR021
UPF0711 protein C18orf21

1

1

High-throughput

0.489

High

1132625

UTP4
U3 small nucleolar RNA-associated protein 4 homolog

1

3

High-throughput

0.489

High

336422

SVIL
Supervillin

1

2

Small-scale

0.481

High

223047

PRC1
Protein regulator of cytokinesis 1

1

6

High-throughput

0.479

High

247911

NUPR1
Nuclear protein 1

1

3

High-throughput

0.479

High

254371

CC14B
Dual specificity protein phosphatase CDC14B

1

11

High-throughput

0.479

High

259957

BRD4
Bromodomain-containing protein 4

1

6

High-throughput

0.479

High

413844

P53
Cellular tumor antigen p53

1

4

High-throughput

0.479

High

418989

H2A1B
Histone H2A type 1-B/E

1

2

High-throughput

0.479

High

535065

BIP
Endoplasmic reticulum chaperone BiP

1

9

High-throughput

0.479

High

588712

RFA2
Replication protein A 32 kDa subunit

1

7

High-throughput

0.479

High

697118

APEX1
DNA repair nuclease/redox regulator APEX1

1

2

High-throughput

0.479

High

754847

H2B1B
Histone H2B type 1-B

1

14

High-throughput

0.479

High

764755

CTNB1
Catenin beta-1

1

8

High-throughput

0.479

High

786605

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

6

High-throughput

0.479

High

799120

BRCA1
Breast cancer type 1 susceptibility protein

1

9

High-throughput

0.479

High

830745

CCNF
Cyclin-F

1

4

High-throughput

0.479

High

855626

CRK
Adapter molecule crk

1

6

High-throughput

0.479

High

879097

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

3

High-throughput

0.479

High

883542

CENPA
Histone H3-like centromeric protein A

1

16

High-throughput

0.479

High

890735

PSN2
Presenilin-2

1

1

High-throughput

0.479

High

910056

RND2
Rho-related GTP-binding protein RhoN

1

6

High-throughput

0.479

High

942617

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

8

High-throughput

0.479

High

962057

RHOA
Transforming protein RhoA

1

3

High-throughput

0.479

High

979664

H4
Histone H4

1

4

High-throughput

0.479

High

1016865

H33
Histone H3.3

1

16

High-throughput

0.479

High

1132602

TNIP1
TNFAIP3-interacting protein 1

1

8

High-throughput

0.479

High

1132605

RBBP5
Retinoblastoma-binding protein 5

1

4

High-throughput

0.479

High

1132616

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.479

High

1132617

MOB2
MOB kinase activator 2

1

2

High-throughput

0.479

High

1132624

ESR2
Estrogen receptor beta

1

12

High-throughput

0.479

High

1132630

SNX27
Sorting nexin-27

1

12

High-throughput

0.479

High

1132636

FACD2
Fanconi anemia group D2 protein

1

2

High-throughput

0.479

High

1132639

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

2

High-throughput

0.479

High

1132642

PKHA4
Pleckstrin homology domain-containing family A member 4

1

16

High-throughput

0.479

High

1132645

RHOF
Rho-related GTP-binding protein RhoF

1

4

High-throughput

0.479

High

1132647

ZRAN1
Ubiquitin thioesterase ZRANB1

1

16

High-throughput

0.479

High

1132651

FZR1
Fizzy-related protein homolog

1

7

High-throughput

0.479

High

1132652

ASF1A
Histone chaperone ASF1A

1

2

High-throughput

0.479

High

1132654

ZN330
Zinc finger protein 330

1

2

High-throughput

0.479

High

867139

CAPZB
F-actin-capping protein subunit beta

1

0

High-throughput

0.458

High

984771

RL31
Large ribosomal subunit protein eL31

1

0

High-throughput

0.458

High

231575

PRKY
Putative serine/threonine-protein kinase PRKY

1

4

High-throughput

0.445

High

105943

APRIO
Alternative prion protein

1

5

High-throughput

0.437

High

501821

CO4A
Complement C4-A

1

1

High-throughput

0.437

High

1132635

DDA1
DET1- and DDB1-associated protein 1

1

1

High-throughput

0.437

High

95786

E5RHT1
Presenilin 2

1

1

High-throughput

0.407

High

501869

CO4B
Complement C4-B

1

1

High-throughput

0.407

High

616754

SDC1
Syndecan-1

1

1

High-throughput

0.407

High

1132653

CNPY2
Protein canopy homolog 2

2

0

High-throughput

0.328

High

1132611

MIC60
MICOS complex subunit MIC60

1

0

High-throughput

0.282

High

246292

MARH6
E3 ubiquitin-protein ligase MARCHF6

1

0

High-throughput

0.279

Low

634110

COX5A
Cytochrome c oxidase subunit 5A, mitochondrial

1

0

High-throughput

0.279

Low

1132634

UTP23
rRNA-processing protein UTP23 homolog

1

0

High-throughput

0.279

Low

1132643

WDCP
WD repeat and coiled-coil-containing protein

1

0

High-throughput

0.279

Low

1132656

CEPT1
Choline/ethanolaminephosphotransferase 1

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025