Protein: ERG1
Squalene monooxygenase (EC 1.14.14.17) (Squalene epoxidase) (SE)

Gene: ERG1, SQLE
Organism: Homo sapiens
Interactions: 67
UniProt ID: Q14534

Gene Ontology (top 5):
GO:0004506 - squalene monooxygenase activity
GO:0005783 - endoplasmic reticulum
GO:0005789 - endoplasmic reticulum membrane
GO:0008203 - cholesterol metabolic process
GO:0016020 - membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

246291

MARH6
E3 ubiquitin-protein ligase MARCHF6

5

1

Small-scale

0.707

High

1127850

FAF2
FAS-associated factor 2

3

0

High-throughput

0.638

High

142130

NPT3
Sodium-dependent phosphate transport protein 3

2

2

High-throughput

0.628

High

1127849

CR3L1
Cyclic AMP-responsive element-binding protein 3-like protein 1

2

1

High-throughput

0.606

High

1032582

AT2B2
Plasma membrane calcium-transporting ATPase 2

2

0

High-throughput

0.602

High

1127840

TMCO3
Transmembrane and coiled-coil domain-containing protein 3

2

0

High-throughput

0.602

High

1127846

ZNRF4
E3 ubiquitin-protein ligase ZNRF4

2

0

High-throughput

0.602

High

1127862

REEP4
Receptor expression-enhancing protein 4

2

0

High-throughput

0.580

High

595048

KCNA2
Potassium voltage-gated channel subfamily A member 2

2

0

High-throughput

0.576

High

926767

VMAT1
Chromaffin granule amine transporter

1

4

High-throughput

0.536

High

1127858

ZNT2
Proton-coupled zinc antiporter SLC30A2

1

2

High-throughput

0.536

High

209010

CYB5B
Cytochrome b5 type B

1

0

High-throughput

0.513

High

981492

RAN
GTP-binding nuclear protein Ran

1

0

High-throughput

0.513

High

1126287

PIGH
Phosphatidylinositol N-acetylglucosaminyltransferase subunit H

1

0

High-throughput

0.513

High

1127834

TTMP
TPA-induced transmembrane protein

1

0

High-throughput

0.513

High

1127853

RUSF1
RUS family member 1

1

0

High-throughput

0.513

High

1127854

ZDH12
Palmitoyltransferase ZDHHC12

1

0

High-throughput

0.513

High

1127844

OR6T1
Olfactory receptor 6T1

1

1

High-throughput

0.489

High

1127865

MARH4
E3 ubiquitin-protein ligase MARCHF4

1

1

High-throughput

0.489

High

1127869

PCDGL
Protocadherin gamma-C4

1

1

High-throughput

0.489

High

1127870

PCDG5
Protocadherin gamma-A5

1

1

High-throughput

0.489

High

230316

CREB3
Cyclic AMP-responsive element-binding protein 3

1

1

High-throughput

0.481

High

1127835

RNFT1
E3 ubiquitin-protein ligase RNFT1

1

1

High-throughput

0.479

High

1127852

RN185
E3 ubiquitin-protein ligase RNF185

1

1

High-throughput

0.479

High

1127866

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

1127868

AMFR
E3 ubiquitin-protein ligase AMFR

1

1

High-throughput

0.479

High

1127860

B2L13
Bcl-2-like protein 13

1

0

Small-scale

0.460

High

1127831

IRF4
Interferon regulatory factor 4

1

0

Small-scale

0.458

High

1052989

VMAT2
Synaptic vesicular amine transporter

1

3

High-throughput

0.445

High

372025

MYC
Myc proto-oncogene protein

1

1

High-throughput

0.437

High

1127841

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.437

High

117221

SIM22
Small integral membrane protein 22

1

0

Small-scale

0.426

High

248872

GSDME
Gasdermin-E

1

0

High-throughput

0.426

High

380542

DRB1
HLA class II histocompatibility antigen, DRB1 beta chain

1

0

High-throughput

0.426

High

437676

HEPS
Serine protease hepsin

1

0

High-throughput

0.426

High

870359

S6A11
Sodium- and chloride-dependent GABA transporter 3

1

0

High-throughput

0.426

High

931516

RD23A
UV excision repair protein RAD23 homolog A

1

0

High-throughput

0.426

High

1127832

TM241
UDP-N-acetylglucosamine transporter TMEM241

1

0

High-throughput

0.426

High

1127837

GP107
Protein GPR107

1

0

High-throughput

0.426

High

1127838

NIPA3
Magnesium transporter NIPA3

1

0

High-throughput

0.426

High

1127847

CTL1
Choline transporter-like protein 1

1

0

High-throughput

0.426

High

1127851

BSCL2
Seipin

1

0

High-throughput

0.426

High

1127857

SL9A7
Sodium/hydrogen exchanger 7

1

0

High-throughput

0.426

High

1127861

DJC25
DnaJ homolog subfamily C member 25

1

0

High-throughput

0.426

High

1127864

SCN3B
Sodium channel regulatory subunit beta-3

1

0

High-throughput

0.426

High

1127867

VATH
V-type proton ATPase subunit H

1

0

High-throughput

0.426

High

50100

S22AN
Solute carrier family 22 member 23

1

2

High-throughput

0.407

High

867617

GPR12
G-protein coupled receptor 12

1

1

High-throughput

0.407

High

1127842

S22A9
Organic anion transporter 7

1

2

High-throughput

0.407

High

1127845

S2540
Mitochondrial glutathione transporter SLC25A40

1

1

High-throughput

0.407

High

1127848

LPAR1
Lysophosphatidic acid receptor 1

1

1

High-throughput

0.407

High

1127833

S39AC
Zinc transporter ZIP12

3

0

High-throughput

0.345

High

1057543

ACHD
Acetylcholine receptor subunit delta

2

0

High-throughput

0.328

High

1127836

TRML2
Trem-like transcript 2 protein

2

0

High-throughput

0.318

High

1127863

TM14B
Transmembrane protein 14B

2

0

High-throughput

0.316

High

489095

ALDOC
Fructose-bisphosphate aldolase C

1

0

High-throughput

0.282

High

1127856

ZN641
Zinc finger protein 641

1

0

High-throughput

0.282

High

1127843

OR2M7
Olfactory receptor 2M7

1

0

High-throughput

0.279

Low

1127855

LCFC1
Sperm-egg fusion protein LLCFC1

1

0

High-throughput

0.279

Low

1127871

PTC2
Protein patched homolog 2

1

0

High-throughput

0.279

Low

964946

WDR5
WD repeat-containing protein 5

1

0

High-throughput

0.249

Low

1004562

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.249

Low

1127830

ZN345
Zinc finger protein 345

1

0

High-throughput

0.249

Low

260865

RAMP3
Receptor activity-modifying protein 3

1

0

High-throughput

0.232

Low

342561

LY86
Lymphocyte antigen 86

1

0

High-throughput

0.232

Low

1127839

ARMC6
Armadillo repeat-containing protein 6

1

0

High-throughput

0.232

Low

1127859

FUZZY
Protein fuzzy homolog

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025