Protein: SRB8
Mediator of RNA polymerase II transcription subunit 12 (Mediator complex subunit 12) (Suppressor of RNA polymerase B 8)

Gene: SRB8
Organism: Saccharomyces cerevisiae S288C
Interactions: 38
UniProt ID: P25648

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000411 - positive regulation of transcription by galactose
GO:0003713 - transcription coactivator activity
GO:0016592 - mediator complex
GO:0045944 - positive regulation of transcription by RNA polymerase II

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

678813

SSN8
RNA polymerase II holoenzyme cyclin-like subunit

6

7

Small-scale

0.735

High

678810

SSN3
Meiotic mRNA stability protein kinase SSN3

6

6

Small-scale

0.733

High

678819

MED7
Mediator of RNA polymerase II transcription subunit 7

4

4

Small-scale

0.691

High

678809

SSN2
Mediator of RNA polymerase II transcription subunit 13

5

0

Small-scale

0.684

High

619403

MED14
Mediator of RNA polymerase II transcription subunit 14

3

3

Small-scale

0.660

High

668468

MED19
Mediator of RNA polymerase II transcription subunit 19

4

0

Small-scale

0.654

High

678808

MED31
Mediator of RNA polymerase II transcription subunit 31

3

3

High-throughput

0.643

High

678822

MED1
Mediator of RNA polymerase II transcription subunit 1

3

0

Small-scale

0.632

High

678815

MED5
Mediator of RNA polymerase II transcription subunit 5

3

0

Small-scale

0.628

High

678820

MED2
Mediator of RNA polymerase II transcription subunit 2

3

0

High-throughput

0.616

High

678801

MED18
Mediator of RNA polymerase II transcription subunit 18

3

0

Small-scale

0.613

High

678800

MED22
Mediator of RNA polymerase II transcription subunit 22

2

0

High-throughput

0.595

High

678817

MED10
Mediator of RNA polymerase II transcription subunit 10

2

3

Small-scale

0.595

High

678797

MED16
Mediator of RNA polymerase II transcription subunit 16

2

0

High-throughput

0.585

High

678814

MED21
Mediator of RNA polymerase II transcription subunit 21

2

0

High-throughput

0.576

High

678799

MED17
Mediator of RNA polymerase II transcription subunit 17

2

0

Small-scale

0.559

High

678811

MED3
Mediator of RNA polymerase II transcription subunit 3

2

0

Small-scale

0.547

High

526048

HSP72
Heat shock protein SSA2

2

2

High-throughput

0.504

High

408393

GAL4
Regulatory protein GAL4

1

0

Small-scale

0.460

High

678803

PDR3
Transcription factor PDR3

1

0

Small-scale

0.458

High

678804

MED9
Mediator of RNA polymerase II transcription subunit 9

1

0

High-throughput

0.458

High

678806

MED8
Mediator of RNA polymerase II transcription subunit 8

1

0

High-throughput

0.458

High

678823

MED4
Mediator of RNA polymerase II transcription subunit 4

1

0

High-throughput

0.458

High

678816

SCC2
Sister chromatid cohesion protein 2

1

1

High-throughput

0.437

High

678821

RIO1
Serine/threonine-protein kinase RIO1

1

0

High-throughput

0.426

High

523207

HSP71
Heat shock protein SSA1

1

2

High-throughput

0.407

High

543989

SSB1
Ribosome-associated molecular chaperone SSB1

1

1

High-throughput

0.407

High

678798

PRP21
Pre-mRNA-splicing factor PRP21

1

0

High-throughput

0.265

Low

578944

HSC82
ATP-dependent molecular chaperone HSC82

1

0

High-throughput

0.249

Low

661460

PSA2
Proteasome subunit alpha type-2

1

0

High-throughput

0.249

Low

662691

EXG1
Glucan 1,3-beta-glucosidase I/II

1

0

High-throughput

0.249

Low

678796

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.249

Low

678802

SMY2
Protein SMY2

1

0

High-throughput

0.249

Low

678805

TTI1
TEL2-interacting protein 1

1

0

High-throughput

0.249

Low

678807

RCK1
Serine/threonine-protein kinase RCK1

1

0

High-throughput

0.249

Low

678812

BNI1
Protein BNI1

1

0

High-throughput

0.249

Low

678818

VAM6
Vacuolar morphogenesis protein 6

1

0

High-throughput

0.249

Low

574856

SAM35
Sorting assembly machinery 35 kDa subunit

1

0

High-throughput

0.238

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025