Protein: MED21
Mediator of RNA polymerase II transcription subunit 21 (Mediator complex subunit 21) (RNAPII complex component SRB7) (Suppressor of RNA polymerase B 7)

Gene: MED21, SRB7
Organism: Saccharomyces cerevisiae S288C
Interactions: 53
UniProt ID: P47822

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0003712 - transcription coregulator activity
GO:0003713 - transcription coactivator activity
GO:0003714 - transcription corepressor activity
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

867878

MED7
Mediator of RNA polymerase II transcription subunit 7

15

1

Small-scale

0.983

High

867877

MED10
Mediator of RNA polymerase II transcription subunit 10

8

0

Small-scale

0.917

High

867884

MED4
Mediator of RNA polymerase II transcription subunit 4

7

0

Small-scale

0.910

High

619437

MED14
Mediator of RNA polymerase II transcription subunit 14

7

0

Small-scale

0.909

High

751214

MED9
Mediator of RNA polymerase II transcription subunit 9

2

0

Small-scale

0.716

High

740422

MED17
Mediator of RNA polymerase II transcription subunit 17

7

0

Small-scale

0.713

High

797712

MED8
Mediator of RNA polymerase II transcription subunit 8

5

1

Small-scale

0.703

High

801154

MED31
Mediator of RNA polymerase II transcription subunit 31

5

0

Small-scale

0.685

High

740466

MED22
Mediator of RNA polymerase II transcription subunit 22

5

0

Small-scale

0.682

High

668496

MED19
Mediator of RNA polymerase II transcription subunit 19

5

0

Small-scale

0.679

High

740808

MED18
Mediator of RNA polymerase II transcription subunit 18

5

0

Small-scale

0.678

High

867873

MED5
Mediator of RNA polymerase II transcription subunit 5

4

0

Small-scale

0.661

High

823219

MED3
Mediator of RNA polymerase II transcription subunit 3

4

0

Small-scale

0.658

High

624926

MED15
Mediator of RNA polymerase II transcription subunit 15

4

0

Small-scale

0.653

High

867883

MED1
Mediator of RNA polymerase II transcription subunit 1

4

0

Small-scale

0.653

High

804028

MED6
Mediator of RNA polymerase II transcription subunit 6

4

0

Small-scale

0.652

High

395253

GCN4
General control transcription factor GCN4

4

0

Small-scale

0.639

High

733550

MED16
Mediator of RNA polymerase II transcription subunit 16

3

0

High-throughput

0.634

High

807826

SSN2
Mediator of RNA polymerase II transcription subunit 13

3

0

Small-scale

0.628

High

867871

MED21
Mediator of RNA polymerase II transcription subunit 21

1

0

Small-scale

0.589

High

598418

TUP1
General transcriptional corepressor TUP1

2

0

Small-scale

0.581

High

678814

SRB8
Mediator of RNA polymerase II transcription subunit 12

2

0

High-throughput

0.576

High

867880

MED2
Mediator of RNA polymerase II transcription subunit 2

2

0

High-throughput

0.576

High

408426

GAL4
Regulatory protein GAL4

2

0

Small-scale

0.561

High

867881

SCC1
Sister chromatid cohesion protein 1

2

0

High-throughput

0.561

High

810654

SSN3
Meiotic mRNA stability protein kinase SSN3

2

0

Small-scale

0.559

High

867872

SKP1
Suppressor of kinetochore protein 1

1

0

Small-scale

0.558

High

408480

GAL80
Galactose/lactose metabolism regulatory protein GAL80

1

0

High-throughput

0.486

High

864413

IKS1
Probable serine/threonine-protein kinase IKS1

1

0

High-throughput

0.480

High

602055

KAR3
Kinesin-like protein KAR3

1

0

High-throughput

0.460

High

867876

NKP2
Inner kinetochore subunit NKP2

1

0

High-throughput

0.460

High

594451

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

0

High-throughput

0.458

High

707557

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.458

High

757589

MED20
Mediator of RNA polymerase II transcription subunit 20

1

0

High-throughput

0.458

High

763346

TAF14
Transcription initiation factor TFIID subunit 14

1

0

High-throughput

0.458

High

776609

DEF1
RNA polymerase II degradation factor 1

1

0

High-throughput

0.458

High

800728

RCK1
Serine/threonine-protein kinase RCK1

1

0

High-throughput

0.458

High

867846

SSN8
RNA polymerase II holoenzyme cyclin-like subunit

1

0

High-throughput

0.458

High

867879

TAF10
SAGA complex/transcription factor TFIID complex subunit TAF10

1

0

High-throughput

0.458

High

867885

SMC6
Structural maintenance of chromosomes protein 6

1

0

High-throughput

0.458

High

867886

MED11
Mediator of RNA polymerase II transcription subunit 11

1

0

High-throughput

0.458

High

741921

HSP7F
Heat shock protein homolog SSE1

1

1

High-throughput

0.445

High

524463

HSP71
Heat shock protein SSA1

1

0

High-throughput

0.426

High

545460

SSB1
Ribosome-associated molecular chaperone SSB1

1

0

High-throughput

0.426

High

867882

RIO1
Serine/threonine-protein kinase RIO1

1

0

High-throughput

0.426

High

817741

TSC11
Target of rapamycin complex 2 subunit TSC11

1

0

High-throughput

0.251

Low

824654

BNR1
BNI1-related protein 1

1

0

High-throughput

0.251

Low

867875

DAD4
DASH complex subunit DAD4

1

0

High-throughput

0.251

Low

682331

SPB4
ATP-dependent rRNA helicase SPB4

1

0

High-throughput

0.249

Low

672427

STE50
Protein STE50

1

0

High-throughput

0.238

Low

864057

MRX5
MIOREX complex component 5

1

0

High-throughput

0.238

Low

867874

DAM1
DASH complex subunit DAM1

1

0

Small-scale

0.238

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025