Protein: MED1
Mediator of RNA polymerase II transcription subunit 1 (Mediator complex subunit 1)

Gene: MED1
Organism: Saccharomyces cerevisiae S288C
Interactions: 68
UniProt ID: Q12321

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0003712 - transcription coregulator activity
GO:0005634 - nucleus
GO:0016592 - mediator complex
GO:0032968 - positive regulation of transcription elongation by RNA polymerase II

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1084756

MED4
Mediator of RNA polymerase II transcription subunit 4

9

0

Small-scale

0.917

High

751222

MED9
Mediator of RNA polymerase II transcription subunit 9

7

0

Small-scale

0.910

High

740819

MED18
Mediator of RNA polymerase II transcription subunit 18

12

0

Small-scale

0.724

High

1062900

MED7
Mediator of RNA polymerase II transcription subunit 7

11

0

Small-scale

0.721

High

797726

MED8
Mediator of RNA polymerase II transcription subunit 8

9

0

Small-scale

0.715

High

619454

MED14
Mediator of RNA polymerase II transcription subunit 14

8

0

Small-scale

0.714

High

740442

MED17
Mediator of RNA polymerase II transcription subunit 17

7

0

Small-scale

0.710

High

917294

MED5
Mediator of RNA polymerase II transcription subunit 5

5

0

Small-scale

0.686

High

740480

MED22
Mediator of RNA polymerase II transcription subunit 22

5

0

Small-scale

0.682

High

823238

MED3
Mediator of RNA polymerase II transcription subunit 3

5

0

Small-scale

0.676

High

624953

MED15
Mediator of RNA polymerase II transcription subunit 15

5

0

Small-scale

0.676

High

801169

MED31
Mediator of RNA polymerase II transcription subunit 31

5

0

Small-scale

0.673

High

810679

SSN3
Meiotic mRNA stability protein kinase SSN3

4

0

Small-scale

0.660

High

668504

MED19
Mediator of RNA polymerase II transcription subunit 19

4

0

High-throughput

0.654

High

1084339

MED2
Mediator of RNA polymerase II transcription subunit 2

4

0

High-throughput

0.654

High

867883

MED21
Mediator of RNA polymerase II transcription subunit 21

4

0

Small-scale

0.653

High

804037

MED6
Mediator of RNA polymerase II transcription subunit 6

3

0

High-throughput

0.634

High

1042403

GCN5
Histone acetyltransferase GCN5

3

0

High-throughput

0.634

High

678822

SRB8
Mediator of RNA polymerase II transcription subunit 12

3

0

Small-scale

0.632

High

1054359

MED10
Mediator of RNA polymerase II transcription subunit 10

3

0

Small-scale

0.622

High

733568

MED16
Mediator of RNA polymerase II transcription subunit 16

2

0

High-throughput

0.585

High

757601

MED20
Mediator of RNA polymerase II transcription subunit 20

2

0

High-throughput

0.585

High

807860

SSN2
Mediator of RNA polymerase II transcription subunit 13

2

0

High-throughput

0.585

High

1084758

MED11
Mediator of RNA polymerase II transcription subunit 11

2

0

High-throughput

0.585

High

382417

H4
Histone H4

2

0

Small-scale

0.577

High

1084572

RIO1
Serine/threonine-protein kinase RIO1

2

0

High-throughput

0.547

High

546786

SSB1
Ribosome-associated molecular chaperone SSB1

2

0

High-throughput

0.528

High

626550

AP1
AP-1-like transcription factor YAP1

1

0

High-throughput

0.513

High

722365

XPO1
Exportin-1

1

0

High-throughput

0.513

High

805239

TRA1
SAGA complex/NuA4 acetyltransferase complex subunit TRA1

1

0

High-throughput

0.513

High

917881

SGF73
SAGA complex subunit SGF73

1

0

High-throughput

0.513

High

1036361

ADA2
SAGA complex subunit ADA2

1

0

High-throughput

0.513

High

381314

H2B1
Histone H2B.1

1

0

Small-scale

0.480

High

963797

H3
Histone H3

1

0

Small-scale

0.480

High

864144

LSM1
LSM1-LSM7 complex subunit LSM1

1

2

Small-scale

0.479

High

865291

LSM8
LSM2-LSM8 complex subunit LSM8

1

2

Small-scale

0.479

High

945361

LSM3
LSM complex subunit LSM3

1

1

Small-scale

0.479

High

402151

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

0

High-throughput

0.458

High

435440

RS3
Small ribosomal subunit protein uS3

1

0

High-throughput

0.458

High

594642

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

0

High-throughput

0.458

High

708566

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.458

High

748102

SMY2
Protein SMY2

1

0

High-throughput

0.458

High

763398

TAF14
Transcription initiation factor TFIID subunit 14

1

0

High-throughput

0.458

High

776675

DEF1
RNA polymerase II degradation factor 1

1

0

High-throughput

0.458

High

800782

RCK1
Serine/threonine-protein kinase RCK1

1

0

High-throughput

0.458

High

865796

MOG1
Nuclear import protein MOG1

1

0

High-throughput

0.458

High

867867

SSN8
RNA polymerase II holoenzyme cyclin-like subunit

1

0

High-throughput

0.458

High

1044849

SCC2
Sister chromatid cohesion protein 2

1

0

High-throughput

0.458

High

1055691

IRC20
Uncharacterized ATP-dependent helicase IRC20

1

0

High-throughput

0.458

High

1084150

TAF10
SAGA complex/transcription factor TFIID complex subunit TAF10

1

0

High-throughput

0.458

High

1084757

SMC6
Structural maintenance of chromosomes protein 6

1

0

High-throughput

0.458

High

525580

HSP71
Heat shock protein SSA1

1

1

High-throughput

0.445

High

528046

HSP72
Heat shock protein SSA2

1

1

High-throughput

0.445

High

742701

HSP7F
Heat shock protein homolog SSE1

1

2

High-throughput

0.445

High

1046592

PANK
Pantothenate kinase CAB1

1

0

High-throughput

0.438

High

470614

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

0

High-throughput

0.426

High

916621

TAF6
SAGA complex/transcription factor TFIID complex subunit TAF6

1

0

High-throughput

0.426

High

1084552

NDOR1
NADPH-dependent diflavin oxidoreductase 1

1

0

High-throughput

0.265

Low

512717

RS6A
Small ribosomal subunit protein eS6A

1

0

High-throughput

0.249

Low

580263

HSC82
ATP-dependent molecular chaperone HSC82

1

0

High-throughput

0.249

Low

812775

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.249

Low

865340

MTNB
Methylthioribulose-1-phosphate dehydratase

1

0

High-throughput

0.249

Low

922990

ARPC2
Actin-related protein 2/3 complex subunit 2

1

0

Small-scale

0.249

Low

798009

ATG12
Ubiquitin-like protein ATG12

1

0

High-throughput

0.238

Low

386918

TBB
Tubulin beta chain

1

0

High-throughput

0.232

Low

395019

EF1A
Elongation factor 1-alpha

1

0

High-throughput

0.232

Low

592586

VATB
V-type proton ATPase subunit B

1

0

High-throughput

0.232

Low

836965

MPG1
Mannose-1-phosphate guanyltransferase

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025