Protein: PRP21
Pre-mRNA-splicing factor PRP21

Gene: PRP21
Organism: Saccharomyces cerevisiae S288C
Interactions: 82
UniProt ID: P32524

Gene Ontology (top 5):
GO:0000398 - mRNA splicing, via spliceosome
GO:0000974 - Prp19 complex
GO:0003723 - RNA binding
GO:0005634 - nucleus
GO:0005681 - spliceosomal complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

739280

PRP11
Pre-mRNA-splicing factor PRP11

14

4

Small-scale

0.982

High

625076

PRP9
Pre-mRNA-splicing factor PRP9

13

4

Small-scale

0.981

High

739234

PRP8
Pre-mRNA-splicing factor 8

2

1

High-throughput

0.789

High

739265

CUS1
Cold sensitive U2 snRNA suppressor 1

4

1

High-throughput

0.694

High

739247

RSMB
Small nuclear ribonucleoprotein-associated protein B

4

2

High-throughput

0.686

High

739283

RU2A
U2 small nuclear ribonucleoprotein A'

4

1

Small-scale

0.686

High

700077

PRP45
Pre-mRNA-processing protein 45

3

1

High-throughput

0.662

High

739264

SMD1
Small nuclear ribonucleoprotein Sm D1

3

1

High-throughput

0.662

High

739276

RSE1
Pre-mRNA-splicing factor RSE1

3

1

High-throughput

0.662

High

739233

BRR2
Pre-mRNA-splicing helicase BRR2

3

5

Small-scale

0.656

High

739291

HSH49
Protein HSH49

3

3

High-throughput

0.656

High

739115

PRP19
Pre-mRNA-processing factor 19

3

3

Small-scale

0.650

High

739250

RUXG
Small nuclear ribonucleoprotein G

3

5

High-throughput

0.643

High

739268

PRP3
U4/U6 small nuclear ribonucleoprotein PRP3

1

1

High-throughput

0.618

High

739236

SN114
Pre-mRNA-splicing factor SNU114

2

1

High-throughput

0.611

High

739255

SF3B1
U2 snRNP component HSH155

2

2

High-throughput

0.611

High

739271

CEF1
Pre-mRNA-splicing factor CEF1

2

2

High-throughput

0.611

High

739242

SP381
Pre-mRNA-splicing factor SPP381

2

0

High-throughput

0.595

High

628195

PRP2
Pre-mRNA-splicing factor ATP-dependent RNA helicase-like protein PRP2

2

1

High-throughput

0.584

High

739282

NCBP2
Nuclear cap-binding protein subunit 2

2

2

Small-scale

0.584

High

739289

SNU66
66 kDa U4/U6.U5 small nuclear ribonucleoprotein component

2

1

Small-scale

0.584

High

739269

CWC21
Pre-mRNA-splicing factor CWC21

2

0

Small-scale

0.559

High

544192

SSB1
Ribosome-associated molecular chaperone SSB1

2

3

High-throughput

0.552

High

627840

PRP4
U4/U6 small nuclear ribonucleoprotein PRP4

1

3

High-throughput

0.536

High

739248

LSM4
LSM complex subunit LSM4

1

3

High-throughput

0.536

High

403413

PABP
Polyadenylate-binding protein, cytoplasmic and nuclear

1

0

High-throughput

0.513

High

721780

XPO1
Exportin-1

1

0

High-throughput

0.513

High

739281

LOT6
NAD(P)H-dependent FMN reductase LOT6

1

0

High-throughput

0.493

High

739240

UBP13
Ubiquitin carboxyl-terminal hydrolase 13

1

0

High-throughput

0.486

High

739258

NOG2
Nucleolar GTP-binding protein 2

1

0

High-throughput

0.486

High

739267

NGL2
RNA exonuclease NGL2

1

0

High-throughput

0.486

High

739270

STE20
Serine/threonine-protein kinase STE20

1

0

High-throughput

0.486

High

679491

CDC48
Cell division control protein 48

1

0

High-throughput

0.479

High

624985

PRP6
Pre-mRNA-splicing factor 6

1

6

High-throughput

0.479

High

638003

PRP5
Pre-mRNA-processing ATP-dependent RNA helicase PRP5

1

3

High-throughput

0.479

High

638052

ISY1
Pre-mRNA-splicing factor ISY1

1

1

High-throughput

0.479

High

739235

NCBP1
Nuclear cap-binding protein complex subunit 1

1

1

High-throughput

0.479

High

739241

SLT11
Pre-mRNA-splicing factor SLT11

1

1

High-throughput

0.479

High

739251

PRP17
Pre-mRNA-processing factor 17

1

3

High-throughput

0.479

High

739252

SMD3
Small nuclear ribonucleoprotein Sm D3

1

6

High-throughput

0.479

High

739254

PRP31
Pre-mRNA-processing factor 31

1

1

High-throughput

0.479

High

739261

RUXF
Small nuclear ribonucleoprotein F

1

2

High-throughput

0.479

High

739263

NAM8
Protein NAM8

1

1

High-throughput

0.479

High

739275

SYF1
Pre-mRNA-splicing factor SYF1

1

6

High-throughput

0.479

High

739278

SMD2
Small nuclear ribonucleoprotein Sm D2

1

1

High-throughput

0.479

High

739279

RDS3
Pre-mRNA-splicing factor RDS3

1

1

High-throughput

0.479

High

739284

CWC2
Pre-mRNA-splicing factor CWC2

1

4

High-throughput

0.479

High

739285

BBP
Branchpoint-bridging protein

1

2

High-throughput

0.479

High

739286

CLF1
Pre-mRNA-splicing factor CLF1

1

6

High-throughput

0.479

High

739288

PRP46
Pre-mRNA-splicing factor PRP46

1

2

High-throughput

0.479

High

672043

BUD31
Pre-mRNA-splicing factor BUD31

1

0

High-throughput

0.458

High

702235

YJU2
Splicing factor YJU2

1

0

High-throughput

0.458

High

706525

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.458

High

739237

YK21
Uncharacterized protein YKR041W

1

0

High-throughput

0.458

High

739243

NTC20
Pre-mRNA-splicing factor NTC20

1

0

High-throughput

0.458

High

739253

CWC26
Pre-mRNA-splicing factor CWC26

1

0

High-throughput

0.458

High

739256

SYF2
Pre-mRNA-splicing factor SYF2

1

0

High-throughput

0.458

High

739257

CWC22
Pre-mRNA-splicing factor CWC22

1

0

High-throughput

0.458

High

739259

CWC25
Pre-mRNA-splicing factor CWC25

1

0

High-throughput

0.458

High

739260

APJ1
J domain-containing protein APJ1

1

0

High-throughput

0.458

High

739266

SLU7
Pre-mRNA-splicing factor SLU7

1

0

High-throughput

0.458

High

739272

CWC15
Pre-mRNA-splicing factor CWC15

1

0

High-throughput

0.458

High

739273

SNU56
56 kDa U1 small nuclear ribonucleoprotein component

1

0

High-throughput

0.458

High

739274

SCC2
Sister chromatid cohesion protein 2

1

0

High-throughput

0.458

High

739277

SN309
Pre-mRNA-splicing factor SNT309

1

0

High-throughput

0.458

High

523380

HSP71
Heat shock protein SSA1

1

3

High-throughput

0.445

High

526196

HSP72
Heat shock protein SSA2

1

3

High-throughput

0.445

High

739249

SSB2
Ribosome-associated molecular chaperone SSB2

1

3

High-throughput

0.445

High

739262

LSM3
LSM complex subunit LSM3

1

7

High-throughput

0.445

High

570794

ABF1
ARS-binding factor 1

1

0

High-throughput

0.426

High

739244

BZZ1
Protein BZZ1

1

0

High-throughput

0.282

High

739246

YEC3
Uncharacterized protein YEL023C

1

0

High-throughput

0.269

Low

535992

SEC7
ADP-ribosylation factor guanine nucleotide-exchange factor SEC7

1

0

High-throughput

0.265

Low

678798

SRB8
Mediator of RNA polymerase II transcription subunit 12

1

0

High-throughput

0.265

Low

739104

PT309
Mitochondrial COX1 translation regulator PET309

1

0

High-throughput

0.265

Low

739238

PXL1
Paxillin-like protein 1

1

0

High-throughput

0.265

Low

739239

ECM21
Protein ECM21

1

0

High-throughput

0.265

Low

739287

MPC70
Sporulation-specific protein 21

1

0

High-throughput

0.265

Low

739290

6P22
6-phosphofructo-2-kinase 2

1

0

High-throughput

0.265

Low

394361

EF1A
Elongation factor 1-alpha

1

0

High-throughput

0.261

Low

739245

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.249

Low

739232

ZUO1
Zuotin

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025