Protein: MED16
Mediator of RNA polymerase II transcription subunit 16 (Global transcriptional regulator SIN4) (Mediator complex subunit 16) (SNF1 suppressor protein 4) (SWI4 suppressor protein 5) (Transcriptional silencing factor 3) (YGP1 expression regulatory protein 1)

Gene: MED16, SIN4
Organism: Saccharomyces cerevisiae S288C
Interactions: 81
UniProt ID: P32259

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0005634 - nucleus
GO:0016592 - mediator complex
GO:0032968 - positive regulation of transcription elongation by RNA polymerase II
GO:0034605 - cellular response to heat

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

733551

MED5
Mediator of RNA polymerase II transcription subunit 5

6

0

Small-scale

0.896

High

733562

MED7
Mediator of RNA polymerase II transcription subunit 7

8

1

Small-scale

0.746

High

733536

MED8
Mediator of RNA polymerase II transcription subunit 8

7

1

Small-scale

0.741

High

733526

MED18
Mediator of RNA polymerase II transcription subunit 18

9

0

Small-scale

0.720

High

619405

MED14
Mediator of RNA polymerase II transcription subunit 14

9

0

Small-scale

0.716

High

624875

MED15
Mediator of RNA polymerase II transcription subunit 15

9

0

Small-scale

0.716

High

733524

MED17
Mediator of RNA polymerase II transcription subunit 17

8

0

Small-scale

0.714

High

733525

MED22
Mediator of RNA polymerase II transcription subunit 22

4

0

Small-scale

0.658

High

668471

MED19
Mediator of RNA polymerase II transcription subunit 19

4

0

High-throughput

0.654

High

733565

MED2
Mediator of RNA polymerase II transcription subunit 2

4

0

High-throughput

0.654

High

733543

MED3
Mediator of RNA polymerase II transcription subunit 3

4

0

Small-scale

0.644

High

733550

MED21
Mediator of RNA polymerase II transcription subunit 21

3

0

High-throughput

0.634

High

733530

MED9
Mediator of RNA polymerase II transcription subunit 9

3

0

Small-scale

0.622

High

733538

MED31
Mediator of RNA polymerase II transcription subunit 31

3

0

High-throughput

0.616

High

733549

SSN8
RNA polymerase II holoenzyme cyclin-like subunit

3

0

High-throughput

0.616

High

733546

TAF1
Transcription initiation factor TFIID subunit 1

2

0

High-throughput

0.595

High

598380

TUP1
General transcriptional corepressor TUP1

1

0

Small-scale

0.586

High

678797

SRB8
Mediator of RNA polymerase II transcription subunit 12

2

0

High-throughput

0.585

High

733531

MED20
Mediator of RNA polymerase II transcription subunit 20

2

0

High-throughput

0.585

High

733540

SSN2
Mediator of RNA polymerase II transcription subunit 13

2

0

High-throughput

0.585

High

733558

TAF12
SAGA complex/transcription factor TFIID complex subunit TAF12

2

0

Small-scale

0.585

High

733568

MED1
Mediator of RNA polymerase II transcription subunit 1

2

0

High-throughput

0.585

High

733560

MED10
Mediator of RNA polymerase II transcription subunit 10

2

0

High-throughput

0.576

High

733570

MED4
Mediator of RNA polymerase II transcription subunit 4

2

0

High-throughput

0.576

High

392386

HSP82
ATP-dependent molecular chaperone HSP82

2

0

High-throughput

0.559

High

401924

RPB1
DNA-directed RNA polymerase II subunit RPB1

2

0

Small-scale

0.559

High

733567

RIO1
Serine/threonine-protein kinase RIO1

2

0

High-throughput

0.547

High

448668

SNF1
Carbon catabolite-derepressing protein kinase

1

0

Small-scale

0.529

High

626479

AP1
AP-1-like transcription factor YAP1

1

0

High-throughput

0.513

High

733564

HFI1
SAGA complex subunit HFI1

1

0

High-throughput

0.513

High

675796

MAS5
Mitochondrial protein import protein MAS5

1

1

High-throughput

0.500

High

628328

SFL1
Flocculation suppression protein

1

0

Small-scale

0.493

High

574781

UBC3
Ubiquitin-conjugating enzyme E2-34 kDa

1

0

High-throughput

0.486

High

733528

PRP40
Pre-mRNA-processing protein PRP40

1

0

High-throughput

0.486

High

733545

GLDS1
Protein GDS1

1

0

High-throughput

0.486

High

733547

MAD3
Spindle assembly checkpoint component MAD3

1

0

High-throughput

0.486

High

733554

APJ1
J domain-containing protein APJ1

1

1

High-throughput

0.479

High

557676

SRS2
ATP-dependent DNA helicase SRS2

1

0

Small-scale

0.460

High

594247

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

0

High-throughput

0.458

High

706450

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.458

High

733523

HOG1
Mitogen-activated protein kinase HOG1

1

0

Small-scale

0.458

High

733527

SMY2
Protein SMY2

1

0

High-throughput

0.458

High

733532

TAF14
Transcription initiation factor TFIID subunit 14

1

0

High-throughput

0.458

High

733533

DEF1
RNA polymerase II degradation factor 1

1

0

High-throughput

0.458

High

733537

RCK1
Serine/threonine-protein kinase RCK1

1

0

High-throughput

0.458

High

733539

MED6
Mediator of RNA polymerase II transcription subunit 6

1

0

High-throughput

0.458

High

733541

SSN3
Meiotic mRNA stability protein kinase SSN3

1

0

High-throughput

0.458

High

733555

H3
Histone H3

1

0

High-throughput

0.458

High

733559

SCC2
Sister chromatid cohesion protein 2

1

0

High-throughput

0.458

High

733566

SCC1
Sister chromatid cohesion protein 1

1

0

High-throughput

0.458

High

733571

SMC6
Structural maintenance of chromosomes protein 6

1

0

High-throughput

0.458

High

733572

MED11
Mediator of RNA polymerase II transcription subunit 11

1

0

High-throughput

0.458

High

381008

H2B1
Histone H2B.1

1

0

High-throughput

0.426

High

470483

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

0

High-throughput

0.426

High

526139

HSP72
Heat shock protein SSA2

1

0

High-throughput

0.426

High

544112

SSB1
Ribosome-associated molecular chaperone SSB1

1

0

High-throughput

0.426

High

733557

GCN5
Histone acetyltransferase GCN5

1

0

High-throughput

0.426

High

725687

RM09
Large ribosomal subunit protein uL3m

2

0

High-throughput

0.307

High

357758

QCR6
Cytochrome b-c1 complex subunit 6, mitochondrial

1

0

High-throughput

0.265

Low

733529

CSE1
Importin alpha re-exporter

1

0

High-throughput

0.265

Low

733544

MAD2
Mitotic spindle checkpoint component MAD2

1

0

High-throughput

0.265

Low

733552

TAM41
Phosphatidate cytidylyltransferase, mitochondrial

1

0

High-throughput

0.265

Low

733553

YG32
Uncharacterized protein YGR117C

1

0

High-throughput

0.265

Low

733556

PT191
Mitochondrial protein PET191

1

0

High-throughput

0.265

Low

394332

EF1A
Elongation factor 1-alpha

1

0

High-throughput

0.261

Low

531269

METK1
S-adenosylmethionine synthase 1

1

0

High-throughput

0.261

Low

733569

HSP42
Heat shock protein 42

1

0

High-throughput

0.261

Low

409992

RL25
Large ribosomal subunit protein uL23

1

0

High-throughput

0.249

Low

433511

RL26A
Large ribosomal subunit protein uL24A

1

0

High-throughput

0.249

Low

435840

RS13
Small ribosomal subunit protein uS15

1

0

High-throughput

0.249

Low

441770

RS14A
Small ribosomal subunit protein uS11A

1

0

High-throughput

0.249

Low

502909

RS22A
Small ribosomal subunit protein uS8A

1

0

High-throughput

0.249

Low

504093

RL31A
Large ribosomal subunit protein eL31A

1

0

High-throughput

0.249

Low

514512

RS18A
Small ribosomal subunit protein uS13A

1

0

High-throughput

0.249

Low

689323

RS7A
Small ribosomal subunit protein eS7A

1

0

High-throughput

0.249

Low

733534

RS27A
Small ribosomal subunit protein eS27A

1

0

High-throughput

0.249

Low

733535

NU170
Nucleoporin NUP170

1

0

High-throughput

0.249

Low

733542

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.249

Low

733561

VAM6
Vacuolar morphogenesis protein 6

1

0

High-throughput

0.249

Low

733563

RS10A
Small ribosomal subunit protein eS10A

1

0

High-throughput

0.249

Low

733548

GPN1
GPN-loop GTPase 1

1

0

High-throughput

0.238

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025