Protein: MED8
Mediator of RNA polymerase II transcription subunit 8 (Mediator complex subunit 8)

Gene: MED8
Organism: Saccharomyces cerevisiae S288C
Interactions: 55
UniProt ID: P38304

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0003712 - transcription coregulator activity
GO:0003714 - transcription corepressor activity
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

740791

MED18
Mediator of RNA polymerase II transcription subunit 18

20

1

Small-scale

0.987

High

740398

MED17
Mediator of RNA polymerase II transcription subunit 17

17

2

Small-scale

0.987

High

797720

MED7
Mediator of RNA polymerase II transcription subunit 7

10

2

Small-scale

0.967

High

797703

MED31
Mediator of RNA polymerase II transcription subunit 31

6

1

Small-scale

0.945

High

797704

MED6
Mediator of RNA polymerase II transcription subunit 6

6

1

Small-scale

0.932

High

740454

MED22
Mediator of RNA polymerase II transcription subunit 22

8

0

Small-scale

0.914

High

797730

MED11
Mediator of RNA polymerase II transcription subunit 11

6

0

Small-scale

0.884

High

619423

MED14
Mediator of RNA polymerase II transcription subunit 14

10

1

Small-scale

0.751

High

733536

MED16
Mediator of RNA polymerase II transcription subunit 16

7

1

Small-scale

0.741

High

797727

MED4
Mediator of RNA polymerase II transcription subunit 4

7

1

Small-scale

0.735

High

757579

MED20
Mediator of RNA polymerase II transcription subunit 20

9

0

Small-scale

0.715

High

797726

MED1
Mediator of RNA polymerase II transcription subunit 1

9

0

Small-scale

0.715

High

624904

MED15
Mediator of RNA polymerase II transcription subunit 15

8

0

Small-scale

0.711

High

797722

MED2
Mediator of RNA polymerase II transcription subunit 2

7

0

Small-scale

0.704

High

797712

MED21
Mediator of RNA polymerase II transcription subunit 21

5

1

Small-scale

0.703

High

797713

MED5
Mediator of RNA polymerase II transcription subunit 5

6

0

Small-scale

0.697

High

797719

MED10
Mediator of RNA polymerase II transcription subunit 10

4

1

Small-scale

0.696

High

751204

MED9
Mediator of RNA polymerase II transcription subunit 9

6

0

Small-scale

0.691

High

668483

MED19
Mediator of RNA polymerase II transcription subunit 19

6

0

Small-scale

0.691

High

797709

MED3
Mediator of RNA polymerase II transcription subunit 3

6

0

Small-scale

0.683

High

797707

SSN3
Meiotic mRNA stability protein kinase SSN3

2

1

Small-scale

0.611

High

401983

RPB1
DNA-directed RNA polymerase II subunit RPB1

2

0

Small-scale

0.559

High

594344

RPB3
DNA-directed RNA polymerase II subunit RPB3

2

0

Small-scale

0.559

High

706940

TF2B
Transcription initiation factor IIB

2

0

High-throughput

0.551

High

416539

HXKB
Hexokinase-2

1

0

Small-scale

0.549

High

561469

TBP
TATA-box-binding protein

1

0

Small-scale

0.545

High

743977

RAD23
UV excision repair protein RAD23

1

0

Small-scale

0.537

High

746329

RGT1
Glucose transport transcription regulator RGT1

1

0

Small-scale

0.529

High

645158

PSB4
Proteasome subunit beta type-4

1

0

Small-scale

0.493

High

661162

SPT6
Transcription elongation factor SPT6

1

0

High-throughput

0.493

High

797706

STM1
Suppressor protein STM1

1

0

High-throughput

0.493

High

382063

H4
Histone H4

1

0

Small-scale

0.480

High

797715

H3
Histone H3

1

0

Small-scale

0.480

High

797710

T2FB
Transcription initiation factor IIF subunit beta

1

0

Small-scale

0.479

High

797705

SSN2
Mediator of RNA polymerase II transcription subunit 13

1

1

High-throughput

0.479

High

797711

SSN8
RNA polymerase II holoenzyme cyclin-like subunit

1

1

High-throughput

0.479

High

797729

CMR1
DNA damage-binding protein CMR1

1

0

High-throughput

0.460

High

678806

SRB8
Mediator of RNA polymerase II transcription subunit 12

1

0

High-throughput

0.458

High

763315

TAF14
Transcription initiation factor TFIID subunit 14

1

0

High-throughput

0.458

High

776559

DEF1
RNA polymerase II degradation factor 1

1

0

High-throughput

0.458

High

797708

CCS1
Superoxide dismutase 1 copper chaperone

1

0

High-throughput

0.458

High

797724

SCC1
Sister chromatid cohesion protein 1

1

0

High-throughput

0.458

High

523769

HSP71
Heat shock protein SSA1

1

1

High-throughput

0.445

High

526540

HSP72
Heat shock protein SSA2

1

1

High-throughput

0.445

High

741471

HSP7F
Heat shock protein homolog SSE1

1

2

High-throughput

0.445

High

797723

PER33
Pore and endoplasmic reticulum protein of 33 kDa

1

1

Small-scale

0.437

High

797725

POM33
Pore membrane protein of 33 kDa

1

1

Small-scale

0.437

High

544670

SSB1
Ribosome-associated molecular chaperone SSB1

1

0

High-throughput

0.426

High

797717

GCN5
Histone acetyltransferase GCN5

1

0

High-throughput

0.426

High

797728

ATP14
ATP synthase subunit H, mitochondrial

1

0

High-throughput

0.282

High

794936

ALG3
Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase

1

0

High-throughput

0.269

Low

797721

THI72
Thiamine transporter THI72

1

0

High-throughput

0.269

Low

797716

HSK3
DASH complex subunit HSK3

1

0

High-throughput

0.251

Low

797714

ARPC2
Actin-related protein 2/3 complex subunit 2

1

0

Small-scale

0.249

Low

797718

NTE1
Lysophospholipase NTE1

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025