Protein: MED19
Mediator of RNA polymerase II transcription subunit 19 (Hypoxic gene repressor protein 3) (Mediator complex subunit 19) (Negative regulator of URS2 protein 3) (SNF1 suppressor protein 7)

Gene: MED19, ROX3
Organism: Saccharomyces cerevisiae S288C
Interactions: 53
UniProt ID: P25046

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0001113 - transcription open complex formation at RNA polymerase II promoter
GO:0003712 - transcription coregulator activity
GO:0003713 - transcription coactivator activity
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

668486

MED6
Mediator of RNA polymerase II transcription subunit 6

6

0

Small-scale

0.887

High

668501

MED7
Mediator of RNA polymerase II transcription subunit 7

6

0

Small-scale

0.881

High

619401

MED14
Mediator of RNA polymerase II transcription subunit 14

5

0

Small-scale

0.861

High

668500

MED10
Mediator of RNA polymerase II transcription subunit 10

4

0

High-throughput

0.836

High

668474

MED18
Mediator of RNA polymerase II transcription subunit 18

8

0

Small-scale

0.714

High

668472

MED17
Mediator of RNA polymerase II transcription subunit 17

8

0

Small-scale

0.712

High

624868

MED15
Mediator of RNA polymerase II transcription subunit 15

6

0

Small-scale

0.695

High

668476

MED9
Mediator of RNA polymerase II transcription subunit 9

6

0

Small-scale

0.694

High

668483

MED8
Mediator of RNA polymerase II transcription subunit 8

6

0

Small-scale

0.691

High

668493

MED3
Mediator of RNA polymerase II transcription subunit 3

6

0

Small-scale

0.689

High

668496

MED21
Mediator of RNA polymerase II transcription subunit 21

5

0

Small-scale

0.679

High

668505

MED4
Mediator of RNA polymerase II transcription subunit 4

5

0

Small-scale

0.679

High

668468

SRB8
Mediator of RNA polymerase II transcription subunit 12

4

0

Small-scale

0.654

High

668471

MED16
Mediator of RNA polymerase II transcription subunit 16

4

0

High-throughput

0.654

High

668504

MED1
Mediator of RNA polymerase II transcription subunit 1

4

0

High-throughput

0.654

High

668497

MED5
Mediator of RNA polymerase II transcription subunit 5

4

0

Small-scale

0.649

High

626472

AP1
AP-1-like transcription factor YAP1

3

0

Small-scale

0.616

High

668473

MED22
Mediator of RNA polymerase II transcription subunit 22

3

0

Small-scale

0.616

High

668478

MED20
Mediator of RNA polymerase II transcription subunit 20

3

0

High-throughput

0.616

High

668488

SSN2
Mediator of RNA polymerase II transcription subunit 13

3

0

High-throughput

0.616

High

668490

SSN3
Meiotic mRNA stability protein kinase SSN3

3

0

High-throughput

0.616

High

668506

MED11
Mediator of RNA polymerase II transcription subunit 11

3

0

High-throughput

0.616

High

668484

MED31
Mediator of RNA polymerase II transcription subunit 31

2

0

High-throughput

0.576

High

668502

MED2
Mediator of RNA polymerase II transcription subunit 2

2

0

High-throughput

0.576

High

668491

SSB2
Ribosome-associated molecular chaperone SSB2

2

1

High-throughput

0.552

High

628324

SFL1
Flocculation suppression protein

1

0

Small-scale

0.493

High

668487

LSM12
Protein LSM12

1

0

High-throughput

0.493

High

668489

STM1
Suppressor protein STM1

1

0

High-throughput

0.493

High

668494

YPP1
Cargo-transport protein YPP1

1

0

High-throughput

0.493

High

668503

YRA1
RNA annealing protein YRA1

1

0

High-throughput

0.493

High

408459

GAL80
Galactose/lactose metabolism regulatory protein GAL80

1

0

High-throughput

0.486

High

668481

MYO3
Myosin-3

1

1

High-throughput

0.464

High

668499

MYO5
Myosin-5

1

1

High-throughput

0.464

High

668479

TAF14
Transcription initiation factor TFIID subunit 14

1

0

High-throughput

0.458

High

668480

DEF1
RNA polymerase II degradation factor 1

1

0

High-throughput

0.458

High

668495

SSN8
RNA polymerase II holoenzyme cyclin-like subunit

1

0

High-throughput

0.458

High

543907

SSB1
Ribosome-associated molecular chaperone SSB1

1

1

High-throughput

0.445

High

668482

ANM1
Protein arginine N-methyltransferase 1

1

0

High-throughput

0.438

High

401899

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

0

Small-scale

0.426

High

531612

RL4A
Large ribosomal subunit protein uL4A

1

0

High-throughput

0.426

High

668469

RL16A
Large ribosomal subunit protein uL13A

1

1

High-throughput

0.407

High

668470

RL16B
Large ribosomal subunit protein uL13B

1

1

High-throughput

0.407

High

668475

RM06
Large ribosomal subunit protein uL6m

2

0

High-throughput

0.307

High

394263

EF1A
Elongation factor 1-alpha

1

0

High-throughput

0.232

Low

433150

RL17A
Large ribosomal subunit protein uL22A

1

0

High-throughput

0.232

Low

433974

RL33A
Large ribosomal subunit protein eL33A

1

0

High-throughput

0.232

Low

569911

RL3
Large ribosomal subunit protein uL3

1

0

High-throughput

0.232

Low

570212

RS17B
Small ribosomal subunit protein eS17B

1

0

High-throughput

0.232

Low

592032

VATB
V-type proton ATPase subunit B

1

0

High-throughput

0.232

Low

668477

HSP78
Heat shock protein 78, mitochondrial

1

0

High-throughput

0.232

Low

668485

RL14B
Large ribosomal subunit protein eL14B

1

0

High-throughput

0.232

Low

668492

RL13B
Large ribosomal subunit protein eL13B

1

0

High-throughput

0.232

Low

668498

RL6A
Large ribosomal subunit protein eL6A

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025