Protein: MED5
Mediator of RNA polymerase II transcription subunit 5 (Mediator complex subunit 5) (Negative regulator of URS2 protein 1)

Gene: MED5, NUT1
Organism: Saccharomyces cerevisiae S288C
Interactions: 66
UniProt ID: P53114

Gene Ontology (top 5):
GO:0003712 - transcription coregulator activity
GO:0005634 - nucleus
GO:0005739 - mitochondrion
GO:0006357 - regulation of transcription by RNA polymerase II
GO:0006366 - transcription by RNA polymerase II

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

733551

MED16
Mediator of RNA polymerase II transcription subunit 16

6

0

Small-scale

0.896

High

740809

MED18
Mediator of RNA polymerase II transcription subunit 18

10

0

Small-scale

0.722

High

917289

MED7
Mediator of RNA polymerase II transcription subunit 7

7

0

Small-scale

0.713

High

740423

MED17
Mediator of RNA polymerase II transcription subunit 17

7

0

Small-scale

0.710

High

797713

MED8
Mediator of RNA polymerase II transcription subunit 8

6

0

Small-scale

0.697

High

917294

MED1
Mediator of RNA polymerase II transcription subunit 1

5

0

Small-scale

0.686

High

740469

MED22
Mediator of RNA polymerase II transcription subunit 22

5

0

Small-scale

0.679

High

917291

MED2
Mediator of RNA polymerase II transcription subunit 2

5

0

Small-scale

0.676

High

624931

MED15
Mediator of RNA polymerase II transcription subunit 15

4

0

Small-scale

0.661

High

751215

MED9
Mediator of RNA polymerase II transcription subunit 9

4

0

Small-scale

0.661

High

867873

MED21
Mediator of RNA polymerase II transcription subunit 21

4

0

Small-scale

0.661

High

917296

MED4
Mediator of RNA polymerase II transcription subunit 4

4

0

Small-scale

0.661

High

619439

MED14
Mediator of RNA polymerase II transcription subunit 14

4

0

Small-scale

0.657

High

757590

MED20
Mediator of RNA polymerase II transcription subunit 20

4

0

Small-scale

0.657

High

804029

MED6
Mediator of RNA polymerase II transcription subunit 6

4

0

Small-scale

0.657

High

668497

MED19
Mediator of RNA polymerase II transcription subunit 19

4

0

Small-scale

0.649

High

823220

MED3
Mediator of RNA polymerase II transcription subunit 3

4

0

Small-scale

0.649

High

678815

SRB8
Mediator of RNA polymerase II transcription subunit 12

3

0

Small-scale

0.628

High

807830

SSN2
Mediator of RNA polymerase II transcription subunit 13

3

0

Small-scale

0.628

High

917298

MED11
Mediator of RNA polymerase II transcription subunit 11

3

0

Small-scale

0.628

High

917288

MED10
Mediator of RNA polymerase II transcription subunit 10

3

0

Small-scale

0.622

High

867852

SSN8
RNA polymerase II holoenzyme cyclin-like subunit

3

0

High-throughput

0.616

High

707685

TF2B
Transcription initiation factor IIB

2

0

Small-scale

0.559

High

545614

SSB1
Ribosome-associated molecular chaperone SSB1

2

1

High-throughput

0.552

High

801157

MED31
Mediator of RNA polymerase II transcription subunit 31

2

0

High-throughput

0.547

High

917293

RIO1
Serine/threonine-protein kinase RIO1

2

0

High-throughput

0.547

High

440958

CDC7
Cell division control protein 7

1

0

High-throughput

0.513

High

626524

AP1
AP-1-like transcription factor YAP1

1

0

High-throughput

0.513

High

917290

HFI1
SAGA complex subunit HFI1

1

0

High-throughput

0.513

High

402060

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

0

Small-scale

0.458

High

435234

RS3
Small ribosomal subunit protein uS3

1

0

High-throughput

0.458

High

454659

RAD2
DNA repair protein RAD2

1

0

Small-scale

0.458

High

514735

RS18A
Small ribosomal subunit protein uS13A

1

0

High-throughput

0.458

High

579763

HSC82
ATP-dependent molecular chaperone HSC82

1

0

High-throughput

0.458

High

594477

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

0

High-throughput

0.458

High

747954

SMY2
Protein SMY2

1

0

High-throughput

0.458

High

763350

TAF14
Transcription initiation factor TFIID subunit 14

1

0

High-throughput

0.458

High

776616

DEF1
RNA polymerase II degradation factor 1

1

0

High-throughput

0.458

High

800736

RCK1
Serine/threonine-protein kinase RCK1

1

0

High-throughput

0.458

High

804116

RPP1
Ribonuclease P/MRP protein subunit RPP1

1

0

High-throughput

0.458

High

810655

SSN3
Meiotic mRNA stability protein kinase SSN3

1

0

High-throughput

0.458

High

916523

SAP4
SIT4-associating protein SAP4

1

0

High-throughput

0.458

High

917286

RUVB1
RuvB-like protein 1

1

0

High-throughput

0.458

High

917287

SCC2
Sister chromatid cohesion protein 2

1

0

High-throughput

0.458

High

917292

SCC1
Sister chromatid cohesion protein 1

1

0

High-throughput

0.458

High

917297

SMC6
Structural maintenance of chromosomes protein 6

1

0

High-throughput

0.458

High

524602

HSP71
Heat shock protein SSA1

1

1

High-throughput

0.445

High

527216

HSP72
Heat shock protein SSA2

1

1

High-throughput

0.445

High

742007

HSP7F
Heat shock protein homolog SSE1

1

2

High-throughput

0.445

High

819303

SSB2
Ribosome-associated molecular chaperone SSB2

1

1

High-throughput

0.445

High

792877

ANM1
Protein arginine N-methyltransferase 1

1

0

High-throughput

0.438

High

381175

H2B1
Histone H2B.1

1

0

High-throughput

0.426

High

597215

BIP
Endoplasmic reticulum chaperone BiP

1

0

High-throughput

0.426

High

752523

HSP78
Heat shock protein 78, mitochondrial

1

0

High-throughput

0.426

High

781770

SET3
SET domain-containing protein 3

1

0

High-throughput

0.426

High

912415

PFD6
Prefoldin subunit 6

1

0

High-throughput

0.426

High

917285

GCN5
Histone acetyltransferase GCN5

1

0

High-throughput

0.426

High

442016

RS14A
Small ribosomal subunit protein uS11A

1

0

High-throughput

0.249

Low

512547

RS6A
Small ribosomal subunit protein eS6A

1

0

High-throughput

0.249

Low

513117

RS8A
Small ribosomal subunit protein eS8A

1

0

High-throughput

0.249

Low

747478

RSSA1
Small ribosomal subunit protein uS2A

1

0

High-throughput

0.249

Low

753478

RS3A1
Small ribosomal subunit protein eS1A

1

0

High-throughput

0.249

Low

874424

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.249

Low

917284

RS15
Small ribosomal subunit protein uS19

1

0

High-throughput

0.249

Low

671668

SCJ1
DnaJ-related protein SCJ1

1

0

High-throughput

0.232

Low

917295

HSP42
Heat shock protein 42

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025