Protein: MED2
Mediator of RNA polymerase II transcription subunit 2 (Mediator complex subunit 2)

Gene: MED2
Organism: Saccharomyces cerevisiae S288C
Interactions: 65
UniProt ID: Q12124

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0003713 - transcription coactivator activity
GO:0005634 - nucleus
GO:0005829 - cytosol
GO:0016592 - mediator complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

823234

MED3
Mediator of RNA polymerase II transcription subunit 3

9

0

Small-scale

0.916

High

740818

MED18
Mediator of RNA polymerase II transcription subunit 18

13

0

Small-scale

0.724

High

740439

MED17
Mediator of RNA polymerase II transcription subunit 17

9

0

Small-scale

0.715

High

1062898

MED7
Mediator of RNA polymerase II transcription subunit 7

8

0

Small-scale

0.713

High

624949

MED15
Mediator of RNA polymerase II transcription subunit 15

8

0

Small-scale

0.711

High

619451

MED14
Mediator of RNA polymerase II transcription subunit 14

7

0

Small-scale

0.706

High

797722

MED8
Mediator of RNA polymerase II transcription subunit 8

7

0

Small-scale

0.704

High

751220

MED9
Mediator of RNA polymerase II transcription subunit 9

6

0

Small-scale

0.691

High

1084340

MED4
Mediator of RNA polymerase II transcription subunit 4

6

0

Small-scale

0.691

High

757599

MED20
Mediator of RNA polymerase II transcription subunit 20

5

0

Small-scale

0.676

High

917291

MED5
Mediator of RNA polymerase II transcription subunit 5

5

0

Small-scale

0.676

High

810676

SSN3
Meiotic mRNA stability protein kinase SSN3

4

0

Small-scale

0.658

High

733565

MED16
Mediator of RNA polymerase II transcription subunit 16

4

0

High-throughput

0.654

High

1054356

MED10
Mediator of RNA polymerase II transcription subunit 10

4

0

High-throughput

0.654

High

1084339

MED1
Mediator of RNA polymerase II transcription subunit 1

4

0

High-throughput

0.654

High

740479

MED22
Mediator of RNA polymerase II transcription subunit 22

4

0

Small-scale

0.644

High

801167

MED31
Mediator of RNA polymerase II transcription subunit 31

3

0

Small-scale

0.622

High

678820

SRB8
Mediator of RNA polymerase II transcription subunit 12

3

0

High-throughput

0.616

High

804034

MED6
Mediator of RNA polymerase II transcription subunit 6

3

0

High-throughput

0.616

High

807856

SSN2
Mediator of RNA polymerase II transcription subunit 13

3

0

High-throughput

0.616

High

1084342

MED11
Mediator of RNA polymerase II transcription subunit 11

3

0

High-throughput

0.616

High

742979

HSP79
Heat shock protein homolog SSE2

2

1

High-throughput

0.588

High

668502

MED19
Mediator of RNA polymerase II transcription subunit 19

2

0

High-throughput

0.576

High

867880

MED21
Mediator of RNA polymerase II transcription subunit 21

2

0

High-throughput

0.576

High

626547

AP1
AP-1-like transcription factor YAP1

2

0

High-throughput

0.563

High

1039065

IMA1
Importin subunit alpha

2

0

High-throughput

0.563

High

594631

RPB3
DNA-directed RNA polymerase II subunit RPB3

2

0

Small-scale

0.559

High

1055885

ARR1
Arsenical-resistance protein ARR1

1

0

Small-scale

0.529

High

525498

HSP71
Heat shock protein SSA1

2

0

High-throughput

0.528

High

546688

SSB1
Ribosome-associated molecular chaperone SSB1

2

0

High-throughput

0.528

High

577584

CYC8
General transcriptional corepressor CYC8

1

0

Small-scale

0.513

High

722347

XPO1
Exportin-1

1

0

High-throughput

0.513

High

408495

GAL80
Galactose/lactose metabolism regulatory protein GAL80

1

0

High-throughput

0.486

High

647853

RFA1
Replication factor A protein 1

1

0

Small-scale

0.460

High

395268

GCN4
General control transcription factor GCN4

1

0

Small-scale

0.458

High

402147

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

0

Small-scale

0.458

High

580233

HSC82
ATP-dependent molecular chaperone HSC82

1

0

High-throughput

0.458

High

598453

TUP1
General transcriptional corepressor TUP1

1

0

Small-scale

0.458

High

763393

TAF14
Transcription initiation factor TFIID subunit 14

1

0

High-throughput

0.458

High

776670

DEF1
RNA polymerase II degradation factor 1

1

0

High-throughput

0.458

High

867866

SSN8
RNA polymerase II holoenzyme cyclin-like subunit

1

0

High-throughput

0.458

High

1084341

SMC6
Structural maintenance of chromosomes protein 6

1

0

High-throughput

0.458

High

531927

RL4A
Large ribosomal subunit protein uL4A

1

1

High-throughput

0.445

High

885113

RL4B
Large ribosomal subunit protein uL4B

1

1

High-throughput

0.445

High

806678

RIX1
Pre-rRNA-processing protein RIX1

1

0

High-throughput

0.438

High

1084338

SAS10
Something about silencing protein 10

1

0

High-throughput

0.438

High

395001

EF1A
Elongation factor 1-alpha

1

0

High-throughput

0.426

High

409800

RL24A
Large ribosomal subunit protein eL24A

1

0

High-throughput

0.426

High

432732

RL7A
Large ribosomal subunit protein uL30A

1

0

High-throughput

0.426

High

442164

RS14A
Small ribosomal subunit protein uS11A

1

0

High-throughput

0.426

High

569881

RL30
Large ribosomal subunit protein eL30

1

0

High-throughput

0.426

High

570184

RL3
Large ribosomal subunit protein uL3

1

0

High-throughput

0.426

High

712695

RL8B
Large ribosomal subunit protein eL8B

1

0

High-throughput

0.426

High

781278

RL14A
Large ribosomal subunit protein eL14A

1

0

High-throughput

0.426

High

835914

RL10
Large ribosomal subunit protein uL16

1

0

High-throughput

0.426

High

863892

RL17B
Large ribosomal subunit protein uL22B

1

0

High-throughput

0.426

High

1044501

RUVB1
RuvB-like protein 1

1

0

High-throughput

0.426

High

796641

EIF3A
Eukaryotic translation initiation factor 3 subunit A

2

0

High-throughput

0.307

High

818586

COG3
Conserved oligomeric Golgi complex subunit 3

2

0

High-throughput

0.307

High

150194

THP2
THO complex subunit THP2

1

0

High-throughput

0.265

Low

453038

CBP8
Cytochrome B pre-mRNA-processing protein 1

1

0

High-throughput

0.249

Low

864068

MRX5
MIOREX complex component 5

1

0

High-throughput

0.238

Low

365221

KPYK1
Pyruvate kinase 1

1

0

High-throughput

0.232

Low

592570

VATB
V-type proton ATPase subunit B

1

0

High-throughput

0.232

Low

893253

IMDH3
Inosine-5'-monophosphate dehydrogenase 3

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025