Protein: CSN1
COP9 signalosome complex subunit 1 (SGN1) (Signalosome subunit 1) (G protein pathway suppressor 1) (GPS-1) (JAB1-containing signalosome subunit 1) (Protein MFH)

Gene: CSN1, GPS1
Organism: Homo sapiens
Interactions: 148
UniProt ID: Q13098

Gene Ontology (top 5):
GO:0000338 - protein deneddylation
GO:0005095 - GTPase inhibitor activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1024241

CSN3
COP9 signalosome complex subunit 3

16

20

Small-scale

0.985

High

1024199

CSN5
COP9 signalosome complex subunit 5

14

20

Small-scale

0.982

High

897237

CSN2
COP9 signalosome complex subunit 2

14

17

Small-scale

0.982

High

1024210

CSN8
COP9 signalosome complex subunit 8

11

5

Small-scale

0.977

High

1024178

CSN6
COP9 signalosome complex subunit 6

9

20

Small-scale

0.975

High

1024211

CSN4
COP9 signalosome complex subunit 4

6

19

Small-scale

0.940

High

1024222

CSN7B
COP9 signalosome complex subunit 7b

5

20

Small-scale

0.924

High

1024236

CSN7A
COP9 signalosome complex subunit 7a

4

20

Small-scale

0.895

High

1024163

ELOB
Elongin-B

2

1

Small-scale

0.768

High

227323

PRKN
E3 ubiquitin-protein ligase parkin

2

12

High-throughput

0.754

High

1024160

CUL4A
Cullin-4A

8

20

Small-scale

0.748

High

1024159

CUL3
Cullin-3

8

20

Small-scale

0.747

High

1024161

CUL4B
Cullin-4B

7

20

Small-scale

0.743

High

1024157

CUL1
Cullin-1

6

20

Small-scale

0.730

High

1024167

DDB1
DNA damage-binding protein 1

5

4

Small-scale

0.717

High

1024166

NEDD8
NEDD8

1

4

High-throughput

0.691

High

1024195

DDB2
DNA damage-binding protein 2

4

10

Small-scale

0.686

High

795625

MAGA1
Melanoma-associated antigen 1

3

1

High-throughput

0.667

High

896056

UBC12
NEDD8-conjugating enzyme Ubc12

3

4

High-throughput

0.667

High

1024158

CUL2
Cullin-2

3

20

Small-scale

0.667

High

1024194

CSN9
COP9 signalosome complex subunit 9

3

1

Small-scale

0.660

High

1024152

ERCC8
DNA excision repair protein ERCC-8

3

8

Small-scale

0.656

High

1024151

CSN1
COP9 signalosome complex subunit 1

1

18

Small-scale

0.647

High

319412

APBB3
Amyloid-beta A4 precursor protein-binding family B member 3

2

2

High-throughput

0.628

High

1024165

STK11
Serine/threonine-protein kinase STK11

2

4

High-throughput

0.628

High

1024172

KLH10
Kelch-like protein 10

2

13

High-throughput

0.628

High

1024179

DET1
DET1 homolog

2

1

High-throughput

0.628

High

1024182

FXL14
F-box/LRR-repeat protein 14

2

2

High-throughput

0.628

High

1024190

DCA11
DDB1- and CUL4-associated factor 11

2

4

High-throughput

0.628

High

1024192

DCAF4
DDB1- and CUL4-associated factor 4

2

3

High-throughput

0.628

High

1024219

BTBD1
BTB/POZ domain-containing protein 1

2

16

High-throughput

0.628

High

1024243

FBX7
F-box only protein 7

2

1

High-throughput

0.628

High

1024154

SKP2
S-phase kinase-associated protein 2

2

3

Small-scale

0.611

High

1024155

IRF5
Interferon regulatory factor 5

2

3

Small-scale

0.611

High

1024200

CUL5
Cullin-5

2

20

High-throughput

0.611

High

1024229

DTL
Denticleless protein homolog

2

7

Small-scale

0.611

High

1024244

DCAF1
DDB1- and CUL4-associated factor 1

2

6

Small-scale

0.611

High

1024234

KLH13
Kelch-like protein 13

2

13

High-throughput

0.601

High

639738

IKBA
NF-kappa-B inhibitor alpha

2

3

Small-scale

0.584

High

779333

CCNF
Cyclin-F

2

9

High-throughput

0.584

High

921238

RBX1
E3 ubiquitin-protein ligase RBX1

2

4

Small-scale

0.584

High

1024181

UBP48
Ubiquitin carboxyl-terminal hydrolase 48

2

4

Small-scale

0.584

High

1024217

AMRA1
Activating molecule in BECN1-regulated autophagy protein 1

2

6

Small-scale

0.584

High

1024230

CNOT2
CCR4-NOT transcription complex subunit 2

2

0

High-throughput

0.580

High

1024220

SP130
Histone deacetylase complex subunit SAP130

1

2

Small-scale

0.561

High

297614

RHBT1
Rho-related BTB domain-containing protein 1

2

8

High-throughput

0.558

High

1024216

RHBT2
Rho-related BTB domain-containing protein 2

2

8

High-throughput

0.558

High

1024237

MALT1
Mucosa-associated lymphoid tissue lymphoma translocation protein 1

1

2

Small-scale

0.554

High

1024214

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

1

2

High-throughput

0.541

High

330997

PAK4
Serine/threonine-protein kinase PAK 4

1

2

High-throughput

0.536

High

804227

NOTC1
Neurogenic locus notch homolog protein 1

1

1

High-throughput

0.536

High

971725

IRF8
Interferon regulatory factor 8

1

3

High-throughput

0.536

High

1024170

DCAF6
DDB1- and CUL4-associated factor 6

1

11

High-throughput

0.536

High

1024173

KLH24
Kelch-like protein 24

1

13

High-throughput

0.536

High

1024185

WDTC1
WD and tetratricopeptide repeats protein 1

1

11

High-throughput

0.536

High

1024197

APBP2
Amyloid protein-binding protein 2

1

4

High-throughput

0.536

High

1024203

FBX17
F-box only protein 17

1

4

High-throughput

0.536

High

1024204

DCNL1
DCN1-like protein 1

1

1

High-throughput

0.536

High

1024205

FEM1C
Protein fem-1 homolog C

1

3

High-throughput

0.536

High

1024206

LLR1
Leucine-rich repeat protein 1

1

2

High-throughput

0.536

High

1024212

BTBD2
BTB/POZ domain-containing protein 2

1

16

High-throughput

0.536

High

1024226

ASB6
Ankyrin repeat and SOCS box protein 6

1

3

High-throughput

0.536

High

1024231

KLHL8
Kelch-like protein 8

1

13

High-throughput

0.536

High

1024232

KLHL9
Kelch-like protein 9

1

13

High-throughput

0.536

High

1024233

KLH42
Kelch-like protein 42

1

14

High-throughput

0.536

High

1024239

FEM1B
Protein fem-1 homolog B

1

3

High-throughput

0.536

High

1024240

FBX10
F-box only protein 10

1

1

High-throughput

0.536

High

1024247

ASB3
Ankyrin repeat and SOCS box protein 3

1

1

High-throughput

0.536

High

1024249

USH1C
Harmonin

1

2

High-throughput

0.536

High

878588

ALR
FAD-linked sulfhydryl oxidase ALR

1

1

Small-scale

0.534

High

1024213

CAR11
Caspase recruitment domain-containing protein 11

1

0

Small-scale

0.530

High

1024235

WRP73
WD repeat-containing protein WRAP73

1

3

High-throughput

0.515

High

200385

HS12A
Heat shock 70 kDa protein 12A

1

0

High-throughput

0.513

High

838631

GDIB
Rab GDP dissociation inhibitor beta

1

0

High-throughput

0.513

High

1024187

KCTD6
BTB/POZ domain-containing protein KCTD6

1

0

High-throughput

0.513

High

1024218

ZY11B
Protein zyg-11 homolog B

1

0

High-throughput

0.513

High

1024225

AP5S1
AP-5 complex subunit sigma-1

1

0

High-throughput

0.513

High

1024227

DCA16
DDB1- and CUL4-associated factor 16

1

0

High-throughput

0.513

High

1024242

NOD1
Nucleotide-binding oligomerization domain-containing protein 1

1

0

Small-scale

0.506

High

174841

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

6

High-throughput

0.501

High

1024196

IP6K1
Inositol hexakisphosphate kinase 1

1

1

Small-scale

0.501

High

1024207

SENP8
Sentrin-specific protease 8

1

1

Small-scale

0.501

High

809290

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

0

High-throughput

0.493

High

49983

PXDNL
Probable oxidoreductase PXDNL

1

1

High-throughput

0.489

High

299514

KLH18
Kelch-like protein 18

1

13

High-throughput

0.489

High

1024169

ANR39
Ankyrin repeat domain-containing protein 39

1

4

High-throughput

0.489

High

1024184

KLH36
Kelch-like protein 36

1

13

High-throughput

0.489

High

1024201

TRI63
E3 ubiquitin-protein ligase TRIM63

1

13

High-throughput

0.481

High

1024215

TRI55
Tripartite motif-containing protein 55

1

15

High-throughput

0.481

High

771938

VHL
von Hippel-Lindau disease tumor suppressor

1

0

Small-scale

0.480

High

1024162

SCRIB
Protein scribble homolog

1

0

High-throughput

0.480

High

1024202

FBXW5
F-box/WD repeat-containing protein 5

1

0

Small-scale

0.479

High

214245

SPOP
Speckle-type POZ protein

1

6

High-throughput

0.479

High

262442

TULP3
Tubby-related protein 3

1

1

High-throughput

0.479

High

294779

RECQ4
ATP-dependent DNA helicase Q4

1

5

High-throughput

0.479

High

504000

HSP7C
Heat shock cognate 71 kDa protein

1

2

High-throughput

0.479

High

552612

RFA2
Replication protein A 32 kDa subunit

1

4

High-throughput

0.479

High

651085

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

4

High-throughput

0.479

High

684677

STIP1
Stress-induced-phosphoprotein 1

1

7

High-throughput

0.479

High

720350

RFA3
Replication protein A 14 kDa subunit

1

4

High-throughput

0.479

High

817997

SOX2
Transcription factor SOX-2

1

2

Small-scale

0.479

High

885035

FBXW4
F-box/WD repeat-containing protein 4

1

6

Small-scale

0.479

High

893660

PSA6
Proteasome subunit alpha type-6

1

20

Small-scale

0.479

High

908464

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

3

High-throughput

0.479

High

978734

TF65
Transcription factor p65

1

1

Small-scale

0.479

High

998633

EP300
Histone acetyltransferase p300

1

7

High-throughput

0.479

High

1014110

CPSF1
Cleavage and polyadenylation specificity factor subunit 1

1

4

Small-scale

0.479

High

1024153

TIF1B
Transcription intermediary factor 1-beta

1

7

High-throughput

0.479

High

1024164

PTN14
Tyrosine-protein phosphatase non-receptor type 14

1

5

High-throughput

0.479

High

1024171

VIR
Protein virilizer homolog

1

4

High-throughput

0.479

High

1024175

TPTE2
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2

1

1

High-throughput

0.479

High

1024177

TRI67
Tripartite motif-containing protein 67

1

12

High-throughput

0.479

High

1024180

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

3

High-throughput

0.479

High

1024188

FBX22
F-box only protein 22

1

1

High-throughput

0.479

High

1024189

RIN3
Ras and Rab interactor 3

1

1

High-throughput

0.479

High

1024193

PHIP
PH-interacting protein

1

5

Small-scale

0.479

High

1024209

CRBN
Protein cereblon

1

1

Small-scale

0.479

High

1024221

PKHA4
Pleckstrin homology domain-containing family A member 4

1

6

High-throughput

0.479

High

1024224

FBX6
F-box only protein 6

1

4

High-throughput

0.479

High

1024228

TLS1
Splicing factor C9orf78

1

1

High-throughput

0.479

High

1024238

ZRAN1
Ubiquitin thioesterase ZRANB1

1

4

High-throughput

0.479

High

1024245

WIPI2
WD repeat domain phosphoinositide-interacting protein 2

1

6

Small-scale

0.479

High

1024246

ASB4
Ankyrin repeat and SOCS box protein 4

1

1

Small-scale

0.479

High

1024248

MAFB
Transcription factor MafB

1

8

High-throughput

0.479

High

205345

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.458

High

318958

CEP43
Centrosomal protein 43

1

0

High-throughput

0.458

High

417258

ENOA
Alpha-enolase

1

0

High-throughput

0.458

High

577488

IL1RA
Interleukin-1 receptor antagonist protein

1

0

Small-scale

0.458

High

624880

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

0

Small-scale

0.458

High

719468

MERL
Merlin

1

0

Small-scale

0.458

High

928893

SKP1
S-phase kinase-associated protein 1

1

0

Small-scale

0.458

High

1024156

ITPK1
Inositol-tetrakisphosphate 1-kinase

1

0

Small-scale

0.458

High

1024183

RHG24
Rho GTPase-activating protein 24

1

0

High-throughput

0.458

High

1024198

REQU
Zinc finger protein ubi-d4

1

0

High-throughput

0.458

High

1024208

CEP63
Centrosomal protein of 63 kDa

1

3

High-throughput

0.457

High

338357

EGFR
Epidermal growth factor receptor

1

1

High-throughput

0.445

High

401924

JUN
Transcription factor Jun

1

7

High-throughput

0.445

High

496946

TAU
Microtubule-associated protein tau

1

4

High-throughput

0.445

High

950960

RHOG
Rho-related GTP-binding protein RhoG

1

1

Small-scale

0.445

High

1024168

KLH12
Kelch-like protein 12

1

13

High-throughput

0.445

High

1024223

TBC17
TBC1 domain family member 17

1

0

High-throughput

0.438

High

100717

APRIO
Alternative prion protein

1

2

High-throughput

0.437

High

384753

NTRK1
High affinity nerve growth factor receptor

1

3

High-throughput

0.437

High

1024174

LMBRL
Protein LMBR1L

1

1

High-throughput

0.437

High

1024186

DC4L2
DDB1- and CUL4-associated factor 4-like protein 2

1

3

Small-scale

0.437

High

1024191

TP4AP
Short transient receptor potential channel 4-associated protein

1

0

High-throughput

0.279

Low

1024176

TIFAB
TRAF-interacting protein with FHA domain-containing protein B

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024