Protein: VMA22
Vacuolar ATPase assembly protein VMA22 (Coiled-coil domain-containing protein 115)

Gene: VMA22
Organism: Homo sapiens
Interactions: 99
UniProt ID: Q96NT0

Gene Ontology (top 5):
GO:0005764 - lysosome
GO:0005768 - endosome
GO:0005783 - endoplasmic reticulum
GO:0005793 - endoplasmic reticulum-Golgi intermediate compartment
GO:0006879 - intracellular iron ion homeostasis

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

961562

VA0D1
V-type proton ATPase subunit d 1

2

1

High-throughput

0.789

High

1331442

VA0D2
V-type proton ATPase subunit d 2

2

1

High-throughput

0.789

High

1399188

VPP2
V-type proton ATPase 116 kDa subunit a 2

4

3

High-throughput

0.691

High

292722

RENR
Renin receptor

5

0

High-throughput

0.686

High

1164264

VATF
V-type proton ATPase subunit F

1

0

High-throughput

0.656

High

926529

SYRC
Arginine--tRNA ligase, cytoplasmic

3

0

High-throughput

0.636

High

1249631

PXDC2
Plexin domain-containing protein 2

2

0

High-throughput

0.602

High

1327041

VMA12
Vacuolar ATPase assembly protein VMA12

2

0

High-throughput

0.602

High

1106808

VPP3
V-type proton ATPase 116 kDa subunit a 3

2

3

High-throughput

0.601

High

1371950

VPP1
V-type proton ATPase 116 kDa subunit a 1

2

3

High-throughput

0.601

High

1399172

VPP4
V-type proton ATPase 116 kDa subunit a 4

2

3

High-throughput

0.601

High

186166

LX15B
Polyunsaturated fatty acid lipoxygenase ALOX15B

2

0

High-throughput

0.580

High

1315473

K2013
Uncharacterized protein KIAA2013

2

0

High-throughput

0.576

High

540626

LAMP1
Lysosome-associated membrane glycoprotein 1

2

0

High-throughput

0.559

High

1399178

ABI2
Abl interactor 2

2

1

High-throughput

0.553

High

1316350

AGRG5
Adhesion G-protein coupled receptor G5

1

1

High-throughput

0.536

High

1316400

AGRF3
Adhesion G-protein coupled receptor F3

1

1

High-throughput

0.536

High

272732

BRE1B
E3 ubiquitin-protein ligase BRE1B

1

0

High-throughput

0.513

High

692253

VATL
V-type proton ATPase 16 kDa proteolipid subunit c

1

0

High-throughput

0.513

High

901499

RAB7A
Ras-related protein Rab-7a

1

0

High-throughput

0.513

High

1026183

CLH1
Clathrin heavy chain 1

1

0

High-throughput

0.513

High

1316280

PACE1
Protein-associating with the carboxyl-terminal domain of ezrin

1

0

High-throughput

0.513

High

1333590

SIDT2
SID1 transmembrane family member 2

1

0

High-throughput

0.513

High

1399183

CC018
Uncharacterized protein C3orf18

1

0

High-throughput

0.513

High

1399187

GOT1B
Vesicle transport protein GOT1B

1

0

High-throughput

0.513

High

1399190

5MP1
eIF5-mimic protein 1

1

0

High-throughput

0.513

High

867664

GPR12
G-protein coupled receptor 12

1

1

High-throughput

0.489

High

1399174

LPAR2
Lysophosphatidic acid receptor 2

1

1

High-throughput

0.489

High

1051291

KPCZ
Protein kinase C zeta type

1

0

High-throughput

0.486

High

422927

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.480

High

48745

ESYT2
Extended synaptotagmin-2

1

1

High-throughput

0.479

High

439827

INSR
Insulin receptor

1

4

High-throughput

0.479

High

465619

IGF1R
Insulin-like growth factor 1 receptor

1

5

High-throughput

0.479

High

541643

FGFR1
Fibroblast growth factor receptor 1

1

2

High-throughput

0.479

High

650366

FGFR3
Fibroblast growth factor receptor 3

1

2

High-throughput

0.479

High

955487

CDC42
Cell division control protein 42 homolog

1

6

High-throughput

0.479

High

962391

RHOA
Transforming protein RhoA

1

7

High-throughput

0.479

High

988619

RAC1
Ras-related C3 botulinum toxin substrate 1

1

6

High-throughput

0.479

High

1312224

MIRO2
Mitochondrial Rho GTPase 2

1

9

High-throughput

0.479

High

1395916

DNJC1
DnaJ homolog subfamily C member 1

1

1

High-throughput

0.479

High

1399168

ESYT1
Extended synaptotagmin-1

1

1

High-throughput

0.479

High

1399176

TMPS4
Transmembrane protease serine 4

1

2

High-throughput

0.479

High

580674

AMPN
Aminopeptidase N

1

0

High-throughput

0.458

High

611299

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

0

High-throughput

0.458

High

699023

CALX
Calnexin

1

0

High-throughput

0.458

High

939960

TPTE
Putative tyrosine-protein phosphatase TPTE

1

0

High-throughput

0.458

High

951363

SC61B
Protein transport protein Sec61 subunit beta

1

0

High-throughput

0.458

High

1125611

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

1

0

High-throughput

0.458

High

1140713

KIF14
Kinesin-like protein KIF14

1

0

High-throughput

0.458

High

1309872

TEX2
Testis-expressed protein 2

1

0

High-throughput

0.458

High

1337636

PDZD8
PDZ domain-containing protein 8

1

0

High-throughput

0.458

High

1399171

TMT1A
Thiol S-methyltransferase TMT1A

1

0

High-throughput

0.458

High

1399175

ST7
Suppressor of tumorigenicity 7 protein

1

0

High-throughput

0.458

High

1399180

TM216
Transmembrane protein 216

1

0

High-throughput

0.458

High

1399182

SEC63
Translocation protein SEC63 homolog

1

0

High-throughput

0.458

High

1399184

CLC4E
C-type lectin domain family 4 member E

1

0

High-throughput

0.458

High

126748

RHOD
Rho-related GTP-binding protein RhoD

1

8

High-throughput

0.437

High

188967

TMPS2
Transmembrane protease serine 2

1

2

High-throughput

0.437

High

466417

RHOC
Rho-related GTP-binding protein RhoC

1

6

High-throughput

0.437

High

581237

RAC2
Ras-related C3 botulinum toxin substrate 2

1

6

High-throughput

0.437

High

953620

RAC3
Ras-related C3 botulinum toxin substrate 3

1

6

High-throughput

0.437

High

1015688

RHOG
Rho-related GTP-binding protein RhoG

1

6

High-throughput

0.437

High

1151823

RHOH
Rho-related GTP-binding protein RhoH

1

7

High-throughput

0.437

High

1157033

NTRK3
NT-3 growth factor receptor

1

5

High-throughput

0.437

High

1238784

TECT3
Tectonic-3

1

1

High-throughput

0.437

High

1286871

TM11B
Transmembrane protease serine 11B

1

2

High-throughput

0.437

High

1392432

TECT2
Tectonic-2

1

1

High-throughput

0.437

High

1399170

DJC25
DnaJ homolog subfamily C member 25

1

1

High-throughput

0.437

High

1399173

RHOF
Rho-related GTP-binding protein RhoF

1

8

High-throughput

0.437

High

1399185

ALK
ALK tyrosine kinase receptor

1

5

High-throughput

0.437

High

256114

S19A2
Thiamine transporter 1

1

0

High-throughput

0.426

High

627394

AT2B1
Plasma membrane calcium-transporting ATPase 1

1

0

High-throughput

0.426

High

1399186

ITM2B
Integral membrane protein 2B

1

0

High-throughput

0.426

High

1390938

TSN17
Tetraspanin-17

3

0

High-throughput

0.347

High

186483

VA0E1
V-type proton ATPase subunit e 1

2

0

High-throughput

0.328

High

1159100

C3AR
C3a anaphylatoxin chemotactic receptor

2

0

High-throughput

0.328

High

1392849

NTAQ1
Protein N-terminal glutamine amidohydrolase

2

0

High-throughput

0.316

High

1399179

MS18A
Protein Mis18-alpha

2

0

High-throughput

0.316

High

1244108

TMM88
Transmembrane protein 88

2

0

High-throughput

0.313

High

158293

COPE
Coatomer subunit epsilon

1

0

High-throughput

0.279

Low

376634

TGFA
Protransforming growth factor alpha [Cleaved into: Transforming growth factor alpha

1

0

High-throughput

0.279

Low

584576

VAV
Proto-oncogene vav

1

0

High-throughput

0.279

Low

590333

MUC1
Mucin-1

1

0

High-throughput

0.279

Low

1205947

MTUS2
Microtubule-associated tumor suppressor candidate 2

1

0

High-throughput

0.279

Low

1352046

MICA1
[F-actin]-monooxygenase MICAL1

1

0

High-throughput

0.279

Low

1399181

TM63C
Osmosensitive cation channel TMEM63C

1

0

High-throughput

0.279

Low

1399189

PCDGL
Protocadherin gamma-C4

1

0

High-throughput

0.279

Low

405531

KITH
Thymidine kinase, cytosolic

1

0

High-throughput

0.265

Low

920206

PLK1
Serine/threonine-protein kinase PLK1

1

0

High-throughput

0.265

Low

995207

CSK2B
Casein kinase II subunit beta

1

0

High-throughput

0.265

Low

223265

PRC1
Protein regulator of cytokinesis 1

1

0

High-throughput

0.249

Low

773605

COPB2
Coatomer subunit beta'

1

0

High-throughput

0.249

Low

939408

EIF3B
Eukaryotic translation initiation factor 3 subunit B

1

0

High-throughput

0.249

Low

1293114

TMM17
Transmembrane protein 17

1

0

High-throughput

0.249

Low

1382914

S2546
Mitochondrial outer membrane protein SLC25A46

1

0

High-throughput

0.249

Low

1399167

RMD3
Regulator of microtubule dynamics protein 3

1

0

High-throughput

0.249

Low

1399169

CCDC8
Coiled-coil domain-containing protein 8

1

0

High-throughput

0.249

Low

1399177

OTULL
Inactive ubiquitin thioesterase OTULINL

1

0

High-throughput

0.249

Low

1253594

SO4C1
Solute carrier organic anion transporter family member 4C1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025