Protein: KGD4
Alpha-ketoglutarate dehydrogenase component 4 (Alpha-ketoglutarate dehydrogenase subunit 4)

Gene: KGD4
Organism: Homo sapiens
Interactions: 103
UniProt ID: P82909

Gene Ontology (top 5):
GO:0005739 - mitochondrion
GO:0005743 - mitochondrial inner membrane
GO:0006099 - tricarboxylic acid cycle
GO:0006103 - 2-oxoglutarate metabolic process
GO:0030674 - protein-macromolecule adaptor activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

484495

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

10

0

High-throughput

0.719

High

1012045

ODO1
2-oxoglutarate dehydrogenase complex component E1

2

2

High-throughput

0.601

High

1012111

OGDHL
2-oxoglutarate dehydrogenase-like, mitochondrial

2

2

High-throughput

0.601

High

1012071

HSC20
Iron-sulfur cluster co-chaperone protein HscB

2

0

High-throughput

0.585

High

279730

CISY
Citrate synthase, mitochondrial

2

0

High-throughput

0.559

High

1012050

GRSF1
G-rich sequence factor 1

2

0

High-throughput

0.559

High

1012058

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

2

0

High-throughput

0.559

High

1012091

TR61B
tRNA

2

0

High-throughput

0.547

High

539316

ODB2
Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial

1

2

High-throughput

0.536

High

787979

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

2

High-throughput

0.536

High

722938

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

0

High-throughput

0.513

High

777603

HMGCL
Hydroxymethylglutaryl-CoA lyase, mitochondrial

1

0

High-throughput

0.513

High

1012073

THEM5
Acyl-coenzyme A thioesterase THEM5

1

0

High-throughput

0.513

High

1012074

TCAIM
T-cell activation inhibitor, mitochondrial

1

0

High-throughput

0.513

High

281932

MPPB
Mitochondrial-processing peptidase subunit beta

1

1

High-throughput

0.479

High

287275

RF1M
Peptide chain release factor 1, mitochondrial

1

2

High-throughput

0.479

High

470972

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

2

High-throughput

0.479

High

856237

IF2M
Translation initiation factor IF-2, mitochondrial

1

1

High-throughput

0.479

High

1012049

MPPA
Mitochondrial-processing peptidase subunit alpha

1

1

High-throughput

0.479

High

1012054

FAKD3
FAST kinase domain-containing protein 3, mitochondrial

1

3

High-throughput

0.479

High

1012063

RUSD3
Mitochondrial mRNA pseudouridine synthase RPUSD3

1

1

High-throughput

0.479

High

1012068

FAKD5
FAST kinase domain-containing protein 5, mitochondrial

1

3

High-throughput

0.479

High

1012076

MCU
Calcium uniporter protein, mitochondrial

1

1

High-throughput

0.479

High

1012078

RRF2M
Ribosome-releasing factor 2, mitochondrial

1

1

High-throughput

0.479

High

1012079

FAKD4
FAST kinase domain-containing protein 4

1

3

High-throughput

0.479

High

1012081

RUSD4
Pseudouridylate synthase RPUSD4, mitochondrial

1

1

High-throughput

0.479

High

1012086

EFGM
Elongation factor G, mitochondrial

1

1

High-throughput

0.479

High

1012097

MTRFR
Mitochondrial translation release factor in rescue

1

2

High-throughput

0.479

High

1012105

MCUB
Calcium uniporter regulatory subunit MCUb, mitochondrial

1

1

High-throughput

0.479

High

1012107

FAKD2
FAST kinase domain-containing protein 2, mitochondrial

1

3

High-throughput

0.479

High

1012110

RF1ML
Peptide chain release factor 1-like, mitochondrial

1

2

High-throughput

0.479

High

61477

VWA8
von Willebrand factor A domain-containing protein 8

1

0

High-throughput

0.458

High

66177

MET15
12S rRNA N(4)-cytidine methyltransferase METTL15

1

0

High-throughput

0.458

High

183627

RT12
Small ribosomal subunit protein uS12m

1

0

High-throughput

0.458

High

296228

SCO1
Protein SCO1 homolog, mitochondrial

1

0

High-throughput

0.458

High

350840

TRUB2
Pseudouridylate synthase TRUB2, mitochondrial

1

0

High-throughput

0.458

High

361628

OTC
Ornithine transcarbamylase, mitochondrial

1

0

High-throughput

0.458

High

519095

COX8A
Cytochrome c oxidase subunit 8A, mitochondrial

1

0

High-throughput

0.458

High

532517

CH60
60 kDa heat shock protein, mitochondrial

1

0

High-throughput

0.458

High

786065

LONM
Lon protease homolog, mitochondrial

1

0

High-throughput

0.458

High

828742

MDHM
Malate dehydrogenase, mitochondrial

1

0

High-throughput

0.458

High

841687

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

0

High-throughput

0.458

High

851867

EFTS
Elongation factor Ts, mitochondrial

1

0

High-throughput

0.458

High

882626

EFTU
Elongation factor Tu, mitochondrial

1

0

High-throughput

0.458

High

1012044

TFAM
Transcription factor A, mitochondrial

1

0

High-throughput

0.458

High

1012046

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

0

High-throughput

0.458

High

1012047

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

0

High-throughput

0.458

High

1012048

QOR
Quinone oxidoreductase

1

0

High-throughput

0.458

High

1012051

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

0

High-throughput

0.458

High

1012052

AUHM
Methylglutaconyl-CoA hydratase, mitochondrial

1

0

High-throughput

0.458

High

1012053

ICT1
Large ribosomal subunit protein mL62

1

0

High-throughput

0.458

High

1012055

PDK1
[Pyruvate dehydrogenase

1

0

High-throughput

0.458

High

1012056

SURF1
Surfeit locus protein 1

1

0

High-throughput

0.458

High

1012060

SYAM
Alanine--tRNA ligase, mitochondrial

1

0

High-throughput

0.458

High

1012062

MRM1
rRNA methyltransferase 1, mitochondrial

1

0

High-throughput

0.458

High

1012064

CH082
UPF0598 protein C8orf82

1

0

High-throughput

0.458

High

1012066

COX15
Heme A synthase COX15

1

0

High-throughput

0.458

High

1012067

DHX30
ATP-dependent RNA helicase DHX30

1

0

High-throughput

0.458

High

1012080

CHCH1
Small ribosomal subunit protein mS37

1

0

High-throughput

0.458

High

1012082

FMT
Methionyl-tRNA formyltransferase, mitochondrial

1

0

High-throughput

0.458

High

1012083

RRFM
Ribosome-recycling factor, mitochondrial

1

0

High-throughput

0.458

High

1012084

MTEF3
Transcription termination factor 3, mitochondrial

1

0

High-throughput

0.458

High

1012085

TEFM
Transcription elongation factor, mitochondrial

1

0

High-throughput

0.458

High

1012087

IMP2L
Mitochondrial inner membrane protease subunit 2

1

0

High-throughput

0.458

High

1012088

TACO1
Translational activator of cytochrome c oxidase 1

1

0

High-throughput

0.458

High

1012089

CQ080
Mitochondrial nucleoid-associated protein 1

1

0

High-throughput

0.458

High

1012090

TMM70
Transmembrane protein 70, mitochondrial

1

0

High-throughput

0.458

High

1012092

HINT2
Adenosine 5'-monophosphoramidase HINT2

1

0

High-throughput

0.458

High

1012093

RT26
Small ribosomal subunit protein mS26

1

0

High-throughput

0.458

High

1012094

SLIRP
SRA stem-loop-interacting RNA-binding protein, mitochondrial

1

0

High-throughput

0.458

High

1012095

CC90B
Coiled-coil domain-containing protein 90B, mitochondrial

1

0

High-throughput

0.458

High

1012096

IF3M
Translation initiation factor IF-3, mitochondrial

1

0

High-throughput

0.458

High

1012098

MTG2
Mitochondrial ribosome-associated GTPase 2

1

0

High-throughput

0.458

High

1012099

MET17
Ribosome assembly protein METTL17, mitochondrial

1

0

High-throughput

0.458

High

1012100

ACAD9
Complex I assembly factor ACAD9, mitochondrial

1

0

High-throughput

0.458

High

1012103

NGRN
Neugrin

1

0

High-throughput

0.458

High

1012104

EXD2
Exonuclease 3'-5' domain-containing protein 2

1

0

High-throughput

0.458

High

1012106

AKIP
Small ribosomal subunit protein mS38

1

0

High-throughput

0.458

High

1012108

MRES1
Mitochondrial transcription rescue factor 1

1

0

High-throughput

0.458

High

1012112

RM11
Large ribosomal subunit protein uL11m

1

0

High-throughput

0.458

High

1012114

DJC15
DnaJ homolog subfamily C member 15

1

0

High-throughput

0.458

High

1012072

GT252
Procollagen galactosyltransferase 2

2

0

High-throughput

0.328

High

174742

SPTN2
Spectrin beta chain, non-erythrocytic 2

1

0

High-throughput

0.279

Low

923492

RPAB4
DNA-directed RNA polymerases I, II, and III subunit RPABC4

1

0

High-throughput

0.279

Low

1012070

SIAH1
E3 ubiquitin-protein ligase SIAH1

1

0

High-throughput

0.279

Low

1012102

CHD8
Chromodomain-helicase-DNA-binding protein 8

1

0

High-throughput

0.279

Low

1012109

HDAC6
Protein deacetylase HDAC6

1

0

High-throughput

0.279

Low

363127

EGFR
Epidermal growth factor receptor

1

0

High-throughput

0.249

Low

464688

CXB1
Gap junction beta-1 protein

1

0

Small-scale

0.249

Low

867042

CAPZB
F-actin-capping protein subunit beta

1

0

High-throughput

0.249

Low

869015

TISD
mRNA decay activator protein ZFP36L2

1

0

High-throughput

0.249

Low

1012043

RHOG
Rho-related GTP-binding protein RhoG

1

0

High-throughput

0.249

Low

1012057

E2F4
Transcription factor E2F4

1

0

High-throughput

0.249

Low

1012065

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

1012069

SLN11
Schlafen family member 11

1

0

High-throughput

0.249

Low

1012077

TNIP2
TNFAIP3-interacting protein 2

1

0

High-throughput

0.249

Low

1012101

TM165
Putative divalent cation/proton antiporter TMEM165

1

0

High-throughput

0.249

Low

1012113

RL36
Large ribosomal subunit protein eL36

1

0

High-throughput

0.249

Low

931497

RD23A
UV excision repair protein RAD23 homolog A

1

0

High-throughput

0.232

Low

976886

ERR3
Estrogen-related receptor gamma

1

0

High-throughput

0.232

Low

1012059

ISX
Intestine-specific homeobox

1

0

High-throughput

0.232

Low

1012061

CP135
Centrosomal protein of 135 kDa

1

0

High-throughput

0.232

Low

1012075

POC5
Centrosomal protein POC5

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025