Protein: EIF3I
Eukaryotic translation initiation factor 3 subunit I (eIF3i) (Eukaryotic translation initiation factor 3 39 kDa subunit) (eIF-3 39 kDa subunit) (eIF3 p39)

Gene: EIF3I, TIF34
Organism: Saccharomyces cerevisiae S288C
Interactions: 105
UniProt ID: P40217

Gene Ontology (top 5):
GO:0001732 - formation of cytoplasmic translation initiation complex
GO:0002183 - cytoplasmic translational initiation
GO:0002188 - translation reinitiation
GO:0003723 - RNA binding
GO:0003743 - translation initiation factor activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

438443

EIF3B
Eukaryotic translation initiation factor 3 subunit B

19

5

Small-scale

0.768

High

821037

EIF3G
Eukaryotic translation initiation factor 3 subunit G

16

7

Small-scale

0.765

High

799750

IF5
Eukaryotic translation initiation factor 5

12

7

Small-scale

0.759

High

796584

EIF3A
Eukaryotic translation initiation factor 3 subunit A

12

15

Small-scale

0.756

High

738388

EIF3C
Eukaryotic translation initiation factor 3 subunit C

10

3

Small-scale

0.756

High

748180

SUI1
Eukaryotic translation initiation factor eIF-1

6

2

Small-scale

0.728

High

821032

SYH1
SMY2 homolog 2

3

12

High-throughput

0.608

High

707249

TF2B
Transcription initiation factor IIB

3

2

High-throughput

0.587

High

392819

HSP82
ATP-dependent molecular chaperone HSP82

3

11

High-throughput

0.585

High

632900

IF2A
Eukaryotic translation initiation factor 2 subunit alpha

2

4

Small-scale

0.584

High

821017

OST1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

2

1

High-throughput

0.567

High

821019

TRM6
tRNA

2

0

Small-scale

0.559

High

818895

SSB2
Ribosome-associated molecular chaperone SSB2

2

11

High-throughput

0.552

High

577146

SEC63
Protein translocation protein SEC63

2

10

High-throughput

0.537

High

821025

BRE5
UBP3-associated protein BRE5

1

7

High-throughput

0.536

High

670777

SIS1
Protein SIS1

1

7

High-throughput

0.515

High

750255

PRP40
Pre-mRNA-processing protein PRP40

1

4

High-throughput

0.501

High

821010

EIF3I
Eukaryotic translation initiation factor 3 subunit I

1

17

Small-scale

0.501

High

721990

XPO1
Exportin-1

1

10

High-throughput

0.489

High

793932

TAF5
SAGA complex/transcription factor TFIID complex subunit TAF5

1

19

High-throughput

0.489

High

821018

COPB2
Coatomer subunit beta'

1

17

High-throughput

0.489

High

821029

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

12

High-throughput

0.489

High

821034

GCN5
Histone acetyltransferase GCN5

1

19

High-throughput

0.489

High

821049

DUF1
DUB-associated factor 1

1

19

High-throughput

0.489

High

553623

ERF1
Eukaryotic peptide chain release factor subunit 1

1

0

Small-scale

0.480

High

403531

PABP
Polyadenylate-binding protein, cytoplasmic and nuclear

1

5

Small-scale

0.479

High

410167

RL25
Large ribosomal subunit protein uL23

1

3

High-throughput

0.479

High

433675

RL26A
Large ribosomal subunit protein uL24A

1

3

High-throughput

0.479

High

435129

RS3
Small ribosomal subunit protein uS3

1

5

High-throughput

0.479

High

444537

DED1
ATP-dependent RNA helicase DED1

1

11

High-throughput

0.479

High

455096

RS19A
Small ribosomal subunit protein eS19A

1

2

High-throughput

0.479

High

737733

IF2G
Eukaryotic translation initiation factor 2 subunit gamma

1

13

Small-scale

0.479

High

747401

RSSA1
Small ribosomal subunit protein uS2A

1

2

High-throughput

0.479

High

778360

RS27A
Small ribosomal subunit protein eS27A

1

2

High-throughput

0.479

High

813985

IF2P
Eukaryotic translation initiation factor 5B

1

2

High-throughput

0.479

High

821016

RLP7
Ribosome biogenesis protein RLP7

1

5

High-throughput

0.479

High

821023

PESC
Pescadillo homolog

1

3

High-throughput

0.479

High

821026

GIS2
Zinc finger protein GIS2

1

4

High-throughput

0.479

High

821030

RS15
Small ribosomal subunit protein uS19

1

1

High-throughput

0.479

High

821038

DHR1
Probable ATP-dependent RNA helicase DHR1

1

11

High-throughput

0.479

High

821043

RS10A
Small ribosomal subunit protein eS10A

1

5

High-throughput

0.479

High

821046

DBP10
ATP-dependent RNA helicase DBP10

1

19

High-throughput

0.479

High

732153

COPG
Coatomer subunit gamma

1

8

High-throughput

0.470

High

796444

SLT11
Pre-mRNA-splicing factor SLT11

1

1

High-throughput

0.470

High

677423

KRR1
KRR1 small subunit processome component

1

0

High-throughput

0.458

High

821040

EIF3J
Eukaryotic translation initiation factor 3 subunit J

1

0

High-throughput

0.458

High

821041

URN1
Pre-mRNA-splicing factor URN1

1

0

High-throughput

0.458

High

821044

YL11B
Transposon Ty1-LR1 Gag-Pol polyprotein

1

0

High-throughput

0.458

High

440943

CDC7
Cell division control protein 7

1

15

High-throughput

0.457

High

651944

ESS1
Peptidyl-prolyl cis-trans isomerase ESS1

1

3

High-throughput

0.457

High

794268

CHK1
Serine/threonine-protein kinase CHK1

1

2

High-throughput

0.457

High

815453

RSP5
E3 ubiquitin-protein ligase RSP5

1

9

High-throughput

0.457

High

821045

KPR5
Ribose-phosphate pyrophosphokinase 5

1

1

High-throughput

0.457

High

149796

RS9A
Small ribosomal subunit protein uS4A

1

4

High-throughput

0.437

High

381122

H2B1
Histone H2B.1

1

5

High-throughput

0.437

High

381529

H2B2
Histone H2B.2

1

5

High-throughput

0.437

High

382134

H4
Histone H4

1

3

High-throughput

0.437

High

383729

RS17A
Small ribosomal subunit protein eS17A

1

1

High-throughput

0.437

High

419438

H2A1
Histone H2A.1

1

7

High-throughput

0.437

High

419756

H2A2
Histone H2A.2

1

7

High-throughput

0.437

High

435997

RS13
Small ribosomal subunit protein uS15

1

3

High-throughput

0.437

High

436434

RS31
Ubiquitin-ribosomal protein eS31 fusion protein [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31

1

6

High-throughput

0.437

High

441940

RS14A
Small ribosomal subunit protein uS11A

1

4

High-throughput

0.437

High

503075

RS22A
Small ribosomal subunit protein uS8A

1

1

High-throughput

0.437

High

504244

RL31A
Large ribosomal subunit protein eL31A

1

1

High-throughput

0.437

High

512472

RS6A
Small ribosomal subunit protein eS6A

1

2

High-throughput

0.437

High

513039

RS8A
Small ribosomal subunit protein eS8A

1

3

High-throughput

0.437

High

514666

RS18A
Small ribosomal subunit protein uS13A

1

2

High-throughput

0.437

High

579492

HSC82
ATP-dependent molecular chaperone HSC82

1

11

High-throughput

0.437

High

674658

RS2
Small ribosomal subunit protein uS5

1

4

High-throughput

0.437

High

689489

RS7A
Small ribosomal subunit protein eS7A

1

2

High-throughput

0.437

High

727071

HS104
Heat shock protein 104

1

3

High-throughput

0.437

High

753402

RS3A1
Small ribosomal subunit protein eS1A

1

1

High-throughput

0.437

High

779245

CENPA
Histone H3-like centromeric protein CSE4

1

7

High-throughput

0.437

High

792078

GBLP
Small ribosomal subunit protein RACK1

1

19

High-throughput

0.437

High

795015

NU170
Nucleoporin NUP170

1

1

High-throughput

0.437

High

802205

RS20
Small ribosomal subunit protein uS10

1

2

High-throughput

0.437

High

811099

TCPZ
T-complex protein 1 subunit zeta

1

20

High-throughput

0.437

High

812353

LAA1
AP-1 accessory protein LAA1

1

1

High-throughput

0.437

High

821013

MLP2
Protein MLP2

1

14

High-throughput

0.437

High

821014

TM108
Protein TMA108

1

2

High-throughput

0.437

High

821020

UTP10
U3 small nucleolar RNA-associated protein 10

1

4

High-throughput

0.437

High

821021

RS12
Small ribosomal subunit protein eS12

1

2

High-throughput

0.437

High

821024

TR112
Multifunctional methyltransferase subunit TRM112

1

1

Small-scale

0.437

High

821028

H3
Histone H3

1

7

High-throughput

0.437

High

821033

TOM1
E3 ubiquitin-protein ligase TOM1

1

9

High-throughput

0.437

High

821035

RUVB1
RuvB-like protein 1

1

6

High-throughput

0.437

High

821047

RUVB2
RuvB-like protein 2

1

6

High-throughput

0.437

High

821048

SMC6
Structural maintenance of chromosomes protein 6

1

4

High-throughput

0.437

High

676044

MAS5
Mitochondrial protein import protein MAS5

1

8

High-throughput

0.407

High

821012

ATAD2
ATPase histone chaperone YTA7

1

9

High-throughput

0.407

High

821022

UBP8
Ubiquitin carboxyl-terminal hydrolase 8

1

13

High-throughput

0.407

High

821031

TIM50
Mitochondrial import inner membrane translocase subunit TIM50

1

2

High-throughput

0.407

High

821039

TAF9
SAGA complex/transcription factor TFIID complex subunit TAF9

1

4

High-throughput

0.407

High

726011

NTH1
Endonuclease III homolog 1

1

0

High-throughput

0.279

Low

598571

RGP1
Guanine nucleotide exchange factor subunit RGP1

1

0

High-throughput

0.269

Low

821011

DOA10
ERAD-associated E3 ubiquitin-protein ligase DOA10

1

0

High-throughput

0.261

Low

797746

AIM4
Altered inheritance of mitochondria protein 4

1

0

High-throughput

0.249

Low

818538

YEY6
MYG1 protein YER156C

1

0

Small-scale

0.249

Low

821015

DSN1
Kinetochore-associated protein DSN1

1

0

High-throughput

0.249

Low

821027

SAM50
Sorting assembly machinery 50 kDa subunit

1

0

High-throughput

0.249

Low

821036

SCC2
Sister chromatid cohesion protein 2

1

0

High-throughput

0.249

Low

821042

SGO1
Shugoshin

1

0

High-throughput

0.249

Low

812227

YM11
Uncharacterized protein YMR124W

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025