Protein: BORG5
Cdc42 effector protein 1 (Binder of Rho GTPases 5) (Serum protein MSE55)

Gene: BORG5, CDC42EP1
Organism: Homo sapiens
Interactions: 138
UniProt ID: Q00587

Gene Ontology (top 5):
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0005856 - cytoskeleton
GO:0005886 - plasma membrane
GO:0005912 - adherens junction

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

955065

CDC42
Cell division control protein 42 homolog

10

20

High-throughput

0.978

High

375415

RASK
GTPase KRas

3

9

High-throughput

0.827

High

1025845

RHOJ
Rho-related GTP-binding protein RhoJ

2

20

High-throughput

0.815

High

373884

RASN
GTPase NRas

2

9

High-throughput

0.754

High

374529

RASH
GTPase HRas

2

6

High-throughput

0.754

High

977940

RHOB
Rho-related GTP-binding protein RhoB

2

20

High-throughput

0.754

High

930675

AAPK2
5'-AMP-activated protein kinase catalytic subunit alpha-2

2

0

High-throughput

0.742

High

1025822

CDK20
Cyclin-dependent kinase 20

2

0

Small-scale

0.660

High

291775

STK16
Serine/threonine-protein kinase 16

1

0

High-throughput

0.656

High

1025816

PKN3
Serine/threonine-protein kinase N3

1

0

High-throughput

0.656

High

1025834

PSKH2
Serine/threonine-protein kinase H2

1

0

High-throughput

0.656

High

1025853

NRBP2
Nuclear receptor-binding protein 2

1

0

High-throughput

0.656

High

126550

RHOD
Rho-related GTP-binding protein RhoD

1

20

High-throughput

0.618

High

466205

RHOC
Rho-related GTP-binding protein RhoC

1

17

High-throughput

0.618

High

580993

RAC2
Ras-related C3 botulinum toxin substrate 2

1

19

High-throughput

0.618

High

601241

RHOQ
Rho-related GTP-binding protein RhoQ

1

20

High-throughput

0.618

High

910012

RND2
Rho-related GTP-binding protein RhoN

1

18

High-throughput

0.618

High

953395

RAC3
Ras-related C3 botulinum toxin substrate 3

1

20

High-throughput

0.618

High

961957

RHOA
Transforming protein RhoA

1

19

High-throughput

0.618

High

962709

RND3
Rho-related GTP-binding protein RhoE

1

20

High-throughput

0.618

High

988283

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.618

High

1015370

RHOG
Rho-related GTP-binding protein RhoG

1

19

High-throughput

0.618

High

1025809

RAB35
Ras-related protein Rab-35

1

1

High-throughput

0.618

High

1025810

RHOH
Rho-related GTP-binding protein RhoH

1

20

High-throughput

0.618

High

1025818

RHOU
Rho-related GTP-binding protein RhoU

1

20

High-throughput

0.618

High

1025832

RHOV
Rho-related GTP-binding protein RhoV

1

20

High-throughput

0.618

High

1025850

RHOF
Rho-related GTP-binding protein RhoF

1

20

High-throughput

0.618

High

729752

1433B
14-3-3 protein beta/alpha

2

8

High-throughput

0.611

High

341024

DIRA3
GTP-binding protein Di-Ras3

1

0

High-throughput

0.586

High

900775

RAB5C
Ras-related protein Rab-5C

1

0

High-throughput

0.586

High

919890

PLK1
Serine/threonine-protein kinase PLK1

1

0

High-throughput

0.586

High

956255

RAB2A
Ras-related protein Rab-2A

1

0

High-throughput

0.586

High

1025830

AURKB
Aurora kinase B

1

0

High-throughput

0.586

High

540404

LAMP1
Lysosome-associated membrane glycoprotein 1

2

3

High-throughput

0.584

High

974986

ARF6
ADP-ribosylation factor 6

2

1

High-throughput

0.584

High

639595

SAT1
Diamine acetyltransferase 1

2

0

High-throughput

0.580

High

943913

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

2

High-throughput

0.575

High

966199

1433G
14-3-3 protein gamma

1

8

High-throughput

0.554

High

1025803

1433F
14-3-3 protein eta

1

8

High-throughput

0.554

High

1025844

Q9H4D1
Receptor-interacting serine/threonine-protein kinase 4

1

2

High-throughput

0.553

High

1025846

DEFI6
Differentially expressed in FDCP 6 homolog

1

0

High-throughput

0.549

High

400661

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.546

High

1025806

FHL3
Four and a half LIM domains protein 3

1

1

High-throughput

0.541

High

1025836

MDFI
MyoD family inhibitor

1

0

High-throughput

0.536

High

258838

DNJA2
DnaJ homolog subfamily A member 2

1

1

High-throughput

0.536

High

922244

LIMK1
LIM domain kinase 1

1

3

High-throughput

0.536

High

997287

TBB4B
Tubulin beta-4B chain

1

2

High-throughput

0.536

High

1025807

TBB2A
Tubulin beta-2A chain

1

2

High-throughput

0.536

High

1025839

TBB2B
Tubulin beta-2B chain

1

2

High-throughput

0.536

High

1025864

CLC11
C-type lectin domain family 11 member A

1

1

High-throughput

0.536

High

180506

PLS1
Phospholipid scramblase 1

1

0

High-throughput

0.518

High

1025826

RBPMS
RNA-binding protein with multiple splicing

1

0

High-throughput

0.518

High

1025837

SIN1
Target of rapamycin complex 2 subunit MAPKAP1

1

0

High-throughput

0.518

High

1025838

KR412
Keratin-associated protein 4-12

1

0

High-throughput

0.518

High

220155

TNF14
Tumor necrosis factor ligand superfamily member 14

1

0

High-throughput

0.513

High

366409

FA12
Coagulation factor XII

1

0

High-throughput

0.513

High

596973

TSHR
Thyrotropin receptor

1

0

High-throughput

0.513

High

1025829

EFMT3
EEF1A lysine methyltransferase 3

1

0

High-throughput

0.513

High

1025840

UBXN6
UBX domain-containing protein 6

1

0

High-throughput

0.513

High

1025841

COMD5
COMM domain-containing protein 5

1

0

High-throughput

0.513

High

1025848

ANTR1
Anthrax toxin receptor 1

1

0

High-throughput

0.513

High

1025861

MD2L2
Mitotic spindle assembly checkpoint protein MAD2B

1

0

High-throughput

0.513

High

1025866

GPR55
G-protein coupled receptor 55

1

0

High-throughput

0.513

High

1025867

KLK5
Kallikrein-5

1

0

High-throughput

0.513

High

1025804

AHNK
Neuroblast differentiation-associated protein AHNAK

1

0

High-throughput

0.493

High

1025859

DJB11
DnaJ homolog subfamily B member 11

1

1

High-throughput

0.489

High

1025865

VSIG4
V-set and immunoglobulin domain-containing protein 4

1

1

High-throughput

0.489

High

185618

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

0

High-throughput

0.480

High

172705

XPO1
Exportin-1

1

1

High-throughput

0.479

High

189515

STX7
Syntaxin-7

1

1

High-throughput

0.479

High

463456

LYN
Tyrosine-protein kinase Lyn

1

1

High-throughput

0.479

High

556016

CADH1
Cadherin-1

1

1

High-throughput

0.479

High

561996

LAMP2
Lysosome-associated membrane glycoprotein 2

1

3

High-throughput

0.479

High

580614

AMPN
Aminopeptidase N

1

1

High-throughput

0.479

High

690909

1433T
14-3-3 protein theta

1

8

High-throughput

0.479

High

710179

EPHA2
Ephrin type-A receptor 2

1

3

High-throughput

0.479

High

715540

MARCS
Myristoylated alanine-rich C-kinase substrate

1

1

High-throughput

0.479

High

730515

1433S
14-3-3 protein sigma

1

8

High-throughput

0.479

High

827171

ARL1
ADP-ribosylation factor-like protein 1

1

2

High-throughput

0.479

High

845604

MUC18
Cell surface glycoprotein MUC18

1

1

High-throughput

0.479

High

934468

TERA
Transitional endoplasmic reticulum ATPase

1

1

High-throughput

0.479

High

941772

ARL4C
ADP-ribosylation factor-like protein 4C

1

6

High-throughput

0.479

High

990099

1433Z
14-3-3 protein zeta/delta

1

8

High-throughput

0.479

High

1025801

CAV1
Caveolin-1

1

1

High-throughput

0.479

High

1025805

CUL3
Cullin-3

1

1

High-throughput

0.479

High

1025812

OCLN
Occludin

1

1

High-throughput

0.479

High

1025815

LTOR1
Ragulator complex protein LAMTOR1

1

1

High-throughput

0.479

High

1025843

DNJC5
DnaJ homolog subfamily C member 5

1

1

High-throughput

0.479

High

1025860

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

1025863

LAMP3
Lysosome-associated membrane glycoprotein 3

1

3

High-throughput

0.479

High

293572

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.458

High

642803

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

0

High-throughput

0.458

High

659211

SP100
Nuclear autoantigen Sp-100

1

0

High-throughput

0.458

High

692928

DPP4
Dipeptidyl peptidase 4

1

0

High-throughput

0.458

High

867048

CAPZB
F-actin-capping protein subunit beta

1

0

High-throughput

0.458

High

971412

1433E
14-3-3 protein epsilon

1

0

High-throughput

0.458

High

1004031

CXAR
Coxsackievirus and adenovirus receptor

1

0

High-throughput

0.458

High

1025802

TF65
Transcription factor p65

1

0

High-throughput

0.458

High

1025808

KIF14
Kinesin-like protein KIF14

1

0

High-throughput

0.458

High

1025811

E2F4
Transcription factor E2F4

1

0

High-throughput

0.458

High

1025813

CL16A
Protein CLEC16A

1

0

High-throughput

0.458

High

1025814

FBW10
F-box/WD repeat-containing protein 10

1

0

High-throughput

0.458

High

1025823

TIP
T-cell immunomodulatory protein

1

0

High-throughput

0.458

High

1025833

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.458

High

1025849

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

1025855

HIF1N
Hypoxia-inducible factor 1-alpha inhibitor

1

0

High-throughput

0.458

High

1025868

CIA2B
Cytosolic iron-sulfur assembly component 2B

1

0

High-throughput

0.458

High

342158

BRD1
Bromodomain-containing protein 1

1

1

High-throughput

0.437

High

639714

TAF1
Transcription initiation factor TFIID subunit 1

1

1

High-throughput

0.437

High

1025828

CK052
Uncharacterized protein C11orf52

1

1

High-throughput

0.437

High

1025842

SPRTN
DNA-dependent metalloprotease SPRTN

1

1

High-throughput

0.437

High

1025856

ARL15
ADP-ribosylation factor-like protein 15

1

4

High-throughput

0.437

High

1025857

SEP10
Septin-10

1

14

High-throughput

0.437

High

1025817

NBEL2
Neurobeachin-like protein 2

1

0

High-throughput

0.426

High

1025852

S22AB
Solute carrier family 22 member 11

1

0

High-throughput

0.426

High

1025858

UVRAG
UV radiation resistance-associated gene protein

1

0

High-throughput

0.426

High

1025847

ARMC7
Armadillo repeat-containing protein 7

2

0

High-throughput

0.316

High

64600

KLH33
Kelch-like protein 33

1

0

High-throughput

0.279

Low

289314

FCN3
Ficolin-3

1

0

High-throughput

0.279

Low

342539

LY86
Lymphocyte antigen 86

1

0

High-throughput

0.279

Low

479051

CEL3A
Chymotrypsin-like elastase family member 3A

1

0

High-throughput

0.279

Low

774759

TIMP3
Metalloproteinase inhibitor 3

1

0

High-throughput

0.279

Low

1025819

LYZL2
Lysozyme-like protein 2

1

0

High-throughput

0.279

Low

1025820

SFPA2
Pulmonary surfactant-associated protein A2

1

0

High-throughput

0.279

Low

1025824

F174A
Membrane protein FAM174A

1

0

High-throughput

0.279

Low

1025825

HUMMR
Protein MGARP

1

0

High-throughput

0.279

Low

1025831

F167A
Protein FAM167A

1

0

High-throughput

0.279

Low

1025835

NPAS1
Neuronal PAS domain-containing protein 1

1

0

High-throughput

0.279

Low

1025851

CAH10
Carbonic anhydrase-related protein 10

1

0

High-throughput

0.279

Low

1025862

DHDH
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase

1

0

High-throughput

0.279

Low

181699

CTDSL
CTD small phosphatase-like protein

1

0

High-throughput

0.249

Low

327225

ZFPL1
Zinc finger protein-like 1

1

0

High-throughput

0.249

Low

1025821

FA20C
Extracellular serine/threonine protein kinase FAM20C

1

0

High-throughput

0.249

Low

1025827

ERGI1
Endoplasmic reticulum-Golgi intermediate compartment protein 1

1

0

High-throughput

0.249

Low

1025854

KBTB4
Kelch repeat and BTB domain-containing protein 4

1

0

Small-scale

0.249

Low

344170

PTBP3
Polypyrimidine tract-binding protein 3

1

0

High-throughput

0.232

Low

371777

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.232

Low

516916

CB27B
Putative uncharacterized protein CDRT15P3

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025