Protein: MCL1
Induced myeloid leukemia cell differentiation protein Mcl-1 (Bcl-2-like protein 3) (Bcl2-L-3) (Bcl-2-related protein EAT/mcl1) (mcl1/EAT)

Gene: MCL1
Organism: Homo sapiens
Interactions: 118
UniProt ID: Q07820

Gene Ontology (top 5):
GO:0001709 - cell fate determination
GO:0001836 - release of cytochrome c from mitochondria
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

206740

B2L11
Bcl-2-like protein 11

31

16

Small-scale

0.992

High

992168

BAK
Bcl-2 homologous antagonist/killer

25

18

Small-scale

0.991

High

992164

APR
Phorbol-12-myristate-13-acetate-induced protein 1

22

7

Small-scale

0.988

High

991995

BAX
Apoptosis regulator BAX

12

16

Small-scale

0.979

High

879515

BID
BH3-interacting domain death agonist

7

10

Small-scale

0.970

High

992190

BMF
Bcl-2-modifying factor

5

7

Small-scale

0.892

High

992195

BBC3
Bcl-2-binding component 3, isoforms 1/2

4

7

Small-scale

0.881

High

992156

MCL1
Induced myeloid leukemia cell differentiation protein Mcl-1

2

18

Small-scale

0.821

High

992165

BECN1
Beclin-1

2

7

Small-scale

0.776

High

992177

HUWE1
E3 ubiquitin-protein ligase HUWE1

20

3

Small-scale

0.768

High

992182

BAD
Bcl2-associated agonist of cell death

2

8

Small-scale

0.767

High

992184

USP9X
Ubiquitin carboxyl-terminal hydrolase 9X

9

2

Small-scale

0.756

High

992191

BBC3B
Bcl-2-binding component 3, isoforms 3/4

10

5

Small-scale

0.752

High

992185

FBXW7
F-box/WD repeat-containing protein 7

10

4

Small-scale

0.749

High

310048

TNKS1
Poly [ADP-ribose] polymerase tankyrase-1

1

1

Small-scale

0.740

High

386600

P53
Cellular tumor antigen p53

2

9

Small-scale

0.727

High

992187

TRI11
E3 ubiquitin-protein ligase TRIM11

4

2

Small-scale

0.702

High

992183

UBP13
Ubiquitin carboxyl-terminal hydrolase 13

4

2

Small-scale

0.692

High

212397

AAKB2
5'-AMP-activated protein kinase subunit beta-2

3

1

High-throughput

0.667

High

992205

STAR9
StAR-related lipid transfer protein 9

3

1

High-throughput

0.667

High

992214

AAKB1
5'-AMP-activated protein kinase subunit beta-1

3

1

High-throughput

0.667

High

992206

SEPT9
Septin-9

3

1

High-throughput

0.650

High

992198

TNKS2
Poly [ADP-ribose] polymerase tankyrase-2

1

1

Small-scale

0.647

High

992174

U17L2
Ubiquitin carboxyl-terminal hydrolase 17

3

1

Small-scale

0.640

High

992160

BIK
Bcl-2-interacting killer

3

5

Small-scale

0.639

High

992159

AAPK1
5'-AMP-activated protein kinase catalytic subunit alpha-1

3

0

High-throughput

0.638

High

517214

PCNA
Proliferating cell nuclear antigen

3

0

Small-scale

0.638

High

992194

EDEM2
ER degradation-enhancing alpha-mannosidase-like protein 2

2

1

High-throughput

0.628

High

992213

FBW1A
F-box/WD repeat-containing protein 1A

2

4

Small-scale

0.624

High

992210

BOK
Bcl-2-related ovarian killer protein

1

18

Small-scale

0.621

High

992066

B2CL1
Bcl-2-like protein 1

1

16

Small-scale

0.618

High

271865

SPB7
Serpin B7

2

2

High-throughput

0.611

High

596269

FILA
Filaggrin

2

1

High-throughput

0.611

High

620664

CPT2
Carnitine O-palmitoyltransferase 2, mitochondrial

2

1

High-throughput

0.611

High

788186

CASP3
Caspase-3

2

6

Small-scale

0.602

High

236417

RNBP6
Ran-binding protein 6

2

0

High-throughput

0.602

High

992157

EP300
Histone acetyltransferase p300

2

5

Small-scale

0.595

High

489403

BCL2
Apoptosis regulator Bcl-2

1

16

Small-scale

0.590

High

871004

AAKG1
5'-AMP-activated protein kinase subunit gamma-1

2

0

High-throughput

0.585

High

992171

APRV1
Retroviral-like aspartic protease 1

2

0

High-throughput

0.585

High

714198

HSP74
Heat shock 70 kDa protein 4

2

2

Small-scale

0.584

High

928885

SKP1
S-phase kinase-associated protein 1

2

1

Small-scale

0.584

High

992163

CUL1
Cullin-1

2

2

Small-scale

0.584

High

992166

JOS1
Josephin-1

2

1

Small-scale

0.584

High

835695

GSK3B
Glycogen synthase kinase-3 beta

1

9

Small-scale

0.578

High

864859

MK10
Mitogen-activated protein kinase 10

1

13

Small-scale

0.569

High

625386

CDK2
Cyclin-dependent kinase 2

1

5

Small-scale

0.561

High

992158

CDC20
Cell division cycle protein 20 homolog

1

3

Small-scale

0.561

High

992162

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

1

2

Small-scale

0.561

High

992193

UHRF2
E3 ubiquitin-protein ligase UHRF2

1

2

Small-scale

0.561

High

992203

SIR3
NAD-dependent protein deacetylase sirtuin-3, mitochondrial

1

2

Small-scale

0.561

High

992215

TRAF6
TNF receptor-associated factor 6

1

3

Small-scale

0.561

High

992199

KCNF1
Potassium voltage-gated channel subfamily F member 1

2

1

High-throughput

0.553

High

805347

IEX1
Radiation-inducible immediate-early gene IEX-1

2

0

Small-scale

0.551

High

119882

HRK
Activator of apoptosis harakiri

2

4

Small-scale

0.545

High

64239

ZAR1L
Protein ZAR1-like

1

1

High-throughput

0.536

High

928272

DYL1
Dynein light chain 1, cytoplasmic

1

4

High-throughput

0.536

High

992188

DYL2
Dynein light chain 2, cytoplasmic

1

4

High-throughput

0.536

High

901916

DAD1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1

1

0

Small-scale

0.529

High

992207

FBW1B
F-box/WD repeat-containing protein 11

1

4

Small-scale

0.527

High

396226

ARGI1
Arginase-1

1

0

High-throughput

0.513

High

795953

MAGA8
Melanoma-associated antigen 8

1

0

High-throughput

0.513

High

885856

YBEY
Endoribonuclease YbeY

1

0

High-throughput

0.513

High

992173

NIPA3
Magnesium transporter NIPA3

1

0

High-throughput

0.513

High

992189

VCIP1
Deubiquitinating protein VCPIP1

1

0

High-throughput

0.513

High

992192

GBP5
Guanylate-binding protein 5

1

0

High-throughput

0.513

High

992212

SC5A6
Sodium-dependent multivitamin transporter

1

0

High-throughput

0.513

High

486161

GRAB
Granzyme B

1

1

Small-scale

0.501

High

601228

VDAC1
Voltage-dependent anion-selective channel protein 1

1

8

Small-scale

0.501

High

658905

MK01
Mitogen-activated protein kinase 1

1

2

Small-scale

0.501

High

800760

MK08
Mitogen-activated protein kinase 8

1

13

Small-scale

0.501

High

800874

MK09
Mitogen-activated protein kinase 9

1

13

Small-scale

0.501

High

835344

GSK3A
Glycogen synthase kinase-3 alpha

1

9

Small-scale

0.501

High

992169

HIF1A
Hypoxia-inducible factor 1-alpha

1

5

Small-scale

0.501

High

992178

SIR2
NAD-dependent protein deacetylase sirtuin-2

1

2

Small-scale

0.501

High

992186

SIR1
NAD-dependent protein deacetylase sirtuin-1

1

2

Small-scale

0.501

High

992176

BOP
Protein Bop

1

6

Small-scale

0.500

High

974778

CAV1
Caveolin-1

1

0

Small-scale

0.493

High

652828

APEX1
DNA repair nuclease/redox regulator APEX1

1

0

Small-scale

0.480

High

992197

UBXN6
UBX domain-containing protein 6

1

0

Small-scale

0.480

High

148720

CTRO
Citron Rho-interacting kinase

1

1

High-throughput

0.479

High

227262

PRKN
E3 ubiquitin-protein ligase parkin

1

7

Small-scale

0.479

High

296715

ATG12
Ubiquitin-like protein ATG12

1

1

Small-scale

0.479

High

314032

BAG4
BAG family molecular chaperone regulator 4

1

5

Small-scale

0.479

High

324361

BAG3
BAG family molecular chaperone regulator 3

1

5

Small-scale

0.479

High

348634

RASN
GTPase NRas

1

6

High-throughput

0.479

High

349266

RASH
GTPase HRas

1

6

High-throughput

0.479

High

350109

RASK
GTPase KRas

1

6

High-throughput

0.479

High

383764

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

1

Small-scale

0.479

High

414888

CDK1
Cyclin-dependent kinase 1

1

5

Small-scale

0.479

High

433720

LYN
Tyrosine-protein kinase Lyn

1

3

Small-scale

0.479

High

523694

XRCC6
X-ray repair cross-complementing protein 6

1

2

Small-scale

0.479

High

532514

TCTP
Translationally-controlled tumor protein

1

1

Small-scale

0.479

High

971150

H11
Histone H1.1

1

1

Small-scale

0.479

High

992161

SQSTM
Sequestosome-1

1

1

Small-scale

0.479

High

992175

TRI67
Tripartite motif-containing protein 67

1

5

High-throughput

0.479

High

992181

KAT2B
Histone acetyltransferase KAT2B

1

1

Small-scale

0.479

High

992196

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

6

Small-scale

0.479

High

992209

FZR1
Fizzy-related protein homolog

1

3

High-throughput

0.479

High

503957

HSP7C
Heat shock cognate 71 kDa protein

1

0

Small-scale

0.458

High

992201

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

992202

DUS22
Dual specificity protein phosphatase 22

1

0

High-throughput

0.458

High

992208

FBX4
F-box only protein 4

1

0

Small-scale

0.458

High

381948

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

1

Small-scale

0.445

High

891719

ACTB
Actin, cytoplasmic 1

1

1

Small-scale

0.445

High

839576

SERPH
Serpin H1

1

3

Small-scale

0.437

High

992180

EDEM1
ER degradation-enhancing alpha-mannosidase-like protein 1

1

1

High-throughput

0.437

High

525488

COX41
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

1

0

Small-scale

0.426

High

626705

EDNRA
Endothelin-1 receptor

3

0

High-throughput

0.347

High

992204

C5AR2
C5a anaphylatoxin chemotactic receptor 2

2

0

High-throughput

0.328

High

992167

ECM1
Extracellular matrix protein 1

2

0

High-throughput

0.318

High

992211

STX8
Syntaxin-8

2

0

High-throughput

0.316

High

436906

ACM4
Muscarinic acetylcholine receptor M4

1

0

High-throughput

0.282

High

992179

ADA32
Disintegrin and metalloproteinase domain-containing protein 32

1

0

High-throughput

0.279

Low

992200

TMPS5
Transmembrane protease serine 5

1

0

High-throughput

0.279

Low

992172

OTUD1
OTU domain-containing protein 1

1

0

Small-scale

0.249

Low

992170

ATG2A
Autophagy-related protein 2 homolog A

1

0

Small-scale

0.232

Low


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Last updated: 15 Jul 2024