Protein: NKAP
NF-kappa-B-activating protein

Gene: NKAP
Organism: Homo sapiens
Interactions: 142
UniProt ID: Q8N5F7

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0003682 - chromatin binding
GO:0003723 - RNA binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

625492

CSK22
Casein kinase II subunit alpha'

7

4

High-throughput

0.747

High

1327672

DDX41
Probable ATP-dependent RNA helicase DDX41

4

2

High-throughput

0.705

High

997858

CSK21
Casein kinase II subunit alpha

4

3

High-throughput

0.699

High

280721

PR40A
Pre-mRNA-processing factor 40 homolog A

3

2

High-throughput

0.677

High

1239625

JMJD6
Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6

3

1

High-throughput

0.675

High

1128058

DHX8
ATP-dependent RNA helicase DHX8

3

1

High-throughput

0.674

High

269787

CAPON
Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein

4

0

High-throughput

0.664

High

995139

CSK2B
Casein kinase II subunit beta

4

0

High-throughput

0.661

High

1145273

RNPS1
RNA-binding protein with serine-rich domain 1

4

0

High-throughput

0.661

High

1327679

NINL
Ninein-like protein

3

1

High-throughput

0.656

High

1208162

NKAPL
NKAP-like protein

2

2

High-throughput

0.628

High

1104968

PPIG
Peptidyl-prolyl cis-trans isomerase G

2

1

High-throughput

0.625

High

1006547

SRPK2
SRSF protein kinase 2

2

3

High-throughput

0.619

High

1327681

LC7L2
Putative RNA-binding protein Luc7-like 2

2

2

High-throughput

0.614

High

1327653

AP1M1
AP-1 complex subunit mu-1

2

1

High-throughput

0.606

High

224321

BUB3
Mitotic checkpoint protein BUB3

2

0

Small-scale

0.605

High

1327657

PININ
Pinin

2

0

High-throughput

0.602

High

1290586

ZCH18
Zinc finger CCCH domain-containing protein 18

2

0

High-throughput

0.585

High

224139

BUB1
Mitotic checkpoint serine/threonine-protein kinase BUB1

2

2

Small-scale

0.584

High

966610

1433G
14-3-3 protein gamma

2

0

High-throughput

0.576

High

1327682

RBMX2
RNA-binding motif protein, X-linked 2

1

1

High-throughput

0.573

High

396508

ESR1
Estrogen receptor

2

1

High-throughput

0.571

High

703645

MK01
Mitogen-activated protein kinase 1

2

1

High-throughput

0.571

High

1327635

SNIP1
Smad nuclear-interacting protein 1

2

0

High-throughput

0.559

High

1327650

SRPK1
SRSF protein kinase 1

1

3

High-throughput

0.550

High

215146

PRPF3
U4/U6 small nuclear ribonucleoprotein Prp3

1

0

High-throughput

0.549

High

1028678

U2AF1
Splicing factor U2AF 35 kDa subunit

1

0

High-throughput

0.549

High

217481

E41L2
Band 4.1-like protein 2

1

3

High-throughput

0.536

High

719564

NKTR
NK-tumor recognition protein

1

1

High-throughput

0.536

High

889148

RBM25
RNA-binding protein 25

1

1

High-throughput

0.536

High

1327641

CUL5
Cullin-5

1

1

High-throughput

0.536

High

1327659

ZCC17
Zinc finger CCHC domain-containing protein 17

1

1

High-throughput

0.536

High

1327673

ACINU
Apoptotic chromatin condensation inducer in the nucleus

1

1

High-throughput

0.536

High

1327680

E41L3
Band 4.1-like protein 3

1

3

High-throughput

0.536

High

1327634

CEP70
Centrosomal protein of 70 kDa

1

0

High-throughput

0.518

High

1327663

THAP1
THAP domain-containing protein 1

1

0

High-throughput

0.518

High

245123

AQR
RNA helicase aquarius

1

0

High-throughput

0.513

High

250705

HNRPQ
Heterogeneous nuclear ribonucleoprotein Q

1

0

High-throughput

0.513

High

391353

FRIL
Ferritin light chain

1

0

High-throughput

0.513

High

478117

SNRPA
U1 small nuclear ribonucleoprotein A

1

0

High-throughput

0.513

High

480223

RU1C
U1 small nuclear ribonucleoprotein C

1

0

High-throughput

0.513

High

574371

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

1

0

High-throughput

0.513

High

649366

H1T
Histone H1t

1

0

High-throughput

0.513

High

871976

PI42A
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha

1

0

High-throughput

0.513

High

1034595

AK17A
A-kinase anchor protein 17A

1

0

High-throughput

0.513

High

1160207

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

1

0

High-throughput

0.513

High

1186492

CHD9
Chromodomain-helicase-DNA-binding protein 9

1

0

High-throughput

0.513

High

1241009

L2GL2
LLGL scribble cell polarity complex component 2

1

0

High-throughput

0.513

High

1243570

RSBNL
Lysine-specific demethylase RSBN1L

1

0

High-throughput

0.513

High

1245389

ZC3HE
Zinc finger CCCH domain-containing protein 14

1

0

High-throughput

0.513

High

1307881

ARMC8
Armadillo repeat-containing protein 8

1

0

High-throughput

0.513

High

1327640

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

0

High-throughput

0.513

High

1327654

REN3B
Regulator of nonsense transcripts 3B

1

0

High-throughput

0.513

High

1327661

TOPRS
E3 ubiquitin-protein ligase Topors

1

0

High-throughput

0.513

High

1327665

LYAR
Cell growth-regulating nucleolar protein

1

0

High-throughput

0.513

High

1327666

ING3
Inhibitor of growth protein 3

1

0

High-throughput

0.513

High

1327667

MYEF2
Myelin expression factor 2

1

0

High-throughput

0.513

High

1327677

SRRM2
Serine/arginine repetitive matrix protein 2

1

0

High-throughput

0.513

High

1327683

CBY1
Protein chibby homolog 1

1

0

High-throughput

0.513

High

207593

DHX15
ATP-dependent RNA helicase DHX15

1

1

High-throughput

0.508

High

1327629

NKAP
NF-kappa-B-activating protein

1

2

High-throughput

0.508

High

207844

ZZEF1
Zinc finger ZZ-type and EF-hand domain-containing protein 1

1

2

High-throughput

0.489

High

370086

CYTS
Cystatin-S

1

2

High-throughput

0.489

High

370213

CYTN
Cystatin-SN

1

2

High-throughput

0.489

High

479935

CYTT
Cystatin-SA

1

2

High-throughput

0.489

High

1212583

HECD3
E3 ubiquitin-protein ligase HECTD3

1

2

High-throughput

0.489

High

1256698

NKAP1
Uncharacterized protein NKAPD1

1

1

High-throughput

0.489

High

1327630

SR1IP
Protein SREK1IP1

1

1

High-throughput

0.489

High

1127005

RBM39
RNA-binding protein 39

1

0

High-throughput

0.486

High

1146946

PCBP2
Poly(rC)-binding protein 2

1

0

High-throughput

0.486

High

1258740

F10C1
Protein FRA10AC1

1

0

High-throughput

0.486

High

185849

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

0

High-throughput

0.480

High

251784

BUB1B
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta

1

2

Small-scale

0.479

High

342960

HERC2
E3 ubiquitin-protein ligase HERC2

1

1

High-throughput

0.479

High

372575

MYC
Myc proto-oncogene protein

1

1

High-throughput

0.479

High

406388

MYCN
N-myc proto-oncogene protein

1

1

High-throughput

0.479

High

472888

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

1

High-throughput

0.479

High

636115

CD11B
Cyclin-dependent kinase 11B

1

2

High-throughput

0.479

High

674247

BRD2
Bromodomain-containing protein 2

1

1

High-throughput

0.479

High

1051022

FAK1
Focal adhesion kinase 1

1

1

Small-scale

0.479

High

1107922

SQSTM
Sequestosome-1

1

2

High-throughput

0.479

High

1141216

BRD3
Bromodomain-containing protein 3

1

1

High-throughput

0.479

High

1215710

RC3H1
Roquin-1

1

1

High-throughput

0.479

High

1293523

CIR1
Corepressor interacting with RBPJ 1

1

2

Small-scale

0.479

High

1327632

CSK23
Casein kinase II subunit alpha 3

1

3

High-throughput

0.479

High

1327637

DYRK2
Dual specificity tyrosine-phosphorylation-regulated kinase 2

1

2

High-throughput

0.479

High

1327638

ESR2
Estrogen receptor beta

1

1

High-throughput

0.479

High

1327644

AP2M1
AP-2 complex subunit mu

1

1

High-throughput

0.479

High

1327648

CI072
Guanine nucleotide exchange factor C9orf72

1

1

High-throughput

0.479

High

1327651

DDX23
Probable ATP-dependent RNA helicase DDX23

1

2

High-throughput

0.479

High

1327652

RIOK2
Serine/threonine-protein kinase RIO2

1

1

High-throughput

0.479

High

1327658

RC3H2
Roquin-2

1

1

High-throughput

0.479

High

1327678

CD11A
Cyclin-dependent kinase 11A

1

2

High-throughput

0.479

High

1327649

TTC14
Tetratricopeptide repeat protein 14

1

1

High-throughput

0.464

High

140997

NOP56
Nucleolar protein 56

1

0

High-throughput

0.458

High

194266

R113A
E3 ubiquitin-protein ligase RNF113A

1

0

High-throughput

0.458

High

401138

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.458

High

443439

CDK1
Cyclin-dependent kinase 1

1

0

High-throughput

0.458

High

540050

BCR
Breakpoint cluster region protein

1

0

High-throughput

0.458

High

606914

CEBPB
CCAAT/enhancer-binding protein beta

1

0

High-throughput

0.458

High

655267

SFPQ
Splicing factor, proline- and glutamine-rich

1

0

Small-scale

0.458

High

702997

DPOD1
DNA polymerase delta catalytic subunit

1

0

High-throughput

0.458

High

831062

CCNF
Cyclin-F

1

0

High-throughput

0.458

High

879270

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.458

High

970775

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

1017023

H33
Histone H3.3

1

0

High-throughput

0.458

High

1035525

CENPE
Centromere-associated protein E

1

0

Small-scale

0.458

High

1045518

TF65
Transcription factor p65

1

0

High-throughput

0.458

High

1276480

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.458

High

1327633

NUP43
Nucleoporin Nup43

1

0

High-throughput

0.458

High

1327639

KAT6A
Histone acetyltransferase KAT6A

1

0

High-throughput

0.458

High

1327642

CHCH1
Small ribosomal subunit protein mS37

1

0

High-throughput

0.458

High

1327643

CHM4C
Charged multivesicular body protein 4c

1

0

High-throughput

0.458

High

1327655

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

0

High-throughput

0.458

High

1327656

ATG5
Autophagy protein 5

1

0

High-throughput

0.458

High

1327662

RAD18
E3 ubiquitin-protein ligase RAD18

1

0

High-throughput

0.458

High

1327669

NXF1
Nuclear RNA export factor 1

1

0

High-throughput

0.458

High

1327670

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

1327671

TBK1
Serine/threonine-protein kinase TBK1

1

0

High-throughput

0.458

High

284588

ECI2
Enoyl-CoA delta isomerase 2

1

1

High-throughput

0.445

High

1092591

ECH1
Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial

1

1

High-throughput

0.445

High

1327664

HIF1N
Hypoxia-inducible factor 1-alpha inhibitor

1

1

High-throughput

0.445

High

1327660

LUC7L
Putative RNA-binding protein Luc7-like 1

1

2

High-throughput

0.437

High

985243

RL10A
Large ribosomal subunit protein uL1

1

0

High-throughput

0.426

High

1209385

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

0

High-throughput

0.426

High

50823

CA226
Uncharacterized protein C1orf226

2

0

High-throughput

0.328

High

1327636

ZCH10
Zinc finger CCHC domain-containing protein 10

2

0

High-throughput

0.313

High

1289914

F124A
Protein FAM124A

1

0

High-throughput

0.282

High

640601

MK
Midkine

1

0

High-throughput

0.279

Low

723939

LCN1
Lipocalin-1

1

0

High-throughput

0.279

Low

1326711

MIA40
Mitochondrial intermembrane space import and assembly protein 40

1

0

High-throughput

0.279

Low

1327645

BPIA2
BPI fold-containing family A member 2

1

0

High-throughput

0.279

Low

1327668

CRNN
Cornulin

1

0

High-throughput

0.279

Low

1327674

ANR50
Ankyrin repeat domain-containing protein 50

1

0

High-throughput

0.279

Low

991881

DYLT1
Dynein light chain Tctex-type 1

1

0

High-throughput

0.249

Low

1087671

M4K2
Mitogen-activated protein kinase kinase kinase kinase 2

1

0

High-throughput

0.249

Low

1327646

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.249

Low

1327675

HECD1
E3 ubiquitin-protein ligase HECTD1

1

0

High-throughput

0.249

Low

1327676

ALK
ALK tyrosine kinase receptor

1

0

High-throughput

0.249

Low

1327631

MOT11
Monocarboxylate transporter 11

1

0

High-throughput

0.232

Low

1327647

NEUL4
Neuralized-like protein 4

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025