Protein: CLSPN
Claspin (hClaspin)

Gene: CLSPN
Organism: Homo sapiens
Interactions: 86
UniProt ID: Q9HAW4

Gene Ontology (top 5):
GO:0000076 - DNA replication checkpoint signaling
GO:0000077 - DNA damage checkpoint signaling
GO:0000217 - DNA secondary structure binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

163167

CHK1
Serine/threonine-protein kinase Chk1

13

2

Small-scale

0.762

High

1437840

FBW1B
F-box/WD repeat-containing protein 11

6

7

Small-scale

0.721

High

1437845

FBW1A
F-box/WD repeat-containing protein 1A

6

7

Small-scale

0.721

High

1437842

FZR1
Fizzy-related protein homolog

4

7

Small-scale

0.697

High

132514

CDC7
Cell division cycle 7-related protein kinase

3

5

Small-scale

0.680

High

1437843

TIM
Protein timeless homolog

3

1

Small-scale

0.664

High

589734

RFA2
Replication protein A 32 kDa subunit

3

3

Small-scale

0.656

High

696554

RFA1
Replication protein A 70 kDa DNA-binding subunit

3

2

Small-scale

0.656

High

281250

CDC45
Cell division control protein 45 homolog

3

0

Small-scale

0.652

High

920283

PLK1
Serine/threonine-protein kinase PLK1

3

3

Small-scale

0.640

High

1411969

PSF3
DNA replication complex GINS protein PSF3

3

0

High-throughput

0.638

High

1406171

RAD9A
Cell cycle checkpoint control protein RAD9A

3

0

Small-scale

0.622

High

769221

RFA3
Replication protein A 14 kDa subunit

2

2

Small-scale

0.611

High

888334

MCM2
DNA replication licensing factor MCM2

2

1

Small-scale

0.611

High

1437835

KC1G1
Casein kinase I isoform gamma-1

2

2

Small-scale

0.602

High

298627

RAD17
Cell cycle checkpoint protein RAD17

2

0

Small-scale

0.598

High

1415774

TIPIN
TIMELESS-interacting protein

2

0

Small-scale

0.598

High

1437846

UBP20
Ubiquitin carboxyl-terminal hydrolase 20

2

1

Small-scale

0.596

High

799484

BRCA1
Breast cancer type 1 susceptibility protein

2

7

Small-scale

0.595

High

343057

HERC2
E3 ubiquitin-protein ligase HERC2

2

2

Small-scale

0.584

High

373190

MYC
Myc proto-oncogene protein

2

5

High-throughput

0.584

High

551268

PCNA
Proliferating cell nuclear antigen

2

1

Small-scale

0.584

High

1371700

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

2

Small-scale

0.561

High

1437834

UBP29
Ubiquitin carboxyl-terminal hydrolase 29

1

1

Small-scale

0.561

High

1109511

ATR
Serine/threonine-protein kinase ATR

2

0

Small-scale

0.559

High

897980

CDK9
Cyclin-dependent kinase 9

1

5

Small-scale

0.554

High

623548

RO52
E3 ubiquitin-protein ligase TRIM21

1

0

Small-scale

0.554

High

1060492

DPOE1
DNA polymerase epsilon catalytic subunit A

1

0

Small-scale

0.537

High

1065436

SSRP1
FACT complex subunit SSRP1

1

4

High-throughput

0.536

High

570988

MIF
Macrophage migration inhibitory factor

1

0

High-throughput

0.513

High

788783

SRP14
Signal recognition particle 14 kDa protein

1

0

High-throughput

0.513

High

1397701

PRIPO
DNA-directed primase/polymerase protein

1

0

Small-scale

0.513

High

1435309

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.513

High

936929

CASP7
Caspase-7

1

3

Small-scale

0.501

High

1006949

KC1G2
Casein kinase I isoform gamma-2

1

3

Small-scale

0.501

High

1437847

KC1G3
Casein kinase I isoform gamma-3

1

3

Small-scale

0.501

High

387146

TNNC2
Troponin C, skeletal muscle

1

2

High-throughput

0.489

High

556959

MYH7
Myosin-7

1

3

High-throughput

0.489

High

191104

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

6

High-throughput

0.479

High

253383

JAK2
Tyrosine-protein kinase JAK2

1

5

High-throughput

0.479

High

291963

WDHD1
WD repeat and HMG-box DNA-binding protein 1

1

5

Small-scale

0.479

High

414650

P53
Cellular tumor antigen p53

1

2

High-throughput

0.479

High

419213

H2A1B
Histone H2A type 1-B/E

1

6

High-throughput

0.479

High

487772

PARP1
Poly [ADP-ribose] polymerase 1

1

5

High-throughput

0.479

High

613186

EGR1
Early growth response protein 1

1

1

High-throughput

0.479

High

691852

MK03
Mitogen-activated protein kinase 3

1

2

High-throughput

0.479

High

703715

MK01
Mitogen-activated protein kinase 1

1

2

High-throughput

0.479

High

891797

GSK3B
Glycogen synthase kinase-3 beta

1

8

Small-scale

0.479

High

965254

WDR5
WD repeat-containing protein 5

1

6

Small-scale

0.479

High

1086913

CDC20
Cell division cycle protein 20 homolog

1

8

Small-scale

0.479

High

1097570

CBX3
Chromobox protein homolog 3

1

5

High-throughput

0.479

High

1114341

CUL3
Cullin-3

1

6

High-throughput

0.479

High

1314427

SLX4
Structure-specific endonuclease subunit SLX4

1

3

High-throughput

0.479

High

1363090

DDB2
DNA damage-binding protein 2

1

7

Small-scale

0.479

High

1364266

TOPB1
DNA topoisomerase 2-binding protein 1

1

1

High-throughput

0.479

High

1381592

UTP4
U3 small nucleolar RNA-associated protein 4 homolog

1

4

High-throughput

0.479

High

1402013

UBP28
Ubiquitin carboxyl-terminal hydrolase 28

1

5

Small-scale

0.479

High

1437833

SP110
Sp110 nuclear body protein

1

6

High-throughput

0.479

High

1437836

NLE1
Notchless protein homolog 1

1

4

High-throughput

0.479

High

1437837

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

1

High-throughput

0.479

High

1437839

ZRAN1
Ubiquitin thioesterase ZRANB1

1

3

High-throughput

0.479

High

1437844

ASF1A
Histone chaperone ASF1A

1

1

High-throughput

0.479

High

173392

XPO1
Exportin-1

1

0

High-throughput

0.458

High

913405

MSH6
DNA mismatch repair protein Msh6

1

0

Small-scale

0.458

High

928712

PMS2
Mismatch repair endonuclease PMS2

1

0

Small-scale

0.458

High

995280

CSK2B
Casein kinase II subunit beta

1

0

High-throughput

0.458

High

1032869

XPC
DNA repair protein complementing XP-C cells

1

0

Small-scale

0.458

High

1213475

DCA12
DDB1- and CUL4-associated factor 12

1

0

High-throughput

0.458

High

1218069

CBPC6
Cytosolic carboxypeptidase 6

1

0

Small-scale

0.458

High

1244835

FBX38
F-box only protein 38

1

0

High-throughput

0.458

High

1363980

SMG7
Nonsense-mediated mRNA decay factor SMG7

1

0

High-throughput

0.458

High

1437838

NXF1
Nuclear RNA export factor 1

1

0

High-throughput

0.458

High

1437841

NUP50
Nuclear pore complex protein Nup50

1

0

High-throughput

0.458

High

377899

TNFB
Lymphotoxin-alpha

1

1

Small-scale

0.437

High

439849

INSR
Insulin receptor

1

11

High-throughput

0.437

High

465654

IGF1R
Insulin-like growth factor 1 receptor

1

9

High-throughput

0.437

High

886324

ARL4D
ADP-ribosylation factor-like protein 4D

1

9

High-throughput

0.437

High

1071191

ARL16
ADP-ribosylation factor-like protein 16

1

5

High-throughput

0.437

High

1311862

DHX40
Probable ATP-dependent RNA helicase DHX40

1

2

High-throughput

0.437

High

1414964

CP250
Centrosome-associated protein CEP250

1

5

High-throughput

0.437

High

1308324

LACC1
Purine nucleoside phosphorylase LACC1

1

0

Small-scale

0.426

High

1240962

S27A4
Long-chain fatty acid transport protein 4

1

3

High-throughput

0.407

High

317926

LTN1
E3 ubiquitin-protein ligase listerin

1

0

High-throughput

0.279

Low

706054

CXB2
Gap junction beta-2 protein

1

0

High-throughput

0.279

Low

884235

SRP09
Signal recognition particle 9 kDa protein

1

0

High-throughput

0.279

Low

1023978

EM55
55 kDa erythrocyte membrane protein

1

0

High-throughput

0.279

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025