Protein: ANF
Natriuretic peptides A (Atrial natriuretic factor prohormone) (proANF) (Atrial natriuretic peptide prohormone) (preproANP) (proANP) (Atriopeptigen) (Cardiodilatin) (CDD) (preproCDD-ANF) [Cleaved into: Long-acting natriuretic peptide (LANP) (Long-acting natriuretic hormone) (LANH) (Pro atrial natriuretic factor 1-30) (proANF 1-30) (Pro atrial natriuretic peptide 1-30) (proANP 1-30); Vessel dilator (VSDL) (Pro atrial natriuretic factor 31-67) (proANF 31-67) (Pro atrial natriuretic peptide 31-67) (proANP 31-67); Kaliuretic peptide (KP) (Pro atrial natriuretic factor 79-98) (proANF 79-98) (Pro atrial natriuretic peptide 79-98) (proANP 79-98); Urodilatin (URO) (CDD 95-126) (CDD-ANP (95-126)) (Pro atrial natriuretic peptide 95-126) (proANP 95-126); Auriculin-C (Atrial natriuretic factor 1-33) (ANF 1-33); Auriculin-D (Atrial natriuretic factor 3-33) (ANF 3-33); Atrial natriuretic peptide (ANP) (Alpha-atrial natriuretic peptide) (Alpha-hANP) (Atrial natriuretic factor) (ANF) (CDD-ANF) (CDD-ANP (99-126)) (Cardionatrin) (Pro atrial natriuretic factor 99-126) (proANF 99-126); Auriculin-B (Atrial natriuretic factor 8-33) (ANF 8-33); Auriculin-A; Atriopeptin-1 (Atriopeptin I); Atriopeptin-2 (Atriopeptin II); Atriopeptin-3 (Atriopeptin III)]

Gene: ANF, NPPA
Organism: Homo sapiens
Interactions: 58
UniProt ID: P01160

Gene Ontology (top 5):
GO:0001666 - response to hypoxia
GO:0003085 - negative regulation of systemic arterial blood pressure
GO:0003161 - cardiac conduction system development
GO:0003180 - aortic valve morphogenesis
GO:0005102 - signaling receptor binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

376973

ANPRC
Atrial natriuretic peptide receptor 3

4

3

Small-scale

0.882

High

376974

ANPRB
Atrial natriuretic peptide receptor 2

3

3

Small-scale

0.845

High

376986

MPPA
Mitochondrial-processing peptidase subunit alpha

3

1

High-throughput

0.662

High

376972

ANPRA
Atrial natriuretic peptide receptor 1

1

3

Small-scale

0.647

High

276555

LX12B
Arachidonate 12-lipoxygenase, 12R-type

2

1

High-throughput

0.628

High

376977

SPB3
Serpin B3

2

1

High-throughput

0.628

High

376981

SPB4
Serpin B4

2

1

High-throughput

0.628

High

377009

UBQL2
Ubiquilin-2

2

2

High-throughput

0.606

High

281853

MPPB
Mitochondrial-processing peptidase subunit beta

3

1

High-throughput

0.604

High

261582

CATL2
Cathepsin L2

2

0

High-throughput

0.602

High

376967

INVO
Involucrin

2

0

High-throughput

0.602

High

376970

PLAK
Junction plakoglobin

2

0

High-throughput

0.602

High

376971

PPAP
Prostatic acid phosphatase

2

0

High-throughput

0.602

High

376983

MAP11
Methionine aminopeptidase 1

2

0

High-throughput

0.602

High

376985

NGAL
Neutrophil gelatinase-associated lipocalin

2

0

High-throughput

0.602

High

376989

ECM1
Extracellular matrix protein 1

2

0

High-throughput

0.602

High

376993

P20D1
N-fatty-acyl-amino acid synthase/hydrolase PM20D1

2

0

High-throughput

0.602

High

376994

NDUF7
Protein arginine methyltransferase NDUFAF7, mitochondrial

2

0

High-throughput

0.602

High

376995

GDPD3
Lysophospholipase D GDPD3

2

0

High-throughput

0.602

High

376997

DR9C7
Short-chain dehydrogenase/reductase family 9C member 7

2

0

High-throughput

0.602

High

377006

SMYD2
N-lysine methyltransferase SMYD2

2

0

High-throughput

0.602

High

377010

CBPA4
Carboxypeptidase A4

2

0

High-throughput

0.602

High

75646

B3KVV6
cDNA FLJ41607 fis, clone CTONG3001370, highly similar to Homo sapiens alpha-2-macroglobulin-like 1

2

1

High-throughput

0.584

High

183835

VGF
Neurosecretory protein VGF [Cleaved into: Neuroendocrine regulatory peptide-1

2

0

High-throughput

0.576

High

376998

TP4AP
Short transient receptor potential channel 4-associated protein

2

0

High-throughput

0.576

High

186156

LX15B
Polyunsaturated fatty acid lipoxygenase ALOX15B

2

1

High-throughput

0.574

High

377011

UBQL1
Ubiquilin-1

1

2

High-throughput

0.573

High

69465

A2ML1
Alpha-2-macroglobulin-like protein 1

2

1

High-throughput

0.552

High

377007

UBQL4
Ubiquilin-4

1

2

High-throughput

0.541

High

161854

IMPA2
Inositol monophosphatase 2

1

0

High-throughput

0.513

High

376965

ARGI1
Arginase-1

1

0

High-throughput

0.513

High

376966

S10A9
Protein S100-A9

1

0

High-throughput

0.513

High

376975

NDKB
Nucleoside diphosphate kinase B

1

0

High-throughput

0.513

High

376980

MAOX
NADP-dependent malic enzyme

1

0

High-throughput

0.513

High

376999

IPO4
Importin-4

1

0

High-throughput

0.513

High

377003

ZNG1A
Zinc-regulated GTPase metalloprotein activator 1A

1

0

High-throughput

0.513

High

377005

PYRG2
CTP synthase 2

1

0

High-throughput

0.513

High

137521

NR5A2
Nuclear receptor subfamily 5 group A member 2

1

2

High-throughput

0.481

High

376964

ESR1
Estrogen receptor

1

1

High-throughput

0.481

High

376978

HNF4A
Hepatocyte nuclear factor 4-alpha

1

1

High-throughput

0.481

High

376968

NEP
Neprilysin

1

0

Small-scale

0.480

High

376969

EPB41
Protein 4.1

1

0

Small-scale

0.480

High

376990

Q58EY0
RAR related orphan receptor B isoform 1

1

1

High-throughput

0.439

High

376979

MAGAC
Melanoma-associated antigen 12

3

0

High-throughput

0.352

High

376976

TGM1
Protein-glutamine gamma-glutamyltransferase K

2

0

High-throughput

0.328

High

376982

ACADV
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial

2

0

High-throughput

0.328

High

376987

PMVK
Phosphomevalonate kinase

2

0

High-throughput

0.328

High

376991

NDUF5
Arginine-hydroxylase NDUFAF5, mitochondrial

2

0

High-throughput

0.328

High

377000

NUDT8
Mitochondrial coenzyme A diphosphatase NUDT8

2

0

High-throughput

0.328

High

269141

HSF2B
Heat shock factor 2-binding protein

2

0

High-throughput

0.316

High

376996

ISCA2
Iron-sulfur cluster assembly 2 homolog, mitochondrial

2

0

High-throughput

0.313

High

376988

CYTM
Cystatin-M

1

0

High-throughput

0.279

Low

376992

OBSCN
Obscurin

1

0

High-throughput

0.279

Low

377001

POF1B
Protein POF1B

1

0

High-throughput

0.279

Low

377002

CPNS2
Calpain small subunit 2

1

0

High-throughput

0.279

Low

377004

DEFM
Peptide deformylase, mitochondrial

1

0

High-throughput

0.279

Low

377008

TM63C
Osmosensitive cation channel TMEM63C

1

0

High-throughput

0.279

Low

376984

TNNC1
Troponin C, slow skeletal and cardiac muscles

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025