Protein: LOC1
60S ribosomal subunit assembly/export protein LOC1 (Localization of ASH1 mRNA protein 1)

Gene: LOC1
Organism: Saccharomyces cerevisiae S288C
Interactions: 157
UniProt ID: P43586

Gene Ontology (top 5):
GO:0000055 - ribosomal large subunit export from nucleus
GO:0000447 - endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000472 - endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000480 - endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0003729 - mRNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

850028

BRX1
Ribosome biogenesis protein BRX1

7

4

Small-scale

0.743

High

850008

HAS1
ATP-dependent RNA helicase HAS1

6

2

High-throughput

0.735

High

850043

DBP10
ATP-dependent RNA helicase DBP10

5

1

High-throughput

0.720

High

780278

EBP2
rRNA-processing protein EBP2

8

0

Small-scale

0.720

High

814336

NOC2
Nucleolar complex protein 2

7

0

Small-scale

0.718

High

830130

NOP2
25S rRNA

5

1

Small-scale

0.712

High

816852

NUG1
Nuclear GTP-binding protein NUG1

5

1

Small-scale

0.711

High

682319

SPB4
ATP-dependent rRNA helicase SPB4

5

2

High-throughput

0.709

High

746639

DRS1
ATP-dependent RNA helicase DRS1

4

1

High-throughput

0.702

High

850046

IF6
Eukaryotic translation initiation factor 6

6

0

Small-scale

0.699

High

850018

FKBP4
FK506-binding protein 4

4

1

High-throughput

0.690

High

677213

SPB1
27S pre-rRNA

5

0

High-throughput

0.688

High

849993

PESC
Pescadillo homolog

5

0

Small-scale

0.684

High

850014

PUF6
Pumilio homology domain family member 6

4

0

Small-scale

0.673

High

807094

FKBP3
Peptidyl-prolyl cis-trans isomerase

3

1

High-throughput

0.670

High

850027

NOP12
Nucleolar protein 12

3

1

High-throughput

0.670

High

780687

RRP14
Ribosomal RNA-processing protein 14

4

0

Small-scale

0.667

High

850006

NOG1
Nucleolar GTP-binding protein 1

4

0

High-throughput

0.660

High

827537

RLP7
Ribosome biogenesis protein RLP7

3

2

High-throughput

0.656

High

781628

DBP7
ATP-dependent RNA helicase DBP7

3

2

High-throughput

0.656

High

850025

NOC3
Nucleolar complex-associated protein 3

3

1

High-throughput

0.650

High

791069

NOP4
Nucleolar protein 4

3

0

High-throughput

0.642

High

850037

NOP53
Ribosome biogenesis protein NOP53

3

0

High-throughput

0.642

High

804625

SSF1
Ribosome biogenesis protein SSF1

3

1

Small-scale

0.640

High

780552

SHE2
SWI5-dependent HO expression protein 2

3

0

Small-scale

0.639

High

793491

MAK5
ATP-dependent RNA helicase MAK5

2

2

High-throughput

0.634

High

850041

MAK21
Ribosome biogenesis protein MAK21

2

2

High-throughput

0.634

High

410197

RL25
Large ribosomal subunit protein uL23

3

0

High-throughput

0.628

High

803879

CIC1
Proteasome-interacting protein CIC1

3

0

Small-scale

0.628

High

805059

RPF1
Ribosome production factor 1

3

0

High-throughput

0.622

High

850016

ERB1
Ribosome biogenesis protein ERB1

3

0

High-throughput

0.622

High

850033

NIP7
60S ribosome subunit biogenesis protein NIP7

3

0

High-throughput

0.622

High

816776

NOP16
Nucleolar protein 16

3

0

High-throughput

0.618

High

818241

NSA2
Ribosome biogenesis protein NSA2

3

0

High-throughput

0.618

High

850000

NOP15
Ribosome biogenesis protein 15

3

0

Small-scale

0.613

High

849985

LOC1
60S ribosomal subunit assembly/export protein LOC1

2

0

High-throughput

0.607

High

849989

PRP43
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43

2

0

High-throughput

0.607

High

850047

RRP12
Ribosomal RNA-processing protein 12

2

0

High-throughput

0.607

High

782362

RPF2
Ribosome biogenesis protein RPF2

3

0

High-throughput

0.606

High

850017

RRP5
rRNA biogenesis protein RRP5

2

0

High-throughput

0.595

High

849994

DBP6
ATP-dependent RNA helicase DBP6

2

2

High-throughput

0.594

High

570057

RL3
Large ribosomal subunit protein uL3

2

0

High-throughput

0.585

High

689063

RL16A
Large ribosomal subunit protein uL13A

2

0

High-throughput

0.585

High

743241

PP12
Serine/threonine-protein phosphatase PP1-2

2

0

High-throughput

0.585

High

750099

MRT4
Ribosome assembly factor MRT4

2

0

High-throughput

0.585

High

849990

NSA1
Ribosome biogenesis protein NSA1

2

0

High-throughput

0.585

High

850035

YTM1
Ribosome biogenesis protein YTM1

2

0

High-throughput

0.585

High

850022

NOC4
Nucleolar complex protein 4

2

2

Small-scale

0.584

High

692579

NSR1
Nuclear localization sequence-binding protein

2

0

High-throughput

0.569

High

849991

CGR1
rRNA-processing protein CGR1

2

0

High-throughput

0.569

High

850030

TMA16
Translation machinery-associated protein 16

2

0

High-throughput

0.569

High

826015

ULP2
Ubiquitin-like-specific protease 2

2

0

High-throughput

0.561

High

633172

MAK11
Protein MAK11

2

0

Small-scale

0.559

High

763089

RRP1
Ribosomal RNA-processing protein 1

2

0

Small-scale

0.559

High

826594

DSN1
Kinetochore-associated protein DSN1

2

0

High-throughput

0.559

High

844504

UTP10
U3 small nucleolar RNA-associated protein 10

2

0

High-throughput

0.559

High

850010

RRP17
Ribosomal RNA-processing protein 17

2

0

High-throughput

0.559

High

850021

RRP15
Ribosomal RNA-processing protein 15

2

0

Small-scale

0.559

High

850026

RLP24
Ribosome biogenesis protein RLP24

2

0

Small-scale

0.559

High

432619

RL7A
Large ribosomal subunit protein uL30A

1

2

High-throughput

0.536

High

849988

RL4B
Large ribosomal subunit protein uL4B

1

1

High-throughput

0.536

High

850042

RL7B
Large ribosomal subunit protein uL30B

1

2

High-throughput

0.536

High

637236

PWP1
Periodic tryptophan protein 1

1

0

High-throughput

0.518

High

700252

GAR1
H/ACA ribonucleoprotein complex subunit GAR1

1

0

High-throughput

0.518

High

849997

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

0

High-throughput

0.518

High

448184

HAP2
Transcriptional activator HAP2

1

0

High-throughput

0.513

High

569806

RL30
Large ribosomal subunit protein eL30

1

0

High-throughput

0.513

High

684764

RL5
Large ribosomal subunit protein uL18

1

0

High-throughput

0.513

High

709411

HRR25
Casein kinase I homolog HRR25

1

0

High-throughput

0.513

High

722036

XPO1
Exportin-1

1

0

High-throughput

0.513

High

849996

ELOA1
Elongin-A

1

0

High-throughput

0.513

High

849998

IPI3
Pre-rRNA-processing protein IPI3

1

0

High-throughput

0.513

High

850011

MUS81
Crossover junction endonuclease MUS81

1

0

High-throughput

0.513

High

656979

BUR1
Serine/threonine-protein kinase BUR1

1

0

High-throughput

0.493

High

850036

THP3
Protein THP3

1

0

High-throughput

0.493

High

712601

RL8B
Large ribosomal subunit protein eL8B

1

1

High-throughput

0.489

High

381146

H2B1
Histone H2B.1

1

1

High-throughput

0.479

High

381545

H2B2
Histone H2B.2

1

1

High-throughput

0.479

High

513518

RL1A
Large ribosomal subunit protein uL1A

1

1

High-throughput

0.479

High

707428

TF2B
Transcription initiation factor IIB

1

1

High-throughput

0.479

High

708755

TF3B
Transcription factor IIIB 70 kDa subunit

1

1

High-throughput

0.479

High

849995

NOG2
Nucleolar GTP-binding protein 2

1

1

Small-scale

0.479

High

850002

RCM1
25S rRNA

1

1

High-throughput

0.479

High

850020

DBP9
ATP-dependent RNA helicase DBP9

1

2

High-throughput

0.479

High

850039

SSF2
Ribosome biogenesis protein SSF2

1

1

High-throughput

0.479

High

850044

NOP56
Nucleolar protein 56

1

1

Small-scale

0.479

High

850045

NOP58
Nucleolar protein 58

1

1

High-throughput

0.479

High

382170

H4
Histone H4

1

0

High-throughput

0.458

High

419781

H2A2
Histone H2A.2

1

0

High-throughput

0.458

High

433705

RL26A
Large ribosomal subunit protein uL24A

1

0

High-throughput

0.458

High

435172

RS3
Small ribosomal subunit protein uS3

1

0

High-throughput

0.458

High

436449

RS31
Ubiquitin-ribosomal protein eS31 fusion protein [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31

1

0

High-throughput

0.458

High

441979

RS14A
Small ribosomal subunit protein uS11A

1

0

High-throughput

0.458

High

513379

RL23B
Large ribosomal subunit protein uL14B

1

0

High-throughput

0.458

High

514690

RS18A
Small ribosomal subunit protein uS13A

1

0

High-throughput

0.458

High

534120

MAK16
Protein MAK16

1

0

High-throughput

0.458

High

558774

CAF20
Cap-associated protein CAF20

1

0

High-throughput

0.458

High

672904

RRP43
Exosome complex component RRP43

1

0

High-throughput

0.458

High

674690

RS2
Small ribosomal subunit protein uS5

1

0

High-throughput

0.458

High

677456

KRR1
KRR1 small subunit processome component

1

0

High-throughput

0.458

High

679810

CDC48
Cell division control protein 48

1

0

High-throughput

0.458

High

689524

RS7A
Small ribosomal subunit protein eS7A

1

0

High-throughput

0.458

High

694572

SPT5
Transcription elongation factor SPT5

1

0

High-throughput

0.458

High

734691

IMB3
Importin subunit beta-3

1

0

Small-scale

0.458

High

735034

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

0

High-throughput

0.458

High

747434

RSSA1
Small ribosomal subunit protein uS2A

1

0

High-throughput

0.458

High

778388

RS27A
Small ribosomal subunit protein eS27A

1

0

High-throughput

0.458

High

780034

EAP1
Protein EAP1

1

0

High-throughput

0.458

High

792107

GBLP
Small ribosomal subunit protein RACK1

1

0

High-throughput

0.458

High

795825

YBC8
UPF0642 protein YBL028C

1

0

High-throughput

0.458

High

798247

ENP1
Essential nuclear protein 1

1

0

High-throughput

0.458

High

802236

RS20
Small ribosomal subunit protein uS10

1

0

High-throughput

0.458

High

812065

DHH1
ATP-dependent RNA helicase DHH1

1

0

Small-scale

0.458

High

815150

IF4F1
Eukaryotic initiation factor 4F subunit p150

1

0

Small-scale

0.458

High

849986

MOG1
Nuclear import protein MOG1

1

0

High-throughput

0.458

High

849987

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.458

High

849992

EIF2A
Eukaryotic translation initiation factor 2A

1

0

High-throughput

0.458

High

849999

NOP13
Nucleolar protein 13

1

0

High-throughput

0.458

High

850001

APJ1
J domain-containing protein APJ1

1

0

High-throughput

0.458

High

850003

ORC1
Origin recognition complex subunit 1

1

0

High-throughput

0.458

High

850005

RS15
Small ribosomal subunit protein uS19

1

0

High-throughput

0.458

High

850007

ISU1
Iron sulfur cluster assembly protein 1, mitochondrial

1

0

Small-scale

0.458

High

850009

ARX1
Probable metalloprotease ARX1

1

0

Small-scale

0.458

High

850012

DHR1
Probable ATP-dependent RNA helicase DHR1

1

0

High-throughput

0.458

High

850013

RRB1
Ribosome assembly protein RRB1

1

0

High-throughput

0.458

High

850019

JIP5
WD repeat-containing protein JIP5

1

0

High-throughput

0.458

High

850023

VAM6
Vacuolar morphogenesis protein 6

1

0

High-throughput

0.458

High

850024

HBT1
Protein HBT1

1

0

High-throughput

0.458

High

850029

SGO1
Shugoshin

1

0

High-throughput

0.458

High

850031

HRK1
Serine/threonine-protein kinase HRK1

1

0

High-throughput

0.458

High

850032

RRS1
Regulator of ribosome biosynthesis

1

0

High-throughput

0.458

High

850034

BMS1
Ribosome biogenesis protein BMS1

1

0

High-throughput

0.458

High

850038

RRP6
Exosome complex exonuclease RRP6

1

0

High-throughput

0.458

High

850040

SCC1
Sister chromatid cohesion protein 1

1

0

High-throughput

0.458

High

531787

RL4A
Large ribosomal subunit protein uL4A

1

1

High-throughput

0.445

High

601073

RL8A
Large ribosomal subunit protein eL8A

1

1

Small-scale

0.437

High

453654

PYR1
Multifunctional protein URA2

1

0

High-throughput

0.426

High

644944

RPA2
DNA-directed RNA polymerase I subunit RPA135

1

0

High-throughput

0.426

High

803405

RL14B
Large ribosomal subunit protein eL14B

1

0

High-throughput

0.426

High

850004

SEN1
Helicase SEN1

1

0

Small-scale

0.426

High

511440

RL43B
Large ribosomal subunit protein eL43B

2

0

Small-scale

0.328

High

504275

RL31A
Large ribosomal subunit protein eL31A

2

0

High-throughput

0.305

High

432865

RL9A
Large ribosomal subunit protein uL6A

1

0

High-throughput

0.279

Low

820909

RL13B
Large ribosomal subunit protein eL13B

1

0

High-throughput

0.279

Low

455123

RS19A
Small ribosomal subunit protein eS19A

1

0

High-throughput

0.249

Low

503107

RS22A
Small ribosomal subunit protein uS8A

1

0

High-throughput

0.249

Low

511220

RL20B
Large ribosomal subunit protein eL20B

1

0

High-throughput

0.249

Low

513074

RS8A
Small ribosomal subunit protein eS8A

1

0

High-throughput

0.249

Low

624772

PMA2
Plasma membrane ATPase 2

1

0

High-throughput

0.249

Low

753435

RS3A1
Small ribosomal subunit protein eS1A

1

0

High-throughput

0.249

Low

796968

PHO88
SRP-independent targeting protein 3

1

0

High-throughput

0.249

Low

802032

HXT5
Probable glucose transporter HXT5

1

0

High-throughput

0.249

Low

812417

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.249

Low

824732

MLP2
Protein MLP2

1

0

High-throughput

0.249

Low

850015

POB3
FACT complex subunit POB3

1

0

High-throughput

0.249

Low

850048

ENV10
SRP-independent targeting protein 2

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025