Protein: P2RX4
P2X purinoceptor 4 (P2X4) (ATP receptor) (Purinergic receptor)

Gene: P2RX4
Organism: Homo sapiens
Interactions: 53
UniProt ID: Q99571

Gene Ontology (top 5):
GO:0001614 - purinergic nucleotide receptor activity
GO:0001894 - tissue homeostasis
GO:0002028 - regulation of sodium ion transport
GO:0002931 - response to ischemia
GO:0004931 - extracellularly ATP-gated monoatomic cation channel activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

270047

XYLK
Glycosaminoglycan xylosylkinase

4

1

High-throughput

0.691

High

1083198

GALT1
Polypeptide N-acetylgalactosaminyltransferase 1

3

2

High-throughput

0.667

High

1124226

EI2BA
Translation initiation factor eIF2B subunit alpha

3

2

High-throughput

0.667

High

1387054

COQ8B
Atypical kinase COQ8B, mitochondrial

3

1

High-throughput

0.667

High

1350046

SPP2B
Signal peptide peptidase-like 2B

3

1

High-throughput

0.662

High

1154820

KCNJ8
ATP-sensitive inward rectifier potassium channel 8

3

0

High-throughput

0.638

High

1387210

TIM14
Mitochondrial import inner membrane translocase subunit TIM14

3

0

High-throughput

0.638

High

1405348

EMC7
Endoplasmic reticulum membrane protein complex subunit 7

3

0

High-throughput

0.638

High

1329303

CGAT2
Chondroitin sulfate N-acetylgalactosaminyltransferase 2

3

0

High-throughput

0.634

High

789953

FDFT
Squalene synthase

2

1

High-throughput

0.611

High

890158

EI2BB
Translation initiation factor eIF2B subunit beta

2

2

High-throughput

0.611

High

1095935

EI2BE
Translation initiation factor eIF2B subunit epsilon

3

2

High-throughput

0.609

High

1405345

CYBC1
Cytochrome b-245 chaperone 1

3

1

High-throughput

0.609

High

1405350

EI2BG
Translation initiation factor eIF2B subunit gamma

3

1

High-throughput

0.609

High

1405352

EI2BD
Translation initiation factor eIF2B subunit delta

3

2

High-throughput

0.609

High

1405354

TNPO3
Transportin-3

3

2

High-throughput

0.609

High

1330368

EMC1
ER membrane protein complex subunit 1

2

0

High-throughput

0.585

High

1277367

NT2NA
Notch homolog 2 N-terminal-like protein A

2

4

High-throughput

0.578

High

1273278

HS2ST
Heparan sulfate 2-O-sulfotransferase 1

2

1

High-throughput

0.571

High

1059724

KRA11
Keratin-associated protein 1-1

2

1

High-throughput

0.553

High

541652

FGFR1
Fibroblast growth factor receptor 1

1

1

High-throughput

0.536

High

1228365

GL8D1
Glycosyltransferase 8 domain-containing protein 1

1

1

High-throughput

0.536

High

1278311

LRP10
Low-density lipoprotein receptor-related protein 10

1

3

High-throughput

0.536

High

685931

KRA59
Keratin-associated protein 5-9

1

3

High-throughput

0.523

High

888271

MCM2
DNA replication licensing factor MCM2

1

0

High-throughput

0.518

High

942195

WNT4
Protein Wnt-4

1

0

High-throughput

0.518

High

231516

ORC4
Origin recognition complex subunit 4

1

0

High-throughput

0.513

High

832444

OPRX
Nociceptin receptor

1

0

High-throughput

0.513

High

1203777

TTMP
TPA-induced transmembrane protein

1

0

High-throughput

0.513

High

1237960

LRC8E
Volume-regulated anion channel subunit LRRC8E

1

0

High-throughput

0.513

High

1390802

GLT14
Polypeptide N-acetylgalactosaminyltransferase 14

1

2

High-throughput

0.489

High

517090

NT2NC
Notch homolog 2 N-terminal-like protein C

1

4

High-throughput

0.470

High

749803

CADH5
Cadherin-5

1

0

Small-scale

0.458

High

1324164

PLD6
Mitochondrial cardiolipin hydrolase

1

0

High-throughput

0.458

High

907050

CCR6
C-C chemokine receptor type 6

1

1

High-throughput

0.445

High

1346764

ZNT5
Proton-coupled zinc antiporter SLC30A5

1

1

High-throughput

0.445

High

1405355

5MP1
eIF5-mimic protein 1

1

1

High-throughput

0.445

High

608

NBPFJ
NBPF family member NBPF19

1

1

High-throughput

0.439

High

1405351

ARMX3
Armadillo repeat-containing X-linked protein 3

1

1

High-throughput

0.437

High

190250

MOT4
Monocarboxylate transporter 4

1

0

High-throughput

0.426

High

1131600

MFS10
Major facilitator superfamily domain-containing protein 10

1

0

High-throughput

0.426

High

1175889

TM241
UDP-N-acetylglucosamine transporter TMEM241

1

0

High-throughput

0.426

High

1236287

MFSD5
Molybdate-anion transporter

1

0

High-throughput

0.426

High

1391453

S35A4
Probable UDP-sugar transporter protein SLC35A4

1

1

High-throughput

0.407

High

1405347

S35A5
UDP-sugar transporter protein SLC35A5

1

1

High-throughput

0.407

High

1126345

PIGH
Phosphatidylinositol N-acetylglucosaminyltransferase subunit H

3

0

High-throughput

0.347

High

949615

KR123
Keratin-associated protein 12-3

2

0

High-throughput

0.316

High

1405349

DAAF6
Dynein axonemal assembly factor 6

1

0

High-throughput

0.299

High

1389568

SAAL1
Protein SAAL1

2

0

High-throughput

0.298

High

1357318

THEM6
Protein THEM6

1

0

High-throughput

0.279

Low

1405353

B3GT5
Beta-1,3-galactosyltransferase 5

1

0

High-throughput

0.279

Low

185031

SPTC2
Serine palmitoyltransferase 2

1

0

High-throughput

0.249

Low

1405346

PGAP4
GPI-N-acetylgalactosamine transferase PGAP4

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025