Protein: CYK2
Cytokinesis protein 2 (Homolog of CDC15 protein 1)

Gene: CYK2, HOF1
Organism: Saccharomyces cerevisiae S288C
Interactions: 109
UniProt ID: Q05080

Gene Ontology (top 5):
GO:0000142 - cellular bud neck contractile ring
GO:0000144 - cellular bud neck septin ring
GO:0000281 - mitotic cytokinesis
GO:0005543 - phospholipid binding
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

798429

RGD1
RHO GTPase-activating protein RGD1

2

7

High-throughput

0.801

High

1050341

CYK2
Cytokinesis protein 2

2

17

Small-scale

0.783

High

924540

INN1
Ingression protein 1

14

2

Small-scale

0.762

High

1050342

CYK3
Cytokinesis protein 3

6

1

Small-scale

0.741

High

824670

BNR1
BNI1-related protein 1

4

11

Small-scale

0.708

High

672267

CDC10
Cell division control protein 10

4

2

Small-scale

0.690

High

790589

VRP1
Verprolin

3

5

Small-scale

0.677

High

1050352

LAS17
Proline-rich protein LAS17

3

20

Small-scale

0.660

High

815775

SAP1
Protein SAP1

2

4

High-throughput

0.643

High

815635

UBP5
Ubiquitin carboxyl-terminal hydrolase 5

2

4

High-throughput

0.632

High

864748

BBC1
Myosin tail region-interacting protein MTI1

2

11

High-throughput

0.620

High

818142

SHO1
High osmolarity signaling protein SHO1

2

0

Small-scale

0.616

High

1050350

IQG1
Ras GTPase-activating-like protein IQG1

2

4

Small-scale

0.614

High

792447

BOI1
BEM1-interacting protein 1

2

4

Small-scale

0.613

High

817223

FIR1
Factor interacting with REF2

2

2

Small-scale

0.613

High

666709

GRR1
SCF E3 ubiquitin ligase complex F-box protein GRR1

2

3

Small-scale

0.611

High

752014

PACC
pH-response transcription factor pacC/RIM101

2

0

High-throughput

0.605

High

1050345

NBA1
Protein NBA1

2

0

Small-scale

0.605

High

477635

MYO1
Myosin-1

2

5

Small-scale

0.595

High

1050355

AIM44
Altered inheritance of mitochondria protein 44

2

0

Small-scale

0.588

High

737342

CDC12
Cell division control protein 12

2

2

Small-scale

0.584

High

654743

SPA2
Protein SPA2

1

1

Small-scale

0.573

High

525145

HSP71
Heat shock protein SSA1

2

8

High-throughput

0.571

High

571042

CHS2
Chitin synthase 2

2

0

Small-scale

0.569

High

677774

STP22
Suppressor protein STP22 of temperature-sensitive alpha-factor receptor and arginine permease

1

4

High-throughput

0.568

High

824701

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

5

High-throughput

0.568

High

917921

YBP2
YAP1-binding protein 2

1

0

High-throughput

0.543

High

757952

SKT5
Chitin synthase regulator SKT5

1

2

Small-scale

0.543

High

737044

CDC3
Cell division control protein 3

1

2

Small-scale

0.541

High

738076

MKK2
MAP kinase kinase MKK2/SSP33

1

6

High-throughput

0.541

High

746506

BEM3
GTPase-activating protein BEM3

1

7

High-throughput

0.541

High

758335

HSL1
Probable serine/threonine-protein kinase HSL1

1

1

High-throughput

0.541

High

864274

ALY2
Arrestin-related trafficking adapter 3

1

3

High-throughput

0.541

High

874380

BRO1
Vacuolar-sorting protein BRO1

1

2

High-throughput

0.541

High

917065

MCM6
DNA replication licensing factor MCM6

1

3

High-throughput

0.541

High

917689

LSG1
Large subunit GTPase 1

1

1

High-throughput

0.541

High

924965

NIS1
Protein NIS1

1

1

High-throughput

0.541

High

1046639

MYO5
Myosin-5

1

4

High-throughput

0.541

High

1050347

ULS1
ATP-dependent helicase ULS1

1

3

High-throughput

0.541

High

1050353

ATC8
Probable phospholipid-transporting ATPase DNF3

1

2

High-throughput

0.541

High

825304

MOB1
DBF2 kinase activator protein MOB1

1

0

Small-scale

0.529

High

737117

CDC11
Cell division control protein 11

1

3

Small-scale

0.527

High

740011

CDC5
Cell cycle serine/threonine-protein kinase CDC5/MSD2

1

4

Small-scale

0.527

High

924925

APP1
Phosphatidate phosphatase APP1

1

2

High-throughput

0.518

High

598917

PFKA1
ATP-dependent 6-phosphofructokinase subunit alpha

1

0

High-throughput

0.518

High

865930

BUD4
Bud site selection protein 4

1

0

High-throughput

0.518

High

1050348

DSE3
Protein DSE3

1

0

High-throughput

0.518

High

917632

MLC1
Myosin light chain 1

1

1

Small-scale

0.516

High

836335

BNI1
Protein BNI1

1

11

Small-scale

0.508

High

464638

PBS2
MAP kinase kinase PBS2

1

7

High-throughput

0.501

High

645979

DBF2
Cell cycle protein kinase DBF2

1

2

Small-scale

0.501

High

793380

AGP2
General amino acid permease AGP2

1

2

High-throughput

0.501

High

948655

ACT
Actin

1

8

Small-scale

0.501

High

797163

AIM3
Altered inheritance of mitochondria protein 3

1

5

High-throughput

0.494

High

1050344

YO036
Uncharacterized protein YOL036W

1

1

High-throughput

0.494

High

804097

GIC1
GTPase-interacting component 1

1

0

High-throughput

0.486

High

574741

KSS1
Mitogen-activated protein kinase KSS1

1

3

High-throughput

0.481

High

667122

CG22
G2/mitotic-specific cyclin-2

1

1

Small-scale

0.481

High

779020

MYO3
Myosin-3

1

6

Small-scale

0.481

High

1050343

SHS1
Seventh homolog of septin 1

1

6

Small-scale

0.481

High

364738

CDK1
Cyclin-dependent kinase 1

1

0

Small-scale

0.480

High

801985

KIC1
Serine/threonine-protein kinase KIC1

1

0

High-throughput

0.480

High

817243

ZRG8
Zinc-regulated protein 8

1

0

High-throughput

0.480

High

808752

ATU2
Copper-transporting ATPase

1

1

High-throughput

0.479

High

816126

SIT1
Siderophore iron transporter 1

1

3

High-throughput

0.479

High

918554

VHT1
Vitamin H transporter

1

1

High-throughput

0.479

High

1045165

SIZ1
E3 SUMO-protein ligase SIZ1

1

4

High-throughput

0.479

High

1050346

ENB1
Siderophore iron transporter ENB1

1

2

High-throughput

0.479

High

581904

SYKC
Lysine--tRNA ligase, cytoplasmic

1

0

High-throughput

0.458

High

709463

HRR25
Casein kinase I homolog HRR25

1

0

Small-scale

0.458

High

751238

DOM34
Protein DOM34

1

0

High-throughput

0.458

High

830092

FET4
Low-affinity Fe(2+) transport protein

1

0

High-throughput

0.458

High

865331

MTNB
Methylthioribulose-1-phosphate dehydratase

1

0

High-throughput

0.458

High

923286

FRE4
Ferric reductase transmembrane component 4

1

0

High-throughput

0.458

High

809288

MET30
F-box protein MET30

1

2

High-throughput

0.457

High

1050349

SOG2
Leucine-rich repeat-containing protein SOG2

1

1

High-throughput

0.457

High

527671

HSP72
Heat shock protein SSA2

1

8

High-throughput

0.445

High

546267

SSB1
Ribosome-associated molecular chaperone SSB1

1

6

High-throughput

0.445

High

676346

MAS5
Mitochondrial protein import protein MAS5

1

4

High-throughput

0.445

High

742389

HSP7F
Heat shock protein homolog SSE1

1

12

High-throughput

0.445

High

742947

HSP79
Heat shock protein homolog SSE2

1

12

High-throughput

0.445

High

804454

SSZ1
Ribosome-associated complex subunit SSZ1

1

3

High-throughput

0.445

High

816404

HSP7E
Heat shock protein SSC3, mitochondrial

1

4

High-throughput

0.445

High

1046605

HSP31
Glutathione-independent glyoxalase HSP31

1

1

High-throughput

0.445

High

1050351

HSP42
Heat shock protein 42

1

1

High-throughput

0.445

High

515173

RL19B
Large ribosomal subunit protein eL19

1

1

High-throughput

0.439

High

672621

ATX10
Ataxin-10 homolog

1

0

High-throughput

0.438

High

792946

ANM1
Protein arginine N-methyltransferase 1

1

1

High-throughput

0.437

High

653901

HSP12
12 kDa heat shock protein

1

0

High-throughput

0.426

High

824549

6P21
6-phosphofructo-2-kinase 1

1

0

High-throughput

0.426

High

865072

TCPQ
T-complex protein 1 subunit theta

1

0

High-throughput

0.426

High

634281

NUP1
Nucleoporin NUP1

1

4

High-throughput

0.417

High

849575

YFG3
Putative UPF0320 protein YFL063W

1

1

High-throughput

0.417

High

866317

YJ9Z
Putative UPF0320 protein YJR162C

1

1

High-throughput

0.417

High

671124

SIS1
Protein SIS1

1

4

High-throughput

0.407

High

790390

DHSD
Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial

1

0

High-throughput

0.282

High

1032106

GCR2
Glycolytic genes transcriptional activator GCR2

1

0

High-throughput

0.282

High

1044250

SPO71
Prospore membrane adapter protein SPO71

1

0

High-throughput

0.282

High

738701

EI2BB
Translation initiation factor eIF2B subunit beta

1

0

High-throughput

0.265

Low

1050354

SRN2
Protein SRN2

1

0

High-throughput

0.265

Low

812969

YAN8
Uncharacterized protein YAR068W

1

0

High-throughput

0.261

Low

619176

IF5A2
Eukaryotic translation initiation factor 5A-2

1

0

High-throughput

0.249

Low

874344

HOSC
Homocitrate synthase, cytosolic isozyme

1

0

High-throughput

0.249

Low

897507

UBC9
SUMO-conjugating enzyme UBC9

1

0

High-throughput

0.249

Low

1046169

PDS5
Sister chromatid cohesion protein PDS5

1

0

High-throughput

0.249

Low

150395

YA069
Putative uncharacterized protein YAL069W

1

0

High-throughput

0.238

Low

797993

ATG12
Ubiquitin-like protein ATG12

1

0

High-throughput

0.238

Low

811038

TCPD
T-complex protein 1 subunit delta

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025