Protein: RQC1
Ribosome quality control complex subunit 1

Gene: RQC1
Organism: Saccharomyces cerevisiae S288C
Interactions: 80
UniProt ID: Q05468

Gene Ontology (top 5):
GO:0005737 - cytoplasm
GO:0030674 - protein-macromolecule adaptor activity
GO:0060090 - molecular adaptor activity
GO:0072344 - rescue of stalled ribosome
GO:1990112 - RQC complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

383364

RL28
Large ribosomal subunit protein uL15

3

0

Small-scale

0.628

High

570144

RL3
Large ribosomal subunit protein uL3

3

0

Small-scale

0.628

High

684844

RL5
Large ribosomal subunit protein uL18

3

0

Small-scale

0.628

High

792577

RL32
Large ribosomal subunit protein eL32

3

0

Small-scale

0.628

High

1048428

LTN1
E3 ubiquitin-protein ligase listerin

3

0

Small-scale

0.628

High

1051128

RQC2
Ribosome quality control complex subunit 2

3

0

Small-scale

0.628

High

569866

RL30
Large ribosomal subunit protein eL30

3

0

Small-scale

0.613

High

835892

RL10
Large ribosomal subunit protein uL16

3

0

Small-scale

0.613

High

427447

RLA0
Large ribosomal subunit protein uL10

3

0

Small-scale

0.606

High

680062

CDC48
Cell division control protein 48

2

0

Small-scale

0.585

High

427753

RLA2
Large ribosomal subunit protein P2A

3

1

Small-scale

0.585

High

531892

RL4A
Large ribosomal subunit protein uL4A

3

1

Small-scale

0.585

High

689138

RL16A
Large ribosomal subunit protein uL13A

3

1

Small-scale

0.585

High

689284

RL16B
Large ribosomal subunit protein uL13B

3

1

Small-scale

0.585

High

1036296

RL6A
Large ribosomal subunit protein eL6A

3

1

Small-scale

0.585

High

433294

RL17A
Large ribosomal subunit protein uL22A

2

1

Small-scale

0.584

High

790292

GLYM
Serine hydroxymethyltransferase, mitochondrial

2

1

Small-scale

0.584

High

885088

RL4B
Large ribosomal subunit protein uL4B

2

1

Small-scale

0.584

High

432703

RL7A
Large ribosomal subunit protein uL30A

2

0

Small-scale

0.559

High

509718

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

2

0

Small-scale

0.559

High

879894

RL38
Large ribosomal subunit protein eL38

2

0

Small-scale

0.559

High

383198

RLA4
Large ribosomal subunit protein P2B

2

1

Small-scale

0.558

High

722258

XPO1
Exportin-1

1

2

High-throughput

0.536

High

792246

GBLP
Small ribosomal subunit protein RACK1

1

1

Small-scale

0.536

High

433850

RL26A
Large ribosomal subunit protein uL24A

2

1

Small-scale

0.533

High

601132

RL8A
Large ribosomal subunit protein eL8A

2

1

Small-scale

0.533

High

712672

RL8B
Large ribosomal subunit protein eL8B

2

1

Small-scale

0.533

High

918337

RL26B
Large ribosomal subunit protein uL24B

2

1

Small-scale

0.533

High

1018159

RL34A
Large ribosomal subunit protein eL34A

2

1

Small-scale

0.533

High

427612

RLA1
Large ribosomal subunit protein P1A

2

1

Small-scale

0.521

High

754450

NPL4
Nuclear protein localization protein 4

1

0

Small-scale

0.513

High

674838

RS2
Small ribosomal subunit protein uS5

1

1

Small-scale

0.479

High

790228

GLYC
Serine hydroxymethyltransferase, cytosolic

1

1

Small-scale

0.479

High

1042230

TOM1
E3 ubiquitin-protein ligase TOM1

1

1

Small-scale

0.479

High

1051126

RQC1
Ribosome quality control complex subunit 1

1

1

Small-scale

0.479

High

415054

RL39
Large ribosomal subunit protein eL39

1

0

High-throughput

0.458

High

806172

NMD3
60S ribosomal export protein NMD3

1

0

High-throughput

0.458

High

814041

IF2P
Eukaryotic translation initiation factor 5B

1

0

High-throughput

0.458

High

916746

UFD1
Ubiquitin fusion degradation protein 1

1

0

Small-scale

0.458

High

917690

LSG1
Large subunit GTPase 1

1

0

High-throughput

0.458

High

1044219

ARX1
Probable metalloprotease ARX1

1

0

High-throughput

0.458

High

1044585

HMO1
High mobility group protein 1

1

0

High-throughput

0.458

High

1051127

RIO1
Serine/threonine-protein kinase RIO1

1

0

High-throughput

0.458

High

433081

RL6B
Large ribosomal subunit protein eL6B

1

1

Small-scale

0.437

High

504416

RL31A
Large ribosomal subunit protein eL31A

1

1

Small-scale

0.437

High

528873

RLA3
Large ribosomal subunit protein P1B

1

1

Small-scale

0.437

High

825908

RL34B
Large ribosomal subunit protein eL34B

1

1

High-throughput

0.437

High

863883

RL17B
Large ribosomal subunit protein uL22B

1

1

Small-scale

0.437

High

879847

RL37A
Large ribosomal subunit protein eL37A

1

1

High-throughput

0.437

High

902701

RL37B
Large ribosomal subunit protein eL37B

1

1

High-throughput

0.437

High

804455

SSZ1
Ribosome-associated complex subunit SSZ1

1

0

High-throughput

0.426

High

806499

NACA
Nascent polypeptide-associated complex subunit alpha

1

0

Small-scale

0.426

High

808585

GGC1
Mitochondrial GTP/GDP carrier protein 1

1

1

Small-scale

0.407

High

410340

RL25
Large ribosomal subunit protein uL23

3

0

Small-scale

0.342

High

432919

RL9A
Large ribosomal subunit protein uL6A

3

0

Small-scale

0.334

High

434088

RL33A
Large ribosomal subunit protein eL33A

3

0

Small-scale

0.334

High

434651

RL22A
Large ribosomal subunit protein eL22A

3

0

Small-scale

0.334

High

409785

RL24A
Large ribosomal subunit protein eL24A

2

0

Small-scale

0.305

High

434443

RL15A
Large ribosomal subunit protein eL15A

2

0

Small-scale

0.305

High

515174

RL19B
Large ribosomal subunit protein eL19

2

0

Small-scale

0.305

High

515326

RL35A
Large ribosomal subunit protein uL29A

2

0

Small-scale

0.305

High

781263

RL14A
Large ribosomal subunit protein eL14A

2

0

Small-scale

0.305

High

820965

RL13B
Large ribosomal subunit protein eL13B

2

0

Small-scale

0.305

High

1038400

RL21A
Large ribosomal subunit protein eL21A

2

0

Small-scale

0.305

High

434195

RL36A
Large ribosomal subunit protein eL36A

1

0

Small-scale

0.249

Low

455263

RS19A
Small ribosomal subunit protein eS19A

1

0

Small-scale

0.249

Low

503437

RL11A
Large ribosomal subunit protein uL5A

1

0

Small-scale

0.249

Low

503851

RL27A
Large ribosomal subunit protein eL27A

1

0

Small-scale

0.249

Low

511295

RL20B
Large ribosomal subunit protein eL20B

1

0

Small-scale

0.249

Low

511489

RL43B
Large ribosomal subunit protein eL43B

1

0

Small-scale

0.249

Low

513413

RL23B
Large ribosomal subunit protein uL14B

1

0

Small-scale

0.249

Low

514063

RL18B
Large ribosomal subunit protein eL18B

1

0

Small-scale

0.249

Low

514367

RL12B
Large ribosomal subunit protein uL11B

1

0

Small-scale

0.249

Low

708182

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.249

Low

747580

RSSA1
Small ribosomal subunit protein uS2A

1

0

Small-scale

0.249

Low

764156

SPT21
Protein SPT21

1

0

High-throughput

0.249

Low

807846

SSN2
Mediator of RNA polymerase II transcription subunit 13

1

0

Small-scale

0.249

Low

812655

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.249

Low

799770

IF5
Eukaryotic translation initiation factor 5

1

0

Small-scale

0.232

Low


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Last updated: 11Aug2025