Protein: SMC2
Structural maintenance of chromosomes protein 2 (SMC protein 2) (SMC-2) (Chromosome-associated protein E) (hCAP-E) (XCAP-E homolog)

Gene: SMC2
Organism: Homo sapiens
Interactions: 228
UniProt ID: O95347

Gene Ontology (top 5):
GO:0000228 - nuclear chromosome
GO:0000785 - chromatin
GO:0000793 - condensed chromosome
GO:0000794 - condensed nuclear chromosome
GO:0000796 - condensin complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

311633

SMC4
Structural maintenance of chromosomes protein 4

8

16

Small-scale

0.965

High

311545

CND2
Condensin complex subunit 2

6

7

Small-scale

0.952

High

311495

CNDD3
Condensin-2 complex subunit D3

3

18

Small-scale

0.847

High

311546

CND1
Condensin complex subunit 1

3

18

Small-scale

0.827

High

311648

SMC3
Structural maintenance of chromosomes protein 3

2

15

High-throughput

0.789

High

224250

RAD21
Double-strand-break repair protein rad21 homolog

2

20

Small-scale

0.737

High

311565

CNDH2
Condensin-2 complex subunit H2

5

3

Small-scale

0.722

High

311610

CND3
Condensin complex subunit 3

5

10

Small-scale

0.709

High

311454

MYC
Myc proto-oncogene protein

4

12

Small-scale

0.686

High

311579

CNDG2
Condensin-2 complex subunit G2

3

2

Small-scale

0.656

High

311481

RFA1
Replication protein A 70 kDa DNA-binding subunit

3

4

Small-scale

0.640

High

311470

DPEP1
Dipeptidase 1

2

1

High-throughput

0.628

High

311476

EPHA1
Ephrin type-A receptor 1

2

6

High-throughput

0.628

High

311555

H2B2E
Histone H2B type 2-E

2

12

Small-scale

0.611

High

311521

SUMO2
Small ubiquitin-related modifier 2

2

7

High-throughput

0.595

High

311632

DISC1
Disrupted in schizophrenia 1 protein

2

1

High-throughput

0.590

High

311643

HECD1
E3 ubiquitin-protein ligase HECTD1

3

7

Small-scale

0.585

High

243741

BRD4
Bromodomain-containing protein 4

2

6

High-throughput

0.584

High

311453

EGFR
Epidermal growth factor receptor

2

2

High-throughput

0.584

High

311469

RFA2
Replication protein A 32 kDa subunit

2

3

High-throughput

0.584

High

311489

RFA3
Replication protein A 14 kDa subunit

2

3

High-throughput

0.584

High

311496

MATR3
Matrin-3

2

4

High-throughput

0.584

High

311500

YAP1
Transcriptional coactivator YAP1

2

6

Small-scale

0.584

High

311641

ZRAN1
Ubiquitin thioesterase ZRANB1

2

3

High-throughput

0.584

High

311468

BMP1
Bone morphogenetic protein 1

2

1

High-throughput

0.574

High

311638

DNM3B
DNA

1

1

Small-scale

0.550

High

311508

DNLI4
DNA ligase 4

1

0

Small-scale

0.549

High

149812

RFXK
DNA-binding protein RFXANK

1

11

High-throughput

0.536

High

208882

FOXS1
Forkhead box protein S1

1

15

High-throughput

0.536

High

277792

SERF1
Small EDRK-rich factor 1

1

1

High-throughput

0.536

High

311449

NFAC1
Nuclear factor of activated T-cells, cytoplasmic 1

1

1

High-throughput

0.536

High

311463

H2AZ
Histone H2A.Z

1

4

Small-scale

0.536

High

311466

PRPS2
Ribose-phosphate pyrophosphokinase 2

1

1

High-throughput

0.536

High

311501

CAZA2
F-actin-capping protein subunit alpha-2

1

1

High-throughput

0.536

High

311503

SOX2
Transcription factor SOX-2

1

6

High-throughput

0.536

High

311509

DYN2
Dynamin-2

1

2

High-throughput

0.536

High

311512

FOXL2
Forkhead box protein L2

1

15

High-throughput

0.536

High

311527

ACTG
Actin, cytoplasmic 2

1

1

High-throughput

0.536

High

311530

TIE2
Angiopoietin-1 receptor

1

13

High-throughput

0.536

High

311532

FOXM1
Forkhead box protein M1

1

17

High-throughput

0.536

High

311534

FOXL1
Forkhead box protein L1

1

15

High-throughput

0.536

High

311543

IRF3
Interferon regulatory factor 3

1

1

High-throughput

0.536

High

311561

FAXC
Failed axon connections homolog

1

1

High-throughput

0.536

High

311566

FOXR1
Forkhead box protein R1

1

15

High-throughput

0.536

High

311589

ARRD4
Arrestin domain-containing protein 4

1

4

High-throughput

0.536

High

311590

ANKK1
Ankyrin repeat and protein kinase domain-containing protein 1

1

8

High-throughput

0.536

High

311599

TRI52
E3 ubiquitin-protein ligase TRIM52

1

2

High-throughput

0.536

High

311600

EFMT3
EEF1A lysine methyltransferase 3

1

5

High-throughput

0.536

High

311601

ARRD3
Arrestin domain-containing protein 3

1

4

High-throughput

0.536

High

311608

CDC5L
Cell division cycle 5-like protein

1

5

High-throughput

0.536

High

311609

FOXB1
Forkhead box protein B1

1

20

High-throughput

0.536

High

311612

LZTS2
Leucine zipper putative tumor suppressor 2

1

11

High-throughput

0.536

High

311615

FOXP3
Forkhead box protein P3

1

13

High-throughput

0.536

High

311616

FOXQ1
Forkhead box protein Q1

1

20

High-throughput

0.536

High

311625

SG196
Protein O-mannose kinase

1

1

High-throughput

0.536

High

311644

FZD10
Frizzled-10

1

1

High-throughput

0.536

High

311649

TN13B
Tumor necrosis factor ligand superfamily member 13B

1

1

High-throughput

0.536

High

311653

ATG4B
Cysteine protease ATG4B

1

1

High-throughput

0.536

High

311593

MIPT3
TRAF3-interacting protein 1

2

5

High-throughput

0.526

High

179385

MRP5
ATP-binding cassette sub-family C member 5

1

0

High-throughput

0.518

High

311640

GULP1
PTB domain-containing engulfment adapter protein 1

1

0

High-throughput

0.518

High

260507

TP4A3
Protein tyrosine phosphatase type IVA 3

1

7

High-throughput

0.515

High

311479

IKBA
NF-kappa-B inhibitor alpha

1

11

Small-scale

0.515

High

311506

CASP4
Caspase-4

1

3

High-throughput

0.515

High

311531

MECOM
Histone-lysine N-methyltransferase MECOM

1

8

High-throughput

0.515

High

311556

KIF4B
Chromosome-associated kinesin KIF4B

1

1

High-throughput

0.515

High

311642

MD2L2
Mitotic spindle assembly checkpoint protein MAD2B

1

2

High-throughput

0.515

High

311497

PRS6B
26S proteasome regulatory subunit 6B

1

0

High-throughput

0.513

High

311502

CAPZB
F-actin-capping protein subunit beta

1

0

High-throughput

0.513

High

311516

CXCR4
C-X-C chemokine receptor type 4

1

0

High-throughput

0.513

High

311580

P66A
Transcriptional repressor p66-alpha

1

0

High-throughput

0.513

High

311585

LRC25
Leucine-rich repeat-containing protein 25

1

0

High-throughput

0.513

High

311595

BSND
Barttin

1

0

High-throughput

0.513

High

311652

RPC10
DNA-directed RNA polymerase III subunit RPC10

1

0

High-throughput

0.513

High

311513

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

5

High-throughput

0.501

High

231933

KDM1A
Lysine-specific histone demethylase 1A

1

1

Small-scale

0.500

High

311541

TF2H3
General transcription factor IIH subunit 3

1

0

High-throughput

0.493

High

311552

JHD2C
Probable JmjC domain-containing histone demethylation protein 2C

1

0

High-throughput

0.493

High

311484

CD6
T-cell differentiation antigen CD6

1

2

High-throughput

0.489

High

311550

P2RY6
P2Y purinoceptor 6

1

2

High-throughput

0.489

High

311578

CMTD1
Catechol O-methyltransferase domain-containing protein 1

1

1

High-throughput

0.489

High

311592

F174A
Membrane protein FAM174A

1

1

High-throughput

0.489

High

311622

UN93B
Protein unc-93 homolog B1

1

3

High-throughput

0.489

High

311627

IFT22
Intraflagellar transport protein 22 homolog

1

2

High-throughput

0.489

High

311452

CHK2
Serine/threonine-protein kinase Chk2

1

8

Small-scale

0.484

High

311514

CDC42
Cell division control protein 42 homolog

1

0

High-throughput

0.480

High

119056

LEG9
Galectin-9

1

3

High-throughput

0.479

High

122424

MEN1
Menin

1

3

High-throughput

0.479

High

150796

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

1

High-throughput

0.479

High

177768

TMPS2
Transmembrane protease serine 2

1

1

High-throughput

0.479

High

302459

CE152
Centrosomal protein of 152 kDa

1

3

High-throughput

0.479

High

302746

HEXI1
Protein HEXIM1

1

1

High-throughput

0.479

High

311448

ZBT7A
Zinc finger and BTB domain-containing protein 7A

1

5

Small-scale

0.479

High

311450

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

8

High-throughput

0.479

High

311451

SNAI1
Zinc finger protein SNAI1

1

10

High-throughput

0.479

High

311455

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

2

High-throughput

0.479

High

311456

ESR1
Estrogen receptor

1

12

Small-scale

0.479

High

311457

MYCN
N-myc proto-oncogene protein

1

10

High-throughput

0.479

High

311458

HLAA
HLA class I histocompatibility antigen, A alpha chain

1

2

High-throughput

0.479

High

311459

NTRK1
High affinity nerve growth factor receptor

1

8

High-throughput

0.479

High

311461

ENOA
Alpha-enolase

1

1

High-throughput

0.479

High

311462

ROS1
Proto-oncogene tyrosine-protein kinase ROS

1

12

High-throughput

0.479

High

311464

HSP7C
Heat shock cognate 71 kDa protein

1

3

High-throughput

0.479

High

311465

FGFR1
Fibroblast growth factor receptor 1

1

20

High-throughput

0.479

High

311467

IMDH2
Inosine-5'-monophosphate dehydrogenase 2

1

1

High-throughput

0.479

High

311472

CEBPB
CCAAT/enhancer-binding protein beta

1

7

High-throughput

0.479

High

311473

VGFR1
Vascular endothelial growth factor receptor 1

1

11

High-throughput

0.479

High

311474

NUCL
Nucleolin

1

3

High-throughput

0.479

High

311477

FGFR3
Fibroblast growth factor receptor 3

1

16

High-throughput

0.479

High

311478

ROA2
Heterogeneous nuclear ribonucleoproteins A2/B1

1

3

High-throughput

0.479

High

311480

MOES
Moesin

1

4

High-throughput

0.479

High

311483

LTK
Leukocyte tyrosine kinase receptor

1

12

High-throughput

0.479

High

311485

UFO
Tyrosine-protein kinase receptor UFO

1

15

High-throughput

0.479

High

311486

STIP1
Stress-induced-phosphoprotein 1

1

4

High-throughput

0.479

High

311488

PHB1
Prohibitin 1

1

3

High-throughput

0.479

High

311490

VGFR3
Vascular endothelial growth factor receptor 3

1

11

High-throughput

0.479

High

311491

FLT3
Receptor-type tyrosine-protein kinase FLT3

1

11

High-throughput

0.479

High

311493

RS19
Small ribosomal subunit protein eS19

1

1

High-throughput

0.479

High

311494

CCNF
Cyclin-F

1

4

High-throughput

0.479

High

311498

GATA4
Transcription factor GATA-4

1

2

High-throughput

0.479

High

311499

ATRX
Transcriptional regulator ATRX

1

15

Small-scale

0.479

High

311504

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

6

High-throughput

0.479

High

311505

UB2R1
Ubiquitin-conjugating enzyme E2 R1

1

4

High-throughput

0.479

High

311510

CDK9
Cyclin-dependent kinase 9

1

9

High-throughput

0.479

High

311517

UBC12
NEDD8-conjugating enzyme Ubc12

1

1

High-throughput

0.479

High

311518

ACTZ
Alpha-centractin

1

2

High-throughput

0.479

High

311519

RL26
Large ribosomal subunit protein uL24

1

2

High-throughput

0.479

High

311520

RL37A
Large ribosomal subunit protein eL43

1

1

High-throughput

0.479

High

311522

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

3

High-throughput

0.479

High

311523

1433E
14-3-3 protein epsilon

1

1

Small-scale

0.479

High

311525

H4
Histone H4

1

5

High-throughput

0.479

High

311526

1433Z
14-3-3 protein zeta/delta

1

4

High-throughput

0.479

High

311529

RED1
Double-stranded RNA-specific editase 1

1

8

High-throughput

0.479

High

311533

EP300
Histone acetyltransferase p300

1

10

High-throughput

0.479

High

311535

TIF1B
Transcription intermediary factor 1-beta

1

7

High-throughput

0.479

High

311536

PTPRS
Receptor-type tyrosine-protein phosphatase S

1

2

High-throughput

0.479

High

311537

BIRC3
Baculoviral IAP repeat-containing protein 3

1

3

High-throughput

0.479

High

311540

CUL3
Cullin-3

1

7

High-throughput

0.479

High

311547

SUZ12
Polycomb protein SUZ12

1

2

High-throughput

0.479

High

311548

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

4

High-throughput

0.479

High

311549

KIF14
Kinesin-like protein KIF14

1

4

High-throughput

0.479

High

311551

PCBP1
Poly(rC)-binding protein 1

1

2

Small-scale

0.479

High

311553

EZH2
Histone-lysine N-methyltransferase EZH2

1

6

High-throughput

0.479

High

311554

H2A2C
Histone H2A type 2-C

1

4

Small-scale

0.479

High

311557

CRY2
Cryptochrome-2

1

1

High-throughput

0.479

High

311558

LARP7
La-related protein 7

1

3

High-throughput

0.479

High

311563

A16L1
Autophagy-related protein 16-1

1

8

High-throughput

0.479

High

311564

VIR
Protein virilizer homolog

1

3

High-throughput

0.479

High

311567

TRI67
Tripartite motif-containing protein 67

1

4

High-throughput

0.479

High

311568

PAXI1
PAX-interacting protein 1

1

4

High-throughput

0.479

High

311569

MOB3C
MOB kinase activator 3C

1

3

High-throughput

0.479

High

311570

H32
Histone H3.2

1

8

Small-scale

0.479

High

311571

TBA1A
Tubulin alpha-1A chain

1

7

High-throughput

0.479

High

311572

MEPCE
7SK snRNA methylphosphate capping enzyme

1

2

High-throughput

0.479

High

311573

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

3

High-throughput

0.479

High

311575

TM11B
Transmembrane protease serine 11B

1

1

High-throughput

0.479

High

311576

ZN598
E3 ubiquitin-protein ligase ZNF598

1

3

High-throughput

0.479

High

311586

SIR6
NAD-dependent protein deacylase sirtuin-6

1

4

Small-scale

0.479

High

311591

RIN3
Ras and Rab interactor 3

1

2

High-throughput

0.479

High

311594

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

3

High-throughput

0.479

High

311596

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

3

High-throughput

0.479

High

311597

ESR2
Estrogen receptor beta

1

12

High-throughput

0.479

High

311598

HDAC2
Histone deacetylase 2

1

8

High-throughput

0.479

High

311602

SPDLY
Protein Spindly

1

3

High-throughput

0.479

High

311603

DDRGK
DDRGK domain-containing protein 1

1

2

High-throughput

0.479

High

311605

LMTK3
Serine/threonine-protein kinase LMTK3

1

16

High-throughput

0.479

High

311607

RUFY1
RUN and FYVE domain-containing protein 1

1

5

High-throughput

0.479

High

311611

GRWD1
Glutamate-rich WD repeat-containing protein 1

1

1

High-throughput

0.479

High

311613

FACD2
Fanconi anemia group D2 protein

1

8

High-throughput

0.479

High

311614

ACE2
Angiotensin-converting enzyme 2

1

1

High-throughput

0.479

High

311619

ASXL3
Putative Polycomb group protein ASXL3

1

4

High-throughput

0.479

High

311620

WWTR1
WW domain-containing transcription regulator protein 1

1

6

High-throughput

0.479

High

311621

CCDC8
Coiled-coil domain-containing protein 8

1

3

High-throughput

0.479

High

311623

TXNIP
Thioredoxin-interacting protein

1

4

Small-scale

0.479

High

311624

PKHA4
Pleckstrin homology domain-containing family A member 4

1

4

High-throughput

0.479

High

311626

EGLN3
Prolyl hydroxylase EGLN3

1

3

High-throughput

0.479

High

311628

NEK6
Serine/threonine-protein kinase Nek6

1

15

High-throughput

0.479

High

311629

BRD7
Bromodomain-containing protein 7

1

9

High-throughput

0.479

High

311630

ANLN
Anillin

1

3

High-throughput

0.479

High

311631

FBX6
F-box only protein 6

1

3

High-throughput

0.479

High

311635

MTMR4
Myotubularin-related protein 4

1

2

High-throughput

0.479

High

311636

TLS1
Splicing factor C9orf78

1

3

High-throughput

0.479

High

311637

PD1L1
Programmed cell death 1 ligand 1

1

2

Small-scale

0.479

High

311645

FZR1
Fizzy-related protein homolog

1

3

High-throughput

0.479

High

311646

TRI33
E3 ubiquitin-protein ligase TRIM33

1

7

High-throughput

0.479

High

311647

PHF8
Histone lysine demethylase PHF8

1

2

Small-scale

0.479

High

311650

NINL
Ninein-like protein

1

5

High-throughput

0.479

High

311654

NEMO
NF-kappa-B essential modulator

1

4

High-throughput

0.479

High

311582

GP135
G-protein coupled receptor 135

1

1

High-throughput

0.470

High

311606

MA7D2
MAP7 domain-containing protein 2

1

8

High-throughput

0.470

High

199856

SPIT2
Kunitz-type protease inhibitor 2

1

0

High-throughput

0.458

High

200456

CP110
Centriolar coiled-coil protein of 110 kDa

1

0

High-throughput

0.458

High

268359

BAF
Barrier-to-autointegration factor

1

0

High-throughput

0.458

High

311475

TFE3
Transcription factor E3

1

0

High-throughput

0.458

High

311482

TPP2
Tripeptidyl-peptidase 2

1

0

High-throughput

0.458

High

311492

SYUA
Alpha-synuclein

1

0

High-throughput

0.458

High

311511

IF6
Eukaryotic translation initiation factor 6

1

0

High-throughput

0.458

High

311524

ARF6
ADP-ribosylation factor 6

1

0

High-throughput

0.458

High

311528

YBOX1
Y-box-binding protein 1

1

0

Small-scale

0.458

High

311544

HAPR1
HUWE1-associated protein modifying stress responses 1

1

0

High-throughput

0.458

High

311583

CCAR2
Cell cycle and apoptosis regulator protein 2

1

0

High-throughput

0.458

High

311587

NHLC2
NHL repeat-containing protein 2

1

0

High-throughput

0.458

High

311651

GSTK1
Glutathione S-transferase kappa 1

1

0

High-throughput

0.458

High

311460

JUN
Transcription factor Jun

1

9

High-throughput

0.445

High

311471

ZNF3
Zinc finger protein 3

1

1

High-throughput

0.445

High

311538

TBB3
Tubulin beta-3 chain

1

3

High-throughput

0.445

High

311539

SNW1
SNW domain-containing protein 1

1

3

High-throughput

0.445

High

311559

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

4

High-throughput

0.445

High

311562

MEX3C
RNA-binding E3 ubiquitin-protein ligase MEX3C

1

7

Small-scale

0.445

High

311604

NEUL4
Neuralized-like protein 4

1

3

High-throughput

0.445

High

311617

ZDHC5
Palmitoyltransferase ZDHHC5

1

3

High-throughput

0.445

High

169346

BET1
BET1 homolog

1

2

High-throughput

0.437

High

311515

GMFB
Glia maturation factor beta

1

1

High-throughput

0.437

High

311542

TRI29
Tripartite motif-containing protein 29

1

5

Small-scale

0.437

High

311577

ZCH18
Zinc finger CCCH domain-containing protein 18

1

8

High-throughput

0.437

High

311639

TR10D
Tumor necrosis factor receptor superfamily member 10D

1

1

High-throughput

0.437

High

311507

CEBPA
CCAAT/enhancer-binding protein alpha

1

7

High-throughput

0.408

High

868

SIM26
Small integral membrane protein 26

1

2

High-throughput

0.407

High

311588

MOT11
Monocarboxylate transporter 11

1

2

High-throughput

0.407

High

311584

SYNE4
Nesprin-4

3

0

High-throughput

0.347

High

234672

G137B
Integral membrane protein GPR137B

2

0

High-throughput

0.318

High

68041

HIDE1
Protein HIDE1

1

0

High-throughput

0.279

Low

311487

SDC2
Syndecan-2

1

0

High-throughput

0.279

Low

311581

C1QL4
Complement C1q-like protein 4

1

0

High-throughput

0.279

Low

311618

SEM4C
Semaphorin-4C

1

0

High-throughput

0.279

Low

311634

B3GN2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

1

0

High-throughput

0.279

Low

311560

RC3H1
Roquin-1

1

0

High-throughput

0.249

Low

311574

RIC3
Protein RIC-3

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024