Protein: SREK1
Splicing regulatory glutamine/lysine-rich protein 1 (Serine/arginine-rich-splicing regulatory protein 86) (SRrp86) (Splicing factor, arginine/serine-rich 12) (Splicing regulatory protein 508) (SRrp508)

Gene: SREK1
Organism: Homo sapiens
Interactions: 180
UniProt ID: Q8WXA9

Gene Ontology (top 5):
GO:0003723 - RNA binding
GO:0005654 - nucleoplasm
GO:0005681 - spliceosomal complex
GO:0006397 - mRNA processing
GO:0008380 - RNA splicing

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1051502

SRS11
Serine/arginine-rich splicing factor 11

4

5

High-throughput

0.904

High

1006592

SRPK2
SRSF protein kinase 2

4

13

High-throughput

0.903

High

1360234

SRSF8
Serine/arginine-rich splicing factor 8

4

13

Small-scale

0.897

High

284190

SRS10
Serine/arginine-rich splicing factor 10

4

16

Small-scale

0.895

High

329779

ZRAB2
Zinc finger Ran-binding domain-containing protein 2

4

2

Small-scale

0.895

High

1145301

RNPS1
RNA-binding protein with serine-rich domain 1

4

15

High-throughput

0.887

High

1360232

SRPK1
SRSF protein kinase 1

3

9

Small-scale

0.866

High

1360236

MK67I
MKI67 FHA domain-interacting nucleolar phosphoprotein

3

15

High-throughput

0.861

High

1127037

RBM39
RNA-binding protein 39

3

12

High-throughput

0.843

High

1099181

SRSF5
Serine/arginine-rich splicing factor 5

3

20

Small-scale

0.839

High

1360244

LN28A
Protein lin-28 homolog A

3

8

High-throughput

0.839

High

1160017

SRSF7
Serine/arginine-rich splicing factor 7

2

18

Small-scale

0.831

High

1029528

SRSF2
Serine/arginine-rich splicing factor 2

2

11

Small-scale

0.807

High

1061074

SRSF1
Serine/arginine-rich splicing factor 1

2

20

Small-scale

0.789

High

1062061

SRSF4
Serine/arginine-rich splicing factor 4

2

19

Small-scale

0.789

High

1099458

SRSF6
Serine/arginine-rich splicing factor 6

2

20

Small-scale

0.789

High

1016540

SRSF3
Serine/arginine-rich splicing factor 3

2

20

Small-scale

0.768

High

794558

RBMX
RNA-binding motif protein, X chromosome

1

8

Small-scale

0.724

High

994684

YBOX1
Y-box-binding protein 1

1

7

Small-scale

0.724

High

1148449

SAFB1
Scaffold attachment factor B1

1

8

Small-scale

0.724

High

1360219

SREK1
Splicing regulatory glutamine/lysine-rich protein 1

1

7

High-throughput

0.698

High

134813

SAP18
Histone deacetylase complex subunit SAP18

1

1

High-throughput

0.691

High

485697

RU2A
U2 small nuclear ribonucleoprotein A'

1

2

High-throughput

0.691

High

879737

MAPK2
MAP kinase-activated protein kinase 2

1

1

High-throughput

0.691

High

978633

RL23A
Large ribosomal subunit protein uL23

1

2

High-throughput

0.691

High

1360249

PUF60
Poly(U)-binding-splicing factor PUF60

1

16

High-throughput

0.691

High

1360251

ZN346
Zinc finger protein 346

1

1

High-throughput

0.691

High

1360257

YBOX2
Y-box-binding protein 2

1

7

High-throughput

0.691

High

1028307

MDM2
E3 ubiquitin-protein ligase Mdm2

1

0

High-throughput

0.687

High

1360242

PININ
Pinin

4

0

Small-scale

0.673

High

1239636

JMJD6
Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6

3

2

High-throughput

0.667

High

658303

RS3
Small ribosomal subunit protein uS3

1

0

High-throughput

0.656

High

1313104

ZC3H3
Zinc finger CCCH domain-containing protein 3

1

1

High-throughput

0.618

High

256651

HNRC1
Heterogeneous nuclear ribonucleoprotein C-like 1

1

5

Small-scale

0.618

High

462536

HNRPC
Heterogeneous nuclear ribonucleoproteins C1/C2

1

7

Small-scale

0.618

High

472926

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

14

High-throughput

0.618

High

485292

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

12

Small-scale

0.618

High

550379

PABP1
Polyadenylate-binding protein 1

1

8

Small-scale

0.618

High

620492

NUCL
Nucleolin

1

8

Small-scale

0.618

High

650874

ROA2
Heterogeneous nuclear ribonucleoproteins A2/B1

1

13

Small-scale

0.618

High

655282

SFPQ
Splicing factor, proline- and glutamine-rich

1

12

Small-scale

0.618

High

729374

HNRH1
Heterogeneous nuclear ribonucleoprotein H

1

11

Small-scale

0.618

High

909635

ROA3
Heterogeneous nuclear ribonucleoprotein A3

1

16

Small-scale

0.618

High

988167

TRA2B
Transformer-2 protein homolog beta

1

13

Small-scale

0.618

High

997894

CSK21
Casein kinase II subunit alpha

1

1

Small-scale

0.618

High

1023129

RBM10
RNA-binding protein 10

1

6

Small-scale

0.618

High

1099002

SRSF9
Serine/arginine-rich splicing factor 9

1

20

Small-scale

0.618

High

1102034

PABP4
Polyadenylate-binding protein 4

1

8

Small-scale

0.618

High

1120257

HNRPD
Heterogeneous nuclear ribonucleoprotein D0

1

17

Small-scale

0.618

High

1147980

SF3B3
Splicing factor 3B subunit 3

1

2

Small-scale

0.618

High

1152562

ELAV1
ELAV-like protein 1

1

8

Small-scale

0.618

High

1360223

KAT6A
Histone acetyltransferase KAT6A

1

7

High-throughput

0.618

High

1360225

CELF1
CUGBP Elav-like family member 1

1

11

High-throughput

0.618

High

1360245

RC3H2
Roquin-2

1

7

High-throughput

0.618

High

1360248

ZRAN1
Ubiquitin thioesterase ZRANB1

1

8

High-throughput

0.618

High

447259

NPM
Nucleophosmin

2

4

Small-scale

0.611

High

1037294

H11
Histone H1.1

2

4

High-throughput

0.611

High

280749

PR40A
Pre-mRNA-processing factor 40 homolog A

2

9

High-throughput

0.606

High

480243

RU1C
U1 small nuclear ribonucleoprotein C

2

2

High-throughput

0.601

High

1088711

SF3A3
Splicing factor 3A subunit 3

1

0

Small-scale

0.586

High

649380

H1T
Histone H1t

2

4

High-throughput

0.574

High

868372

CDX1
Homeobox protein CDX-1

2

2

High-throughput

0.574

High

396602

ESR1
Estrogen receptor

2

12

High-throughput

0.571

High

1360224

DDX17
Probable ATP-dependent RNA helicase DDX17

1

4

Small-scale

0.561

High

821166

TXLNA
Alpha-taxilin

2

9

High-throughput

0.553

High

157672

CTRO
Citron Rho-interacting kinase

1

7

High-throughput

0.553

High

284758

RMXL2
RNA-binding motif protein, X-linked-like-2

1

6

Small-scale

0.553

High

1360255

SRPK3
SRSF protein kinase 3

1

10

Small-scale

0.553

High

287070

PRKRA
Interferon-inducible double-stranded RNA-dependent protein kinase activator A

1

11

High-throughput

0.536

High

476766

RSSA
Small ribosomal subunit protein uS2

1

3

High-throughput

0.536

High

521836

H14
Histone H1.4

1

4

High-throughput

0.536

High

586804

RS2
Small ribosomal subunit protein uS5

1

1

High-throughput

0.536

High

596266

H12
Histone H1.2

1

4

High-throughput

0.536

High

634554

LMNB1
Lamin-B1

1

6

High-throughput

0.536

High

686309

RL13
Large ribosomal subunit protein eL13

1

2

High-throughput

0.536

High

809753

RS19
Small ribosomal subunit protein eS19

1

2

High-throughput

0.536

High

969336

RS8
Small ribosomal subunit protein eS8

1

2

High-throughput

0.536

High

984875

RL31
Large ribosomal subunit protein eL31

1

1

High-throughput

0.536

High

985260

RL10A
Large ribosomal subunit protein uL1

1

1

High-throughput

0.536

High

1112624

CUL1
Cullin-1

1

10

High-throughput

0.536

High

1360233

CDC5L
Cell division cycle 5-like protein

1

4

High-throughput

0.536

High

1360260

RL36
Large ribosomal subunit protein eL36

1

2

High-throughput

0.536

High

177027

CE290
Centrosomal protein of 290 kDa

2

9

High-throughput

0.521

High

1226198

CP135
Centrosomal protein of 135 kDa

2

1

High-throughput

0.521

High

2868

A0A0C4DG62
ADP-ribosylation factor-like protein 6-interacting protein 4

1

1

High-throughput

0.515

High

824261

RL13A
Large ribosomal subunit protein uL13

1

0

High-throughput

0.513

High

842458

RL35
Large ribosomal subunit protein uL29

1

0

High-throughput

0.513

High

860858

RS10
Small ribosomal subunit protein eS10

1

0

High-throughput

0.513

High

959881

RS3A
Small ribosomal subunit protein eS1

1

0

High-throughput

0.513

High

961787

RL37A
Large ribosomal subunit protein eL43

1

0

High-throughput

0.513

High

979095

RS6
Small ribosomal subunit protein eS6

1

0

High-throughput

0.513

High

1016132

RL19
Large ribosomal subunit protein eL19

1

0

High-throughput

0.513

High

1139976

RRS1
Ribosome biogenesis regulatory protein homolog

1

0

High-throughput

0.513

High

1360222

DGCR8
Microprocessor complex subunit DGCR8

1

0

High-throughput

0.513

High

1360230

NEIL1
Endonuclease 8-like 1

1

0

High-throughput

0.513

High

1360240

PAIP1
Polyadenylate-binding protein-interacting protein 1

1

0

High-throughput

0.513

High

1360250

PURG
Purine-rich element-binding protein gamma

1

0

High-throughput

0.513

High

191728

MAGB2
Melanoma-associated antigen B2

1

1

High-throughput

0.489

High

488070

IFI6
Interferon alpha-inducible protein 6

1

1

High-throughput

0.489

High

502452

H2A1
Histone H2A type 1

1

8

High-throughput

0.489

High

848690

MAGA9
Melanoma-associated antigen 9

1

1

High-throughput

0.489

High

1348927

ZCH10
Zinc finger CCHC domain-containing protein 10

1

1

High-throughput

0.489

High

1360227

I27L1
Interferon alpha-inducible protein 27-like protein 1

1

1

High-throughput

0.489

High

1360231

ZN668
Zinc finger protein 668

1

1

High-throughput

0.489

High

944837

PCBP3
Poly(rC)-binding protein 3

1

7

High-throughput

0.481

High

1226787

AR6P4
ADP-ribosylation factor-like protein 6-interacting protein 4

1

1

High-throughput

0.481

High

1360246

SHLB2
Endophilin-B2

1

3

Small-scale

0.481

High

129287

MEN1
Menin

1

4

High-throughput

0.479

High

141585

DDX3X
ATP-dependent RNA helicase DDX3X

1

5

Small-scale

0.479

High

325953

UBR5
E3 ubiquitin-protein ligase UBR5

1

3

High-throughput

0.479

High

342985

HERC2
E3 ubiquitin-protein ligase HERC2

1

1

High-throughput

0.479

High

346120

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

11

High-throughput

0.479

High

372696

MYC
Myc proto-oncogene protein

1

10

High-throughput

0.479

High

487578

PARP1
Poly [ADP-ribose] polymerase 1

1

7

Small-scale

0.479

High

589270

RFA2
Replication protein A 32 kDa subunit

1

5

High-throughput

0.479

High

679220

DNJB1
DnaJ homolog subfamily B member 1

1

2

High-throughput

0.479

High

696056

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

4

High-throughput

0.479

High

768756

RFA3
Replication protein A 14 kDa subunit

1

4

High-throughput

0.479

High

770240

RL22
Large ribosomal subunit protein eL22

1

1

High-throughput

0.479

High

810249

RL3
Large ribosomal subunit protein uL3

1

2

High-throughput

0.479

High

879307

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

6

High-throughput

0.479

High

904973

MECP2
Methyl-CpG-binding protein 2

1

5

High-throughput

0.479

High

965796

HNRPK
Heterogeneous nuclear ribonucleoprotein K

1

8

Small-scale

0.479

High

974432

SMD1
Small nuclear ribonucleoprotein Sm D1

1

3

Small-scale

0.479

High

974797

SMD3
Small nuclear ribonucleoprotein Sm D3

1

3

Small-scale

0.479

High

992885

RACK1
Small ribosomal subunit protein RACK1

1

7

Small-scale

0.479

High

1027623

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

3

Small-scale

0.479

High

1065324

SSRP1
FACT complex subunit SSRP1

1

11

Small-scale

0.479

High

1089485

ILF2
Interleukin enhancer-binding factor 2

1

2

Small-scale

0.479

High

1115323

CUL4B
Cullin-4B

1

10

High-throughput

0.479

High

1118109

DX39B
Spliceosome RNA helicase DDX39B

1

12

Small-scale

0.479

High

1121832

EIF3A
Eukaryotic translation initiation factor 3 subunit A

1

4

High-throughput

0.479

High

1138439

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

3

Small-scale

0.479

High

1156797

E2F4
Transcription factor E2F4

1

1

High-throughput

0.479

High

1206503

PRC2B
Protein PRRC2B

1

4

High-throughput

0.479

High

1215736

RC3H1
Roquin-1

1

2

High-throughput

0.479

High

1313294

SMC5
Structural maintenance of chromosomes protein 5

1

7

High-throughput

0.479

High

1338867

NUP43
Nucleoporin Nup43

1

7

High-throughput

0.479

High

1360220

DNJC9
DnaJ homolog subfamily C member 9

1

3

High-throughput

0.479

High

1360229

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

8

High-throughput

0.479

High

1360235

DDX23
Probable ATP-dependent RNA helicase DDX23

1

9

High-throughput

0.479

High

1360243

ECT2
Protein ECT2

1

8

High-throughput

0.479

High

1360247

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

4

High-throughput

0.479

High

1360252

MKLN1
Muskelin

1

1

High-throughput

0.479

High

1360258

TR150
Thyroid hormone receptor-associated protein 3

1

7

Small-scale

0.479

High

1360259

LC7L2
Putative RNA-binding protein Luc7-like 2

1

2

High-throughput

0.479

High

1360261

SP16H
FACT complex subunit SPT16

1

3

Small-scale

0.479

High

67841

SRRM4
Serine/arginine repetitive matrix protein 4

1

0

High-throughput

0.460

High

1103836

TARB1
tRNA

1

0

Small-scale

0.460

High

1360237

RM37
Large ribosomal subunit protein mL37

1

0

High-throughput

0.460

High

1360241

NAT10
RNA cytidine acetyltransferase

1

0

High-throughput

0.460

High

298421

DNJC8
DnaJ homolog subfamily C member 8

1

0

High-throughput

0.458

High

1028830

SPTB2
Spectrin beta chain, non-erythrocytic 1

1

0

High-throughput

0.458

High

1058171

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

0

Small-scale

0.458

High

1360238

IN80B
INO80 complex subunit B

1

0

High-throughput

0.458

High

1034600

AK17A
A-kinase anchor protein 17A

1

6

High-throughput

0.445

High

1128070

DHX8
ATP-dependent RNA helicase DHX8

1

9

High-throughput

0.445

High

1136825

MO4L2
Mortality factor 4-like protein 2

1

1

High-throughput

0.445

High

1337405

SRFB1
Serum response factor-binding protein 1

1

1

High-throughput

0.445

High

1360254

ABT1
Activator of basal transcription 1

1

1

High-throughput

0.445

High

412333

NTRK1
High affinity nerve growth factor receptor

1

8

High-throughput

0.437

High

970847

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

3

High-throughput

0.437

High

1141236

BRD3
Bromodomain-containing protein 3

1

12

High-throughput

0.437

High

1254834

TRI67
Tripartite motif-containing protein 67

1

6

High-throughput

0.437

High

1338297

FBX22
F-box only protein 22

1

1

High-throughput

0.437

High

1179336

TSR1
Pre-rRNA-processing protein TSR1 homolog

1

0

High-throughput

0.426

High

1360239

REXO4
RNA exonuclease 4

1

0

High-throughput

0.426

High

47552

RPSA2
Small ribosomal subunit protein uS2B

1

3

High-throughput

0.407

High

1360228

GASP2
G-protein coupled receptor-associated sorting protein 2

2

0

High-throughput

0.316

High

1360256

ADIP
Afadin- and alpha-actinin-binding protein

2

0

High-throughput

0.298

High

1127446

FGFP1
Fibroblast growth factor-binding protein 1

1

0

High-throughput

0.279

Low

1219193

SPAT1
Spermatogenesis-associated protein 1

1

0

High-throughput

0.279

Low

1360221

CHC10
Coiled-coil-helix-coiled-coil-helix domain-containing protein 10, mitochondrial

1

0

High-throughput

0.279

Low

1360226

FGF13
Fibroblast growth factor 13

1

0

High-throughput

0.279

Low

1360253

PAI2B
Polyadenylate-binding protein-interacting protein 2B

1

0

High-throughput

0.279

Low

900954

RAB5C
Ras-related protein Rab-5C

1

0

High-throughput

0.251

Low

1162652

DGKD
Diacylglycerol kinase delta

1

0

Small-scale

0.251

Low

1359525

CKAP2
Cytoskeleton-associated protein 2

1

0

High-throughput

0.251

Low

583329

FOLR1
Folate receptor alpha

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025