Protein: RIPK1
Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Cell death protein RIP) (Receptor-interacting protein 1) (RIP-1)

Gene: RIPK1
Organism: Homo sapiens
Interactions: 199
UniProt ID: Q13546

Gene Ontology (top 5):
GO:0001934 - positive regulation of protein phosphorylation
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity
GO:0004706 - JUN kinase kinase kinase activity
GO:0005123 - death receptor binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

584401

TNR1A
Tumor necrosis factor receptor superfamily member 1A

50

18

Small-scale

0.995

High

1026616

FADD
FAS-associated death domain protein

33

20

Small-scale

0.993

High

1038346

RIPK3
Receptor-interacting serine/threonine-protein kinase 3

25

20

Small-scale

0.992

High

1036265

BIRC2
Baculoviral IAP repeat-containing protein 2

14

20

Small-scale

0.986

High

1035698

BIRC3
Baculoviral IAP repeat-containing protein 3

10

20

Small-scale

0.979

High

1038252

RIPK1
Receptor-interacting serine/threonine-protein kinase 1

9

17

Small-scale

0.975

High

1038257

TRADD
Tumor necrosis factor receptor type 1-associated DEATH domain protein

7

2

Small-scale

0.965

High

201329

M3K7
Mitogen-activated protein kinase kinase kinase 7

4

20

Small-scale

0.881

High

167541

IKKA
Inhibitor of nuclear factor kappa-B kinase subunit alpha

4

19

Small-scale

0.873

High

1038311

M3K3
Mitogen-activated protein kinase kinase kinase 3

4

20

Small-scale

0.873

High

158468

IKKB
Inhibitor of nuclear factor kappa-B kinase subunit beta

3

16

Small-scale

0.834

High

154359

TR10B
Tumor necrosis factor receptor superfamily member 10B

3

18

Small-scale

0.827

High

1038310

M3K14
Mitogen-activated protein kinase kinase kinase 14

3

20

Small-scale

0.827

High

1038324

PIDD1
p53-induced death domain-containing protein 1

3

20

Small-scale

0.827

High

957698

XIAP
E3 ubiquitin-protein ligase XIAP

2

20

Small-scale

0.785

High

944720

CRADD
Death domain-containing protein CRADD

2

1

Small-scale

0.778

High

1038256

CASP8
Caspase-8

48

8

Small-scale

0.771

High

1038348

NEMO
NF-kappa-B essential modulator

28

20

Small-scale

0.769

High

352610

TNFA
Tumor necrosis factor

33

8

Small-scale

0.768

High

1020645

TRAF2
TNF receptor-associated factor 2

25

20

Small-scale

0.768

High

599661

TNAP3
Tumor necrosis factor alpha-induced protein 3

8

4

Small-scale

0.755

High

179938

TLR3
Toll-like receptor 3

2

20

Small-scale

0.754

High

983830

KPCZ
Protein kinase C zeta type

2

20

Small-scale

0.754

High

1038276

TCAM1
TIR domain-containing adapter molecule 1

9

5

Small-scale

0.747

High

822012

KC1A
Casein kinase I isoform alpha

1

11

Small-scale

0.747

High

934150

CSK21
Casein kinase II subunit alpha

2

20

High-throughput

0.737

High

1038285

CSK23
Casein kinase II subunit alpha 3

2

19

High-throughput

0.737

High

1023653

TRAF1
TNF receptor-associated factor 1

5

20

Small-scale

0.722

High

181613

CFLAR
CASP8 and FADD-like apoptosis regulator

5

8

Small-scale

0.714

High

1038326

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

5

5

Small-scale

0.702

High

1036545

SQSTM
Sequestosome-1

4

15

Small-scale

0.702

High

1038347

MRCKB
Serine/threonine-protein kinase MRCK beta

1

18

High-throughput

0.698

High

1038301

OPTN
Optineurin

4

20

Small-scale

0.696

High

1038329

TAB2
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2

4

14

Small-scale

0.687

High

1038275

TAXB1
Tax1-binding protein 1

4

13

Small-scale

0.683

High

1038318

ZBP1
Z-DNA-binding protein 1

4

4

Small-scale

0.674

High

1038264

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

20

Small-scale

0.665

High

1038335

ASC
Apoptosis-associated speck-like protein containing a CARD

1

1

High-throughput

0.665

High

1024671

TRAF3
TNF receptor-associated factor 3

3

20

Small-scale

0.664

High

1038328

RN216
E3 ubiquitin-protein ligase RNF216

3

5

Small-scale

0.661

High

632270

TNR6
Tumor necrosis factor receptor superfamily member 6

1

18

Small-scale

0.656

High

896436

UBE2N
Ubiquitin-conjugating enzyme E2 N

3

7

Small-scale

0.655

High

1038253

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

20

Small-scale

0.647

High

1038331

TBK1
Serine/threonine-protein kinase TBK1

1

20

Small-scale

0.647

High

1038345

TRAF6
TNF receptor-associated factor 6

2

20

Small-scale

0.646

High

431824

HS90A
Heat shock protein HSP 90-alpha

3

20

Small-scale

0.640

High

475721

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

3

11

Small-scale

0.640

High

271088

UBP2
Ubiquitin carboxyl-terminal hydrolase 2

2

10

Small-scale

0.634

High

1038305

PELI1
E3 ubiquitin-protein ligase pellino homolog 1

2

6

Small-scale

0.634

High

311700

ATG7
Ubiquitin-like modifier-activating enzyme ATG7

2

4

High-throughput

0.628

High

227379

PRKN
E3 ubiquitin-protein ligase parkin

2

19

Small-scale

0.624

High

148774

CTRO
Citron Rho-interacting kinase

1

16

High-throughput

0.618

High

201793

RIPK2
Receptor-interacting serine/threonine-protein kinase 2

1

17

Small-scale

0.618

High

265519

ERN1
Serine/threonine-protein kinase/endoribonuclease IRE1

1

4

Small-scale

0.618

High

338389

EGFR
Epidermal growth factor receptor

1

20

Small-scale

0.618

High

783324

M3K8
Mitogen-activated protein kinase kinase kinase 8

1

17

Small-scale

0.618

High

784002

KPCI
Protein kinase C iota type

1

20

Small-scale

0.618

High

1038283

MLKL
Mixed lineage kinase domain-like protein

1

17

Small-scale

0.618

High

1038297

TNR25
Tumor necrosis factor receptor superfamily member 25

1

18

Small-scale

0.618

High

1038314

CARD6
Caspase recruitment domain-containing protein 6

1

12

Small-scale

0.618

High

1038325

NOD2
Nucleotide-binding oligomerization domain-containing protein 2

1

14

Small-scale

0.618

High

376232

ANXA1
Annexin A1

2

3

Small-scale

0.612

High

1024324

UBP4
Ubiquitin carboxyl-terminal hydrolase 4

2

11

Small-scale

0.612

High

1038258

TAB1
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1

2

8

Small-scale

0.611

High

1038299

MIB2
E3 ubiquitin-protein ligase MIB2

2

20

Small-scale

0.611

High

1038349

AP1M2
AP-1 complex subunit mu-2

2

5

High-throughput

0.611

High

885518

MLF1
Myeloid leukemia factor 1

3

3

High-throughput

0.609

High

1038267

DAB2P
Disabled homolog 2-interacting protein

2

18

Small-scale

0.601

High

1038295

CASPA
Caspase-10

2

8

Small-scale

0.601

High

1038316

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

2

13

Small-scale

0.601

High

1038334

UBP21
Ubiquitin carboxyl-terminal hydrolase 21

2

8

Small-scale

0.595

High

129559

TRAF5
TNF receptor-associated factor 5

2

20

Small-scale

0.584

High

438144

HS90B
Heat shock protein HSP 90-beta

2

20

High-throughput

0.584

High

841069

TNF10
Tumor necrosis factor ligand superfamily member 10

2

8

Small-scale

0.584

High

1038274

MAVS
Mitochondrial antiviral-signaling protein

2

16

Small-scale

0.584

High

1038303

RNF31
E3 ubiquitin-protein ligase RNF31

2

5

Small-scale

0.584

High

1038307

ITCH
E3 ubiquitin-protein ligase Itchy homolog

2

13

Small-scale

0.584

High

1038321

EGLN3
Prolyl hydroxylase EGLN3

2

3

Small-scale

0.584

High

217879

PRKY
Putative serine/threonine-protein kinase PRKY

1

13

High-throughput

0.575

High

1038265

OTUD1
OTU domain-containing protein 1

2

5

Small-scale

0.575

High

1038270

THSD4
Thrombospondin type-1 domain-containing protein 4

2

2

High-throughput

0.574

High

1038309

GPX7
Glutathione peroxidase 7

2

2

High-throughput

0.574

High

124206

TAF4
Transcription initiation factor TFIID subunit 4

2

8

High-throughput

0.571

High

323737

BAG2
BAG family molecular chaperone regulator 2

2

5

High-throughput

0.571

High

388420

HSPB1
Heat shock protein beta-1

2

5

High-throughput

0.571

High

423222

PDIA1
Protein disulfide-isomerase

2

12

High-throughput

0.571

High

642942

S10A4
Protein S100-A4

2

1

High-throughput

0.571

High

664230

TPP2
Tripeptidyl-peptidase 2

2

1

High-throughput

0.571

High

897720

ABCE1
ATP-binding cassette sub-family E member 1

2

5

High-throughput

0.571

High

923980

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein

2

6

High-throughput

0.571

High

929197

RS21
Small ribosomal subunit protein eS21

2

1

High-throughput

0.571

High

1038280

CCAR2
Cell cycle and apoptosis regulator protein 2

2

1

High-throughput

0.571

High

1038291

PHLA1
Pleckstrin homology-like domain family A member 1

2

4

High-throughput

0.571

High

1038312

ANM1
Protein arginine N-methyltransferase 1

2

4

High-throughput

0.571

High

1038313

NADAP
Kanadaptin

2

2

High-throughput

0.571

High

1038327

ARGL1
Arginine and glutamate-rich protein 1

2

1

High-throughput

0.571

High

1038341

TR150
Thyroid hormone receptor-associated protein 3

2

12

High-throughput

0.571

High

991751

KHDR1
KH domain-containing, RNA-binding, signal transduction-associated protein 1

1

8

Small-scale

0.561

High

1038279

AN13A
Ankyrin repeat domain-containing protein 13A

1

3

Small-scale

0.561

High

1038292

RFFL
E3 ubiquitin-protein ligase rififylin

1

20

Small-scale

0.561

High

1038339

UBP20
Ubiquitin carboxyl-terminal hydrolase 20

1

13

Small-scale

0.561

High

996478

FGL1
Fibrinogen-like protein 1

2

1

High-throughput

0.558

High

1038272

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.553

High

445392

RSSA
Small ribosomal subunit protein uS2

2

0

High-throughput

0.547

High

912287

SMD1
Small nuclear ribonucleoprotein Sm D1

2

0

High-throughput

0.547

High

912446

SMD2
Small nuclear ribonucleoprotein Sm D2

2

0

High-throughput

0.547

High

948430

RT06
Small ribosomal subunit protein bS6m

2

0

High-throughput

0.547

High

62140

RCCD1
RCC1 domain-containing protein 1

1

7

High-throughput

0.536

High

207167

TGM5
Protein-glutamine gamma-glutamyltransferase 5

1

1

High-throughput

0.536

High

335258

DYR
Dihydrofolate reductase

1

1

High-throughput

0.536

High

416619

S10A6
Protein S100-A6

1

1

High-throughput

0.536

High

508984

TOP2A
DNA topoisomerase 2-alpha

1

1

High-throughput

0.536

High

656216

PSA5
Proteasome subunit alpha type-5

1

4

High-throughput

0.536

High

656457

PSB4
Proteasome subunit beta type-4

1

8

High-throughput

0.536

High

719374

SPB6
Serpin B6

1

7

High-throughput

0.536

High

729077

K22E
Keratin, type II cytoskeletal 2 epidermal

1

1

High-throughput

0.536

High

800370

CBX5
Chromobox protein homolog 5

1

2

High-throughput

0.536

High

1038255

NBR1
Next to BRCA1 gene 1 protein

1

2

High-throughput

0.536

High

1038278

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

1

High-throughput

0.536

High

1038281

D2HDH
D-2-hydroxyglutarate dehydrogenase, mitochondrial

1

2

High-throughput

0.536

High

1038293

RPGF5
Rap guanine nucleotide exchange factor 5

1

5

High-throughput

0.536

High

1038300

EFMT3
EEF1A lysine methyltransferase 3

1

4

High-throughput

0.536

High

1038315

DUS16
Dual specificity protein phosphatase 16

1

11

High-throughput

0.536

High

1038317

UBXN6
UBX domain-containing protein 6

1

1

High-throughput

0.536

High

1038322

CNO10
CCR4-NOT transcription complex subunit 10

1

2

High-throughput

0.536

High

1038323

CYBP
Calcyclin-binding protein

1

1

High-throughput

0.536

High

1038333

HSPB8
Heat shock protein beta-8

1

5

High-throughput

0.536

High

1038337

PSG11
Pregnancy-specific beta-1-glycoprotein 11

1

3

High-throughput

0.536

High

1038342

SGT1
Protein SGT1 homolog

1

11

High-throughput

0.536

High

1038277

CCD50
Coiled-coil domain-containing protein 50

1

1

Small-scale

0.534

High

202151

HNRPR
Heterogeneous nuclear ribonucleoprotein R

2

1

High-throughput

0.521

High

1038287

RP9
Retinitis pigmentosa 9 protein

2

1

High-throughput

0.521

High

1038336

SRRM2
Serine/arginine repetitive matrix protein 2

2

9

High-throughput

0.521

High

278608

DCTN3
Dynactin subunit 3

1

0

High-throughput

0.513

High

470015

H2AZ
Histone H2A.Z

1

0

High-throughput

0.513

High

1038273

BOP
Protein Bop

1

0

High-throughput

0.513

High

1038286

TNIP2
TNFAIP3-interacting protein 2

1

0

High-throughput

0.513

High

1038271

TRI72
Tripartite motif-containing protein 72

1

13

Small-scale

0.512

High

135023

TRI38
E3 ubiquitin-protein ligase TRIM38

1

13

Small-scale

0.506

High

849323

UB2D1
Ubiquitin-conjugating enzyme E2 D1

1

7

Small-scale

0.501

High

1038330

DAXX
Death domain-associated protein 6

1

2

Small-scale

0.501

High

1038289

TP4AP
Short transient receptor potential channel 4-associated protein

1

0

Small-scale

0.493

High

608548

H1T
Histone H1t

1

4

High-throughput

0.489

High

1038260

INF2
Inverted formin-2

1

5

High-throughput

0.489

High

1038282

ABTB2
Ankyrin repeat and BTB/POZ domain-containing protein 2

1

9

High-throughput

0.489

High

1038266

OTU1
Ubiquitin thioesterase OTU1

1

0

Small-scale

0.480

High

64205

UBP27
Ubiquitin carboxyl-terminal hydrolase 27

1

4

Small-scale

0.479

High

162716

XPO1
Exportin-1

1

10

High-throughput

0.479

High

296300

UBP1
Ubiquitin carboxyl-terminal hydrolase 1

1

7

Small-scale

0.479

High

319826

HERC2
E3 ubiquitin-protein ligase HERC2

1

16

High-throughput

0.479

High

381193

TBB4A
Tubulin beta-4A chain

1

20

High-throughput

0.479

High

397376

ADT2
ADP/ATP translocase 2

1

12

High-throughput

0.479

High

428187

TBB5
Tubulin beta chain

1

20

High-throughput

0.479

High

455408

PARP1
Poly [ADP-ribose] polymerase 1

1

5

High-throughput

0.479

High

487963

RARA
Retinoic acid receptor alpha

1

3

Small-scale

0.479

High

502070

BIP
Endoplasmic reticulum chaperone BiP

1

20

High-throughput

0.479

High

504035

HSP7C
Heat shock cognate 71 kDa protein

1

20

High-throughput

0.479

High

536815

TRI27
Zinc finger protein RFP

1

13

Small-scale

0.479

High

584951

RO52
E3 ubiquitin-protein ligase TRIM21

1

13

Small-scale

0.479

High

591326

TNR1B
Tumor necrosis factor receptor superfamily member 1B

1

18

Small-scale

0.479

High

610391

CBL
E3 ubiquitin-protein ligase CBL

1

20

Small-scale

0.479

High

653254

PYR1
Multifunctional protein CAD

1

6

High-throughput

0.479

High

681435

DNJA1
DnaJ homolog subfamily A member 1

1

20

High-throughput

0.479

High

713961

HS71L
Heat shock 70 kDa protein 1-like

1

20

High-throughput

0.479

High

751616

GRP75
Stress-70 protein, mitochondrial

1

20

High-throughput

0.479

High

779368

CCNF
Cyclin-F

1

3

High-throughput

0.479

High

919384

RL23
Large ribosomal subunit protein uL14

1

1

High-throughput

0.479

High

929853

ACTG
Actin, cytoplasmic 2

1

4

High-throughput

0.479

High

1029389

TIF1B
Transcription intermediary factor 1-beta

1

10

Small-scale

0.479

High

1038259

CDC37
Hsp90 co-chaperone Cdc37

1

13

High-throughput

0.479

High

1038262

TIM50
Mitochondrial import inner membrane translocase subunit TIM50

1

6

High-throughput

0.479

High

1038263

BRDT
Bromodomain testis-specific protein

1

9

High-throughput

0.479

High

1038268

XAF1
XIAP-associated factor 1

1

4

Small-scale

0.479

High

1038288

WDR48
WD repeat-containing protein 48

1

10

Small-scale

0.479

High

1038294

TANK
TRAF family member-associated NF-kappa-B activator

1

1

Small-scale

0.479

High

1038296

IRF7
Interferon regulatory factor 7

1

1

Small-scale

0.479

High

1038302

CLIP3
CAP-Gly domain-containing linker protein 3

1

10

Small-scale

0.479

High

1038304

DNJA3
DnaJ homolog subfamily A member 3, mitochondrial

1

17

High-throughput

0.479

High

1038306

PGAM5
Serine/threonine-protein phosphatase PGAM5, mitochondrial

1

1

Small-scale

0.479

High

1038319

ATG5
Autophagy protein 5

1

1

Small-scale

0.479

High

1038332

UBQL2
Ubiquilin-2

1

7

High-throughput

0.479

High

1038338

Q9UQC1
Heat shock protein 72

1

20

High-throughput

0.479

High

1038344

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

1

10

Small-scale

0.479

High

1038284

NHLC2
NHL repeat-containing protein 2

1

0

High-throughput

0.458

High

651137

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

4

Small-scale

0.457

High

352416

TNFB
Lymphotoxin-alpha

1

8

Small-scale

0.445

High

1038350

NUMBL
Numb-like protein

1

11

High-throughput

0.439

High

1038254

RCN2
Reticulocalbin-2

1

10

High-throughput

0.437

High

1038308

ZFP91
E3 ubiquitin-protein ligase ZFP91

1

1

Small-scale

0.437

High

1038343

RNF11
RING finger protein 11

1

7

Small-scale

0.437

High

1038298

NTAN1
Protein N-terminal asparagine amidohydrolase

3

0

High-throughput

0.345

High

1038340

RT17
Small ribosomal subunit protein uS17m

2

0

High-throughput

0.298

High

1038320

PPDPF
Pancreatic progenitor cell differentiation and proliferation factor

1

0

Small-scale

0.292

High

245685

B4GT2
Beta-1,4-galactosyltransferase 2

1

0

High-throughput

0.279

Low

1038261

CF184
Cilia- and flagella-associated protein 184

1

0

High-throughput

0.279

Low

1038290

NPRL2
GATOR1 complex protein NPRL2

1

0

High-throughput

0.279

Low

594902

COX5A
Cytochrome c oxidase subunit 5A, mitochondrial

1

0

Small-scale

0.249

Low

1038269

ANGL8
Angiopoietin-like protein 8

1

0

Small-scale

0.249

Low


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Last updated: 15 Jul 2024