Protein: PDCD6
Programmed cell death protein 6 (Apoptosis-linked gene 2 protein homolog) (ALG-2)

Gene: PDCD6
Organism: Homo sapiens
Interactions: 162
UniProt ID: O75340

Gene Ontology (top 5):
GO:0000287 - magnesium ion binding
GO:0001525 - angiogenesis
GO:0001938 - positive regulation of endothelial cell proliferation
GO:0005509 - calcium ion binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

276536

PEF1
Peflin

11

16

Small-scale

0.982

High

276543

HEBP2
Heme-binding protein 2

6

1

Small-scale

0.956

High

276397

PDCD6
Programmed cell death protein 6

4

15

Small-scale

0.899

High

276494

PDC6I
Programmed cell death 6-interacting protein

8

13

Small-scale

0.757

High

276447

DAPK1
Death-associated protein kinase 1

1

16

Small-scale

0.740

High

276400

SC31A
Protein transport protein Sec31A

6

4

Small-scale

0.740

High

276410

RAF1
RAF proto-oncogene serine/threonine-protein kinase

2

5

High-throughput

0.737

High

276512

M3K5
Mitogen-activated protein kinase kinase kinase 5

1

9

Small-scale

0.724

High

276445

ANX11
Annexin A11

5

5

Small-scale

0.721

High

67522

MYH7B
Myosin-7B

1

4

High-throughput

0.691

High

276418

MYH7
Myosin-7

1

4

High-throughput

0.691

High

276475

KLH12
Kelch-like protein 12

3

3

Small-scale

0.678

High

63159

VP37C
Vacuolar protein sorting-associated protein 37C

3

6

High-throughput

0.675

High

276464

CUL3
Cullin-3

3

7

Small-scale

0.664

High

276419

CFTR
Cystic fibrosis transmembrane conductance regulator

3

5

High-throughput

0.643

High

276450

SEC13
Protein SEC13 homolog

2

1

Small-scale

0.639

High

156760

CTRO
Citron Rho-interacting kinase

1

7

High-throughput

0.618

High

169850

AURKA
Aurora kinase A

1

7

High-throughput

0.618

High

276421

P4HA1
Prolyl 4-hydroxylase subunit alpha-1

1

1

Small-scale

0.618

High

276427

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

5

Small-scale

0.618

High

276453

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

3

High-throughput

0.618

High

276406

MYC
Myc proto-oncogene protein

2

9

High-throughput

0.611

High

276544

S23IP
SEC23-interacting protein

2

4

Small-scale

0.611

High

276402

BAG4
BAG family molecular chaperone regulator 4

2

4

High-throughput

0.606

High

276531

PLS3
Phospholipid scramblase 3

1

1

Small-scale

0.601

High

276426

VCAM1
Vascular cell adhesion protein 1

2

4

High-throughput

0.601

High

276416

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

2

4

Small-scale

0.595

High

276430

TNR6
Tumor necrosis factor receptor superfamily member 6

1

2

Small-scale

0.586

High

276413

P53
Cellular tumor antigen p53

2

4

Small-scale

0.584

High

276513

TS101
Tumor susceptibility gene 101 protein

2

2

Small-scale

0.584

High

66355

PRR19
Proline-rich protein 19

2

0

High-throughput

0.580

High

276504

SARAF
Store-operated calcium entry-associated regulatory factor

1

3

Small-scale

0.578

High

276409

ESR1
Estrogen receptor

2

5

High-throughput

0.571

High

188129

HDAC3
Histone deacetylase 3

1

1

High-throughput

0.536

High

276423

CCNB1
G2/mitotic-specific cyclin-B1

1

1

High-throughput

0.536

High

276425

H2AX
Histone H2AX

1

2

High-throughput

0.536

High

276429

CCNA2
Cyclin-A2

1

1

High-throughput

0.536

High

276433

GRN
Progranulin

1

1

High-throughput

0.536

High

276440

MAGA1
Melanoma-associated antigen 1

1

4

High-throughput

0.536

High

276441

MAP1B
Microtubule-associated protein 1B

1

3

High-throughput

0.536

High

276448

IST1
IST1 homolog

1

3

High-throughput

0.536

High

276457

HTRA4
Serine protease HTRA4

1

2

High-throughput

0.536

High

276462

CUL1
Cullin-1

1

7

High-throughput

0.536

High

276463

CUL2
Cullin-2

1

7

High-throughput

0.536

High

276465

SCRB2
Lysosome membrane protein 2

1

1

High-throughput

0.536

High

276479

SAMD1
Sterile alpha motif domain-containing protein 1

1

4

High-throughput

0.536

High

276483

URP2
Fermitin family homolog 3

1

2

High-throughput

0.536

High

276501

CUL5
Cullin-5

1

7

High-throughput

0.536

High

276527

TF7L2
Transcription factor 7-like 2

1

4

High-throughput

0.536

High

276437

VGFR2
Vascular endothelial growth factor receptor 2

1

2

Small-scale

0.529

High

276480

RHG36
Rho GTPase-activating protein 36

2

8

High-throughput

0.521

High

276439

CDN2A
Cyclin-dependent kinase inhibitor 2A

1

4

Small-scale

0.516

High

276438

CCNF
Cyclin-F

1

6

High-throughput

0.515

High

276476

Q5T0G8
Annexin

1

5

High-throughput

0.515

High

276484

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

0

High-throughput

0.513

High

276496

RTF1
RNA polymerase-associated protein RTF1 homolog

1

0

High-throughput

0.513

High

276511

TSNAX
Translin-associated protein X

1

0

High-throughput

0.513

High

276525

MED20
Mediator of RNA polymerase II transcription subunit 20

1

0

High-throughput

0.513

High

276526

MED4
Mediator of RNA polymerase II transcription subunit 4

1

0

High-throughput

0.513

High

276541

GOT1B
Vesicle transport protein GOT1B

1

0

High-throughput

0.513

High

276520

PTN23
Tyrosine-protein phosphatase non-receptor type 23

1

6

Small-scale

0.506

High

276431

1433T
14-3-3 protein theta

1

6

High-throughput

0.501

High

276503

SH3K1
SH3 domain-containing kinase-binding protein 1

1

3

Small-scale

0.501

High

276532

DIAP3
Protein diaphanous homolog 3

1

6

Small-scale

0.501

High

276539

FND3A
Fibronectin type-III domain-containing protein 3A

1

7

Small-scale

0.501

High

276489

MISSL
MAPK-interacting and spindle-stabilizing protein-like

1

3

High-throughput

0.494

High

276461

DCTN2
Dynactin subunit 2

1

0

Small-scale

0.493

High

131618

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

7

High-throughput

0.479

High

154591

ARI1A
AT-rich interactive domain-containing protein 1A

1

4

Small-scale

0.479

High

172328

XPO1
Exportin-1

1

3

High-throughput

0.479

High

174865

SC16A
Protein transport protein Sec16A

1

3

Small-scale

0.479

High

188743

TMPS2
Transmembrane protease serine 2

1

1

High-throughput

0.479

High

276398

UBXN7
UBX domain-containing protein 7

1

1

High-throughput

0.479

High

276399

TRI37
E3 ubiquitin-protein ligase TRIM37

1

6

High-throughput

0.479

High

276401

KI20A
Kinesin-like protein KIF20A

1

11

High-throughput

0.479

High

276403

SC24B
Protein transport protein Sec24B

1

3

Small-scale

0.479

High

276405

BAG3
BAG family molecular chaperone regulator 3

1

4

High-throughput

0.479

High

276407

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

3

High-throughput

0.479

High

276408

FINC
Fibronectin

1

5

High-throughput

0.479

High

276411

GCR
Glucocorticoid receptor

1

5

High-throughput

0.479

High

276412

MYCN
N-myc proto-oncogene protein

1

9

High-throughput

0.479

High

276414

NFIC
Nuclear factor 1 C-type

1

1

High-throughput

0.479

High

276415

PARP1
Poly [ADP-ribose] polymerase 1

1

2

High-throughput

0.479

High

276420

ITA4
Integrin alpha-4

1

5

High-throughput

0.479

High

276424

RFA2
Replication protein A 32 kDa subunit

1

3

High-throughput

0.479

High

276428

ANXA7
Annexin A7

1

6

Small-scale

0.479

High

276432

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

5

High-throughput

0.479

High

276434

MERL
Merlin

1

5

High-throughput

0.479

High

276435

RFA3
Replication protein A 14 kDa subunit

1

4

High-throughput

0.479

High

276436

VGFR3
Vascular endothelial growth factor receptor 3

1

2

High-throughput

0.479

High

276444

MCM2
DNA replication licensing factor MCM2

1

4

High-throughput

0.479

High

276449

TERA
Transitional endoplasmic reticulum ATPase

1

5

High-throughput

0.479

High

276451

NLRP6
NACHT, LRR and PYD domains-containing protein 6

1

2

High-throughput

0.479

High

276454

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

4

High-throughput

0.479

High

276456

1433Z
14-3-3 protein zeta/delta

1

6

High-throughput

0.479

High

276458

KIF23
Kinesin-like protein KIF23

1

8

High-throughput

0.479

High

276460

SQSTM
Sequestosome-1

1

1

High-throughput

0.479

High

276467

CUL7
Cullin-7

1

4

High-throughput

0.479

High

276469

TNIP1
TNFAIP3-interacting protein 1

1

8

Small-scale

0.479

High

276470

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

3

High-throughput

0.479

High

276471

KIF14
Kinesin-like protein KIF14

1

7

High-throughput

0.479

High

276472

SC23A
Protein transport protein Sec23A

1

3

Small-scale

0.479

High

276474

CL16A
Protein CLEC16A

1

1

High-throughput

0.479

High

276481

TRI67
Tripartite motif-containing protein 67

1

12

High-throughput

0.479

High

276482

KI21A
Kinesin-like protein KIF21A

1

4

High-throughput

0.479

High

276486

CHERP
Calcium homeostasis endoplasmic reticulum protein

1

2

Small-scale

0.479

High

276488

SERB1
SERPINE1 mRNA-binding protein 1

1

1

High-throughput

0.479

High

276490

ARI1B
AT-rich interactive domain-containing protein 1B

1

3

Small-scale

0.479

High

276491

TNIP2
TNFAIP3-interacting protein 2

1

3

High-throughput

0.479

High

276492

SMRC2
SWI/SNF complex subunit SMARCC2

1

5

Small-scale

0.479

High

276493

RHBL4
Rhomboid-related protein 4

1

5

Small-scale

0.479

High

276497

ESR2
Estrogen receptor beta

1

5

High-throughput

0.479

High

276498

TFG
Protein TFG

1

4

Small-scale

0.479

High

276499

REQU
Zinc finger protein ubi-d4

1

5

Small-scale

0.479

High

276500

SMRC1
SWI/SNF complex subunit SMARCC1

1

2

Small-scale

0.479

High

276502

SMCE1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1

1

4

Small-scale

0.479

High

276505

CHM4C
Charged multivesicular body protein 4c

1

3

High-throughput

0.479

High

276509

CI072
Guanine nucleotide exchange factor C9orf72

1

1

High-throughput

0.479

High

276510

KCD15
BTB/POZ domain-containing protein KCTD15

1

6

Small-scale

0.479

High

276514

OVOL2
Transcription factor Ovo-like 2

1

1

Small-scale

0.479

High

276516

ACE2
Angiotensin-converting enzyme 2

1

2

High-throughput

0.479

High

276518

TOLIP
Toll-interacting protein

1

1

High-throughput

0.479

High

276521

CHM4B
Charged multivesicular body protein 4b

1

3

High-throughput

0.479

High

276523

DUS21
Dual specificity protein phosphatase 21

1

5

High-throughput

0.479

High

276524

ECT2
Protein ECT2

1

8

High-throughput

0.479

High

276528

ANLN
Anillin

1

4

High-throughput

0.479

High

276529

PLS4
Phospholipid scramblase 4

1

1

Small-scale

0.479

High

276530

RNC
Ribonuclease 3

1

2

High-throughput

0.479

High

276533

HAUS2
HAUS augmin-like complex subunit 2

1

1

High-throughput

0.479

High

276534

PIHD1
PIH1 domain-containing protein 1

1

3

High-throughput

0.479

High

276535

HDAC6
Protein deacetylase HDAC6

1

1

High-throughput

0.479

High

276537

ZRAN1
Ubiquitin thioesterase ZRANB1

1

6

High-throughput

0.479

High

276538

UBQL2
Ubiquilin-2

1

5

High-throughput

0.479

High

276542

ARI1
E3 ubiquitin-protein ligase ARIH1

1

10

High-throughput

0.479

High

128666

MEN1
Menin

1

0

High-throughput

0.458

High

276422

TCTP
Translationally-controlled tumor protein

1

0

High-throughput

0.458

High

276442

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.458

High

276446

SMCA2
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2

1

0

Small-scale

0.458

High

276459

SNF5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

1

0

Small-scale

0.458

High

276466

NBR1
Next to BRCA1 gene 1 protein

1

0

High-throughput

0.458

High

276468

SUZ12
Polycomb protein SUZ12

1

0

High-throughput

0.458

High

276478

VIR
Protein virilizer homolog

1

0

High-throughput

0.458

High

276487

TM192
Transmembrane protein 192

1

0

High-throughput

0.458

High

276495

P66B
Transcriptional repressor p66-beta

1

0

High-throughput

0.458

High

276507

MB12A
Multivesicular body subunit 12A

1

0

Small-scale

0.458

High

276508

SMRD1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1

1

0

Small-scale

0.458

High

276404

PTBP3
Polypyrimidine tract-binding protein 3

1

1

High-throughput

0.445

High

276417

TAU
Microtubule-associated protein tau

1

15

High-throughput

0.445

High

276452

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

7

High-throughput

0.445

High

276455

GRB2
Growth factor receptor-bound protein 2

1

1

High-throughput

0.445

High

276517

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

7

High-throughput

0.445

High

276522

MLP3A
Microtubule-associated protein 1 light chain 3 alpha

1

7

High-throughput

0.445

High

104947

APRIO
Alternative prion protein

1

4

High-throughput

0.437

High

276477

RC3H1
Roquin-1

1

1

High-throughput

0.437

High

276540

AAR2
Protein AAR2 homolog

1

2

High-throughput

0.437

High

276473

NEDD8
Ubiquitin-like protein NEDD8

1

0

High-throughput

0.426

High

276443

CEBPA
CCAAT/enhancer-binding protein alpha

1

2

High-throughput

0.408

High

276519

GCP60
Golgi resident protein GCP60

1

2

Small-scale

0.407

High

276506

SHSA4
Protein shisa-4

1

0

Small-scale

0.279

Low

276485

SL9A9
Sodium/hydrogen exchanger 9

1

0

Small-scale

0.249

Low

276515

CNPY3
Protein canopy homolog 3

1

0

Small-scale

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025