Protein: GPTC1
G patch domain-containing protein 1 (Evolutionarily conserved G-patch domain-containing protein)

Gene: GPTC1, GPATCH1
Organism: Homo sapiens
Interactions: 104
UniProt ID: Q9BRR8

Gene Ontology (top 5):
GO:0000398 - mRNA splicing, via spliceosome
GO:0003723 - RNA binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0071013 - catalytic step 2 spliceosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1128098

DHX8
ATP-dependent RNA helicase DHX8

2

4

High-throughput

0.737

High

1411660

WDR83
WD repeat domain-containing protein 83

4

12

High-throughput

0.691

High

1411674

PPIE
Peptidyl-prolyl cis-trans isomerase E

3

2

High-throughput

0.667

High

1411678

TSSC4
U5 small nuclear ribonucleoprotein TSSC4

4

0

High-throughput

0.664

High

1201278

EAPP
E2F-associated phosphoprotein

3

0

High-throughput

0.638

High

1410070

USB1
U6 snRNA phosphodiesterase 1

3

0

High-throughput

0.638

High

1411661

YJU2
Splicing factor YJU2

3

0

High-throughput

0.638

High

222522

PLRG1
Pleiotropic regulator 1

2

7

High-throughput

0.628

High

351349

SYF2
Pre-mRNA-splicing factor SYF2

2

1

High-throughput

0.628

High

974028

RUXF
Small nuclear ribonucleoprotein F

2

2

High-throughput

0.628

High

991235

RSMN
Small nuclear ribonucleoprotein-associated protein N

2

4

High-throughput

0.628

High

1411673

PRP19
Pre-mRNA-processing factor 19

2

6

High-throughput

0.628

High

974188

RUXG
Small nuclear ribonucleoprotein G

2

6

High-throughput

0.611

High

1387526

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

2

6

High-throughput

0.611

High

973806

RUXE
Small nuclear ribonucleoprotein E

2

0

High-throughput

0.602

High

1138568

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

2

4

High-throughput

0.601

High

1364981

TSC1
Hamartin

1

12

High-throughput

0.541

High

298066

SPF27
Pre-mRNA-splicing factor SPF27

1

1

High-throughput

0.536

High

574448

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

1

3

High-throughput

0.536

High

974828

SMD3
Small nuclear ribonucleoprotein Sm D3

1

3

High-throughput

0.536

High

1111230

SNW1
SNW domain-containing protein 1

1

3

High-throughput

0.536

High

1411666

DJC17
DnaJ homolog subfamily C member 17

1

5

High-throughput

0.536

High

1411671

ISY1
Pre-mRNA-splicing factor ISY1 homolog

1

1

High-throughput

0.536

High

1411677

PPIL1
Peptidyl-prolyl cis-trans isomerase-like 1

1

1

High-throughput

0.536

High

1226248

CP135
Centrosomal protein of 135 kDa

2

4

High-throughput

0.533

High

1356565

CCD12
Coiled-coil domain-containing protein 12

1

0

High-throughput

0.513

High

1384116

ARRD3
Arrestin domain-containing protein 3

1

6

High-throughput

0.489

High

129376

MEN1
Menin

1

1

High-throughput

0.479

High

177051

CE290
Centrosomal protein of 290 kDa

1

6

High-throughput

0.479

High

324203

CE152
Centrosomal protein of 152 kDa

1

2

High-throughput

0.479

High

386164

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

8

High-throughput

0.479

High

406572

MYCN
N-myc proto-oncogene protein

1

6

High-throughput

0.479

High

558370

XRCC6
X-ray repair cross-complementing protein 6

1

1

High-throughput

0.479

High

564293

CFTR
Cystic fibrosis transmembrane conductance regulator

1

1

High-throughput

0.479

High

589545

RFA2
Replication protein A 32 kDa subunit

1

4

High-throughput

0.479

High

696351

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

2

High-throughput

0.479

High

769025

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.479

High

831326

CCNF
Cyclin-F

1

1

High-throughput

0.479

High

970992

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

3

High-throughput

0.479

High

980230

H4
Histone H4

1

3

High-throughput

0.479

High

1045708

TF65
Transcription factor p65

1

1

High-throughput

0.479

High

1048080

TLE3
Transducin-like enhancer protein 3

1

6

High-throughput

0.479

High

1096802

RFA4
Replication protein A 30 kDa subunit

1

4

High-throughput

0.479

High

1134699

NUMA1
Nuclear mitotic apparatus protein 1

1

9

High-throughput

0.479

High

1145517

RBBP5
Retinoblastoma-binding protein 5

1

7

High-throughput

0.479

High

1203242

ODFP2
Outer dense fiber protein 2

1

3

High-throughput

0.479

High

1215501

CE162
Centrosomal protein of 162 kDa

1

8

High-throughput

0.479

High

1276714

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

3

High-throughput

0.479

High

1289585

NAA40
N-alpha-acetyltransferase 40

1

1

High-throughput

0.479

High

1291350

LCA5
Lebercilin

1

4

High-throughput

0.479

High

1313383

SMC5
Structural maintenance of chromosomes protein 5

1

6

High-throughput

0.479

High

1314387

SLX4
Structure-specific endonuclease subunit SLX4

1

5

High-throughput

0.479

High

1326324

NIN
Ninein

1

8

High-throughput

0.479

High

1329838

SIR6
NAD-dependent protein deacylase sirtuin-6

1

3

High-throughput

0.479

High

1338931

NUP43
Nucleoporin Nup43

1

5

High-throughput

0.479

High

1346905

SNIP1
Smad nuclear-interacting protein 1

1

1

High-throughput

0.479

High

1367140

ESR2
Estrogen receptor beta

1

13

High-throughput

0.479

High

1411667

NLE1
Notchless protein homolog 1

1

1

High-throughput

0.479

High

1411669

ZRAN1
Ubiquitin thioesterase ZRANB1

1

3

High-throughput

0.479

High

134846

SAP18
Histone deacetylase complex subunit SAP18

1

0

High-throughput

0.458

High

290129

OFD1
Centriole and centriolar satellite protein OFD1

1

0

High-throughput

0.458

High

342024

CEP43
Centrosomal protein 43

1

0

High-throughput

0.458

High

1143499

PCM1
Pericentriolar material 1 protein

1

0

High-throughput

0.458

High

1149361

STIL
SCL-interrupting locus protein

1

0

High-throughput

0.458

High

1213467

DCA12
DDB1- and CUL4-associated factor 12

1

0

High-throughput

0.458

High

1357539

DCAF4
DDB1- and CUL4-associated factor 4

1

0

High-throughput

0.458

High

1397099

CEP19
Centrosomal protein of 19 kDa

1

0

High-throughput

0.458

High

1405668

NECD
Necdin

1

0

High-throughput

0.458

High

1411675

ADIP
Afadin- and alpha-actinin-binding protein

1

0

High-throughput

0.458

High

423002

A4
Amyloid-beta precursor protein

1

1

High-throughput

0.457

High

71609

RUXGL
Putative small nuclear ribonucleoprotein G-like protein 15

1

6

High-throughput

0.445

High

1145343

RNPS1
RNA-binding protein with serine-rich domain 1

1

4

High-throughput

0.445

High

302938

CIAO1
Probable cytosolic iron-sulfur protein assembly protein CIAO1

1

5

High-throughput

0.437

High

886314

ARL4D
ADP-ribosylation factor-like protein 4D

1

4

High-throughput

0.437

High

1123793

DCTN1
Dynactin subunit 1

1

5

High-throughput

0.437

High

1141896

EEA1
Early endosome antigen 1

1

7

High-throughput

0.437

High

1228466

FTM
Protein fantom

1

6

High-throughput

0.437

High

1246957

RICTR
Rapamycin-insensitive companion of mTOR

1

2

High-throughput

0.437

High

1248186

SAS6
Spindle assembly abnormal protein 6 homolog

1

2

High-throughput

0.437

High

1252203

SYNE3
Nesprin-3

1

2

High-throughput

0.437

High

1256574

CE128
Centrosomal protein of 128 kDa

1

8

High-throughput

0.437

High

1280909

CNTRL
Centriolin

1

4

High-throughput

0.437

High

1291570

HOOK3
Protein Hook homolog 3

1

8

High-throughput

0.437

High

1331553

CE120
Centrosomal protein of 120 kDa

1

7

High-throughput

0.437

High

1350432

BICD2
Protein bicaudal D homolog 2

1

4

High-throughput

0.437

High

1353132

FBF1
Fas-binding factor 1

1

8

High-throughput

0.437

High

1391166

BICD1
Protein bicaudal D homolog 1

1

4

High-throughput

0.437

High

1396183

RPGR1
X-linked retinitis pigmentosa GTPase regulator-interacting protein 1

1

9

High-throughput

0.437

High

1403066

CEP89
Centrosomal protein of 89 kDa

1

9

High-throughput

0.437

High

1411664

PKHA4
Pleckstrin homology domain-containing family A member 4

1

4

High-throughput

0.437

High

1411665

CPAP
Centrosomal P4.1-associated protein

1

3

High-throughput

0.437

High

1411670

HOOK1
Protein Hook homolog 1

1

3

High-throughput

0.437

High

1411672

HECD1
E3 ubiquitin-protein ligase HECTD1

1

4

High-throughput

0.437

High

1411676

NINL
Ninein-like protein

1

10

High-throughput

0.437

High

1256724

NKAP1
Uncharacterized protein NKAPD1

2

0

High-throughput

0.328

High

1383598

K1143
Uncharacterized protein KIAA1143

2

0

High-throughput

0.328

High

1348947

ZCH10
Zinc finger CCHC domain-containing protein 10

2

0

High-throughput

0.313

High

184315

NPHP1
Nephrocystin-1

1

0

High-throughput

0.249

Low

245358

CE104
Centrosomal protein of 104 kDa

1

0

High-throughput

0.249

Low

1147671

TOM20
Mitochondrial import receptor subunit TOM20 homolog

1

0

High-throughput

0.249

Low

1404176

SEC62
Translocation protein SEC62

1

0

High-throughput

0.249

Low

1411662

LGR4
Leucine-rich repeat-containing G-protein coupled receptor 4

1

0

High-throughput

0.249

Low

1411663

CEP44
Centrosomal protein of 44 kDa

1

0

High-throughput

0.249

Low

1411668

C2D2A
Coiled-coil and C2 domain-containing protein 2A

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025