Protein: ERCC3
General transcription and DNA repair factor IIH helicase/translocase subunit XPB (TFIIH subunit XPB) (EC 5.6.2.4) (Basic transcription factor 2 89 kDa subunit) (BTF2 p89) (DNA 3'-5' helicase/translocase XPB) (DNA excision repair protein ERCC-3) (DNA repair protein complementing XP-B cells) (TFIIH basal transcription factor complex 89 kDa subunit) (TFIIH 89 kDa subunit) (TFIIH p89) (Xeroderma pigmentosum group B-complementing protein)

Gene: ERCC3
Organism: Homo sapiens
Interactions: 156
UniProt ID: P19447

Gene Ontology (top 5):
GO:0000112 - nucleotide-excision repair factor 3 complex
GO:0000439 - transcription factor TFIIH core complex
GO:0003684 - damaged DNA binding
GO:0003677 - DNA binding
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

622769

TF2H1
General transcription factor IIH subunit 1

15

2

Small-scale

0.980

High

622806

TF2H2
General transcription factor IIH subunit 2

13

2

Small-scale

0.980

High

622840

TF2H4
General transcription factor IIH subunit 4

9

3

Small-scale

0.971

High

622782

MAT1
CDK-activating kinase assembly factor MAT1

8

1

Small-scale

0.966

High

622829

TF2H5
General transcription factor IIH subunit 5

8

0

Small-scale

0.925

High

622822

T2H2L
General transcription factor IIH subunit 2-like protein

3

2

High-throughput

0.861

High

622796

XPC
DNA repair protein complementing XP-C cells

3

1

Small-scale

0.853

High

622754

RPB1
DNA-directed RNA polymerase II subunit RPB1

3

8

Small-scale

0.827

High

622778

CDK7
Cyclin-dependent kinase 7

17

9

Small-scale

0.763

High

611639

ERCC2
General transcription and DNA repair factor IIH helicase subunit XPD

9

2

Small-scale

0.754

High

622807

TF2H3
General transcription factor IIH subunit 3

10

1

Small-scale

0.754

High

622781

CCNH
Cyclin-H

10

4

Small-scale

0.749

High

539941

BCR
Breakpoint cluster region protein

5

2

Small-scale

0.724

High

622760

ERCC5
DNA excision repair protein ERCC-5

4

1

Small-scale

0.697

High

413165

P53
Cellular tumor antigen p53

4

5

Small-scale

0.696

High

371133

MYC
Myc proto-oncogene protein

3

12

Small-scale

0.656

High

138627

IMA4
Importin subunit alpha-4

3

2

High-throughput

0.654

High

571868

TRI27
Zinc finger protein RFP

3

3

High-throughput

0.650

High

622783

ZN143
Zinc finger protein 143

2

1

High-throughput

0.628

High

622801

NSUN2
RNA cytosine C(5)-methyltransferase NSUN2

2

4

High-throughput

0.628

High

622842

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

2

14

High-throughput

0.628

High

622793

XIAP
E3 ubiquitin-protein ligase XIAP

2

8

High-throughput

0.628

High

622797

ERCC6
DNA excision repair protein ERCC-6

1

20

Small-scale

0.618

High

622805

SNW1
SNW domain-containing protein 1

2

3

High-throughput

0.606

High

622808

TRI14
Tripartite motif-containing protein 14

2

7

High-throughput

0.606

High

622865

MAGD1
Melanoma-associated antigen D1

2

8

High-throughput

0.606

High

622762

T2EA
General transcription factor IIE subunit 1

2

2

Small-scale

0.602

High

622811

LRC41
Leucine-rich repeat-containing protein 41

2

0

High-throughput

0.602

High

622790

PRS8
26S proteasome regulatory subunit 8

1

4

Small-scale

0.597

High

320622

UBXN7
UBX domain-containing protein 7

2

2

Small-scale

0.584

High

622825

ATL4
ADAMTS-like protein 4

2

0

High-throughput

0.580

High

622850

GO45
Golgin-45

2

0

High-throughput

0.580

High

622853

ROP1A
Ropporin-1A

2

0

High-throughput

0.580

High

519730

ANDR
Androgen receptor

1

20

Small-scale

0.578

High

622848

LZTS2
Leucine zipper putative tumor suppressor 2

2

9

High-throughput

0.574

High

395471

ESR1
Estrogen receptor

2

20

High-throughput

0.571

High

622817

UVSSA
UV-stimulated scaffold protein A

2

0

Small-scale

0.559

High

622791

SRPK2
SRSF protein kinase 2

1

20

High-throughput

0.550

High

622834

ZSCA1
Zinc finger and SCAN domain-containing protein 1

1

4

High-throughput

0.541

High

132430

CDC7
Cell division cycle 7-related protein kinase

1

10

High-throughput

0.536

High

258758

DNJA2
DnaJ homolog subfamily A member 2

1

2

High-throughput

0.536

High

424133

S10A8
Protein S100-A8

1

9

High-throughput

0.536

High

444896

S10A9
Protein S100-A9

1

11

High-throughput

0.536

High

577608

PLAK
Junction plakoglobin

1

7

High-throughput

0.536

High

578631

GLNA
Glutamine synthetase

1

1

High-throughput

0.536

High

621553

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

7

Small-scale

0.536

High

622748

FILA
Filaggrin

1

13

High-throughput

0.536

High

622755

ZA2G
Zinc-alpha-2-glycoprotein

1

1

High-throughput

0.536

High

622757

S100P
Protein S100-P

1

11

High-throughput

0.536

High

622764

SPB3
Serpin B3

1

6

High-throughput

0.536

High

622767

S10A7
Protein S100-A7

1

11

High-throughput

0.536

High

622768

CASPE
Caspase-14

1

5

High-throughput

0.536

High

622771

CETN2
Centrin-2

1

1

High-throughput

0.536

High

622774

KI67
Proliferation marker protein Ki-67

1

6

High-throughput

0.536

High

622775

LEG7
Galectin-7

1

4

High-throughput

0.536

High

622855

PRD11
PR domain-containing protein 11

1

4

High-throughput

0.536

High

622779

FXR1
RNA-binding protein FXR1

1

7

High-throughput

0.515

High

423605

ARGI1
Arginase-1

1

0

High-throughput

0.513

High

582543

PPAP
Prostatic acid phosphatase

1

0

High-throughput

0.513

High

622751

CRCM
Colorectal mutant cancer protein

1

0

High-throughput

0.513

High

622854

MED4
Mediator of RNA polymerase II transcription subunit 4

1

0

High-throughput

0.513

High

622804

SQSTM
Sequestosome-1

1

7

Small-scale

0.506

High

622750

TBG1
Tubulin gamma-1 chain

1

2

Small-scale

0.501

High

622753

CCNC
Cyclin-C

1

4

Small-scale

0.501

High

622763

T2EB
Transcription initiation factor IIE subunit beta

1

1

Small-scale

0.501

High

622777

CDK8
Cyclin-dependent kinase 8

1

7

Small-scale

0.501

High

622788

CDC42
Cell division control protein 42 homolog

1

12

Small-scale

0.501

High

622795

E2F1
Transcription factor E2F1

1

5

Small-scale

0.501

High

622773

RAD52
DNA repair protein RAD52 homolog

1

0

Small-scale

0.493

High

261598

CATL2
Cathepsin L2

1

1

High-throughput

0.489

High

457834

INVO
Involucrin

1

2

High-throughput

0.489

High

485777

CATH
Pro-cathepsin H [Cleaved into: Cathepsin H mini chain; Cathepsin H

1

1

High-throughput

0.489

High

568944

ANXA8
Annexin A8

1

3

High-throughput

0.489

High

622749

TGM1
Protein-glutamine gamma-glutamyltransferase K

1

2

High-throughput

0.489

High

622758

CALL3
Calmodulin-like protein 3

1

1

High-throughput

0.489

High

622761

S10A2
Protein S100-A2

1

11

High-throughput

0.489

High

622766

CD6
T-cell differentiation antigen CD6

1

5

High-throughput

0.489

High

622772

THIM
3-ketoacyl-CoA thiolase, mitochondrial

1

2

High-throughput

0.489

High

622776

SPB4
Serpin B4

1

6

High-throughput

0.489

High

622792

NGAL
Neutrophil gelatinase-associated lipocalin

1

3

High-throughput

0.489

High

622828

FBX50
F-box only protein 50

1

5

High-throughput

0.489

High

622832

S1A7A
Protein S100-A7A

1

11

High-throughput

0.489

High

622841

EVPL
Envoplakin

1

3

High-throughput

0.489

High

622859

CRNN
Cornulin

1

11

High-throughput

0.489

High

240717

PRKN
E3 ubiquitin-protein ligase parkin

1

15

High-throughput

0.479

High

247665

NUPR1
Nuclear protein 1

1

6

High-throughput

0.479

High

259423

BRD4
Bromodomain-containing protein 4

1

19

High-throughput

0.479

High

400257

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

6

High-throughput

0.479

High

533874

IRF1
Interferon regulatory factor 1

1

1

Small-scale

0.479

High

622752

CCND1
G1/S-specific cyclin-D1

1

1

Small-scale

0.479

High

622756

BRD2
Bromodomain-containing protein 2

1

20

High-throughput

0.479

High

622759

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

6

High-throughput

0.479

High

622765

PML
Protein PML

1

12

High-throughput

0.479

High

622780

MECP2
Methyl-CpG-binding protein 2

1

14

High-throughput

0.479

High

622784

RD23B
UV excision repair protein RAD23 homolog B

1

4

Small-scale

0.479

High

622785

TERA
Transitional endoplasmic reticulum ATPase

1

5

Small-scale

0.479

High

622786

ANM2
Protein arginine N-methyltransferase 2

1

6

High-throughput

0.479

High

622787

MLF1
Myeloid leukemia factor 1

1

1

High-throughput

0.479

High

622794

VIGLN
Vigilin

1

14

High-throughput

0.479

High

622798

TF65
Transcription factor p65

1

6

High-throughput

0.479

High

622802

TP53B
TP53-binding protein 1

1

1

High-throughput

0.479

High

622803

NFAC2
Nuclear factor of activated T-cells, cytoplasmic 2

1

8

High-throughput

0.479

High

622809

TNIP1
TNFAIP3-interacting protein 1

1

18

High-throughput

0.479

High

622810

BRD3
Bromodomain-containing protein 3

1

18

High-throughput

0.479

High

622812

PCBP1
Poly(rC)-binding protein 1

1

12

High-throughput

0.479

High

622813

TAF7
Transcription initiation factor TFIID subunit 7

1

1

Small-scale

0.479

High

622814

MLF2
Myeloid leukemia factor 2

1

1

High-throughput

0.479

High

622815

SMAD2
Mothers against decapentaplegic homolog 2

1

14

High-throughput

0.479

High

622819

BRDT
Bromodomain testis-specific protein

1

20

High-throughput

0.479

High

622826

MCAF1
Activating transcription factor 7-interacting protein 1

1

6

Small-scale

0.479

High

622833

SIR6
NAD-dependent protein deacylase sirtuin-6

1

8

High-throughput

0.479

High

622843

ZBT10
Zinc finger and BTB domain-containing protein 10

1

3

Small-scale

0.479

High

622856

ANLN
Anillin

1

5

High-throughput

0.479

High

622857

CDK12
Cyclin-dependent kinase 12

1

8

High-throughput

0.479

High

622860

ZRAN1
Ubiquitin thioesterase ZRANB1

1

8

High-throughput

0.479

High

622863

CHIP
E3 ubiquitin-protein ligase CHIP

1

1

High-throughput

0.479

High

622864

PPIE
Peptidyl-prolyl cis-trans isomerase E

1

5

High-throughput

0.479

High

622799

GOGA2
Golgin subfamily A member 2

1

6

High-throughput

0.464

High

622770

T2FA
General transcription factor IIF subunit 1

1

0

High-throughput

0.458

High

622789

CSN2
COP9 signalosome complex subunit 2

1

0

Small-scale

0.458

High

622847

MMS19
MMS19 nucleotide excision repair protein homolog

1

0

Small-scale

0.458

High

622852

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

622858

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.458

High

622831

HDGR2
Hepatoma-derived growth factor-related protein 2

1

5

High-throughput

0.445

High

622849

HIRP3
HIRA-interacting protein 3

1

2

High-throughput

0.445

High

75654

B3KVV6
cDNA FLJ41607 fis, clone CTONG3001370, highly similar to Homo sapiens alpha-2-macroglobulin-like 1

1

2

High-throughput

0.437

High

345357

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

20

High-throughput

0.437

High

386436

SPTA1
Spectrin alpha chain, erythrocytic 1

1

3

Small-scale

0.437

High

622827

TRI67
Tripartite motif-containing protein 67

1

14

High-throughput

0.437

High

622839

GCN1
Stalled ribosome sensor GCN1

1

14

High-throughput

0.437

High

622851

PKHA4
Pleckstrin homology domain-containing family A member 4

1

14

High-throughput

0.437

High

622862

HECD1
E3 ubiquitin-protein ligase HECTD1

1

20

High-throughput

0.437

High

622844

EAF1
ELL-associated factor 1

1

0

High-throughput

0.426

High

69475

A2ML1
Alpha-2-macroglobulin-like protein 1

1

2

High-throughput

0.407

High

622800

FGL1
Fibrinogen-like protein 1

4

0

High-throughput

0.360

High

622866

COX11
Cytochrome c oxidase assembly protein COX11, mitochondrial

2

0

High-throughput

0.328

High

622836

CEP76
Centrosomal protein of 76 kDa

2

0

High-throughput

0.316

High

622835

CEP70
Centrosomal protein of 70 kDa

1

0

High-throughput

0.299

High

161858

IMPA2
Inositol monophosphatase 2

1

0

High-throughput

0.279

Low

276564

LX12B
Arachidonate 12-lipoxygenase, 12R-type

1

0

High-throughput

0.279

Low

609292

SAP3
Ganglioside GM2 activator

1

0

High-throughput

0.279

Low

622747

TYPH
Thymidine phosphorylase

1

0

High-throughput

0.279

Low

622816

ECM1
Extracellular matrix protein 1

1

0

High-throughput

0.279

Low

622821

KPRP
Keratinocyte proline-rich protein

1

0

High-throughput

0.279

Low

622824

PLBL1
Phospholipase B-like 1

1

0

High-throughput

0.279

Low

622830

GDPD3
Lysophospholipase D GDPD3

1

0

High-throughput

0.279

Low

622837

ZCH10
Zinc finger CCHC domain-containing protein 10

1

0

High-throughput

0.279

Low

622838

POF1B
Protein POF1B

1

0

High-throughput

0.279

Low

622846

GSDMA
Gasdermin-A

1

0

High-throughput

0.279

Low

622861

CBPA4
Carboxypeptidase A4

1

0

High-throughput

0.279

Low

533811

MCF2
Proto-oncogene DBL

1

0

Small-scale

0.261

Low

622823

MSD2
Myb/SANT-like DNA-binding domain-containing protein 2

1

0

High-throughput

0.251

Low

76511

B4DYC6
cDNA FLJ60958, highly similar to Homo sapiens SGT1, suppressor of G2 allele of SKP1

1

0

High-throughput

0.249

Low

622820

EFHC2
EF-hand domain-containing family member C2

1

0

High-throughput

0.238

Low

622818

ASTRB
Protein Aster-B

1

0

High-throughput

0.232

Low

622845

NEUL4
Neuralized-like protein 4

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025