Protein: P3H3
Prolyl 3-hydroxylase 3 (EC 1.14.11.7) (Leprecan-like protein 2) (Protein B)

Gene: P3H3
Organism: Homo sapiens
Interactions: 99
UniProt ID: Q8IVL6

Gene Ontology (top 5):
GO:0005506 - iron ion binding
GO:0005783 - endoplasmic reticulum
GO:0008285 - negative regulation of cell population proliferation
GO:0017185 - peptidyl-lysine hydroxylation
GO:0019797 - procollagen-proline 3-dioxygenase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1181392

P3H1
Prolyl 3-hydroxylase 1

1

3

High-throughput

0.691

High

1144631

PTPRK
Receptor-type tyrosine-protein phosphatase kappa

3

0

High-throughput

0.638

High

505836

C1T9A
Complement C1q and tumor necrosis factor-related protein 9A

4

20

High-throughput

0.630

High

869501

TNFL6
Tumor necrosis factor ligand superfamily member 6

4

1

High-throughput

0.630

High

1038900

PLOD1
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1

2

3

High-throughput

0.628

High

1105502

OS9
Protein OS-9

2

1

High-throughput

0.628

High

566745

PDIA4
Protein disulfide-isomerase A4

1

2

High-throughput

0.618

High

370419

KNG1
Kininogen-1

3

5

High-throughput

0.609

High

388724

C1QB
Complement C1q subcomponent subunit B

3

20

High-throughput

0.609

High

647374

IDS
Iduronate 2-sulfatase

3

3

High-throughput

0.609

High

1249411

OLFM4
Olfactomedin-4

3

1

High-throughput

0.609

High

1308848

C1QT2
Complement C1q tumor necrosis factor-related protein 2

3

20

High-throughput

0.609

High

1121449

KEAP1
Kelch-like ECH-associated protein 1

2

0

High-throughput

0.602

High

1155005

ADIPO
Adiponectin

2

20

High-throughput

0.601

High

1308861

COLQ
Acetylcholinesterase collagenic tail peptide

2

10

High-throughput

0.574

High

1307407

KRA13
Keratin-associated protein 1-3

2

1

High-throughput

0.553

High

1308849

KRA92
Keratin-associated protein 9-2

2

2

High-throughput

0.553

High

73832

C1T9B
Complement C1q and tumor necrosis factor-related protein 9B

2

20

High-throughput

0.549

High

388647

C1QA
Complement C1q subcomponent subunit A

2

20

High-throughput

0.549

High

1308841

CA054
Uncharacterized protein C1orf54

2

1

High-throughput

0.549

High

405611

HRG
Histidine-rich glycoprotein

1

5

High-throughput

0.536

High

535268

BIP
Endoplasmic reticulum chaperone BiP

1

2

High-throughput

0.536

High

1308839

FIBIN
Fin bud initiation factor homolog

1

1

High-throughput

0.536

High

1308851

RTN4R
Reticulon-4 receptor

1

1

High-throughput

0.536

High

1308853

SDF2L
Stromal cell-derived factor 2-like protein 1

1

1

High-throughput

0.536

High

1308858

DNJB9
DnaJ homolog subfamily B member 9

1

3

High-throughput

0.536

High

650283

FGFR3
Fibroblast growth factor receptor 3

1

3

High-throughput

0.515

High

1308860

UBQL1
Ubiquilin-1

1

1

High-throughput

0.515

High

351789

LGI1
Leucine-rich glioma-inactivated protein 1

1

0

High-throughput

0.513

High

1308843

TRI63
E3 ubiquitin-protein ligase TRIM63

1

7

High-throughput

0.494

High

1308850

TRI55
Tripartite motif-containing protein 55

1

7

High-throughput

0.494

High

843740

HD
Huntingtin

1

0

High-throughput

0.493

High

168427

NCTR3
Natural cytotoxicity triggering receptor 3

1

2

High-throughput

0.489

High

214130

DHH
Desert hedgehog protein

1

1

High-throughput

0.489

High

224499

PI15
Peptidase inhibitor 15

1

2

High-throughput

0.489

High

273773

ATS4
A disintegrin and metalloproteinase with thrombospondin motifs 4

1

2

High-throughput

0.489

High

416629

REL1
Prorelaxin H1 [Cleaved into: Relaxin B chain; Relaxin A chain]

1

1

High-throughput

0.489

High

426113

PPB1
Alkaline phosphatase, placental type

1

1

High-throughput

0.489

High

506869

CFC1
Cryptic protein

1

1

High-throughput

0.489

High

567910

PRG2
Bone marrow proteoglycan

1

5

High-throughput

0.489

High

570693

EDN3
Endothelin-3

1

1

High-throughput

0.489

High

593430

PGFRA
Platelet-derived growth factor receptor alpha

1

2

High-throughput

0.489

High

651602

IBP4
Insulin-like growth factor-binding protein 4

1

1

High-throughput

0.489

High

935761

MFAP4
Microfibril-associated glycoprotein 4

1

2

High-throughput

0.489

High

946247

ATS12
A disintegrin and metalloproteinase with thrombospondin motifs 12

1

2

High-throughput

0.489

High

953831

C1QT8
Complement C1q tumor necrosis factor-related protein 8

1

20

High-throughput

0.489

High

1030187

IL5RA
Interleukin-5 receptor subunit alpha

1

1

High-throughput

0.489

High

1147365

EPHA7
Ephrin type-A receptor 7

1

2

High-throughput

0.489

High

1160198

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

1

6

High-throughput

0.489

High

1308837

SFPA2
Pulmonary surfactant-associated protein A2

1

13

High-throughput

0.489

High

1308842

GGH
Gamma-glutamyl hydrolase

1

1

High-throughput

0.489

High

1308847

C1QT7
Complement C1q tumor necrosis factor-related protein 7

1

20

High-throughput

0.489

High

1308852

SIRPD
Signal-regulatory protein delta

1

1

High-throughput

0.489

High

1308854

EMIL3
EMILIN-3

1

4

High-throughput

0.489

High

1308855

CBLN4
Cerebellin-4

1

20

High-throughput

0.489

High

1308859

EPDR1
Mammalian ependymin-related protein 1

1

1

High-throughput

0.489

High

1308863

LIPG
Endothelial lipase

1

2

High-throughput

0.489

High

1308844

LRC59
Leucine-rich repeat-containing protein 59

1

1

High-throughput

0.479

High

1308845

OPTN
Optineurin

1

1

High-throughput

0.470

High

251931

PLOD3
Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 [Includes: Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3

1

3

High-throughput

0.445

High

384172

CO1A1
Collagen alpha-1(I) chain

1

3

Small-scale

0.445

High

714248

PML
Protein PML

1

2

High-throughput

0.445

High

132148

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

2

High-throughput

0.437

High

218422

TGON2
Trans-Golgi network integral membrane protein 2

1

5

High-throughput

0.437

High

342240

BRD1
Bromodomain-containing protein 1

1

1

High-throughput

0.437

High

1254521

TRI67
Tripartite motif-containing protein 67

1

7

High-throughput

0.437

High

1308856

T106B
Transmembrane protein 106B

1

3

High-throughput

0.437

High

388786

C1QC
Complement C1q subcomponent subunit C

1

20

High-throughput

0.407

High

1150297

TAF1C
TATA box-binding protein-associated factor RNA polymerase I subunit C

1

1

High-throughput

0.407

High

1207956

COL12
Collectin-12

1

11

High-throughput

0.407

High

1308838

SCPDL
Saccharopine dehydrogenase-like oxidoreductase

1

1

High-throughput

0.407

High

1308846

ZN414
Zinc finger protein 414

1

1

High-throughput

0.407

High

1042646

UPAR
Urokinase plasminogen activator surface receptor

3

0

High-throughput

0.347

High

1295006

TMM25
Transmembrane protein 25

3

0

High-throughput

0.347

High

537466

HSP7C
Heat shock cognate 71 kDa protein

2

0

High-throughput

0.328

High

575160

IDE
Insulin-degrading enzyme

2

0

High-throughput

0.328

High

1101376

SG2A2
Mammaglobin-A

2

0

High-throughput

0.328

High

1308862

INSL5
Insulin-like peptide INSL5

2

0

High-throughput

0.328

High

949585

KR123
Keratin-associated protein 12-3

2

0

High-throughput

0.316

High

1146023

K1H1
Keratin, type I cuticular Ha1

2

0

High-throughput

0.316

High

74540

HNRC2
Heterogeneous nuclear ribonucleoprotein C-like 2

1

0

High-throughput

0.279

Low

155167

SOCS7
Suppressor of cytokine signaling 7

1

0

High-throughput

0.279

Low

485945

GIP
Gastric inhibitory polypeptide

1

0

High-throughput

0.279

Low

505654

DC8L2
DDB1- and CUL4-associated factor 8-like protein 2

1

0

High-throughput

0.279

Low

518869

CCL3
C-C motif chemokine 3

1

0

High-throughput

0.279

Low

656010

CAH6
Carbonic anhydrase 6

1

0

High-throughput

0.279

Low

731873

CEAM8
Cell adhesion molecule CEACAM8

1

0

High-throughput

0.279

Low

908637

PRELP
Prolargin

1

0

High-throughput

0.279

Low

1116240

PTC1
Protein patched homolog 1

1

0

High-throughput

0.279

Low

1157294

PROL4
Proline-rich protein 4

1

0

High-throughput

0.279

Low

1193168

AKD1A
Ankyrin repeat and death domain-containing protein 1A

1

0

High-throughput

0.279

Low

1308857

SPMA2
Sperm microtubule associated protein 2

1

0

High-throughput

0.279

Low

1308865

RT18B
Small ribosomal subunit protein mS40

1

0

High-throughput

0.279

Low

1279613

SPRE1
Sprouty-related, EVH1 domain-containing protein 1

1

0

High-throughput

0.268

Low

1308864

Q9Y649
GW128

1

0

High-throughput

0.268

Low

947221

NLRP6
NACHT, LRR and PYD domains-containing protein 6

1

0

High-throughput

0.249

Low

1248528

KIRR2
Kin of IRRE-like protein 2

1

0

High-throughput

0.249

Low

388542

CRP

1

0

High-throughput

0.232

Low

1308840

IASPP
RelA-associated inhibitor

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025