Protein: CATB
Cathepsin B (EC 3.4.22.1) (APP secretase) (APPS) (Cathepsin B1) [Cleaved into: Cathepsin B light chain; Cathepsin B heavy chain]

Gene: CATB, CTSB
Organism: Homo sapiens
Interactions: 192
UniProt ID: P07858

Gene Ontology (top 5):
GO:0004197 - cysteine-type endopeptidase activity
GO:0005518 - collagen binding
GO:0005576 - extracellular region
GO:0005615 - extracellular space
GO:0005764 - lysosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

345045

CYTA
Cystatin-A

4

7

Small-scale

0.896

High

376060

CYTB
Cystatin-B

3

7

Small-scale

0.840

High

344816

CYTC
Cystatin-C

2

17

Small-scale

0.799

High

431158

CATB
Cathepsin B

1

10

High-throughput

0.665

High

431175

CATS
Cathepsin S

1

8

High-throughput

0.618

High

363403

AMBP
Protein AMBP

2

3

Small-scale

0.608

High

427405

ANXA2
Annexin A2

2

2

Small-scale

0.595

High

431188

BAG6
Large proline-rich protein BAG6

1

2

High-throughput

0.541

High

431206

CCL20
C-C motif chemokine 20

1

2

Small-scale

0.536

High

431185

MLH1
DNA mismatch repair protein Mlh1

1

2

Small-scale

0.535

High

377014

GCR
Glucocorticoid receptor

2

3

Small-scale

0.533

High

431170

BRAF
Serine/threonine-protein kinase B-raf

2

5

High-throughput

0.521

High

431229

STK11
Serine/threonine-protein kinase STK11

1

0

High-throughput

0.518

High

117560

MYO1C
Unconventional myosin-Ic

1

8

High-throughput

0.515

High

164554

SPTN2
Spectrin beta chain, non-erythrocytic 2

1

10

High-throughput

0.515

High

169017

ARPC3
Actin-related protein 2/3 complex subunit 3

1

2

High-throughput

0.515

High

211466

ACTN4
Alpha-actinin-4

1

7

High-throughput

0.515

High

214471

MYO1B
Unconventional myosin-Ib

1

8

High-throughput

0.515

High

254033

WDR1
WD repeat-containing protein 1

1

3

High-throughput

0.515

High

297272

MYO1D
Unconventional myosin-Id

1

8

High-throughput

0.515

High

382266

HLAA
HLA class I histocompatibility antigen, A alpha chain

1

4

High-throughput

0.515

High

385935

P53
Cellular tumor antigen p53

1

2

High-throughput

0.515

High

390021

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

3

High-throughput

0.515

High

429292

SAP
Prosaposin

1

2

High-throughput

0.515

High

431162

MPRI
Cation-independent mannose-6-phosphate receptor

1

7

High-throughput

0.515

High

431163

ACTN1
Alpha-actinin-1

1

7

High-throughput

0.515

High

431166

PDIA4
Protein disulfide-isomerase A4

1

11

High-throughput

0.515

High

431168

ENPL
Endoplasmin

1

3

High-throughput

0.515

High

431173

PFKAL
ATP-dependent 6-phosphofructokinase, liver type

1

5

High-throughput

0.515

High

431176

CALR
Calreticulin

1

6

High-throughput

0.515

High

431177

GRN
Progranulin

1

1

High-throughput

0.515

High

431179

PDIA3
Protein disulfide-isomerase A3

1

12

High-throughput

0.515

High

431191

LMAN1
Protein ERGIC-53

1

2

High-throughput

0.515

High

431193

SERPH
Serpin H1

1

5

High-throughput

0.515

High

431203

TPM4
Tropomyosin alpha-4 chain

1

3

High-throughput

0.515

High

431207

NUCB2
Nucleobindin-2

1

1

High-throughput

0.515

High

431208

PFKAP
ATP-dependent 6-phosphofructokinase, platelet type

1

5

High-throughput

0.515

High

431213

CKAP4
Cytoskeleton-associated protein 4

1

3

High-throughput

0.515

High

431216

TWF1
Twinfilin-1

1

1

High-throughput

0.515

High

431218

PRDX4
Peroxiredoxin-4

1

2

High-throughput

0.515

High

431222

SPTN1
Spectrin alpha chain, non-erythrocytic 1

1

10

High-throughput

0.515

High

431226

GANAB
Neutral alpha-glucosidase AB

1

2

High-throughput

0.515

High

431273

AIF1L
Allograft inflammatory factor 1-like

1

3

High-throughput

0.515

High

431292

DJB11
DnaJ homolog subfamily B member 11

1

5

High-throughput

0.515

High

431297

BAG5
BAG family molecular chaperone regulator 5

1

2

High-throughput

0.515

High

431298

MYO6
Unconventional myosin-VI

1

2

High-throughput

0.515

High

431302

HYOU1
Hypoxia up-regulated protein 1

1

3

High-throughput

0.515

High

431275

UN93B
Protein unc-93 homolog B1

1

0

High-throughput

0.513

High

431174

ANXA7
Annexin A7

1

2

High-throughput

0.508

High

431242

ATL4
ADAMTS-like protein 4

1

1

Small-scale

0.506

High

431200

S10AA
Protein S100-A10

1

0

Small-scale

0.504

High

431262

SH3K1
SH3 domain-containing kinase-binding protein 1

1

2

Small-scale

0.504

High

393945

A4
Amyloid-beta precursor protein

1

3

High-throughput

0.501

High

431159

PARP1
Poly [ADP-ribose] polymerase 1

1

1

Small-scale

0.501

High

431278

UBP29
Ubiquitin carboxyl-terminal hydrolase 29

1

0

High-throughput

0.493

High

156593

PPE1
Serine/threonine-protein phosphatase with EF-hands 1

1

3

High-throughput

0.489

High

431190

PTSS1
Phosphatidylserine synthase 1

1

2

High-throughput

0.489

High

431251

HIPK4
Homeodomain-interacting protein kinase 4

1

2

High-throughput

0.489

High

431280

ST7
Suppressor of tumorigenicity 7 protein

1

2

High-throughput

0.489

High

431183

CDN1A
Cyclin-dependent kinase inhibitor 1

1

0

High-throughput

0.486

High

431283

UBQL4
Ubiquilin-4

1

4

Small-scale

0.481

High

164756

SC16A
Protein transport protein Sec16A

1

2

High-throughput

0.479

High

216146

CALU
Calumenin

1

5

High-throughput

0.479

High

237014

PLOD3
Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 [Includes: Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3

1

5

High-throughput

0.479

High

344751

CO5
Complement C5

1

1

Small-scale

0.479

High

351892

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

1

High-throughput

0.479

High

363992

VTDB
Vitamin D-binding protein

1

1

Small-scale

0.479

High

372977

VTNC
Vitronectin

1

1

Small-scale

0.479

High

373542

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

6

High-throughput

0.479

High

431160

HLAC
HLA class I histocompatibility antigen, C alpha chain

1

4

High-throughput

0.479

High

431164

CADH1
Cadherin-1

1

3

High-throughput

0.479

High

431169

MMP9
Matrix metalloproteinase-9

1

2

Small-scale

0.479

High

431178

ERP29
Endoplasmic reticulum resident protein 29

1

12

High-throughput

0.479

High

431180

AMRP
Alpha-2-macroglobulin receptor-associated protein

1

1

High-throughput

0.479

High

431182

PHB1
Prohibitin 1

1

3

High-throughput

0.479

High

431192

TMEDA
Transmembrane emp24 domain-containing protein 10

1

1

High-throughput

0.479

High

431195

SYYC
Tyrosine--tRNA ligase, cytoplasmic

1

3

High-throughput

0.479

High

431196

MANF
Mesencephalic astrocyte-derived neurotrophic factor

1

1

High-throughput

0.479

High

431211

COEA1
Collagen alpha-1(XIV) chain

1

3

High-throughput

0.479

High

431214

DSC1
Desmocollin-1

1

3

Small-scale

0.479

High

431217

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

1

3

High-throughput

0.479

High

431220

CUL3
Cullin-3

1

3

High-throughput

0.479

High

431224

DSC3
Desmocollin-3

1

3

High-throughput

0.479

High

431227

SYK
Lysine--tRNA ligase

1

3

High-throughput

0.479

High

431236

DHB12
Very-long-chain 3-oxoacyl-CoA reductase

1

2

High-throughput

0.479

High

431249

NHLC2
NHL repeat-containing protein 2

1

1

High-throughput

0.479

High

431258

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

1

High-throughput

0.479

High

431263

ERO1A
ERO1-like protein alpha

1

1

High-throughput

0.479

High

431279

SDF2L
Stromal cell-derived factor 2-like protein 1

1

2

High-throughput

0.479

High

431281

FBX6
F-box only protein 6

1

3

High-throughput

0.479

High

431289

UGGG1
UDP-glucose:glycoprotein glucosyltransferase 1

1

3

High-throughput

0.479

High

431299

MINP1
Multiple inositol polyphosphate phosphatase 1

1

1

High-throughput

0.479

High

431300

CE164
Centrosomal protein of 164 kDa

1

2

High-throughput

0.479

High

299822

ERLN2
Erlin-2

1

2

High-throughput

0.470

High

323550

BAG2
BAG family molecular chaperone regulator 2

1

2

High-throughput

0.470

High

390662

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

2

High-throughput

0.470

High

431167

P4HA1
Prolyl 4-hydroxylase subunit alpha-1

1

2

High-throughput

0.470

High

431184

OST48
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit

1

2

High-throughput

0.470

High

431198

RBM11
Splicing regulator RBM11

1

2

High-throughput

0.470

High

431205

PRKDC
DNA-dependent protein kinase catalytic subunit

1

2

High-throughput

0.470

High

431215

DMWD
Dystrophia myotonica WD repeat-containing protein

1

3

High-throughput

0.470

High

431219

OS9
Protein OS-9

1

1

High-throughput

0.470

High

431228

RCN1
Reticulocalbin-1

1

5

High-throughput

0.470

High

431233

GLO2
Hydroxyacylglutathione hydrolase, mitochondrial

1

1

High-throughput

0.470

High

431239

UBR4
E3 ubiquitin-protein ligase UBR4

1

2

High-throughput

0.470

High

431250

GT251
Procollagen galactosyltransferase 1

1

5

High-throughput

0.470

High

431255

IPO4
Importin-4

1

2

High-throughput

0.470

High

431259

MY18A
Unconventional myosin-XVIIIa

1

2

High-throughput

0.470

High

431268

RBM15
RNA-binding protein 15

1

1

High-throughput

0.470

High

431270

RNF5
E3 ubiquitin-protein ligase RNF5

1

3

High-throughput

0.470

High

431293

SE1L1
Protein sel-1 homolog 1

1

2

High-throughput

0.470

High

431296

RALY
RNA-binding protein Raly

1

1

High-throughput

0.470

High

208089

SPY2
Protein sprouty homolog 2

1

1

High-throughput

0.464

High

155244

NRP1
Neuropilin-1

1

0

High-throughput

0.458

High

337787

EGFR
Epidermal growth factor receptor

1

0

High-throughput

0.458

High

361654

APOC2
Apolipoprotein C-II

1

0

Small-scale

0.458

High

362422

SAMP
Serum amyloid P-component

1

0

Small-scale

0.458

High

363552

TTHY
Transthyretin

1

0

Small-scale

0.458

High

373339

CATA
Catalase

1

0

Small-scale

0.458

High

431161

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.458

High

431186

CCNF
Cyclin-F

1

0

High-throughput

0.458

High

431194

LUM
Lumican

1

0

Small-scale

0.458

High

431269

SORT
Sortilin

1

0

High-throughput

0.458

High

431295

HERC5
E3 ISG15--protein ligase HERC5

1

0

Small-scale

0.458

High

384110

NTRK1
High affinity nerve growth factor receptor

1

1

High-throughput

0.457

High

431197

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

3

High-throughput

0.445

High

431248

XRN1
5'-3' exoribonuclease 1

1

2

High-throughput

0.439

High

431282

DISC1
Disrupted in schizophrenia 1 protein

1

0

High-throughput

0.438

High

122252

RN103
E3 ubiquitin-protein ligase RNF103

1

2

High-throughput

0.437

High

282486

RNF8
E3 ubiquitin-protein ligase RNF8

1

3

High-throughput

0.437

High

327156

TXD12
Thioredoxin domain-containing protein 12

1

2

High-throughput

0.437

High

431172

CEBPB
CCAAT/enhancer-binding protein beta

1

1

High-throughput

0.437

High

431189

CD151
CD151 antigen

1

2

Small-scale

0.437

High

431204

NOMO3
BOS complex subunit NOMO3

1

2

High-throughput

0.437

High

431209

M2OM
Mitochondrial 2-oxoglutarate/malate carrier protein

1

5

High-throughput

0.437

High

431212

CDK18
Cyclin-dependent kinase 18

1

1

High-throughput

0.437

High

431221

CUL4A
Cullin-4A

1

3

High-throughput

0.437

High

431225

MESD
LRP chaperone MESD

1

1

High-throughput

0.437

High

431232

HIF1A
Hypoxia-inducible factor 1-alpha

1

1

High-throughput

0.437

High

431235

GXLT1
Glucoside xylosyltransferase 1

1

1

High-throughput

0.437

High

431237

TGO1
Transport and Golgi organization protein 1 homolog

1

2

High-throughput

0.437

High

431238

TOIP1
Torsin-1A-interacting protein 1

1

1

High-throughput

0.437

High

431240

FTM
Protein fantom

1

3

High-throughput

0.437

High

431243

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.437

High

431245

YTHD3
YTH domain-containing family protein 3

1

4

High-throughput

0.437

High

431246

DJC10
DnaJ homolog subfamily C member 10

1

14

High-throughput

0.437

High

431247

S15A3
Solute carrier family 15 member 3

1

1

High-throughput

0.437

High

431252

STT3B
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B

1

2

High-throughput

0.437

High

431253

PO210
Nuclear pore membrane glycoprotein 210

1

1

High-throughput

0.437

High

431254

FBF1
Fas-binding factor 1

1

4

High-throughput

0.437

High

431256

RN139
E3 ubiquitin-protein ligase RNF139

1

1

High-throughput

0.437

High

431257

ZNRF4
E3 ubiquitin-protein ligase ZNRF4

1

2

High-throughput

0.437

High

431260

ESR2
Estrogen receptor beta

1

3

High-throughput

0.437

High

431261

EFMT3
EEF1A lysine methyltransferase 3

1

1

High-throughput

0.437

High

431266

SCLT1
Sodium channel and clathrin linker 1

1

3

High-throughput

0.437

High

431267

NEB2
Neurabin-2

1

1

High-throughput

0.437

High

431274

CNPY3
Protein canopy homolog 3

1

1

High-throughput

0.437

High

431276

WDR26
WD repeat-containing protein 26

1

2

High-throughput

0.437

High

431277

XPO5
Exportin-5

1

3

High-throughput

0.437

High

431285

GID8
Glucose-induced degradation protein 8 homolog

1

1

High-throughput

0.437

High

431288

UGGG2
UDP-glucose:glycoprotein glucosyltransferase 2

1

5

High-throughput

0.437

High

431294

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.437

High

431301

CNPY2
Protein canopy homolog 2

1

1

High-throughput

0.437

High

431165

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.426

High

99545

F5H1C8
Solute carrier family 15 member 3

1

1

High-throughput

0.407

High

431181

BMI1
Polycomb complex protein BMI-1

1

1

High-throughput

0.407

High

431187

RGS2
Regulator of G-protein signaling 2

2

0

High-throughput

0.307

High

431265

LCOR
Ligand-dependent corepressor

1

0

High-throughput

0.282

High

63988

SPDE4
Speedy protein E4

1

0

High-throughput

0.279

Low

151690

IRS4
Insulin receptor substrate 4

1

0

High-throughput

0.279

Low

431264

BOD1
Biorientation of chromosomes in cell division protein 1

1

0

High-throughput

0.268

Low

431231

HSPB2
Heat shock protein beta-2

1

0

High-throughput

0.265

Low

431272

F118B
Protein FAM118B

1

0

High-throughput

0.265

Low

431210

ERCC6
DNA excision repair protein ERCC-6

1

0

High-throughput

0.261

Low

431287

SPHK1
Sphingosine kinase 1

1

0

Small-scale

0.261

Low

431223

HNRPD
Heterogeneous nuclear ribonucleoprotein D0

1

0

High-throughput

0.251

Low

246152

NBN
Nibrin

1

0

High-throughput

0.249

Low

345716

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.249

Low

431171

H13
Histone H1.3

1

0

Small-scale

0.249

Low

431201

ABCE1
ATP-binding cassette sub-family E member 1

1

0

High-throughput

0.249

Low

431202

WDR5
WD repeat-containing protein 5

1

0

High-throughput

0.249

Low

431230

EZH2
Histone-lysine N-methyltransferase EZH2

1

0

High-throughput

0.249

Low

431234

CL16A
Protein CLEC16A

1

0

High-throughput

0.249

Low

431241

RICTR
Rapamycin-insensitive companion of mTOR

1

0

High-throughput

0.249

Low

431244

TPGS1
Tubulin polyglutamylase complex subunit 1

1

0

High-throughput

0.249

Low

431271

PTN18
Tyrosine-protein phosphatase non-receptor type 18

1

0

High-throughput

0.249

Low

431284

RMND1
Required for meiotic nuclear division protein 1 homolog

1

0

High-throughput

0.249

Low

431286

TEX10
Testis-expressed protein 10

1

0

High-throughput

0.249

Low

431290

TMOD2
Tropomodulin-2

1

0

High-throughput

0.249

Low

431291

MARH4
E3 ubiquitin-protein ligase MARCHF4

1

0

High-throughput

0.249

Low

431199

DSCR9
Down syndrome critical region protein 9

1

0

High-throughput

0.238

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024