Protein: SYEM
Nondiscriminating glutamyl-tRNA synthetase EARS2, mitochondrial (EC 6.1.1.24) (Glutamate--tRNA(Gln) ligase EARS2, mitochondrial) (EC 6.1.1.17) (Glutamyl-tRNA synthetase) (GluRS) (Mitochondrial glutamyl-tRNA synthetase) (mtGluRS)

Gene: SYEM, EARS2
Organism: Homo sapiens
Interactions: 88
UniProt ID: Q5JPH6

Gene Ontology (top 5):
GO:0000049 - tRNA binding
GO:0004818 - glutamate-tRNA ligase activity
GO:0005524 - ATP binding
GO:0005739 - mitochondrion
GO:0005759 - mitochondrial matrix

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

726239

BASI
Basigin

3

1

High-throughput

0.667

High

1126905

HSC20
Iron-sulfur cluster co-chaperone protein HscB

2

1

High-throughput

0.611

High

262836

CISY
Citrate synthase, mitochondrial

2

0

High-throughput

0.559

High

1086593

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

2

0

High-throughput

0.559

High

1126908

TRI43
Tripartite motif-containing protein 43

1

3

High-throughput

0.536

High

1126910

IMP1L
Mitochondrial inner membrane protease subunit 1

1

1

High-throughput

0.536

High

1126915

MYL10
Myosin regulatory light chain 10

1

1

High-throughput

0.536

High

203954

HTRA2
Serine protease HTRA2, mitochondrial

1

0

High-throughput

0.513

High

505416

GTR1
Solute carrier family 2, facilitated glucose transporter member 1

1

0

High-throughput

0.513

High

646410

KAD4
Adenylate kinase 4, mitochondrial

1

0

High-throughput

0.513

High

815379

UCRI
Cytochrome b-c1 complex subunit Rieske, mitochondrial

1

0

High-throughput

0.513

High

1084708

TAZ
Tafazzin

1

0

High-throughput

0.513

High

1126901

ACSM5
Acyl-coenzyme A synthetase ACSM5, mitochondrial

1

0

High-throughput

0.513

High

1126902

FAHD1
Oxaloacetate decarboxylase, mitochondrial

1

0

High-throughput

0.513

High

1126926

DIC
Mitochondrial dicarboxylate carrier

1

0

High-throughput

0.513

High

1126927

NPS3A
Protein NipSnap homolog 3A

1

0

High-throughput

0.513

High

1126930

AMACR
Alpha-methylacyl-CoA racemase

1

0

High-throughput

0.513

High

1126934

SYYM
Tyrosine--tRNA ligase, mitochondrial

1

0

High-throughput

0.513

High

1126912

IMP2L
Mitochondrial inner membrane protease subunit 2

1

1

High-throughput

0.506

High

174946

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

2

High-throughput

0.501

High

126599

P2Y10
Putative P2Y purinoceptor 10

1

1

High-throughput

0.489

High

172026

GP182
G-protein coupled receptor 182

1

1

High-throughput

0.489

High

380114

MAS
Proto-oncogene Mas

1

1

High-throughput

0.489

High

1126931

TSP50
Probable threonine protease PRSS50

1

2

High-throughput

0.489

High

1126933

GPR55
G-protein coupled receptor 55

1

2

High-throughput

0.489

High

1126937

NPTN
Neuroplastin

1

1

High-throughput

0.489

High

227668

PRKN
E3 ubiquitin-protein ligase parkin

1

4

High-throughput

0.479

High

325204

AIFM1
Apoptosis-inducing factor 1, mitochondrial

1

3

High-throughput

0.479

High

360014

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

1

High-throughput

0.479

High

384960

NTRK1
High affinity nerve growth factor receptor

1

4

High-throughput

0.479

High

600160

TAF1
Transcription initiation factor TFIID subunit 1

1

3

High-throughput

0.479

High

779540

CCNF
Cyclin-F

1

2

High-throughput

0.479

High

827414

EFTU
Elongation factor Tu, mitochondrial

1

1

High-throughput

0.479

High

882352

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

2

High-throughput

0.479

High

958928

TFAM
Transcription factor A, mitochondrial

1

1

High-throughput

0.479

High

1020447

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

6

High-throughput

0.479

High

1035463

SMAD4
Mothers against decapentaplegic homolog 4

1

1

High-throughput

0.479

High

1036638

SQSTM
Sequestosome-1

1

1

High-throughput

0.479

High

1041732

CUL3
Cullin-3

1

4

High-throughput

0.479

High

1085581

HIF1A
Hypoxia-inducible factor 1-alpha

1

1

High-throughput

0.479

High

1126899

SYAM
Alanine--tRNA ligase, mitochondrial

1

2

High-throughput

0.479

High

1126904

TRI67
Tripartite motif-containing protein 67

1

4

High-throughput

0.479

High

1126911

EFGM
Elongation factor G, mitochondrial

1

2

High-throughput

0.479

High

1126917

MTRFR
Mitochondrial translation release factor in rescue

1

1

High-throughput

0.479

High

1126921

ACAD9
Complex I assembly factor ACAD9, mitochondrial

1

2

High-throughput

0.479

High

1126923

EXD2
Exonuclease 3'-5' domain-containing protein 2

1

2

High-throughput

0.479

High

1126928

RF1ML
Peptide chain release factor 1-like, mitochondrial

1

1

High-throughput

0.479

High

1126929

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.479

High

327456

TRUB2
Pseudouridylate synthase TRUB2, mitochondrial

1

0

High-throughput

0.458

High

440551

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

0

High-throughput

0.458

High

486539

COX8A
Cytochrome c oxidase subunit 8A, mitochondrial

1

0

High-throughput

0.458

High

525526

COX41
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

1

0

High-throughput

0.458

High

777584

MDHM
Malate dehydrogenase, mitochondrial

1

0

High-throughput

0.458

High

789825

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

0

High-throughput

0.458

High

799242

EFTS
Elongation factor Ts, mitochondrial

1

0

High-throughput

0.458

High

981277

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

0

High-throughput

0.458

High

990096

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

0

High-throughput

0.458

High

1017913

GRSF1
G-rich sequence factor 1

1

0

High-throughput

0.458

High

1045771

AUHM
Methylglutaconyl-CoA hydratase, mitochondrial

1

0

High-throughput

0.458

High

1101087

CL16A
Protein CLEC16A

1

0

High-throughput

0.458

High

1126907

FAKD4
FAST kinase domain-containing protein 4

1

0

High-throughput

0.458

High

1126909

RRFM
Ribosome-recycling factor, mitochondrial

1

0

High-throughput

0.458

High

1126914

TACO1
Translational activator of cytochrome c oxidase 1

1

0

High-throughput

0.458

High

1126919

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

1126920

MET17
Ribosome assembly protein METTL17, mitochondrial

1

0

High-throughput

0.458

High

1126924

MRES1
Mitochondrial transcription rescue factor 1

1

0

High-throughput

0.458

High

1126935

RM11
Large ribosomal subunit protein uL11m

1

0

High-throughput

0.458

High

1068

SIM26
Small integral membrane protein 26

1

2

High-throughput

0.445

High

1126900

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

3

High-throughput

0.445

High

1126932

ITM2B
Integral membrane protein 2B

1

1

High-throughput

0.445

High

319219

BRD1
Bromodomain-containing protein 1

1

1

High-throughput

0.437

High

720632

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.437

High

815783

SC6A8
Sodium- and chloride-dependent creatine transporter 1

1

1

Small-scale

0.437

High

1126903

LMBRL
Protein LMBR1L

1

2

High-throughput

0.437

High

1126918

PKHA4
Pleckstrin homology domain-containing family A member 4

1

5

High-throughput

0.437

High

1126922

MET14
N6-adenosine-methyltransferase non-catalytic subunit

1

1

High-throughput

0.437

High

207244

TNF14
Tumor necrosis factor ligand superfamily member 14

1

0

High-throughput

0.279

Low

598953

FPR1
fMet-Leu-Phe receptor

1

0

High-throughput

0.279

Low

686304

VIPR1
Vasoactive intestinal polypeptide receptor 1

1

0

High-throughput

0.279

Low

702358

TNFL8
Tumor necrosis factor ligand superfamily member 8

1

0

High-throughput

0.279

Low

968841

NAAA
N-acylethanolamine-hydrolyzing acid amidase

1

0

High-throughput

0.279

Low

1126906

MFD4A
Major facilitator superfamily domain-containing protein 4A

1

0

High-throughput

0.279

Low

1126913

GML
Glycosyl-phosphatidylinositol-anchored molecule-like protein

1

0

High-throughput

0.279

Low

1126925

HCST
Hematopoietic cell signal transducer

1

0

High-throughput

0.279

Low

1126936

GPR45
Probable G-protein coupled receptor 45

1

0

High-throughput

0.279

Low

942515

CTG1B
Cancer/testis antigen 1

1

0

High-throughput

0.269

Low

100834

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

1126916

SPRTN
DNA-dependent metalloprotease SPRTN

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024