Protein: SIAE
Sialate O-acetylesterase (SIAE) (EC 3.1.1.53) (H-Lse) (Sialic acid-specific 9-O-acetylesterase)

Gene: SIAE
Organism: Homo sapiens
Interactions: 64
UniProt ID: Q9HAT2

Gene Ontology (top 5):
GO:0001681 - sialate O-acetylesterase activity
GO:0002682 - regulation of immune system process
GO:0005615 - extracellular space
GO:0005764 - lysosome
GO:0005975 - carbohydrate metabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

586388

ARSB
Arylsulfatase B

2

3

High-throughput

0.611

High

1248928

ARSK
Arylsulfatase K

2

3

High-throughput

0.611

High

1437650

LCAP
Leucyl-cystinyl aminopeptidase

2

1

High-throughput

0.611

High

1154260

NPTX1
Neuronal pentraxin-1

3

1

High-throughput

0.599

High

335404

GDF11
Growth/differentiation factor 11

2

0

High-throughput

0.585

High

599132

CBPE
Carboxypeptidase E

2

0

High-throughput

0.585

High

810635

COIA1
Collagen alpha-1(XVIII) chain [Cleaved into: Endostatin; Non-collagenous domain 1

2

0

High-throughput

0.585

High

934029

PLTP
Phospholipid transfer protein

2

0

High-throughput

0.585

High

937441

LAMB2
Laminin subunit beta-2

2

0

High-throughput

0.585

High

1034823

NAAA
N-acylethanolamine-hydrolyzing acid amidase

2

0

High-throughput

0.585

High

1041646

TGBR3
Transforming growth factor beta receptor type 3

2

0

High-throughput

0.585

High

1179148

TECT1
Tectonic-1

2

0

High-throughput

0.585

High

1237886

MYORG
Myogenesis-regulating glycosidase

2

0

High-throughput

0.585

High

1437649

CEIP2
Cell surface hyaluronidase CEMIP2

2

0

High-throughput

0.585

High

1437652

MA2B2
Epididymis-specific alpha-mannosidase

2

0

High-throughput

0.585

High

249061

NRP2
Neuropilin-2

2

1

High-throughput

0.558

High

1217322

MANEL
Glycoprotein endo-alpha-1,2-mannosidase-like protein

2

1

High-throughput

0.558

High

1399566

DCBD2
Discoidin, CUB and LCCL domain-containing protein 2

2

2

High-throughput

0.558

High

756586

GALNS
N-acetylgalactosamine-6-sulfatase

1

3

High-throughput

0.536

High

1108717

TBB3
Tubulin beta-3 chain

1

1

High-throughput

0.536

High

1191985

TBB8
Tubulin beta-8 chain

1

1

High-throughput

0.536

High

1437642

FBX6
F-box only protein 6

2

1

High-throughput

0.533

High

932390

ANAG
Alpha-N-acetylglucosaminidase

1

0

High-throughput

0.513

High

1098481

DNJC3
DnaJ homolog subfamily C member 3

1

0

High-throughput

0.513

High

1127321

EP3A
Epididymal secretory protein E3-alpha

1

0

High-throughput

0.513

High

1437648

CATF
Cathepsin F

1

0

High-throughput

0.513

High

338744

NPTXR
Neuronal pentraxin receptor

1

1

High-throughput

0.489

High

1437651

FBX2
F-box only protein 2

1

1

High-throughput

0.489

High

907225

SPHM
N-sulphoglucosamine sulphohydrolase

1

3

High-throughput

0.479

High

1376961

HMR1
Major histocompatibility complex class I-related protein 1

1

1

High-throughput

0.479

High

1437644

ERAP1
Endoplasmic reticulum aminopeptidase 1

1

1

High-throughput

0.479

High

175433

PLXB2
Plexin-B2

1

0

High-throughput

0.458

High

277039

ENTP6
Ectonucleoside triphosphate diphosphohydrolase 6

1

0

High-throughput

0.458

High

1175845

T132A
Transmembrane protein 132A

1

0

High-throughput

0.458

High

1248292

MOXD1
DBH-like monooxygenase protein 1

1

0

High-throughput

0.458

High

1286305

GALT7
N-acetylgalactosaminyltransferase 7

1

0

High-throughput

0.458

High

1360642

AGRV1
Adhesion G-protein coupled receptor V1

1

0

High-throughput

0.458

High

380149

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

1

High-throughput

0.445

High

1210415

MANEA
Glycoprotein endo-alpha-1,2-mannosidase

1

1

High-throughput

0.437

High

1181080

DB109
Beta-defensin 109B

1

0

High-throughput

0.426

High

215731

COCH
Cochlin

2

0

High-throughput

0.318

High

914875

NDST2
Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2

2

0

High-throughput

0.318

High

1131490

MBTP1
Membrane-bound transcription factor site-1 protease

2

0

High-throughput

0.318

High

1258461

CHSS3
Chondroitin sulfate synthase 3

2

0

High-throughput

0.318

High

1288104

OAF
Out at first protein homolog

2

0

High-throughput

0.318

High

1334177

POC1A
POC1 centriolar protein homolog A

2

0

High-throughput

0.318

High

1419495

CNTP3
Contactin-associated protein-like 3

2

0

High-throughput

0.318

High

1437646

TEN3
Teneurin-3

2

0

High-throughput

0.318

High

136634

MANBA
Beta-mannosidase

1

0

High-throughput

0.249

Low

218794

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.249

Low

317479

GFPT2
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2

1

0

High-throughput

0.249

Low

922840

ITA8
Integrin alpha-8 [Cleaved into: Integrin alpha-8 heavy chain; Integrin alpha-8 light chain]

1

0

High-throughput

0.249

Low

1005773

RPP38
Ribonuclease P protein subunit p38

1

0

High-throughput

0.249

Low

1135935

FAKD3
FAST kinase domain-containing protein 3, mitochondrial

1

0

High-throughput

0.249

Low

1144669

PTPRK
Receptor-type tyrosine-protein phosphatase kappa

1

0

High-throughput

0.249

Low

1255599

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

1364154

TM131
Transmembrane protein 131

1

0

High-throughput

0.249

Low

1382114

F162A
Protein FAM162A

1

0

High-throughput

0.249

Low

1430386

DDX47
Probable ATP-dependent RNA helicase DDX47

1

0

High-throughput

0.249

Low

1437643

CC50A
Cell cycle control protein 50A

1

0

High-throughput

0.249

Low

1437645

SELN
Selenoprotein N

1

0

High-throughput

0.249

Low

1437647

FPRP
Prostaglandin F2 receptor negative regulator

1

0

High-throughput

0.249

Low

640291

EPHA1
Ephrin type-A receptor 1

1

0

High-throughput

0.238

Low

170971

CLGN
Calmegin

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025