Protein: ITPI2
Protein ITPRID2 (Cleavage signal-1 protein) (CS-1) (ITPR-interacting domain-containing protein 2) (Ki-ras-induced actin-interacting protein) (Sperm-specific antigen 2)

Gene: ITPI2, ITPRID2
Organism: Homo sapiens
Interactions: 134
UniProt ID: P28290

Gene Ontology (top 5):
GO:0005102 - signaling receptor binding
GO:0005654 - nucleoplasm
GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0051015 - actin filament binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

690754

1433T
14-3-3 protein theta

5

11

High-throughput

0.705

High

702089

1433G
14-3-3 protein gamma

4

11

High-throughput

0.693

High

702071

1433B
14-3-3 protein beta/alpha

4

11

High-throughput

0.678

High

702091

1433E
14-3-3 protein epsilon

3

1

High-throughput

0.669

High

702130

TPTE2
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2

3

1

High-throughput

0.667

High

702147

SGF29
SAGA-associated factor 29

4

0

High-throughput

0.661

High

395540

ESR1
Estrogen receptor

3

2

High-throughput

0.650

High

702095

1433F
14-3-3 protein eta

3

11

High-throughput

0.650

High

702092

1433Z
14-3-3 protein zeta/delta

3

11

High-throughput

0.641

High

60620

TESP1
Protein TESPA1

3

0

High-throughput

0.638

High

298252

BODG
Gamma-butyrobetaine dioxygenase

3

0

High-throughput

0.638

High

378954

PIGR
Polymeric immunoglobulin receptor

3

0

High-throughput

0.638

High

651165

CBL
E3 ubiquitin-protein ligase CBL

3

0

High-throughput

0.638

High

702117

PCM1
Pericentriolar material 1 protein

3

0

High-throughput

0.638

High

702159

VP33B
Vacuolar protein sorting-associated protein 33B

3

0

High-throughput

0.638

High

286625

STX11
Syntaxin-11

2

1

High-throughput

0.628

High

702163

ANLN
Anillin

3

0

High-throughput

0.628

High

702125

FKB15
FK506-binding protein 15

3

1

High-throughput

0.609

High

702134

ARC
Activity-regulated cytoskeleton-associated protein

2

0

High-throughput

0.602

High

702145

LMBL2
Lethal(3)malignant brain tumor-like protein 2

2

0

High-throughput

0.602

High

387102

TNNC2
Troponin C, skeletal muscle

2

2

High-throughput

0.601

High

702154

TS101
Tumor susceptibility gene 101 protein

2

0

High-throughput

0.577

High

702101

DUS4
Dual specificity protein phosphatase 4

2

1

High-throughput

0.571

High

702116

KPCD1
Serine/threonine-protein kinase D1

2

1

High-throughput

0.571

High

702137

SH2D3
SH2 domain-containing protein 3C

2

2

High-throughput

0.571

High

702076

BRCA1
Breast cancer type 1 susceptibility protein

2

0

High-throughput

0.561

High

379617

IGHA1
Immunoglobulin heavy constant alpha 1

2

1

High-throughput

0.552

High

379727

IGHA2
Immunoglobulin heavy constant alpha 2

2

1

High-throughput

0.552

High

123599

MYO1C
Unconventional myosin-Ic

1

1

High-throughput

0.536

High

227205

KRT86
Keratin, type II cuticular Hb6

1

2

High-throughput

0.536

High

248673

PEPL
Periplakin

1

2

High-throughput

0.536

High

702090

PP1B
Serine/threonine-protein phosphatase PP1-beta catalytic subunit

1

1

High-throughput

0.536

High

702093

KRT83
Keratin, type II cuticular Hb3

1

2

High-throughput

0.536

High

702096

CALD1
Caldesmon

1

3

High-throughput

0.536

High

702102

KCC2B
Calcium/calmodulin-dependent protein kinase type II subunit beta

1

3

High-throughput

0.536

High

702103

KCC2G
Calcium/calmodulin-dependent protein kinase type II subunit gamma

1

3

High-throughput

0.536

High

702104

KCC2D
Calcium/calmodulin-dependent protein kinase type II subunit delta

1

3

High-throughput

0.536

High

702108

SRC8
Src substrate cortactin

1

1

High-throughput

0.536

High

702111

KRT81
Keratin, type II cuticular Hb1

1

2

High-throughput

0.536

High

702126

KIF24
Kinesin-like protein KIF24

1

1

High-throughput

0.536

High

702142

MY18A
Unconventional myosin-XVIIIa

1

1

High-throughput

0.536

High

702150

MYO19
Unconventional myosin-XIX

1

1

High-throughput

0.536

High

702157

DUS16
Dual specificity protein phosphatase 16

1

1

High-throughput

0.536

High

702166

KCC2A
Calcium/calmodulin-dependent protein kinase type II subunit alpha

1

3

High-throughput

0.536

High

702085

SMCA2
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2

1

0

High-throughput

0.518

High

249572

SNX3
Sorting nexin-3

1

0

High-throughput

0.513

High

536560

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.513

High

598694

ANFB
Natriuretic peptides B

1

0

High-throughput

0.513

High

637358

FLNA
Filamin-A

1

0

High-throughput

0.513

High

702074

MYH9
Myosin-9

1

0

High-throughput

0.513

High

702079

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

0

High-throughput

0.513

High

702080

CAZA2
F-actin-capping protein subunit alpha-2

1

0

High-throughput

0.513

High

702082

KC1A
Casein kinase I isoform alpha

1

0

High-throughput

0.513

High

702084

RAB7A
Ras-related protein Rab-7a

1

0

High-throughput

0.513

High

702098

PCDH1
Protocadherin-1

1

0

High-throughput

0.513

High

702107

SCRB2
Lysosome membrane protein 2

1

0

High-throughput

0.513

High

702118

MARE1
Microtubule-associated protein RP/EB family member 1

1

0

High-throughput

0.513

High

702135

MYPN
Myopalladin

1

0

High-throughput

0.513

High

702148

VMP1
Vacuole membrane protein 1

1

0

High-throughput

0.513

High

702149

GWL
Serine/threonine-protein kinase greatwall

1

0

High-throughput

0.513

High

702087

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

1

Small-scale

0.501

High

374418

RASH
GTPase HRas

1

0

High-throughput

0.493

High

442241

GELS
Gelsolin

1

0

High-throughput

0.493

High

692654

CALL3
Calmodulin-like protein 3

1

1

High-throughput

0.489

High

184686

ATX7
Ataxin-7

1

0

High-throughput

0.486

High

323191

TRI37
E3 ubiquitin-protein ligase TRIM37

1

1

High-throughput

0.479

High

330680

KI20A
Kinesin-like protein KIF20A

1

1

High-throughput

0.479

High

519768

ANDR
Androgen receptor

1

2

High-throughput

0.479

High

534678

BIP
Endoplasmic reticulum chaperone BiP

1

1

High-throughput

0.479

High

702072

1433S
14-3-3 protein sigma

1

11

High-throughput

0.479

High

702075

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

1

High-throughput

0.479

High

702099

STX4
Syntaxin-4

1

1

High-throughput

0.479

High

702114

TNIP1
TNFAIP3-interacting protein 1

1

1

High-throughput

0.479

High

702131

SYNE3
Nesprin-3

1

1

High-throughput

0.479

High

702143

ESR2
Estrogen receptor beta

1

2

High-throughput

0.479

High

702152

DNJC1
DnaJ homolog subfamily C member 1

1

1

High-throughput

0.479

High

702097

KHDR1
KH domain-containing, RNA-binding, signal transduction-associated protein 1

1

0

High-throughput

0.460

High

247688

NUPR1
Nuclear protein 1

1

0

High-throughput

0.458

High

486986

PARP1
Poly [ADP-ribose] polymerase 1

1

0

High-throughput

0.458

High

555890

CADH1
Cadherin-1

1

0

High-throughput

0.458

High

583462

ATF2
Cyclic AMP-dependent transcription factor ATF-2

1

0

High-throughput

0.458

High

629584

BTF3
Transcription factor BTF3

1

0

High-throughput

0.458

High

657491

GCSP
Glycine dehydrogenase

1

0

High-throughput

0.458

High

702070

DPOD1
DNA polymerase delta catalytic subunit

1

0

High-throughput

0.458

High

702081

SOX2
Transcription factor SOX-2

1

0

High-throughput

0.458

High

702083

EMD
Emerin

1

0

High-throughput

0.458

High

702086

PSA
Puromycin-sensitive aminopeptidase

1

0

High-throughput

0.458

High

702088

ABCE1
ATP-binding cassette sub-family E member 1

1

0

High-throughput

0.458

High

702094

TF65
Transcription factor p65

1

0

High-throughput

0.458

High

702100

UBP4
Ubiquitin carboxyl-terminal hydrolase 4

1

0

High-throughput

0.458

High

702105

STIM1
Stromal interaction molecule 1

1

0

High-throughput

0.458

High

702106

CUL3
Cullin-3

1

0

High-throughput

0.458

High

702110

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

1

0

High-throughput

0.458

High

702115

KIF14
Kinesin-like protein KIF14

1

0

High-throughput

0.458

High

702120

IF16
Gamma-interferon-inducible protein 16

1

0

High-throughput

0.458

High

702140

ZBT38
Zinc finger and BTB domain-containing protein 38

1

0

High-throughput

0.458

High

702141

NUP43
Nucleoporin Nup43

1

0

High-throughput

0.458

High

702144

TF3B
Transcription factor IIIB 90 kDa subunit

1

0

Small-scale

0.458

High

702156

FACD2
Fanconi anemia group D2 protein

1

0

High-throughput

0.458

High

702158

CCDC8
Coiled-coil domain-containing protein 8

1

0

High-throughput

0.458

High

702160

CHM4B
Charged multivesicular body protein 4b

1

0

High-throughput

0.458

High

702165

ALK
ALK tyrosine kinase receptor

1

0

High-throughput

0.458

High

702161

WNK1
Serine/threonine-protein kinase WNK1

1

3

High-throughput

0.457

High

516469

CALM3
Calmodulin-3

1

1

High-throughput

0.445

High

702133

CR3L2
Cyclic AMP-responsive element-binding protein 3-like protein 2

1

1

High-throughput

0.445

High

702151

P121A
Nuclear envelope pore membrane protein POM 121

1

1

High-throughput

0.445

High

351207

MOT3
Monocarboxylate transporter 3

1

0

High-throughput

0.426

High

563250

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.426

High

702073

BMI1
Polycomb complex protein BMI-1

1

0

High-throughput

0.426

High

702164

MS18A
Protein Mis18-alpha

1

0

High-throughput

0.426

High

702109

FGL2
Fibroleukin

3

0

High-throughput

0.347

High

702123

TFDP3
Transcription factor Dp family member 3

3

0

High-throughput

0.347

High

702136

DJC10
DnaJ homolog subfamily C member 10

2

0

High-throughput

0.328

High

702153

TAFA4
Chemokine-like protein TAFA-4

2

0

High-throughput

0.328

High

702155

AASD1
Alanyl-tRNA editing protein Aarsd1

2

0

High-throughput

0.328

High

702162

ZCC17
Zinc finger CCHC domain-containing protein 17

2

0

High-throughput

0.328

High

702167

LC7L2
Putative RNA-binding protein Luc7-like 2

1

0

High-throughput

0.282

High

702078

MAGA9
Melanoma-associated antigen 9

1

0

High-throughput

0.279

Low

702119

DREB
Drebrin

1

0

High-throughput

0.279

Low

702121

CF184
Cilia- and flagella-associated protein 184

1

0

High-throughput

0.279

Low

702122

UROL1
Uromodulin-like 1

1

0

High-throughput

0.279

Low

702138

FA24B
Protein FAM24B

1

0

High-throughput

0.279

Low

702139

ABTB2
Ankyrin repeat and BTB/POZ domain-containing protein 2

1

0

High-throughput

0.279

Low

702168

IRAG1
Inositol 1,4,5-triphosphate receptor associated 1

1

0

High-throughput

0.279

Low

352750

F107A
Actin-associated protein FAM107A

1

0

Small-scale

0.251

Low

702077

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

0

High-throughput

0.249

Low

702113

HAPR1
HUWE1-associated protein modifying stress responses 1

1

0

High-throughput

0.249

Low

702129

LRC31
Leucine-rich repeat-containing protein 31

1

0

High-throughput

0.249

Low

702132

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

702146

LRC59
Leucine-rich repeat-containing protein 59

1

0

High-throughput

0.249

Low

702112

MFS10
Major facilitator superfamily domain-containing protein 10

1

0

High-throughput

0.232

Low

702124

CF141
Uncharacterized protein C6orf141

1

0

High-throughput

0.232

Low

702127

SFRP4
Secreted frizzled-related protein 4

1

0

High-throughput

0.232

Low

702128

NPAL3
NIPA-like protein 3

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025