Protein: RGPS2
Ras-specific guanine nucleotide-releasing factor RalGPS2 (Ral GEF with PH domain and SH3-binding motif 2) (RalA exchange factor RalGPS2)

Gene: RGPS2, RALGPS2
Organism: Homo sapiens
Interactions: 46
UniProt ID: Q86X27

Gene Ontology (top 5):
GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0005737 - cytoplasm
GO:0005886 - plasma membrane
GO:0007265 - Ras protein signal transduction

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

374724

RASH
GTPase HRas

2

20

High-throughput

0.754

High

730022

1433B
14-3-3 protein beta/alpha

8

20

High-throughput

0.751

High

990448

1433Z
14-3-3 protein zeta/delta

6

20

High-throughput

0.739

High

966566

1433G
14-3-3 protein gamma

6

20

High-throughput

0.738

High

691203

1433T
14-3-3 protein theta

5

20

High-throughput

0.714

High

1049515

1433F
14-3-3 protein eta

4

20

High-throughput

0.699

High

245247

MAST3
Microtubule-associated serine/threonine-protein kinase 3

1

6

High-throughput

0.618

High

269578

SRGP2
SLIT-ROBO Rho GTPase-activating protein 2

1

1

High-throughput

0.618

High

374026

RASN
GTPase NRas

1

20

High-throughput

0.618

High

375680

RASK
GTPase KRas

1

20

High-throughput

0.618

High

1216006

M3K21
Mitogen-activated protein kinase kinase kinase 21

1

6

High-throughput

0.618

High

1216067

SPD2A
SH3 and PX domain-containing protein 2A

1

17

High-throughput

0.618

High

1293237

KSR1
Kinase suppressor of Ras 1

1

5

High-throughput

0.618

High

1293245

KI13B
Kinesin-like protein KIF13B

1

3

High-throughput

0.618

High

971737

1433E
14-3-3 protein epsilon

2

4

High-throughput

0.611

High

1293243

OSBL3
Oxysterol-binding protein-related protein 3

2

1

High-throughput

0.606

High

730738

1433S
14-3-3 protein sigma

2

20

High-throughput

0.601

High

1065728

CAMP2
Calmodulin-regulated spectrin-associated protein 2

1

4

High-throughput

0.553

High

1293239

SH3R3
E3 ubiquitin-protein ligase SH3RF3

1

20

High-throughput

0.553

High

1293241

RTKN
Rhotekin

1

0

High-throughput

0.517

High

348597

AIFM1
Apoptosis-inducing factor 1, mitochondrial

1

0

High-throughput

0.493

High

208699

SI1L1
Signal-induced proliferation-associated 1-like protein 1

1

2

High-throughput

0.479

High

637921

NF1
Neurofibromin

1

2

High-throughput

0.479

High

719345

MPIP3
M-phase inducer phosphatase 3

1

2

High-throughput

0.479

High

941009

HDAC4
Histone deacetylase 4

1

2

High-throughput

0.479

High

1090155

PTN13
Tyrosine-protein phosphatase non-receptor type 13

1

9

High-throughput

0.479

High

1219596

DEN4C
DENN domain-containing protein 4C

1

1

High-throughput

0.479

High

1293238

DEN1A
DENN domain-containing protein 1A

1

2

High-throughput

0.479

High

1293242

OSBL6
Oxysterol-binding protein-related protein 6

1

1

High-throughput

0.479

High

1293246

INP5E
Phosphatidylinositol polyphosphate 5-phosphatase type IV

1

2

High-throughput

0.479

High

1293248

CING
Cingulin

1

1

High-throughput

0.479

High

1293251

PPM1H
Protein phosphatase 1H

1

1

High-throughput

0.479

High

1293253

KCTD3
BTB/POZ domain-containing protein KCTD3

1

5

High-throughput

0.479

High

252106

IF4E2
Eukaryotic translation initiation factor 4E type 2

1

0

High-throughput

0.458

High

1293247

LRFN1
Leucine-rich repeat and fibronectin type III domain-containing protein 1

1

0

High-throughput

0.458

High

281364

GGYF1
GRB10-interacting GYF protein 1

1

4

High-throughput

0.437

High

1251370

GGYF2
GRB10-interacting GYF protein 2

1

6

High-throughput

0.437

High

1290571

ZCH18
Zinc finger CCCH domain-containing protein 18

1

4

High-throughput

0.437

High

1293244

TANC2
Protein TANC2

1

6

High-throughput

0.437

High

1293249

NGAP
Ras GTPase-activating protein nGAP

1

2

High-throughput

0.437

High

339091

NADK
NAD kinase

1

0

High-throughput

0.249

Low

372468

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.249

Low

1293240

LPIN3
Phosphatidate phosphatase LPIN3

1

0

High-throughput

0.249

Low

1293250

ZBT21
Zinc finger and BTB domain-containing protein 21

1

0

High-throughput

0.249

Low

1293252

CBY1
Protein chibby homolog 1

1

0

High-throughput

0.249

Low

1258488

CR3L2
Cyclic AMP-responsive element-binding protein 3-like protein 2

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025