Protein: PPM1H
Protein phosphatase 1H (EC 3.1.3.16)

Gene: PPM1H
Organism: Homo sapiens
Interactions: 122
UniProt ID: Q9ULR3

Gene Ontology (top 5):
GO:0004721 - phosphoprotein phosphatase activity
GO:0004741 - [pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1205811

PPM1J
Protein phosphatase 1J

3

6

Small-scale

0.855

High

1461670

PPM1H
Protein phosphatase 1H

2

6

High-throughput

0.783

High

730346

1433B
14-3-3 protein beta/alpha

4

8

High-throughput

0.697

High

967011

1433G
14-3-3 protein gamma

4

8

High-throughput

0.697

High

1049900

1433F
14-3-3 protein eta

4

8

High-throughput

0.697

High

728477

AKT1
RAC-alpha serine/threonine-protein kinase

1

3

Small-scale

0.647

High

691532

1433T
14-3-3 protein theta

2

8

High-throughput

0.628

High

972120

1433E
14-3-3 protein epsilon

2

1

High-throughput

0.628

High

990861

1433Z
14-3-3 protein zeta/delta

2

8

High-throughput

0.628

High

176896

DCLK1
Serine/threonine-protein kinase DCLK1

1

13

High-throughput

0.618

High

245289

MAST3
Microtubule-associated serine/threonine-protein kinase 3

1

3

High-throughput

0.618

High

1025606

CDK16
Cyclin-dependent kinase 16

1

5

High-throughput

0.618

High

1209788

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

2

Small-scale

0.575

High

1129995

MELK
Maternal embryonic leucine zipper kinase

1

17

High-throughput

0.553

High

926430

BLM
RecQ-like DNA helicase BLM

1

1

High-throughput

0.536

High

1398875

ZN641
Zinc finger protein 641

1

0

High-throughput

0.513

High

1454290

ZN492
Zinc finger protein 492

1

0

High-throughput

0.513

High

215456

TPD54
Tumor protein D54

1

1

High-throughput

0.479

High

230592

KIF1C
Kinesin-like protein KIF1C

1

1

High-throughput

0.479

High

269633

SRGP2
SLIT-ROBO Rho GTPase-activating protein 2

1

1

High-throughput

0.479

High

637975

NF1
Neurofibromin

1

1

High-throughput

0.479

High

719280

MPIP2
M-phase inducer phosphatase 2

1

1

High-throughput

0.479

High

719386

MPIP3
M-phase inducer phosphatase 3

1

1

High-throughput

0.479

High

938084

TPD52
Tumor protein D52

1

1

High-throughput

0.479

High

941089

HDAC4
Histone deacetylase 4

1

3

High-throughput

0.479

High

1090203

PTN13
Tyrosine-protein phosphatase non-receptor type 13

1

2

High-throughput

0.479

High

1152064

PTN14
Tyrosine-protein phosphatase non-receptor type 14

1

2

High-throughput

0.479

High

1216037

M3K21
Mitogen-activated protein kinase kinase kinase 21

1

5

High-throughput

0.479

High

1216107

SPD2A
SH3 and PX domain-containing protein 2A

1

1

High-throughput

0.479

High

1235021

PKHA7
Pleckstrin homology domain-containing family A member 7

1

2

High-throughput

0.479

High

1245766

LARP1
La-related protein 1

1

1

High-throughput

0.479

High

1256069

TRI67
Tripartite motif-containing protein 67

1

4

High-throughput

0.479

High

1257055

SYDE1
Rho GTPase-activating protein SYDE1

1

3

High-throughput

0.479

High

1272895

RFIP2
Rab11 family-interacting protein 2

1

3

High-throughput

0.479

High

1277720

MYCPP
C-myc promoter-binding protein

1

3

High-throughput

0.479

High

1293251

RGPS2
Ras-specific guanine nucleotide-releasing factor RalGPS2

1

1

High-throughput

0.479

High

1309264

KSR1
Kinase suppressor of Ras 1

1

2

High-throughput

0.479

High

1322674

RPTOR
Regulatory-associated protein of mTOR

1

1

High-throughput

0.479

High

1349485

F110B
Protein FAM110B

1

1

High-throughput

0.479

High

1356781

HDAC7
Histone deacetylase 7

1

3

High-throughput

0.479

High

1360418

SRS12
Serine/arginine-rich splicing factor 12

1

1

High-throughput

0.479

High

1365020

TSC1
Hamartin

1

2

High-throughput

0.479

High

1368203

HDAC2
Histone deacetylase 2

1

1

High-throughput

0.479

High

1401137

MAGI1
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1

1

1

High-throughput

0.479

High

1402228

TESK2
Dual specificity testis-specific protein kinase 2

1

2

High-throughput

0.479

High

1410267

F110A
Protein FAM110A

1

1

High-throughput

0.479

High

1437683

PKHA5
Pleckstrin homology domain-containing family A member 5

1

2

High-throughput

0.479

High

1447280

KI13B
Kinesin-like protein KIF13B

1

1

High-throughput

0.479

High

1448826

INP5E
Phosphatidylinositol polyphosphate 5-phosphatase type IV

1

1

High-throughput

0.479

High

1451954

MIOS
GATOR2 complex protein MIOS

1

1

High-throughput

0.479

High

1459287

ZRAN1
Ubiquitin thioesterase ZRANB1

1

3

High-throughput

0.479

High

1460598

NGAP
Ras GTPase-activating protein nGAP

1

1

High-throughput

0.479

High

1460942

UBP21
Ubiquitin carboxyl-terminal hydrolase 21

1

1

High-throughput

0.479

High

1461673

GAB2
GRB2-associated-binding protein 2

1

4

High-throughput

0.479

High

1461675

STA13
StAR-related lipid transfer protein 13

1

2

High-throughput

0.479

High

160922

STX16
Syntaxin-16

1

0

High-throughput

0.458

High

181458

PGRC2
Membrane-associated progesterone receptor component 2

1

0

High-throughput

0.458

High

208757

SI1L1
Signal-induced proliferation-associated 1-like protein 1

1

0

High-throughput

0.458

High

252192

IF4E2
Eukaryotic translation initiation factor 4E type 2

1

0

High-throughput

0.458

High

431936

ITB1
Integrin beta-1

1

0

High-throughput

0.458

High

548639

MPRI
Cation-independent mannose-6-phosphate receptor

1

0

High-throughput

0.458

High

1010889

TMF1
TATA element modulatory factor

1

0

High-throughput

0.458

High

1061318

RHG01
Rho GTPase-activating protein 1

1

0

High-throughput

0.458

High

1102685

MTA1
Metastasis-associated protein MTA1

1

0

High-throughput

0.458

High

1105677

GOGA4
Golgin subfamily A member 4

1

0

High-throughput

0.458

High

1134085

ZN638
Zinc finger protein 638

1

0

High-throughput

0.458

High

1338126

NAV1
Neuron navigator 1

1

0

High-throughput

0.458

High

1409802

SIN1
Target of rapamycin complex 2 subunit MAPKAP1

1

0

High-throughput

0.458

High

1410859

LPIN3
Phosphatidate phosphatase LPIN3

1

0

High-throughput

0.458

High

1412893

RTKN
Rhotekin

1

0

High-throughput

0.458

High

1419932

WDR11
WD repeat-containing protein 11

1

0

High-throughput

0.458

High

1452552

FA53C
Protein FAM53C

1

0

High-throughput

0.458

High

1460465

LCAP
Leucyl-cystinyl aminopeptidase

1

0

High-throughput

0.458

High

1461586

ZBT21
Zinc finger and BTB domain-containing protein 21

1

0

High-throughput

0.458

High

1461674

CBY1
Protein chibby homolog 1

1

0

High-throughput

0.458

High

144333

ACACB
Acetyl-CoA carboxylase 2

1

1

Small-scale

0.445

High

170548

RAB7L
Ras-related protein Rab-7L1

1

7

Small-scale

0.445

High

631555

RAB5A
Ras-related protein Rab-5A

1

5

Small-scale

0.445

High

901674

RAB7A
Ras-related protein Rab-7a

1

6

Small-scale

0.445

High

956025

RAB8A
Ras-related protein Rab-8A

1

5

Small-scale

0.445

High

1094282

ACACA
Acetyl-CoA carboxylase 1

1

1

Small-scale

0.445

High

281455

GGYF1
GRB10-interacting GYF protein 1

1

1

High-throughput

0.437

High

989397

VAMP2
Vesicle-associated membrane protein 2

1

1

High-throughput

0.437

High

1092515

TIAM1
Rho guanine nucleotide exchange factor TIAM1

1

1

High-throughput

0.437

High

1154783

VAMP3
Vesicle-associated membrane protein 3

1

1

High-throughput

0.437

High

1219640

DEN4C
DENN domain-containing protein 4C

1

3

High-throughput

0.437

High

1229911

AN34A
Ankyrin repeat domain-containing protein 34A

1

3

High-throughput

0.437

High

1251469

GGYF2
GRB10-interacting GYF protein 2

1

3

High-throughput

0.437

High

1352623

DEN1A
DENN domain-containing protein 1A

1

3

High-throughput

0.437

High

1352642

SH3R3
E3 ubiquitin-protein ligase SH3RF3

1

5

High-throughput

0.437

High

1357445

DEP1B
DEP domain-containing protein 1B

1

1

High-throughput

0.437

High

1461672

AGAP1
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1

1

1

High-throughput

0.437

High

980531

H4
Histone H4

1

0

Small-scale

0.426

High

1398396

CEP63
Centrosomal protein of 63 kDa

1

0

High-throughput

0.426

High

1408040

H2B1M
Histone H2B type 1-M

1

0

Small-scale

0.426

High

1432821

GCP60
Golgi resident protein GCP60

1

0

Small-scale

0.426

High

901102

RAB5C
Ras-related protein Rab-5C

1

6

Small-scale

0.407

High

902233

RAB13
Ras-related protein Rab-13

1

5

Small-scale

0.407

High

956624

RAB5B
Ras-related protein Rab-5B

1

6

Small-scale

0.407

High

956802

RAB10
Ras-related protein Rab-10

1

5

Small-scale

0.407

High

981380

RAB1A
Ras-related protein Rab-1A

1

3

Small-scale

0.407

High

1145169

RAB35
Ras-related protein Rab-35

1

6

Small-scale

0.407

High

1370784

RAB8B
Ras-related protein Rab-8B

1

5

Small-scale

0.407

High

1430489

RAB1B
Ras-related protein Rab-1B

1

4

Small-scale

0.407

High

178858

SCAM1
Secretory carrier-associated membrane protein 1

1

0

High-throughput

0.249

Low

300063

CBPD
Carboxypeptidase D

1

0

High-throughput

0.249

Low

339120

NADK
NAD kinase

1

0

High-throughput

0.249

Low

880741

LMAN1
Protein ERGIC-53

1

0

High-throughput

0.249

Low

1065784

CAMP2
Calmodulin-regulated spectrin-associated protein 2

1

0

High-throughput

0.249

Low

1187148

TBC25
TBC1 domain family member 25

1

0

High-throughput

0.249

Low

1225986

F91A1
Protein FAM91A1

1

0

High-throughput

0.249

Low

1286562

PHLB2
Pleckstrin homology-like domain family B member 2

1

0

High-throughput

0.249

Low

1419846

OSBL6
Oxysterol-binding protein-related protein 6

1

0

High-throughput

0.249

Low

1431955

S6A15
Sodium-dependent neutral amino acid transporter B(0)AT2

1

0

High-throughput

0.249

Low

1438856

TANC2
Protein TANC2

1

0

High-throughput

0.249

Low

1454250

LRFN1
Leucine-rich repeat and fibronectin type III domain-containing protein 1

1

0

High-throughput

0.249

Low

1454714

CING
Cingulin

1

0

High-throughput

0.249

Low

1459748

LIMA1
LIM domain and actin-binding protein 1

1

0

High-throughput

0.249

Low

1461671

S12A4
Solute carrier family 12 member 4

1

0

High-throughput

0.249

Low

1461676

KCTD3
BTB/POZ domain-containing protein KCTD3

1

0

High-throughput

0.249

Low

187819

EIF3D
Eukaryotic translation initiation factor 3 subunit D

1

0

Small-scale

0.232

Low


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Last updated: 11Aug2025