Protein: TRM2A
tRNA (uracil-5-)-methyltransferase homolog A (EC 2.1.1.35) (mRNA (uracil-5-)-methyltransferase TRMT2A) (EC 2.1.1.-)

Gene: TRM2A, TRMT2A
Organism: Homo sapiens
Interactions: 146
UniProt ID: Q8IZ69

Gene Ontology (top 5):
GO:0003723 - RNA binding
GO:0005829 - cytosol
GO:0006397 - mRNA processing
GO:0008033 - tRNA processing
GO:0008169 - C-methyltransferase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1316052

PASK
PAS domain-containing serine/threonine-protein kinase

3

2

High-throughput

0.667

High

431183

LA
Lupus La protein

3

0

High-throughput

0.646

High

177257

ANR28
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A

2

5

High-throughput

0.628

High

273687

PP6R2
Serine/threonine-protein phosphatase 6 regulatory subunit 2

2

2

High-throughput

0.628

High

274191

ANR17
Ankyrin repeat domain-containing protein 17

2

5

High-throughput

0.628

High

1149128

SF3A1
Splicing factor 3A subunit 1

2

1

High-throughput

0.628

High

1204758

PP6R3
Serine/threonine-protein phosphatase 6 regulatory subunit 3

2

2

High-throughput

0.628

High

1316074

PP6R1
Serine/threonine-protein phosphatase 6 regulatory subunit 1

2

2

High-throughput

0.628

High

1311336

ANKH1
Ankyrin repeat and KH domain-containing protein 1

2

5

High-throughput

0.611

High

1150663

TRBP2
RISC-loading complex subunit TARBP2

2

0

High-throughput

0.602

High

1316049

UBP47
Ubiquitin carboxyl-terminal hydrolase 47

2

0

High-throughput

0.602

High

1316075

DICER
Endoribonuclease Dicer

2

0

High-throughput

0.602

High

659531

CRCM
Colorectal mutant cancer protein

2

0

High-throughput

0.580

High

1316065

PICK1
PRKCA-binding protein

2

0

High-throughput

0.580

High

422551

A4
Amyloid-beta precursor protein

2

0

High-throughput

0.577

High

258979

DNJA2
DnaJ homolog subfamily A member 2

2

0

High-throughput

0.576

High

831042

CCNF
Cyclin-F

2

0

High-throughput

0.576

High

1316035

ANR44
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B

2

5

High-throughput

0.574

High

1316036

ANR52
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C

2

5

High-throughput

0.574

High

1316041

APBP2
Amyloid protein-binding protein 2

2

1

High-throughput

0.553

High

1118519

TBB2A
Tubulin beta-2A chain

2

1

High-throughput

0.549

High

997419

TBB4B
Tubulin beta-4B chain

1

1

High-throughput

0.536

High

1316042

IRF7
Interferon regulatory factor 7

1

1

High-throughput

0.536

High

372539

MYC
Myc proto-oncogene protein

2

1

High-throughput

0.533

High

533950

IRF1
Interferon regulatory factor 1

1

1

High-throughput

0.515

High

143660

PPP6
Serine/threonine-protein phosphatase 6 catalytic subunit

1

0

High-throughput

0.513

High

230352

CREB3
Cyclic AMP-responsive element-binding protein 3

1

0

High-throughput

0.513

High

547466

DMD
Dystrophin

1

0

High-throughput

0.513

High

593435

PGFRA
Platelet-derived growth factor receptor alpha

1

0

High-throughput

0.513

High

656013

CAH6
Carbonic anhydrase 6

1

0

High-throughput

0.513

High

896576

VASP
Vasodilator-stimulated phosphoprotein

1

0

High-throughput

0.513

High

1088704

SF3A3
Splicing factor 3A subunit 3

1

0

High-throughput

0.513

High

1226705

2ABD
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform

1

0

High-throughput

0.513

High

1272830

DHX32
Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32

1

0

High-throughput

0.513

High

1316059

THTPA
Thiamine-triphosphatase

1

0

High-throughput

0.513

High

1316060

LST8
Target of rapamycin complex subunit LST8

1

0

High-throughput

0.513

High

1316066

SMYD2
N-lysine methyltransferase SMYD2

1

0

High-throughput

0.513

High

1316067

ANM7
Protein arginine N-methyltransferase 7

1

0

High-throughput

0.513

High

549191

CDK4
Cyclin-dependent kinase 4

1

1

High-throughput

0.508

High

635729

RASA1
Ras GTPase-activating protein 1

1

1

High-throughput

0.508

High

1316040

P55G
Phosphatidylinositol 3-kinase regulatory subunit gamma

1

2

High-throughput

0.508

High

710860

EPHB2
Ephrin type-B receptor 2

1

2

High-throughput

0.500

High

221944

FOXS1
Forkhead box protein S1

1

2

High-throughput

0.489

High

288118

FOXH1
Forkhead box protein H1

1

2

High-throughput

0.489

High

665272

GA45A
Growth arrest and DNA damage-inducible protein GADD45 alpha

1

1

High-throughput

0.489

High

706214

S10A2
Protein S100-A2

1

1

High-throughput

0.489

High

710729

EPHA8
Ephrin type-A receptor 8

1

2

High-throughput

0.489

High

945714

FOXL2
Forkhead box protein L2

1

2

High-throughput

0.489

High

1091316

FOXL1
Forkhead box protein L1

1

2

High-throughput

0.489

High

1147371

EPHA7
Ephrin type-A receptor 7

1

2

High-throughput

0.489

High

1316034

KCD17
BTB/POZ domain-containing protein KCTD17

1

1

High-throughput

0.489

High

1316039

OIT3
Oncoprotein-induced transcript 3 protein

1

1

High-throughput

0.489

High

405508

KITH
Thymidine kinase, cytosolic

1

0

High-throughput

0.486

High

627991

ANXA7
Annexin A7

1

0

High-throughput

0.486

High

808116

CDN1A
Cyclin-dependent kinase inhibitor 1

1

0

High-throughput

0.486

High

1096588

AIMP2
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

1

0

High-throughput

0.486

High

1109321

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

1

0

High-throughput

0.486

High

1160512

SMN
Survival motor neuron protein

1

0

High-throughput

0.486

High

508266

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

0

High-throughput

0.480

High

363549

EGFR
Epidermal growth factor receptor

1

2

High-throughput

0.479

High

902858

BLK
Tyrosine-protein kinase Blk

1

1

High-throughput

0.479

High

942741

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

1

High-throughput

0.479

High

1113651

CUL3
Cullin-3

1

1

High-throughput

0.479

High

1232452

Q6FHY5
MEOX2 protein

1

1

High-throughput

0.470

High

332164

GA45G
Growth arrest and DNA damage-inducible protein GADD45 gamma

1

1

High-throughput

0.464

High

616342

RCC1
Regulator of chromosome condensation

1

1

High-throughput

0.464

High

317887

LTN1
E3 ubiquitin-protein ligase listerin

1

0

High-throughput

0.458

High

342952

HERC2
E3 ubiquitin-protein ligase HERC2

1

0

High-throughput

0.458

High

472882

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

0

High-throughput

0.458

High

905617

IRAK1
Interleukin-1 receptor-associated kinase 1

1

0

High-throughput

0.458

High

1105994

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

0

High-throughput

0.458

High

1137850

TNIP1
TNFAIP3-interacting protein 1

1

0

High-throughput

0.458

High

1178241

CL16A
Protein CLEC16A

1

0

High-throughput

0.458

High

1229466

CDCA2
Cell division cycle-associated protein 2

1

0

High-throughput

0.458

High

1306897

DCP2
m7GpppN-mRNA hydrolase

1

0

High-throughput

0.458

High

1316043

FBX32
F-box only protein 32

1

0

High-throughput

0.458

High

1316046

RBM33
RNA-binding protein 33

1

0

High-throughput

0.458

High

1316051

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.458

High

1316055

MMS19
MMS19 nucleotide excision repair protein homolog

1

0

High-throughput

0.458

High

1316068

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.458

High

1316070

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

686836

S10A4
Protein S100-A4

1

1

High-throughput

0.445

High

894003

MEOX2
Homeobox protein MOX-2

1

1

High-throughput

0.439

High

406377

MYCN
N-myc proto-oncogene protein

1

1

High-throughput

0.437

High

1316064

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.437

High

1316073

HECD1
E3 ubiquitin-protein ligase HECTD1

1

3

Small-scale

0.437

High

401125

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.426

High

430119

JUN
Transcription factor Jun

1

0

High-throughput

0.426

High

1161143

MK06
Mitogen-activated protein kinase 6

1

0

High-throughput

0.426

High

96881

E9PDP5
Ankyrin repeat and KH domain containing 1

1

5

High-throughput

0.407

High

1315335

THNS1
Threonine synthase-like 1

2

0

High-throughput

0.328

High

1316050

TOPK
Lymphokine-activated killer T-cell-originated protein kinase

2

0

High-throughput

0.328

High

1316054

ERBIN
Erbin

2

0

High-throughput

0.328

High

1316056

ATP5S
ATP synthase subunit s, mitochondrial

2

0

High-throughput

0.328

High

1316063

SMRCD
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1

2

0

High-throughput

0.328

High

1316071

FEZ2
Fasciculation and elongation protein zeta-2

2

0

High-throughput

0.328

High

1316078

ACOT9
Acyl-coenzyme A thioesterase 9, mitochondrial

2

0

High-throughput

0.328

High

1061771

TLE5
TLE family member 5

2

0

High-throughput

0.316

High

1131197

MESD
LRP chaperone MESD

2

0

High-throughput

0.316

High

1316045

ZN837
Zinc finger protein 837

2

0

High-throughput

0.316

High

239125

ZNRD2
Protein ZNRD2

2

0

High-throughput

0.313

High

154848

ISLR
Immunoglobulin superfamily containing leucine-rich repeat protein

1

0

High-throughput

0.279

Low

260905

RAMP3
Receptor activity-modifying protein 3

1

0

High-throughput

0.279

Low

449613

KLK1
Kallikrein-1

1

0

High-throughput

0.279

Low

472189

TRFM
Melanotransferrin

1

0

High-throughput

0.279

Low

549821

CD79A
B-cell antigen receptor complex-associated protein alpha chain

1

0

High-throughput

0.279

Low

647377

IDS
Iduronate 2-sulfatase

1

0

High-throughput

0.279

Low

841567

I12R1
Interleukin-12 receptor subunit beta-1

1

0

High-throughput

0.279

Low

848674

MAGA9
Melanoma-associated antigen 9

1

0

High-throughput

0.279

Low

933198

SLUR1
Secreted Ly-6/uPAR-related protein 1

1

0

High-throughput

0.279

Low

945940

LOXL3
Lysyl oxidase homolog 3

1

0

High-throughput

0.279

Low

1057102

FMOD
Fibromodulin

1

0

High-throughput

0.279

Low

1066237

DMWD
Dystrophia myotonica WD repeat-containing protein

1

0

High-throughput

0.279

Low

1108798

ASAH1
Acid ceramidase

1

0

High-throughput

0.279

Low

1116244

PTC1
Protein patched homolog 1

1

0

High-throughput

0.279

Low

1207370

EFHC1
EF-hand domain-containing protein 1

1

0

High-throughput

0.279

Low

1279819

BTLA
B- and T-lymphocyte attenuator

1

0

High-throughput

0.279

Low

1291392

TXND2
Thioredoxin domain-containing protein 2

1

0

High-throughput

0.279

Low

1295008

TMM25
Transmembrane protein 25

1

0

High-throughput

0.279

Low

1316032

MIA40
Mitochondrial intermembrane space import and assembly protein 40

1

0

High-throughput

0.279

Low

1316037

F174A
Membrane protein FAM174A

1

0

High-throughput

0.279

Low

1316038

DCA11
DDB1- and CUL4-associated factor 11

1

0

High-throughput

0.279

Low

1316044

TTC28
Tetratricopeptide repeat protein 28

1

0

High-throughput

0.279

Low

1316048

DCAF5
DDB1- and CUL4-associated factor 5

1

0

High-throughput

0.279

Low

1316057

ZNG1A
Zinc-regulated GTPase metalloprotein activator 1A

1

0

High-throughput

0.279

Low

1316058

UPK3B
Uroplakin-3b

1

0

High-throughput

0.279

Low

1316061

RTN4R
Reticulon-4 receptor

1

0

High-throughput

0.279

Low

1316076

LAMP3
Lysosome-associated membrane glycoprotein 3

1

0

High-throughput

0.279

Low

1316077

CLC11
C-type lectin domain family 11 member A

1

0

High-throughput

0.279

Low

164698

TNF11
Tumor necrosis factor ligand superfamily member 11

1

0

High-throughput

0.265

Low

420818

AT1B1
Sodium/potassium-transporting ATPase subunit beta-1

1

0

High-throughput

0.265

Low

174551

TRI66
Tripartite motif-containing protein 66

1

0

High-throughput

0.249

Low

293994

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.249

Low

342246

BRD1
Bromodomain-containing protein 1

1

0

High-throughput

0.249

Low

1088909

TP53B
TP53-binding protein 1

1

0

High-throughput

0.249

Low

1254578

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

1316033

FBXL6
F-box/LRR-repeat protein 6

1

0

High-throughput

0.249

Low

1316047

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.249

Low

1316053

CIC
Protein capicua homolog

1

0

High-throughput

0.249

Low

1316069

HECW2
E3 ubiquitin-protein ligase HECW2

1

0

High-throughput

0.249

Low

62557

S35F4
Solute carrier family 35 member F4

1

0

High-throughput

0.232

Low

1193264

SV2C
Synaptic vesicle glycoprotein 2C

1

0

High-throughput

0.232

Low

1208259

SPXN3
Sperm protein associated with the nucleus on the X chromosome N3

1

0

High-throughput

0.232

Low

1292262

S2611
Sodium-independent sulfate anion transporter

1

0

High-throughput

0.232

Low

1316062

MAGT1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit MAGT1

1

0

High-throughput

0.232

Low

1316072

PNMA2
Paraneoplastic antigen Ma2

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025