Protein: SMYD2
N-lysine methyltransferase SMYD2 (EC 2.1.1.-) (HSKM-B) (Histone methyltransferase SMYD2) (EC 2.1.1.354) (Lysine N-methyltransferase 3C) (SET and MYND domain-containing protein 2)

Gene: SMYD2
Organism: Homo sapiens
Interactions: 77
UniProt ID: Q9NRG4

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000993 - RNA polymerase II complex binding
GO:0002039 - p53 binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

414693

P53
Cellular tumor antigen p53

5

2

Small-scale

0.725

High

1105667

GOGA4
Golgin subfamily A member 4

3

3

High-throughput

0.667

High

1144180

TEBP
Prostaglandin E synthase 3

3

2

High-throughput

0.667

High

630050

BTF3
Transcription factor BTF3

3

1

High-throughput

0.665

High

1258959

H32
Histone H3.2

1

7

Small-scale

0.647

High

340784

CPSF4
Cleavage and polyadenylation specificity factor subunit 4

2

2

High-throughput

0.628

High

1158564

CDC37
Hsp90 co-chaperone Cdc37

2

1

High-throughput

0.621

High

1323079

AHI1
Jouberin

1

1

High-throughput

0.618

High

930803

AAPK2
5'-AMP-activated protein kinase catalytic subunit alpha-2

2

1

High-throughput

0.611

High

1448461

SNX11
Sorting nexin-11

2

1

High-throughput

0.606

High

244776

ZC3H1
Zinc finger C3H1 domain-containing protein

2

0

High-throughput

0.602

High

377006

ANF
Natriuretic peptides A

2

0

High-throughput

0.602

High

1420202

FOXP3
Forkhead box protein P3

2

0

High-throughput

0.602

High

1436999

ZN408
Zinc finger protein 408

2

0

High-throughput

0.602

High

1448457

CELA1
Chymotrypsin-like elastase family member 1

2

0

High-throughput

0.602

High

1448459

CILK1
Serine/threonine-protein kinase ICK

2

0

High-throughput

0.595

High

461966

HS90A
Heat shock protein HSP 90-alpha

2

6

Small-scale

0.595

High

1395083

JPH4
Junctophilin-4

1

0

High-throughput

0.578

High

1448460

E41L3
Band 4.1-like protein 3

2

0

Small-scale

0.576

High

442814

RB
Retinoblastoma-associated protein

1

0

Small-scale

0.554

High

1395608

BT3L4
Transcription factor BTF3 homolog 4

2

1

High-throughput

0.553

High

943624

HUNK
Hormonally up-regulated neu tumor-associated kinase

1

2

High-throughput

0.541

High

1090941

TRAF2
TNF receptor-associated factor 2

1

0

Small-scale

0.537

High

155809

TXND9
Thioredoxin domain-containing protein 9

1

1

High-throughput

0.536

High

344028

HS74L
Heat shock 70 kDa protein 4L

1

2

High-throughput

0.536

High

731636

STIP1
Stress-induced-phosphoprotein 1

1

1

High-throughput

0.536

High

827267

ARL1
ADP-ribosylation factor-like protein 1

1

1

High-throughput

0.536

High

933741

PSMD4
26S proteasome non-ATPase regulatory subunit 4

1

1

High-throughput

0.536

High

1117156

NACA
Nascent polypeptide-associated complex subunit alpha

1

2

High-throughput

0.536

High

1179742

ZXDC
Zinc finger protein ZXDC

1

1

High-throughput

0.536

High

1259691

RS27L
Ribosomal protein eS27-like

1

1

High-throughput

0.536

High

1411952

PELO
Protein pelota homolog

1

1

High-throughput

0.536

High

1417601

BEX2
Protein BEX2

1

1

High-throughput

0.536

High

1434614

ZBTB3
Zinc finger and BTB domain-containing protein 3

1

3

High-throughput

0.536

High

1438299

BEX1
Protein BEX1

1

1

High-throughput

0.536

High

891815

GSK3B
Glycogen synthase kinase-3 beta

1

2

High-throughput

0.515

High

549696

PRPS2
Ribose-phosphate pyrophosphokinase 2

1

0

High-throughput

0.513

High

905689

IRAK1
Interleukin-1 receptor-associated kinase 1

1

0

High-throughput

0.513

High

930370

AAKG1
5'-AMP-activated protein kinase subunit gamma-1

1

0

High-throughput

0.513

High

973097

RS29
Small ribosomal subunit protein uS14

1

0

High-throughput

0.513

High

1005830

RPP30
Ribonuclease P protein subunit p30

1

0

High-throughput

0.513

High

1054335

GFPT1
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1

1

0

High-throughput

0.513

High

1099794

MD2L1
Mitotic spindle assembly checkpoint protein MAD2A

1

0

High-throughput

0.513

High

1307362

ZNG1B
Zinc-regulated GTPase metalloprotein activator 1B

1

0

High-throughput

0.513

High

1316066

TRM2A
tRNA

1

0

High-throughput

0.513

High

1352169

MORC4
MORC family CW-type zinc finger protein 4

1

0

High-throughput

0.513

High

1448458

DIM1
Dimethyladenosine transferase

1

0

High-throughput

0.513

High

1448462

NUBP2
Cytosolic Fe-S cluster assembly factor NUBP2

1

0

High-throughput

0.513

High

397021

ESR1
Estrogen receptor

1

1

Small-scale

0.501

High

181181

AXIN1
Axin-1

1

0

High-throughput

0.493

High

1448454

IF2B1
Insulin-like growth factor 2 mRNA-binding protein 1

1

0

High-throughput

0.493

High

1448456

AKA11
A-kinase anchor protein 11

1

0

High-throughput

0.493

High

921462

SUCA
Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial

1

1

High-throughput

0.489

High

556877

MYH1
Myosin-1

1

2

High-throughput

0.479

High

563034

MYH6
Myosin-6

1

2

High-throughput

0.479

High

972582

RS14
Small ribosomal subunit protein uS11

1

1

High-throughput

0.479

High

1149201

SF3A1
Splicing factor 3A subunit 1

1

2

High-throughput

0.479

High

1316888

ASPM
Abnormal spindle-like microcephaly-associated protein

1

3

High-throughput

0.479

High

1396136

Z512B
Zinc finger protein 512B

1

1

High-throughput

0.479

High

1408542

AKAP9
A-kinase anchor protein 9

1

3

High-throughput

0.479

High

1248873

MPZL3
Myelin protein zero-like protein 3

1

1

High-throughput

0.470

High

167126

GEMI2
Gem-associated protein 2

1

0

High-throughput

0.458

High

270985

CLAP2
CLIP-associating protein 2

1

0

High-throughput

0.458

High

281788

VP26A
Vacuolar protein sorting-associated protein 26A

1

0

High-throughput

0.458

High

445604

IF4E
Eukaryotic translation initiation factor 4E

1

0

High-throughput

0.458

High

471932

RU2B
U2 small nuclear ribonucleoprotein B''

1

0

High-throughput

0.458

High

576571

HNRPL
Heterogeneous nuclear ribonucleoprotein L

1

0

High-throughput

0.458

High

717354

PEBP1
Phosphatidylethanolamine-binding protein 1

1

0

High-throughput

0.458

High

978751

RL23A
Large ribosomal subunit protein uL23

1

0

High-throughput

0.458

High

1115452

CUL4B
Cullin-4B

1

0

Small-scale

0.458

High

1387446

CMBL
Carboxymethylenebutenolidase homolog

1

0

High-throughput

0.458

High

1448453

SMC4
Structural maintenance of chromosomes protein 4

1

0

High-throughput

0.458

High

1448455

GSKIP
GSK3B-interacting protein

1

0

High-throughput

0.458

High

1395007

RADIL
Ras-associating and dilute domain-containing protein

1

1

High-throughput

0.437

High

1421294

CCSE1
Serine-rich coiled-coil domain-containing protein 1

2

0

High-throughput

0.328

High

155212

NCKP5
Nck-associated protein 5

1

0

High-throughput

0.279

Low

1435926

RDD1
Required for drug-induced death protein 1

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025