Protein: PRDM6
Putative histone-lysine N-methyltransferase PRDM6 (EC 2.1.1.361) (PR domain zinc finger protein 6) (PR domain-containing protein 6)

Gene: PRDM6
Organism: Homo sapiens
Interactions: 91
UniProt ID: Q9NQX0

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0005634 - nucleus
GO:0008270 - zinc ion binding
GO:0010468 - regulation of gene expression
GO:0022008 - neurogenesis

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

216196

MTG8R
Protein CBFA2T2

5

8

High-throughput

0.924

High

1447531

PRDM6
Putative histone-lysine N-methyltransferase PRDM6

3

14

Small-scale

0.843

High

1429051

PRD14
PR domain zinc finger protein 14

2

18

High-throughput

0.811

High

930801

AAPK2
5'-AMP-activated protein kinase catalytic subunit alpha-2

2

1

High-throughput

0.783

High

1055278

MTG8
Protein CBFA2T1

2

8

High-throughput

0.783

High

1165320

LONF1
LON peptidase N-terminal domain and RING finger protein 1

2

9

High-throughput

0.783

High

1438123

PATZ1
POZ-, AT hook-, and zinc finger-containing protein 1

2

17

High-throughput

0.783

High

1438782

NEK6
Serine/threonine-protein kinase Nek6

2

8

High-throughput

0.783

High

291868

STK16
Serine/threonine-protein kinase 16

2

4

High-throughput

0.700

High

270277

MTG16
Protein CBFA2T3

1

8

High-throughput

0.691

High

1399899

TSSK3
Testis-specific serine/threonine-protein kinase 3

2

0

High-throughput

0.655

High

222213

NCK2
Cytoplasmic protein NCK2

2

2

High-throughput

0.606

High

292397

RA51D
DNA repair protein RAD51 homolog 4

2

1

High-throughput

0.606

High

347946

BAG3
BAG family molecular chaperone regulator 3

2

2

High-throughput

0.606

High

681935

RBTN2
Rhombotin-2

2

9

High-throughput

0.606

High

682107

RBTN1
Rhombotin-1

2

9

High-throughput

0.606

High

715968

AQP1
Aquaporin-1

2

2

High-throughput

0.606

High

725115

HXC8
Homeobox protein Hox-C8

2

12

High-throughput

0.606

High

933899

GEM
GTP-binding protein GEM

2

2

High-throughput

0.606

High

1044711

ARI5A
AT-rich interactive domain-containing protein 5A

2

3

High-throughput

0.606

High

1061892

TLE5
TLE family member 5

2

3

High-throughput

0.606

High

1118423

PTK6
Protein-tyrosine kinase 6

2

3

High-throughput

0.606

High

1121343

TRI14
Tripartite motif-containing protein 14

2

20

High-throughput

0.606

High

1123140

FHL2
Four and a half LIM domains protein 2

2

9

High-throughput

0.606

High

1225084

KANK2
KN motif and ankyrin repeat domain-containing protein 2

2

6

High-throughput

0.606

High

1228890

ZFY26
Zinc finger FYVE domain-containing protein 26

2

4

High-throughput

0.606

High

1341236

IKBD
NF-kappa-B inhibitor delta

2

1

High-throughput

0.606

High

1350725

CCHCR
Coiled-coil alpha-helical rod protein 1

2

10

High-throughput

0.606

High

1359002

TEKT4
Tektin-4

2

1

High-throughput

0.606

High

1371304

KAT5
Histone acetyltransferase KAT5

2

1

High-throughput

0.606

High

1434474

BAFL
Barrier-to-autointegration factor-like protein

2

1

High-throughput

0.606

High

1438649

CBX8
Chromobox protein homolog 8

2

20

High-throughput

0.606

High

1447229

EXOS5
Exosome complex component RRP46

2

1

High-throughput

0.606

High

1447532

FX4L1
Forkhead box protein D4-like 1

2

2

High-throughput

0.606

High

1447533

AIRIM
AFG2-interacting ribosome maturation factor

2

1

High-throughput

0.606

High

1447534

ABI2
Abl interactor 2

2

2

High-throughput

0.606

High

50937

SYCE3
Synaptonemal complex central element protein 3

2

0

High-throughput

0.602

High

750481

CSTF2
Cleavage stimulation factor subunit 2

2

0

High-throughput

0.580

High

1272351

ATOSB
Atos homolog protein B

2

0

High-throughput

0.580

High

1420692

FTO
Alpha-ketoglutarate-dependent dioxygenase FTO

2

0

High-throughput

0.580

High

1437630

ROP1A
Ropporin-1A

2

0

High-throughput

0.580

High

1447535

CCNL1
Cyclin-L1

2

0

High-throughput

0.580

High

350503

GPAN1
G patch domain and ankyrin repeat-containing protein 1

2

1

High-throughput

0.553

High

943819

UBS3A
Ubiquitin-associated and SH3 domain-containing protein A

2

1

High-throughput

0.553

High

1119787

IL16
Pro-interleukin-16 [Cleaved into: Interleukin-16

2

4

High-throughput

0.553

High

1124418

ELOA1
Elongin-A

2

3

High-throughput

0.553

High

1180028

CCD57
Coiled-coil domain-containing protein 57

2

10

High-throughput

0.553

High

1328075

ATPF2
ATP synthase mitochondrial F1 complex assembly factor 2

2

2

High-throughput

0.553

High

1332051

BANP
Protein BANP

2

1

High-throughput

0.553

High

1415238

KIFC3
Kinesin-like protein KIFC3

2

2

High-throughput

0.553

High

1420310

TSG10
Testis-specific gene 10 protein

2

15

High-throughput

0.553

High

1430118

ENKD1
Enkurin domain-containing protein 1

2

1

High-throughput

0.553

High

1447537

TCAF1
TRPM8 channel-associated factor 1

2

3

High-throughput

0.553

High

587230

ITF2
Transcription factor 4

1

1

High-throughput

0.536

High

143284

NFIB
Nuclear factor 1 B-type

1

20

High-throughput

0.479

High

188372

HDAC3
Histone deacetylase 3

1

13

Small-scale

0.479

High

474319

NFIC
Nuclear factor 1 C-type

1

20

High-throughput

0.479

High

942470

GSC
Homeobox protein goosecoid

1

11

High-throughput

0.479

High

998843

H31
Histone H3.1

1

20

Small-scale

0.479

High

1014212

CBX1
Chromobox protein homolog 1

1

20

Small-scale

0.479

High

1067749

EP300
Histone acetyltransferase p300

1

10

Small-scale

0.479

High

1088047

NFIA
Nuclear factor 1 A-type

1

20

High-throughput

0.479

High

1110109

HDAC1
Histone deacetylase 1

1

13

Small-scale

0.479

High

1114386

CUL3
Cullin-3

1

20

High-throughput

0.479

High

1368139

HDAC2
Histone deacetylase 2

1

13

Small-scale

0.479

High

1436917

EHMT1
Histone-lysine N-methyltransferase EHMT1

1

4

Small-scale

0.479

High

1193630

Q49AR9
ANKS1A protein

1

3

High-throughput

0.470

High

1366039

ANS1A
Ankyrin repeat and SAM domain-containing protein 1A

1

3

High-throughput

0.439

High

71661

GRCR1
Glutaredoxin domain-containing cysteine-rich protein 1

2

0

High-throughput

0.316

High

220308

FRS3
Fibroblast growth factor receptor substrate 3

2

0

High-throughput

0.316

High

230119

SAHH2
S-adenosylhomocysteine hydrolase-like protein 1

2

0

High-throughput

0.316

High

528519

COX5B
Cytochrome c oxidase subunit 5B, mitochondrial

2

0

High-throughput

0.316

High

638862

AGT1
Alanine--glyoxylate aminotransferase

2

0

High-throughput

0.316

High

868263

SYQ
Glutamine--tRNA ligase

2

0

High-throughput

0.316

High

1187691

T10IP
Testis-specific protein 10-interacting protein

2

0

High-throughput

0.316

High

1199872

TYW2
tRNA wybutosine-synthesizing protein 2 homolog

2

0

High-throughput

0.316

High

1220049

TTC23
Tetratricopeptide repeat protein 23

2

0

High-throughput

0.316

High

1258195

UBP54
Ubiquitin carboxyl-terminal hydrolase 54

2

0

High-throughput

0.316

High

1271416

KCTD9
BTB/POZ domain-containing protein KCTD9

2

0

High-throughput

0.316

High

1295112

F90A1
Protein FAM90A1

2

0

High-throughput

0.316

High

1315788

CE57L
Centrosomal protein CEP57L1

2

0

High-throughput

0.316

High

1332377

IQUB
IQ motif and ubiquitin-like domain-containing protein

2

0

High-throughput

0.316

High

1347096

G45IP
Large ribosomal subunit protein mL64

2

0

High-throughput

0.316

High

1350976

MYOZ3
Myozenin-3

2

0

High-throughput

0.316

High

1359133

PIHD2
PIH1 domain-containing protein 2

2

0

High-throughput

0.316

High

1392997

CC120
Coiled-coil domain-containing protein 120

2

0

High-throughput

0.316

High

1447536

SMAG1
Protein Smaug homolog 1

2

0

High-throughput

0.316

High

1200421

CB083
Putative solute carrier family 19 member 4

1

0

High-throughput

0.251

Low

1213440

AT7L2
Ataxin-7-like protein 2

1

0

High-throughput

0.251

Low

1038706

FKBP4
Peptidyl-prolyl cis-trans isomerase FKBP4

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025