Protein: MCA3
Eukaryotic translation elongation factor 1 epsilon-1 (Aminoacyl tRNA synthetase complex-interacting multifunctional protein 3) (Elongation factor p18) (Multisynthase complex auxiliary component p18)

Gene: MCA3, EEF1E1
Organism: Homo sapiens
Interactions: 108
UniProt ID: O43324

Gene Ontology (top 5):
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005730 - nucleolus
GO:0005737 - cytoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

140065

SDCB1
Syntenin-1

4

3

High-throughput

0.691

High

214245

SYLC
Leucine--tRNA ligase, cytoplasmic

3

9

High-throughput

0.667

High

214184

SYQ
Glutamine--tRNA ligase

2

5

High-throughput

0.628

High

214189

SYRC
Arginine--tRNA ligase, cytoplasmic

2

2

High-throughput

0.628

High

214199

AIMP1
Aminoacyl tRNA synthase complex-interacting multifunctional protein 1

2

3

High-throughput

0.628

High

214207

SYK
Lysine--tRNA ligase

2

12

High-throughput

0.628

High

214148

MCA3
Eukaryotic translation elongation factor 1 epsilon-1

1

17

High-throughput

0.618

High

214202

AIMP2
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

1

3

High-throughput

0.618

High

214159

RAF1
RAF proto-oncogene serine/threonine-protein kinase

2

9

High-throughput

0.601

High

214190

SYMC
Methionine--tRNA ligase, cytoplasmic

1

8

Small-scale

0.590

High

214201

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

1

4

High-throughput

0.573

High

214155

MTA2
Metastasis-associated protein MTA2

2

3

High-throughput

0.571

High

214213

RHG29
Rho GTPase-activating protein 29

2

1

High-throughput

0.571

High

214149

STRN
Striatin

1

7

High-throughput

0.536

High

214163

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

1

High-throughput

0.536

High

214165

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

6

High-throughput

0.536

High

214174

VDAC1
Non-selective voltage-gated ion channel VDAC1

1

3

High-throughput

0.536

High

214181

SYIC
Isoleucine--tRNA ligase, cytoplasmic

1

8

High-throughput

0.536

High

214183

CAPZB
F-actin-capping protein subunit beta

1

1

High-throughput

0.536

High

214188

BLK
Tyrosine-protein kinase Blk

1

4

High-throughput

0.536

High

214205

CND2
Condensin complex subunit 2

1

1

High-throughput

0.536

High

214210

PKN2
Serine/threonine-protein kinase N2

1

9

High-throughput

0.536

High

214217

JMJD6
Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6

1

1

High-throughput

0.536

High

214231

PGTA
Geranylgeranyl transferase type-2 subunit alpha

1

1

High-throughput

0.536

High

214235

M3K14
Mitogen-activated protein kinase kinase kinase 14

1

7

High-throughput

0.536

High

214236

HCD2
3-hydroxyacyl-CoA dehydrogenase type-2

1

4

High-throughput

0.536

High

214220

COX15
Heme A synthase COX15

1

0

High-throughput

0.513

High

214234

CHAP1
Chromosome alignment-maintaining phosphoprotein 1

1

0

High-throughput

0.513

High

214242

MED4
Mediator of RNA polymerase II transcription subunit 4

1

0

High-throughput

0.513

High

214249

MB212
Protein mab-21-like 2

1

0

High-throughput

0.513

High

214192

CDC42
Cell division control protein 42 homolog

1

3

High-throughput

0.501

High

214179

SOAT1
Sterol O-acyltransferase 1

1

2

High-throughput

0.489

High

214208

P2RY6
P2Y purinoceptor 6

1

1

High-throughput

0.489

High

131595

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

10

High-throughput

0.479

High

156720

CTRO
Citron Rho-interacting kinase

1

8

High-throughput

0.479

High

193909

R113A
E3 ubiquitin-protein ligase RNF113A

1

2

High-throughput

0.479

High

214150

PRKN
E3 ubiquitin-protein ligase parkin

1

9

High-throughput

0.479

High

214153

CD123
Translation initiation factor eIF2 assembly protein

1

2

High-throughput

0.479

High

214154

RECQ4
ATP-dependent DNA helicase Q4

1

3

High-throughput

0.479

High

214156

UFL1
E3 UFM1-protein ligase 1

1

2

High-throughput

0.479

High

214157

HEXI1
Protein HEXIM1

1

3

High-throughput

0.479

High

214158

SNAI1
Zinc finger protein SNAI1

1

1

High-throughput

0.479

High

214162

CATL1
Procathepsin L

1

1

High-throughput

0.479

High

214166

ARAF
Serine/threonine-protein kinase A-Raf

1

9

High-throughput

0.479

High

214169

SYDC
Aspartate--tRNA ligase, cytoplasmic

1

12

High-throughput

0.479

High

214170

RFA2
Replication protein A 32 kDa subunit

1

5

High-throughput

0.479

High

214173

RO52
E3 ubiquitin-protein ligase TRIM21

1

1

High-throughput

0.479

High

214175

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

4

High-throughput

0.479

High

214176

MARCS
Myristoylated alanine-rich C-kinase substrate

1

1

High-throughput

0.479

High

214178

RFA3
Replication protein A 14 kDa subunit

1

3

High-throughput

0.479

High

214186

MCM2
DNA replication licensing factor MCM2

1

2

High-throughput

0.479

High

214187

CDK7
Cyclin-dependent kinase 7

1

7

High-throughput

0.479

High

214193

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

4

High-throughput

0.479

High

214194

ARF6
ADP-ribosylation factor 6

1

1

High-throughput

0.479

High

214195

H4
Histone H4

1

2

High-throughput

0.479

High

214197

K1C17
Keratin, type I cytoskeletal 17

1

2

High-throughput

0.479

High

214200

NFX1
Transcriptional repressor NF-X1

1

3

High-throughput

0.479

High

214203

RFA4
Replication protein A 30 kDa subunit

1

5

High-throughput

0.479

High

214204

CUL3
Cullin-3

1

6

High-throughput

0.479

High

214206

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

6

High-throughput

0.479

High

214211

LARP7
La-related protein 7

1

6

High-throughput

0.479

High

214216

VIR
Protein virilizer homolog

1

3

High-throughput

0.479

High

214218

TRI67
Tripartite motif-containing protein 67

1

8

High-throughput

0.479

High

214219

ASXL2
Putative Polycomb group protein ASXL2

1

5

High-throughput

0.479

High

214221

MEPCE
7SK snRNA methylphosphate capping enzyme

1

2

High-throughput

0.479

High

214222

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

2

High-throughput

0.479

High

214223

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

11

High-throughput

0.479

High

214225

TAXB1
Tax1-binding protein 1

1

5

High-throughput

0.479

High

214226

SMC5
Structural maintenance of chromosomes protein 5

1

2

High-throughput

0.479

High

214227

SERB1
SERPINE1 mRNA-binding protein 1

1

3

High-throughput

0.479

High

214230

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

8

High-throughput

0.479

High

214232

FBXW7
F-box/WD repeat-containing protein 7

1

8

High-throughput

0.479

High

214233

DDRGK
DDRGK domain-containing protein 1

1

2

High-throughput

0.479

High

214239

ATG5
Autophagy protein 5

1

2

High-throughput

0.479

High

214240

PKHA4
Pleckstrin homology domain-containing family A member 4

1

5

High-throughput

0.479

High

214243

PIHD1
PIH1 domain-containing protein 1

1

3

High-throughput

0.479

High

214244

HIF1N
Hypoxia-inducible factor 1-alpha inhibitor

1

1

High-throughput

0.479

High

214246

ZRAN1
Ubiquitin thioesterase ZRANB1

1

3

High-throughput

0.479

High

214247

UBQL1
Ubiquilin-1

1

5

High-throughput

0.479

High

213504

MTSS1
Protein MTSS 1

1

0

Small-scale

0.458

High

214241

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

214160

JUN
Transcription factor Jun

1

9

High-throughput

0.445

High

214164

PGFRB
Platelet-derived growth factor receptor beta

1

4

High-throughput

0.445

High

214167

TAU
Microtubule-associated protein tau

1

4

High-throughput

0.445

High

214196

TAGL
Transgelin

1

5

High-throughput

0.445

High

214214

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

4

High-throughput

0.445

High

214238

ZDHC5
Palmitoyltransferase ZDHHC5

1

2

High-throughput

0.445

High

214168

ITA4
Integrin alpha-4

1

2

High-throughput

0.437

High

214177

UFO
Tyrosine-protein kinase receptor UFO

1

4

High-throughput

0.437

High

214180

FLT3
Receptor-type tyrosine-protein kinase FLT3

1

2

High-throughput

0.437

High

214198

RON
Macrophage-stimulating protein receptor

1

5

High-throughput

0.437

High

214224

ZCH18
Zinc finger CCCH domain-containing protein 18

1

2

High-throughput

0.437

High

214228

TIP
T-cell immunomodulatory protein

1

1

High-throughput

0.437

High

214248

AAR2
Protein AAR2 homolog

1

3

High-throughput

0.437

High

214185

CEBPA
CCAAT/enhancer-binding protein alpha

1

7

High-throughput

0.408

High

214172

VCAM1
Vascular cell adhesion protein 1

1

3

High-throughput

0.407

High

214191

SYJ2B
Synaptojanin-2-binding protein

1

4

High-throughput

0.407

High

214209

CD226
CD226 antigen

1

1

High-throughput

0.407

High

214212

S22A6
Solute carrier family 22 member 6

1

2

High-throughput

0.407

High

214215

LITD1
LINE-1 type transposase domain-containing protein 1

1

1

High-throughput

0.407

High

214237

NAT9
Alpha/beta-tubulin-N-acetyltransferase 9

2

0

High-throughput

0.334

High

214171

EGLN
Endoglin

1

0

High-throughput

0.279

Low

214151

EIF1B
Eukaryotic translation initiation factor 1b

1

0

High-throughput

0.249

Low

214152

SCN2B
Sodium channel regulatory subunit beta-2

1

0

High-throughput

0.232

Low

214161

HEPS
Serine protease hepsin

1

0

High-throughput

0.232

Low

214182

VIPR2
Vasoactive intestinal polypeptide receptor 2

1

0

High-throughput

0.232

Low

214229

HAVR2
Hepatitis A virus cellular receptor 2

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025