Protein: SYMC
Methionine--tRNA ligase, cytoplasmic (EC 6.1.1.10) (Methionyl-tRNA synthetase) (MetRS)

Gene: SYMC, MARS1
Organism: Homo sapiens
Interactions: 213
UniProt ID: P56192

Gene Ontology (top 5):
GO:0000049 - tRNA binding
GO:0004825 - methionine-tRNA ligase activity
GO:0005524 - ATP binding
GO:0005730 - nucleolus
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

940324

SYLC
Leucine--tRNA ligase, cytoplasmic

3

14

High-throughput

0.861

High

940232

AIMP2
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

2

3

Small-scale

0.754

High

834406

SYIC
Isoleucine--tRNA ligase, cytoplasmic

1

13

High-throughput

0.691

High

140199

SDCB1
Syntenin-1

4

1

High-throughput

0.691

High

371585

MYC
Myc proto-oncogene protein

4

3

High-throughput

0.686

High

395771

ESR1
Estrogen receptor

4

4

Small-scale

0.672

High

563493

CFTR
Cystic fibrosis transmembrane conductance regulator

3

1

High-throughput

0.662

High

241223

PRKN
E3 ubiquitin-protein ligase parkin

3

8

High-throughput

0.640

High

868125

SYQ
Glutamine--tRNA ligase

2

9

High-throughput

0.628

High

926446

SYRC
Arginine--tRNA ligase, cytoplasmic

2

4

High-throughput

0.628

High

940229

AIMP1
Aminoacyl tRNA synthase complex-interacting multifunctional protein 1

2

11

High-throughput

0.628

High

940249

SYK
Lysine--tRNA ligase

2

11

High-throughput

0.628

High

940214

SYMC
Methionine--tRNA ligase, cytoplasmic

1

13

High-throughput

0.618

High

940238

CUL3
Cullin-3

2

6

High-throughput

0.611

High

214190

MCA3
Eukaryotic translation elongation factor 1 epsilon-1

1

8

Small-scale

0.590

High

413497

P53
Cellular tumor antigen p53

2

1

Small-scale

0.584

High

897680

CDK9
Cyclin-dependent kinase 9

2

5

High-throughput

0.584

High

940245

HAPR1
HUWE1-associated protein modifying stress responses 1

2

2

High-throughput

0.584

High

940267

HUWE1
E3 ubiquitin-protein ligase HUWE1

2

9

High-throughput

0.584

High

940317

ANLN
Anillin

2

1

High-throughput

0.584

High

619647

VCAM1
Vascular cell adhesion protein 1

2

3

High-throughput

0.571

High

168661

CSKP
Peripheral plasma membrane protein CASK

1

3

High-throughput

0.541

High

215525

EMC8
ER membrane protein complex subunit 8

1

1

High-throughput

0.536

High

446810

NPM
Nucleophosmin

1

1

High-throughput

0.536

High

470948

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

4

High-throughput

0.536

High

572796

NCF1
Neutrophil cytosol factor 1

1

4

High-throughput

0.536

High

859163

RL5
Large ribosomal subunit protein uL18

1

2

High-throughput

0.536

High

866941

CAPZB
F-actin-capping protein subunit beta

1

1

High-throughput

0.536

High

884006

SRP09
Signal recognition particle 9 kDa protein

1

1

High-throughput

0.536

High

940217

RS16
Small ribosomal subunit protein uS9

1

3

High-throughput

0.536

High

940220

RACK1
Small ribosomal subunit protein RACK1

1

8

High-throughput

0.536

High

940237

CUL1
Cullin-1

1

6

High-throughput

0.536

High

940242

CAPR1
Caprin-1

1

1

High-throughput

0.536

High

940246

CND2
Condensin complex subunit 2

1

1

High-throughput

0.536

High

940252

PKN2
Serine/threonine-protein kinase N2

1

7

High-throughput

0.536

High

940271

CMTD1
Catechol O-methyltransferase domain-containing protein 1

1

1

High-throughput

0.536

High

940274

PDZD8
PDZ domain-containing protein 8

1

1

High-throughput

0.536

High

940283

PSPC1
Paraspeckle component 1

1

1

High-throughput

0.536

High

940314

ZCC17
Zinc finger CCHC domain-containing protein 17

1

1

High-throughput

0.536

High

940331

G3BP2
Ras GTPase-activating protein-binding protein 2

1

4

High-throughput

0.536

High

940337

EMC9
ER membrane protein complex subunit 9

1

1

High-throughput

0.536

High

940327

DUX4
Double homeobox protein 4

1

3

High-throughput

0.516

High

659418

CRCM
Colorectal mutant cancer protein

1

2

High-throughput

0.515

High

830431

CCNF
Cyclin-F

1

2

High-throughput

0.515

High

940235

ILK
Scaffold protein ILK

1

2

High-throughput

0.515

High

940342

USH1C
Harmonin

1

2

High-throughput

0.515

High

271459

ATG13
Autophagy-related protein 13

1

0

High-throughput

0.513

High

787954

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

0

High-throughput

0.513

High

940255

H2B2E
Histone H2B type 2-E

1

0

High-throughput

0.513

High

940334

TN13B
Tumor necrosis factor ligand superfamily member 13B

1

0

High-throughput

0.513

High

840657

RS27
Small ribosomal subunit protein eS27

1

3

High-throughput

0.508

High

662392

GATA2
Endothelial transcription factor GATA-2

1

1

High-throughput

0.500

High

167586

GIPC1
PDZ domain-containing protein GIPC1

1

0

High-throughput

0.493

High

940338

AAKB1
5'-AMP-activated protein kinase subunit beta-1

1

0

High-throughput

0.493

High

940251

P2RY6
P2Y purinoceptor 6

1

3

High-throughput

0.489

High

568549

TNNT1
Troponin T, slow skeletal muscle

1

0

High-throughput

0.486

High

125361

LEG9
Galectin-9

1

1

High-throughput

0.479

High

128902

MEN1
Menin

1

1

High-throughput

0.479

High

131865

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

7

High-throughput

0.479

High

157146

CTRO
Citron Rho-interacting kinase

1

6

High-throughput

0.479

High

293439

CD123
Translation initiation factor eIF2 assembly protein

1

1

High-throughput

0.479

High

315343

RECQ4
ATP-dependent DNA helicase Q4

1

2

High-throughput

0.479

High

324681

HEXI1
Protein HEXIM1

1

1

High-throughput

0.479

High

345575

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

5

High-throughput

0.479

High

363046

EGFR
Epidermal growth factor receptor

1

4

High-throughput

0.479

High

379969

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

1

High-throughput

0.479

High

389192

FINC
Fibronectin

1

2

High-throughput

0.479

High

405950

MYCN
N-myc proto-oncogene protein

1

3

High-throughput

0.479

High

411665

NTRK1
High affinity nerve growth factor receptor

1

4

High-throughput

0.479

High

425406

ISG15
Ubiquitin-like protein ISG15

1

6

High-throughput

0.479

High

431038

LA
Lupus La protein

1

2

High-throughput

0.479

High

459258

CATL1
Procathepsin L

1

1

High-throughput

0.479

High

507737

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

4

Small-scale

0.479

High

521263

ARAF
Serine/threonine-protein kinase A-Raf

1

4

High-throughput

0.479

High

565260

ITA4
Integrin alpha-4

1

2

High-throughput

0.479

High

606512

CEBPB
CCAAT/enhancer-binding protein beta

1

7

High-throughput

0.479

High

624233

TFE3
Transcription factor E3

1

2

High-throughput

0.479

High

642754

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

2

High-throughput

0.479

High

713984

PML
Protein PML

1

4

High-throughput

0.479

High

731133

STIP1
Stress-induced-phosphoprotein 1

1

5

High-throughput

0.479

High

766358

PHB1
Prohibitin 1

1

2

High-throughput

0.479

High

786993

FLT3
Receptor-type tyrosine-protein kinase FLT3

1

4

High-throughput

0.479

High

798909

BRCA1
Breast cancer type 1 susceptibility protein

1

4

High-throughput

0.479

High

837492

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

2

High-throughput

0.479

High

861961

YAP1
Transcriptional coactivator YAP1

1

14

High-throughput

0.479

High

883193

UB2R1
Ubiquitin-conjugating enzyme E2 R1

1

2

High-throughput

0.479

High

887877

MCM2
DNA replication licensing factor MCM2

1

2

High-throughput

0.479

High

891407

GSK3B
Glycogen synthase kinase-3 beta

1

2

High-throughput

0.479

High

926905

ATX3
Ataxin-3

1

2

High-throughput

0.479

High

929859

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

2

High-throughput

0.479

High

940218

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

2

High-throughput

0.479

High

940219

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

4

High-throughput

0.479

High

940221

RNF4
E3 ubiquitin-protein ligase RNF4

1

1

High-throughput

0.479

High

940222

NFKB2
Nuclear factor NF-kappa-B p100 subunit

1

5

High-throughput

0.479

High

940223

MDM2
E3 ubiquitin-protein ligase Mdm2

1

1

High-throughput

0.479

High

940224

KIF23
Kinesin-like protein KIF23

1

3

High-throughput

0.479

High

940225

TF65
Transcription factor p65

1

3

High-throughput

0.479

High

940227

EP300
Histone acetyltransferase p300

1

5

High-throughput

0.479

High

940230

NFX1
Transcriptional repressor NF-X1

1

1

High-throughput

0.479

High

940231

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

1

2

High-throughput

0.479

High

940233

M3K1
Mitogen-activated protein kinase kinase kinase 1

1

9

High-throughput

0.479

High

940234

G3BP1
Ras GTPase-activating protein-binding protein 1

1

3

High-throughput

0.479

High

940236

BIRC3
Baculoviral IAP repeat-containing protein 3

1

2

High-throughput

0.479

High

940239

CUL4A
Cullin-4A

1

6

High-throughput

0.479

High

940244

CUL7
Cullin-7

1

1

High-throughput

0.479

High

940247

TNIP1
TNFAIP3-interacting protein 1

1

9

High-throughput

0.479

High

940248

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

7

High-throughput

0.479

High

940253

CRY1
Cryptochrome-1

1

3

High-throughput

0.479

High

940254

IF16
Gamma-interferon-inducible protein 16

1

1

High-throughput

0.479

High

940257

CRY2
Cryptochrome-2

1

3

High-throughput

0.479

High

940258

A16L1
Autophagy-related protein 16-1

1

7

High-throughput

0.479

High

940259

VIR
Protein virilizer homolog

1

2

High-throughput

0.479

High

940260

ZN746
Zinc finger protein 746

1

2

High-throughput

0.479

High

940262

PRP8
Pre-mRNA-processing-splicing factor 8

1

2

High-throughput

0.479

High

940264

TRI67
Tripartite motif-containing protein 67

1

6

High-throughput

0.479

High

940265

MOB3C
MOB kinase activator 3C

1

2

High-throughput

0.479

High

940268

ZN598
E3 ubiquitin-protein ligase ZNF598

1

1

High-throughput

0.479

High

940272

RHG24
Rho GTPase-activating protein 24

1

2

High-throughput

0.479

High

940273

SERB1
SERPINE1 mRNA-binding protein 1

1

2

High-throughput

0.479

High

940276

TIP
T-cell immunomodulatory protein

1

1

High-throughput

0.479

High

940277

LNX1
E3 ubiquitin-protein ligase LNX

1

1

Small-scale

0.479

High

940280

RBCC1
RB1-inducible coiled-coil protein 1

1

6

High-throughput

0.479

High

940281

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

1

High-throughput

0.479

High

940284

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

3

High-throughput

0.479

High

940286

HDAC2
Histone deacetylase 2

1

3

High-throughput

0.479

High

940287

FBXW7
F-box/WD repeat-containing protein 7

1

5

Small-scale

0.479

High

940289

ARMC5
Armadillo repeat-containing protein 5

1

1

High-throughput

0.479

High

940290

CHM4C
Charged multivesicular body protein 4c

1

2

High-throughput

0.479

High

940293

DDRGK
DDRGK domain-containing protein 1

1

1

High-throughput

0.479

High

940294

CI072
Guanine nucleotide exchange factor C9orf72

1

2

High-throughput

0.479

High

940295

RUFY1
RUN and FYVE domain-containing protein 1

1

3

High-throughput

0.479

High

940296

RING2
E3 ubiquitin-protein ligase RING2

1

6

High-throughput

0.479

High

940297

M3K3
Mitogen-activated protein kinase kinase kinase 3

1

3

High-throughput

0.479

High

940298

AKAP9
A-kinase anchor protein 9

1

4

High-throughput

0.479

High

940300

GRWD1
Glutamate-rich WD repeat-containing protein 1

1

8

High-throughput

0.479

High

940301

RIOK1
Serine/threonine-protein kinase RIO1

1

1

High-throughput

0.479

High

940304

ACE2
Angiotensin-converting enzyme 2

1

2

High-throughput

0.479

High

940306

CCDC8
Coiled-coil domain-containing protein 8

1

2

High-throughput

0.479

High

940309

CHM4B
Charged multivesicular body protein 4b

1

2

High-throughput

0.479

High

940311

PKHA4
Pleckstrin homology domain-containing family A member 4

1

7

High-throughput

0.479

High

940313

SMUF1
E3 ubiquitin-protein ligase SMURF1

1

9

High-throughput

0.479

High

940315

BRD7
Bromodomain-containing protein 7

1

3

High-throughput

0.479

High

940316

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

2

High-throughput

0.479

High

940318

FBX6
F-box only protein 6

1

2

High-throughput

0.479

High

940319

RAD18
E3 ubiquitin-protein ligase RAD18

1

1

High-throughput

0.479

High

940320

PIHD1
PIH1 domain-containing protein 1

1

2

High-throughput

0.479

High

940322

WWOX
WW domain-containing oxidoreductase

1

2

High-throughput

0.479

High

940325

WRP73
WD repeat-containing protein WRAP73

1

3

High-throughput

0.479

High

940328

ZRAN1
Ubiquitin thioesterase ZRANB1

1

3

High-throughput

0.479

High

940329

UBQL2
Ubiquilin-2

1

3

High-throughput

0.479

High

940330

FZR1
Fizzy-related protein homolog

1

5

High-throughput

0.479

High

940333

HDAC5
Histone deacetylase 5

1

4

High-throughput

0.479

High

940339

TRAF6
TNF receptor-associated factor 6

1

6

High-throughput

0.479

High

940340

RBM8A
RNA-binding protein 8A

1

4

High-throughput

0.479

High

940341

NEMO
NF-kappa-B essential modulator

1

6

High-throughput

0.479

High

940312

BRF2
Transcription factor IIIB 50 kDa subunit

1

2

High-throughput

0.470

High

222860

PRC1
Protein regulator of cytokinesis 1

1

0

High-throughput

0.458

High

692902

DPP4
Dipeptidyl peptidase 4

1

0

High-throughput

0.458

High

876795

KC1A
Casein kinase I isoform alpha

1

0

High-throughput

0.458

High

940228

TFCP2
Alpha-globin transcription factor CP2

1

0

High-throughput

0.458

High

940240

BYST
Bystin

1

0

High-throughput

0.458

High

940250

IQCB1
IQ calmodulin-binding motif-containing protein 1

1

0

High-throughput

0.458

High

940269

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

940275

FBX22
F-box only protein 22

1

0

High-throughput

0.458

High

940278

FBX25
F-box only protein 25

1

0

High-throughput

0.458

High

940307

STMN4
Stathmin-4

1

0

High-throughput

0.458

High

940216

SUMO2
Small ubiquitin-related modifier 2

1

3

High-throughput

0.457

High

461316

HS90A
Heat shock protein HSP 90-alpha

1

7

Small-scale

0.457

High

605186

TAL1
T-cell acute lymphocytic leukemia protein 1

1

1

High-throughput

0.457

High

400554

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

4

High-throughput

0.445

High

529443

TAU
Microtubule-associated protein tau

1

2

High-throughput

0.445

High

911525

NCBP2
Nuclear cap-binding protein subunit 2

1

1

High-throughput

0.445

High

934339

TERA
Transitional endoplasmic reticulum ATPase

1

2

High-throughput

0.445

High

940215

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

6

High-throughput

0.445

High

940261

S27A4
Long-chain fatty acid transport protein 4

1

2

High-throughput

0.445

High

940310

MLP3A
Microtubule-associated protein 1 light chain 3 alpha

1

6

High-throughput

0.445

High

940335

ITM2B
Integral membrane protein 2B

1

2

High-throughput

0.445

High

884819

PPM1F
Protein phosphatase 1F

1

0

High-throughput

0.438

High

105659

APRIO
Alternative prion protein

1

2

High-throughput

0.437

High

194075

R113A
E3 ubiquitin-protein ligase RNF113A

1

1

High-throughput

0.437

High

353157

AGR2
Anterior gradient protein 2 homolog

1

1

High-throughput

0.437

High

588327

RFA2
Replication protein A 32 kDa subunit

1

4

High-throughput

0.437

High

695054

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

5

High-throughput

0.437

High

767818

RFA3
Replication protein A 14 kDa subunit

1

5

High-throughput

0.437

High

878848

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

2

High-throughput

0.437

High

937679

FOXA1
Hepatocyte nuclear factor 3-alpha

1

14

High-throughput

0.437

High

940226

TLE2
Transducin-like enhancer protein 2

1

8

High-throughput

0.437

High

940241

GRM2
Metabotropic glutamate receptor 2

1

1

High-throughput

0.437

High

940243

RBM39
RNA-binding protein 39

1

2

High-throughput

0.437

High

940256

ANR55
Ankyrin repeat domain-containing protein 55

1

2

High-throughput

0.437

High

940263

LMBRL
Protein LMBR1L

1

2

High-throughput

0.437

High

940266

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

2

High-throughput

0.437

High

940270

ZCH18
Zinc finger CCCH domain-containing protein 18

1

1

High-throughput

0.437

High

940285

ESR2
Estrogen receptor beta

1

4

High-throughput

0.437

High

940288

LENG1
Leukocyte receptor cluster member 1

1

1

High-throughput

0.437

High

940299

Q9BPW0
Serine/threonine-protein phosphatase

1

1

High-throughput

0.437

High

940305

SPRTN
DNA-dependent metalloprotease SPRTN

1

1

High-throughput

0.437

High

940326

TR10D
Tumor necrosis factor receptor superfamily member 10D

1

1

High-throughput

0.437

High

940332

TRI33
E3 ubiquitin-protein ligase TRIM33

1

3

High-throughput

0.437

High

940336

AAR2
Protein AAR2 homolog

1

2

High-throughput

0.437

High

940302

HNRL1
Heterogeneous nuclear ribonucleoprotein U-like protein 1

1

3

High-throughput

0.417

High

886683

CEBPA
CCAAT/enhancer-binding protein alpha

1

6

High-throughput

0.408

High

991

SIM26
Small integral membrane protein 26

1

1

High-throughput

0.407

High

429601

JUN
Transcription factor Jun

1

10

High-throughput

0.407

High

940291

RMC1
Regulator of MON1-CCZ1 complex

1

0

High-throughput

0.279

Low

940292

COQ2
4-hydroxybenzoate polyprenyltransferase, mitochondrial

1

0

High-throughput

0.279

Low

940303

TM147
BOS complex subunit TMEM147

1

0

High-throughput

0.279

Low

940308

UN93B
Protein unc-93 homolog B1

1

0

High-throughput

0.279

Low

940279

OXER1
Oxoeicosanoid receptor 1

1

0

High-throughput

0.269

Low

940282

DCAF4
DDB1- and CUL4-associated factor 4

1

0

High-throughput

0.249

Low

940321

B3GN2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

1

0

High-throughput

0.249

Low

940323

CWC15
Spliceosome-associated protein CWC15 homolog

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025