Protein: CD177
CD177 antigen (Human neutrophil alloantigen 2a) (HNA-2a) (NB1 glycoprotein) (NB1 GP) (Polycythemia rubra vera protein 1) (PRV-1) (CD antigen CD177)

Gene: CD177
Organism: Homo sapiens
Interactions: 101
UniProt ID: Q8N6Q3

Gene Ontology (top 5):
GO:0002020 - protease binding
GO:0005178 - integrin binding
GO:0005886 - plasma membrane
GO:0007155 - cell adhesion
GO:0007159 - leukocyte cell-cell adhesion

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1329627

CSEN
Calsenilin

4

2

High-throughput

0.705

High

1329619

TX101
Testis-expressed protein 101

1

1

High-throughput

0.691

High

1033074

EWS
RNA-binding protein EWS

1

0

High-throughput

0.518

High

407814

SHBG
Sex hormone-binding globulin

1

0

Small-scale

0.460

High

72705

MYO1G
Unconventional myosin-Ig [Cleaved into: Minor histocompatibility antigen HA-2

1

1

Small-scale

0.445

High

297361

DYSF
Dysferlin

1

1

Small-scale

0.445

High

299288

FLOT1
Flotillin-1

1

2

Small-scale

0.445

High

321305

ERLN2
Erlin-2

1

3

Small-scale

0.445

High

343184

RAB3D
Ras-related protein Rab-3D

1

7

Small-scale

0.445

High

391050

TRFL
Lactotransferrin

1

1

Small-scale

0.445

High

418704

GNAI2
Guanine nucleotide-binding protein G(i) subunit alpha-2

1

4

Small-scale

0.445

High

424089

ITB2
Integrin beta-2

1

2

Small-scale

0.445

High

424223

S10A8
Protein S100-A8

1

1

Small-scale

0.445

High

424963

ADT2
ADP/ATP translocase 2

1

2

Small-scale

0.445

High

426027

PPBT
Alkaline phosphatase, tissue-nonspecific isozyme

1

2

Small-scale

0.445

High

445027

S10A9
Protein S100-A9

1

1

Small-scale

0.445

High

463652

LYN
Tyrosine-protein kinase Lyn

1

1

Small-scale

0.445

High

469814

CATG
Cathepsin G

1

1

Small-scale

0.445

High

470317

NEP
Neprilysin

1

1

Small-scale

0.445

High

470427

ITA2B
Integrin alpha-IIb

1

4

Small-scale

0.445

High

473444

HCK
Tyrosine-protein kinase HCK

1

1

Small-scale

0.445

High

475999

GNAI3
Guanine nucleotide-binding protein G(i) subunit alpha-3

1

5

Small-scale

0.445

High

539481

ITAM
Integrin alpha-M

1

4

Small-scale

0.445

High

547019

GNAT1
Guanine nucleotide-binding protein G(t) subunit alpha-1

1

5

Small-scale

0.445

High

548546

MPRI
Cation-independent mannose-6-phosphate receptor

1

1

Small-scale

0.445

High

580657

AMPN
Aminopeptidase N

1

1

Small-scale

0.445

High

630429

RAB3A
Ras-related protein Rab-3A

1

8

Small-scale

0.445

High

630885

RAB4A
Ras-related protein Rab-4A

1

8

Small-scale

0.445

High

631672

RAB6A
Ras-related protein Rab-6A

1

7

Small-scale

0.445

High

634726

ITAL
Integrin alpha-L

1

4

Small-scale

0.445

High

640954

VDAC1
Non-selective voltage-gated ion channel VDAC1

1

2

Small-scale

0.445

High

652633

CAH4
Carbonic anhydrase 4

1

1

Small-scale

0.445

High

717542

PDIA3
Protein disulfide-isomerase A3

1

1

Small-scale

0.445

High

766691

PHB1
Prohibitin 1

1

1

Small-scale

0.445

High

773227

MYH10
Myosin-10

1

2

Small-scale

0.445

High

799629

GNAL
Guanine nucleotide-binding protein G(olf) subunit alpha

1

5

Small-scale

0.445

High

862906

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

1

Small-scale

0.445

High

900924

RAB5C
Ras-related protein Rab-5C

1

7

Small-scale

0.445

High

901390

RAB7A
Ras-related protein Rab-7a

1

5

Small-scale

0.445

High

922468

CLH2
Clathrin heavy chain 2

1

2

Small-scale

0.445

High

947475

RAB15
Ras-related protein Rab-15

1

6

Small-scale

0.445

High

955967

RAB8A
Ras-related protein Rab-8A

1

5

Small-scale

0.445

High

956393

RAB2A
Ras-related protein Rab-2A

1

8

Small-scale

0.445

High

956752

RAB10
Ras-related protein Rab-10

1

5

Small-scale

0.445

High

957969

RAB14
Ras-related protein Rab-14

1

7

Small-scale

0.445

High

959363

RAP1B
Ras-related protein Rap-1b

1

6

Small-scale

0.445

High

981317

RAB1A
Ras-related protein Rab-1A

1

6

Small-scale

0.445

High

982102

RAP1A
Ras-related protein Rap-1A

1

5

Small-scale

0.445

High

983532

GBB1
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

1

3

Small-scale

0.445

High

984196

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

3

Small-scale

0.445

High

989759

GNAS2
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short

1

4

Small-scale

0.445

High

997428

TBB4B
Tubulin beta-4B chain

1

5

Small-scale

0.445

High

1026131

CLH1
Clathrin heavy chain 1

1

2

Small-scale

0.445

High

1040973

GNA12
Guanine nucleotide-binding protein subunit alpha-12

1

4

Small-scale

0.445

High

1118523

TBB2A
Tubulin beta-2A chain

1

5

Small-scale

0.445

High

1124859

FLOT2
Flotillin-2

1

2

Small-scale

0.445

High

1125903

GNA13
Guanine nucleotide-binding protein subunit alpha-13

1

4

Small-scale

0.445

High

1133948

RB39A
Ras-related protein Rab-39A

1

9

Small-scale

0.445

High

1145015

RAB35
Ras-related protein Rab-35

1

5

Small-scale

0.445

High

1155367

RB11B
Ras-related protein Rab-11B

1

6

Small-scale

0.445

High

1234811

RAB12
Ras-related protein Rab-12

1

8

Small-scale

0.445

High

1329615

RAB8B
Ras-related protein Rab-8B

1

4

Small-scale

0.445

High

1329616

RAB3C
Ras-related protein Rab-3C

1

7

Small-scale

0.445

High

1329617

PHB2
Prohibitin-2

1

1

Small-scale

0.445

High

1329618

ESYT1
Extended synaptotagmin-1

1

1

Small-scale

0.445

High

1329621

RAB1B
Ras-related protein Rab-1B

1

4

Small-scale

0.445

High

1329623

GBB4
Guanine nucleotide-binding protein subunit beta-4

1

3

Small-scale

0.445

High

1329626

VDAC3
Non-selective voltage-gated ion channel VDAC3

1

2

Small-scale

0.445

High

1329629

TLN1
Talin-1

1

1

Small-scale

0.445

High

286683

STX11
Syntaxin-11

1

0

Small-scale

0.426

High

416964

CY24B
NADPH oxidase 2

1

0

Small-scale

0.426

High

420617

AT1A1
Sodium/potassium-transporting ATPase subunit alpha-1

1

0

Small-scale

0.426

High

425739

PERM
Myeloperoxidase

1

0

Small-scale

0.426

High

443882

ATPB
ATP synthase F(1) complex subunit beta, mitochondrial

1

0

Small-scale

0.426

High

471551

CD14
Monocyte differentiation antigen CD14

1

0

Small-scale

0.426

High

471749

PTPRC
Receptor-type tyrosine-protein phosphatase C

1

0

Small-scale

0.426

High

474825

VIME
Vimentin

1

0

Small-scale

0.426

High

587738

DESP
Desmoplakin

1

0

Small-scale

0.426

High

602995

BPI
Bactericidal permeability-increasing protein

1

0

Small-scale

0.426

High

683869

MOES
Moesin

1

0

Small-scale

0.426

High

890636

RGS19
Regulator of G-protein signaling 19

1

0

Small-scale

0.426

High

952604

MYL6
Myosin light polypeptide 6

1

0

Small-scale

0.426

High

961543

VA0D1
V-type proton ATPase subunit d 1

1

0

Small-scale

0.426

High

1015599

RHOG
Rho-related GTP-binding protein RhoG

1

0

Small-scale

0.426

High

1329614

SORL
Sortilin-related receptor

1

0

Small-scale

0.426

High

1329622

EHD1
EH domain-containing protein 1

1

0

Small-scale

0.426

High

1329625

MMP25
Matrix metalloproteinase-25

1

0

Small-scale

0.426

High

283306

ERLN1
Erlin-1

1

1

Small-scale

0.407

High

552312

ADT3
ADP/ATP translocase 3

1

2

Small-scale

0.407

High

572370

CX7A2
Cytochrome c oxidase subunit 7A2, mitochondrial

1

1

Small-scale

0.407

High

651834

QCR2
Cytochrome b-c1 complex subunit 2, mitochondrial

1

2

Small-scale

0.407

High

888537

ACADV
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial

1

2

Small-scale

0.407

High

1005400

CP4F2
Cytochrome P450 4F2

1

1

Small-scale

0.407

High

1064265

CP4F3
Cytochrome P450 4F3

1

1

Small-scale

0.407

High

1153501

RAB30
Ras-related protein Rab-30

1

6

Small-scale

0.407

High

1199212

DHB12
Very-long-chain 3-oxoacyl-CoA reductase

1

1

Small-scale

0.407

High

1329620

RB33B
Ras-related protein Rab-33B

1

8

Small-scale

0.407

High

1329624

APMAP
Adipocyte plasma membrane-associated protein

1

1

Small-scale

0.407

High

702625

NDUS1
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial

1

0

Small-scale

0.232

Low

1315578

MICU2
Calcium uptake protein 2, mitochondrial

1

0

Small-scale

0.232

Low

1329628

DHRS7
Dehydrogenase/reductase SDR family member 7

1

0

Small-scale

0.232

Low


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Last updated: 11Aug2025