Protein: PTTG1
Securin (Esp1-associated protein) (Pituitary tumor-transforming gene 1 protein) (Tumor-transforming protein 1) (hPTTG)

Gene: PTTG1
Organism: Homo sapiens
Interactions: 61
UniProt ID: O95997

Gene Ontology (top 5):
GO:0004869 - cysteine-type endopeptidase inhibitor activity
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0006281 - DNA repair

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

353814

ESPL1
Separin

9

0

Small-scale

0.925

High

353810

CDC20
Cell division cycle protein 20 homolog

28

1

Small-scale

0.769

High

353830

FZR1
Fizzy-related protein homolog

24

1

Small-scale

0.767

High

353793

CDC27
Cell division cycle protein 27 homolog

5

0

Small-scale

0.680

High

353816

DECR
2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial

4

0

High-throughput

0.667

High

353827

APC11
Anaphase-promoting complex subunit 11

3

0

Small-scale

0.627

High

353783

P53
Cellular tumor antigen p53

2

0

Small-scale

0.603

High

353829

ANC2
Anaphase-promoting complex subunit 2

2

1

Small-scale

0.602

High

353796

CRK
Adapter molecule crk

2

1

High-throughput

0.576

High

353789

PLCG2
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2

2

0

High-throughput

0.569

High

353818

2ABD
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform

1

0

Small-scale

0.561

High

251689

BUB1B
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta

1

2

Small-scale

0.561

High

353802

PTTG
Pituitary tumor-transforming gene 1 protein-interacting protein

1

0

Small-scale

0.549

High

353794

DNJA1
DnaJ homolog subfamily A member 1

1

0

Small-scale

0.537

High

353798

RS10
Small ribosomal subunit protein eS10

1

0

Small-scale

0.537

High

353811

CUL1
Cullin-1

1

0

Small-scale

0.537

High

353787

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.518

High

250394

HNRPQ
Heterogeneous nuclear ribonucleoprotein Q

1

0

High-throughput

0.513

High

340275

YETS4
YEATS domain-containing protein 4

1

0

High-throughput

0.513

High

353797

BAG6
Large proline-rich protein BAG6

1

0

High-throughput

0.513

High

353803

PMS1
PMS1 protein homolog 1

1

0

High-throughput

0.513

High

353817

ACTBL
Beta-actin-like protein 2

1

0

High-throughput

0.513

High

353819

TTLL5
Tubulin polyglutamylase TTLL5

1

0

High-throughput

0.513

High

353820

ZC3H3
Zinc finger CCCH domain-containing protein 3

1

0

High-throughput

0.513

High

353821

ROAA
Heterogeneous nuclear ribonucleoprotein A/B

1

0

High-throughput

0.513

High

353785

XRCC6
X-ray repair cross-complementing protein 6

1

0

Small-scale

0.504

High

325636

UBR5
E3 ubiquitin-protein ligase UBR5

1

1

Small-scale

0.501

High

353782

PTTG1
Securin

1

0

High-throughput

0.493

High

169876

AURKA
Aurora kinase A

1

0

Small-scale

0.480

High

240411

PRKN
E3 ubiquitin-protein ligase parkin

1

0

Small-scale

0.480

High

303069

ZFAN5
AN1-type zinc finger protein 5

1

0

Small-scale

0.480

High

353784

CADH1
Cadherin-1

1

0

Small-scale

0.480

High

353799

UB2R1
Ubiquitin-conjugating enzyme E2 R1

1

0

Small-scale

0.480

High

353805

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

0

Small-scale

0.480

High

353812

UBE4A
Ubiquitin conjugation factor E4 A

1

0

Small-scale

0.480

High

353815

2A5A
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform

1

0

Small-scale

0.480

High

353824

APC1
Anaphase-promoting complex subunit 1

1

0

Small-scale

0.480

High

353828

APC4
Anaphase-promoting complex subunit 4

1

0

Small-scale

0.480

High

353831

KCC2A
Calcium/calmodulin-dependent protein kinase type II subunit alpha

1

0

Small-scale

0.480

High

353791

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

1

Small-scale

0.479

High

353792

MK01
Mitogen-activated protein kinase 1

1

1

Small-scale

0.479

High

353795

PK3CA
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

1

1

Small-scale

0.479

High

353804

RD23A
UV excision repair protein RAD23 homolog A

1

1

Small-scale

0.479

High

172383

XPO1
Exportin-1

1

0

High-throughput

0.458

High

221226

DCX
Neuronal migration protein doublecortin

1

0

Small-scale

0.458

High

353788

CREB1
Cyclic AMP-responsive element-binding protein 1

1

0

High-throughput

0.458

High

353790

TNR6
Tumor necrosis factor receptor superfamily member 6

1

0

High-throughput

0.458

High

353800

CEBPD
CCAAT/enhancer-binding protein delta

1

0

Small-scale

0.458

High

353801

NUP98
Nuclear pore complex protein Nup98-Nup96

1

0

Small-scale

0.458

High

353806

RS14
Small ribosomal subunit protein uS11

1

0

Small-scale

0.458

High

353807

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

1

0

Small-scale

0.458

High

353808

RAE1L
mRNA export factor RAE1

1

0

Small-scale

0.458

High

353823

UBP44
Ubiquitin carboxyl-terminal hydrolase 44

1

0

Small-scale

0.458

High

353825

SMUF1
E3 ubiquitin-protein ligase SMURF1

1

0

Small-scale

0.458

High

353832

FBW1A
F-box/WD repeat-containing protein 1A

1

0

Small-scale

0.458

High

353813

KEAP1
Kelch-like ECH-associated protein 1

1

0

High-throughput

0.391

High

353809

PGBM
Basement membrane-specific heparan sulfate proteoglycan core protein

1

0

High-throughput

0.279

Low

353822

RM01
Large ribosomal subunit protein uL1m

1

0

High-throughput

0.279

Low

353826

ZCC17
Zinc finger CCHC domain-containing protein 17

1

0

High-throughput

0.279

Low

353786

LYL1
Protein lyl-1

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025